Mayo Clinic Holidays

Book a Hotel + Flight or Car together to unlock savings

Where to stay in Mayo Clinic

Find the best Mayo Clinic areas and neighborhoods for the activities you enjoy most. Learn more about Mayo Clinic

The U.S. Airways Center with a large illuminated sign, surrounded by glass buildings and potted plants.

Downtown Phoenix

3 out of top 10 points of interest in this area

Known for its ample dining options and great live music, there's plenty to explore in Downtown Phoenix. You can visit top attractions like Chase Field and Mortgage Matchup Center, and jump on the metro at 12th Street - Jefferson Station or 12th Street - Washington Station to see more of the city.

A building with a sign reading "MODE SALON + SPA" and a brick facade.

Old Town

Gourmet restaurants interesting history and top sights from Scottsdale Waterfront to Western Spirit: Scottsdale's Museum of the West – discover Old Town, a destination also famous for its shopping.

A hiker on a rocky trail with mountains in the background.

Rio Verde Foothills

If you're looking for some top things to see and do in Rio Verde Foothills and surrounding area, you can visit Tom's Thumb Trail and Golf Club Scottsdale.

A desert landscape with a large rock arch, a group of people climbing a hill, and distant mountains.

Camelback East

You might take some time to check out the abundant dining options in Camelback East. Spend some time visiting top spots like Biltmore Fashion Park, and catch the metro at 44th Street - Washington Station or 50th Street Station to see more of the area.

An aerial view of a residential area with a lake, boats, and houses.

The Islands

The Islands might not have many top sights, but Chandler Center for the Arts and Golfland Sunsplash are two attractions nearby that you can check out.

Top hotels in Mayo Clinic

Hilton Phoenix Tapatio Cliffs Resort

11111 N 7th St Phoenix AZ

Fully refundableReserve now, pay when you stay

2.655.475 ₫

4.149.038 ₫ total

28 Aug - 29 Aug

includes taxes & fees

8.8/10 Excellent! (3,024 reviews)

"Was excellent stay! Staff was fantastic and I love how you can text to ask questions or if you need things."

Reviewed on 25 Aug 2026

FOUNDRE Phoenix

1100 N Central Avenue Phoenix AZ

Fully refundableReserve now, pay when you stay

2.232.918 ₫

3.233.683 ₫ total

26 Aug - 27 Aug

includes taxes & fees

9/10 Wonderful! (2,832 reviews)

"It’s so nice and pet friendly (: great little bar down stairs w good food too! Great location as well. I loved staying here."

Reviewed on 25 Aug 2026

Talking Stick Resort

9800 E. Talking Stick Way Scottsdale AZ

3.113.027 ₫

4.294.040 ₫ total

7 Sept - 8 Sept

includes taxes & fees

9.4/10 Exceptional! (5,091 reviews)

"Good clean room, nice casino and poker room."

Reviewed on 25 Aug 2026

See all 13,310 properties in Mayo Clinic

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Mayo Clinic holiday package cost?

Starting from as low as , a package is your gateway to low-priced travel. Customize your Mayo Clinic trip by choosing from our extensive range of hotels, flights and rental cars.

How do I get a cheap travel package to Mayo Clinic?

Our Mayo Clinic holiday packages promise plenty of savings for the savvy globetrotter. For the best deals, simply combine your flights, hotels and activities into an affordable package. But low prices are just the beginning of your next unforgettable adventure. Book with Expedia and and you'll have over 550 airlines and 1null000null000 properties throughout the world to pick from. No matter your budget or style, there's a holiday package that's perfect for you.

Where should I stay in Mayo Clinic?

Cross Tournament Players Club of Scottsdale off your must-see list and then stay right near it. Soak up the exciting vibe around this terrific attraction and drop by whenever the mood strikes!

What are the top hotels in Mayo Clinic?

Whether you plan to stay for a night or a week in Mayo Clinic, you'll get a great night's rest at Sonesta Select Scottsdale at Mayo Clinic Campus. This option is popular with plenty of travellers.

How far in advance should I book my Mayo Clinic holiday?

Search Expedia to compare international flights as early as possible. In most cases, you can purchase a seat up to 12 months prior to departure. If it's too early for your preferred carrier, or you have to book last minute, don't despair. Cheap fares to Mayo Clinic sometimes occur within weeks of departure.

What does an Expedia Mayo Clinic travel package include?

It all depends on what sort of trip you have in the works. Mayo Clinic holiday deals can include car rentals, hotels and flights. You can mix and match to find the travel package that suits your style and budget. You can also add on activities and experiences after you've booked to score even bigger discounts.

What should I know before booking a Mayo Clinic travel package?

When you book your flights, hotels and car rentals together, you'll walk away with awesome discounts. Whether you're planning a beach break in a villa or want to stay in a fancy hotel in the city, Expedia will help make it happen.

Can I choose my airline with a Mayo Clinic Expedia holiday package?

You can, and with over 550 airlines to choose from all over the world, you've got lots of choice. Take a look at the available options and find out which airline fits your budget and needs.

If I'm not able to travel, can I cancel my Mayo Clinic holiday package?

You sure can, and we'll help you every step of the way. You may be able to cancel and rebook your Mayo Clinic holiday package at no cost if you booked in the last 24 hours. But you may incur a fee from your hotel, airline or car rental company if you booked more than 24 hours ago. If your travel plans suddenly change, have a look at our Customer Service Portal for further information.