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Check prices for these dates

Next weekend
9 Oct - 11 Oct
In two weeks
16 Oct - 18 Oct

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Our top choices for Medical Center District hotels

A spacious lobby with multiple seating areas, a central coffee table, and a view of the upper floors.

1. Drury Inn & Suites San Antonio Northwest Medical Center

Drury Inn & Suites San Antonio Northwest Medical Center
3.0 star property
Medical Center District
9.2 out of 10, Wonderful, (1,471 reviews)
"Breakfast was delicious, everything very clean and organized. Pool area was great easy check in and check out."
United States
Alba
The price is 2.337.400 ₫
2.763.019 ₫ total
includes taxes & fees
26 Oct - 27 Oct
Drury Inn & Suites San Antonio Northwest Medical Center
A hotel dining area with multiple tables and chairs, a counter with a coffee machine, and a view of the outside through large windows.

2. La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
3.0 star property
Medical Center District
8.4 out of 10, Very good, (3,700 reviews)
"We had a great stay"
United States
Maria
The price is 2.306.491 ₫
2.726.231 ₫ total
includes taxes & fees
4 Oct - 5 Oct
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
A modern bar area with wooden bar counters, black bar stools, and pendant lighting.

3. Courtyard by Marriott Medical Center San Antonio

Courtyard by Marriott Medical Center San Antonio
3.0 star property
Medical Center District
8.8 out of 10, Excellent, (1,005 reviews)
"Amazing stay!!!!"
United States
Erik
The price is 2.548.049 ₫
3.012.023 ₫ total
includes taxes & fees
11 Oct - 12 Oct
Courtyard by Marriott Medical Center San Antonio
A spacious lobby with a central staircase, seating area, and large windows.

4. San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center
3.5 star property
Medical Center District
8.6 out of 10, Excellent, (1,168 reviews)
"The property was beautiful the staff was incredible"
United States
Adreanne
The price is 2.609.809 ₫
3.101.401 ₫ total
includes taxes & fees
2 Nov - 3 Nov
San Antonio Marriott Northwest Medical Center
A modern living room with a fireplace, a flat-screen TV, and a stone accent wall.

5. Fairfield Inn & Suites by Marriott San Antonio Medical Center

Fairfield Inn & Suites by Marriott San Antonio Medical Center
3.0 star property
Medical Center District
9.0 out of 10, Wonderful, (1,089 reviews)
"Great service, nice and neat hotel."
United States
Freddie
The price is 2.247.356 ₫
2.623.788 ₫ total
includes taxes & fees
1 Nov - 2 Nov
Fairfield Inn & Suites by Marriott San Antonio Medical Center
A modern kitchen with a large window, wooden counter, and two bar stools.

6. Park Inn by Radisson, Medical Center

Park Inn by Radisson, Medical Center
2.0 star property
Medical Center District
7.4 out of 10, Good, (1,000 reviews)
"My room was clean, the staff were very helpful and kind."
United States
Joanne
The price is 1.744.154 ₫
2.036.299 ₫ total
includes taxes & fees
1 Nov - 2 Nov
Park Inn by Radisson, Medical Center
A hotel room with two beds, a desk, a chair, a mirror, and a bathroom.

7. Studio 6 San Antonio, Tx - Northwest Medical Center

Studio 6 San Antonio, Tx - Northwest Medical Center
2.0 star property
Medical Center District
7.4 out of 10, Good, (384 reviews)
"It's a good place to stay I"
United States
Ruben
The price is 1.218.440 ₫
1.422.530 ₫ total
includes taxes & fees
15 Oct - 16 Oct
Studio 6 San Antonio, Tx - Northwest Medical Center
A modern bedroom with a large bed, bedside tables, a desk, and a chair.

8. Motel 6 San Antonio, TX - Northwest Medical Center

Motel 6 San Antonio, TX - Northwest Medical Center
2.0 star property
Medical Center District
6.0 out of 10, (999 reviews)
"Staff was very helpful. Room was ok."
United States
Brian
The price is 1.168.830 ₫
1.485.558 ₫ total
includes taxes & fees
16 Oct - 17 Oct
Motel 6 San Antonio, TX - Northwest Medical Center
A gas station with a sign for 'Atria Inn & Suites' and a 'Clearance - 12' sign.

9. Atria Inn & Suites

Atria Inn & Suites
2.0 star property
Medical Center District
7.4 out of 10, Good, (316 reviews)
"Amazing comfortable and affordable"
United States
José
The price is 1.499.998 ₫
1.751.248 ₫ total
includes taxes & fees
4 Oct - 5 Oct
Atria Inn & Suites
A building entrance with a glass door, a Pepsi vending machine, and a yellow bollard.

10. OYO Inn & Suites Medical Center San Antonio

OYO Inn & Suites Medical Center San Antonio
2.0 star property
Medical Center District
7.4 out of 10, Good, (248 reviews)
"great place to stay close to the hospital. Would stay there again"
United States
Melanie
The price is 1.681.816 ₫
2.131.702 ₫ total
includes taxes & fees
1 Nov - 2 Nov
OYO Inn & Suites Medical Center San Antonio
A hotel room with a large bed, a desk with a chair, a television on a stand, and a mirror on the wall.

11. Flex Studios

Flex Studios
2.5 star property
Medical Center District
6.2 out of 10, (574 reviews)
"Yes I would stay again"
United States
Jasper
The price is 1.142.856 ₫
1.350.960 ₫ total
includes taxes & fees
4 Oct - 5 Oct
Flex Studios
A hotel room with two beds, a TV, a desk, and a kitchenette in the background.

12. Studio 6 Extended Stay - San Antonio, TX - Medical Center

Studio 6 Extended Stay - San Antonio, TX - Medical Center
2.0 star property
Medical Center District
6.8 out of 10, (995 reviews)
"Good for a short stay traveling through the SA area."
United States
Jerron
Studio 6 Extended Stay - San Antonio, TX - Medical Center
A modern bar area with a central island, bar stools, and a kitchen counter with appliances.

13. Hyatt Place San Antonio-Northwest/Medical Center

Hyatt Place San Antonio-Northwest/Medical Center
3.0 star property
3.7 km from Medical Center District
8.4 out of 10, Very good, (1,066 reviews)
"Clean room, good Staff and delicious breakfast."
United States
Alejandra
The price is 2.416.791 ₫
2.888.570 ₫ total
includes taxes & fees
18 Oct - 19 Oct
Hyatt Place San Antonio-Northwest/Medical Center
A covered outdoor seating area with lounge chairs and umbrellas, a pool in the background, and potted plants.

14. Embassy Suites by Hilton San Antonio Landmark

Embassy Suites by Hilton San Antonio Landmark
3.5 star property
La Cantera District, 9.2 km from Medical Center District
9.6 out of 10, Exceptional, (1,002 reviews)
"Very nice employees, great welcoming, great breakfast"
United States
Lenita
The price is 4.474.961 ₫
5.289.807 ₫ total
includes taxes & fees
1 Nov - 2 Nov
Embassy Suites by Hilton San Antonio Landmark
A hotel pool area with lounge chairs and a building with large windows in the background.

15. The Westin San Antonio North

The Westin San Antonio North
4.0 star property
3.4 km from Medical Center District
8.4 out of 10, Very good, (1,646 reviews)
"Safe and secure location, nice hotel. It's on my list now."
United States
Jack
The price is 2.429.784 ₫
2.913.023 ₫ total
includes taxes & fees
2 Nov - 3 Nov
The Westin San Antonio North
A modern lobby with a sofa, patterned chairs, a central ottoman, and a chandelier.

16. Drury Plaza Hotel San Antonio Airport

Drury Plaza Hotel San Antonio Airport
3.0 star property
9 km from Medical Center District
9.4 out of 10, Exceptional, (2,300 reviews)
"Very close to the airport, food nearby"
United States
Jay
The price is 2.960.776 ₫
3.499.904 ₫ total
includes taxes & fees
15 Oct - 16 Oct
Drury Plaza Hotel San Antonio Airport
A modern lobby with seating areas, a stone accent wall, and a wooden ceiling.

17. Heritage Inn & Suites San Antonio Airport, Trademark Wyndham

Heritage Inn & Suites San Antonio Airport, Trademark Wyndham
2.5 star property
Uptown Central, 9.3 km from Medical Center District
9.0 out of 10, Wonderful, (2,270 reviews)
"It was a great place to stay!"
United States
Amy
The price is 2.077.660 ₫
2.456.101 ₫ total
includes taxes & fees
4 Oct - 5 Oct
Heritage Inn & Suites San Antonio Airport, Trademark Wyndham
A modern kitchen with a central island, built-in appliances, and a coffee station.

18. Wyndham Garden San Antonio Airport

Wyndham Garden San Antonio Airport
3.0 star property
Uptown Central, 9.2 km from Medical Center District
8.6 out of 10, Excellent, (1,970 reviews)
"Location is good and close to airport"
United States
SWAROOP JADHAV
The price is 2.257.490 ₫
2.668.556 ₫ total
includes taxes & fees
4 Oct - 5 Oct
Wyndham Garden San Antonio Airport
A hotel room with a bed, a sofa, a desk, and a chair.

19. Holiday Inn Express & Suites San Antonio Medical-Six Flags by IHG

Holiday Inn Express & Suites San Antonio Medical-Six Flags by IHG
2.5 star property
Northwest Side, 4.3 km from Medical Center District
8.0 out of 10, Very good, (1,250 reviews)
"Clean, nice location, great breakfast, and very comfortable rooms."
United States
Madecael
The price is 2.155.842 ₫
2.548.309 ₫ total
includes taxes & fees
27 Oct - 28 Oct
Holiday Inn Express & Suites San Antonio Medical-Six Flags by IHG
A modern building with a distinctive roof structure and a large illuminated sign.

20. Aloft by Marriott San Antonio UTSA Area

Aloft by Marriott San Antonio UTSA Area
3.0 star property
Northwest Side, 7.8 km from Medical Center District
9.0 out of 10, Wonderful, (1,001 reviews)
"Good stay"
United States
Juan
The price is 2.747.530 ₫
3.247.828 ₫ total
includes taxes & fees
11 Oct - 12 Oct
Aloft by Marriott San Antonio UTSA Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in Medical Center District

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A spacious lobby with multiple seating areas, a central coffee table, and a view of the upper floors.
Drury Inn & Suites San Antonio Northwest Medical Center
3.0 star property
9.2
Wonderful
1,471 reviews
View
A modern living room with a fireplace, a flat-screen TV, and a stone accent wall.
Fairfield Inn & Suites by Marriott San Antonio Medical Center
3.0 star property
9.0
Wonderful
1,089 reviews
View
A modern bar area with wooden bar counters, black bar stools, and pendant lighting.
Courtyard by Marriott Medical Center San Antonio
3.0 star property
8.8
Excellent
1,005 reviews
View
A spacious lobby with a central staircase, seating area, and large windows.
San Antonio Marriott Northwest Medical Center
3.5 star property
8.6
Excellent
1,168 reviews
View
A hotel dining area with multiple tables and chairs, a counter with a coffee machine, and a view of the outside through large windows.
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
3.0 star property
8.4
Very good
3,700 reviews
View

Where to stay in Medical Center District

Find the best Medical Center District areas for the activities you enjoy most.
A boat tour on a canal with a bridge in the background.

Downtown San Antonio

A scenic riverfront great entertainment and top sights from Alamo to Alamodome – discover Downtown San Antonio, a destination also famous for its historic sites.

A riverside walkway with colorful umbrellas, a stone bridge, and historic buildings.

Far West Side

While visiting Far West Side, you might make a stop by sights like Aquatica San Antonio Waterpark and Hill Country Golf Club.

A riverside walkway adorned with colorful umbrellas and festive lights.

Uptown Central

If you're spending some time in Uptown Central, Marion Koogler McNay Art Museum and Alamo Quarry Market are top sights worth seeing.

A historic stone building with a central arched doorway, a flagpole with a flag, and a paved courtyard.

Northwest Side

If you're spending some time in Northwest Side, Huebner Oaks and Crystal Ice Palace are top sights worth seeing.

A historic stone building with a large wooden door, arched windows, and ornate columns.

Stone Oak

Stone Oak is known for its abundant dining options, and you can plan a trip to Shops at Hardy Oak and Alta Vista at Stone Oak while you're in town.

Top Medical Center District Hotel Reviews

Drury Plaza Hotel San Antonio Riverwalk

Drury Plaza Hotel San Antonio Riverwalk

10/10 Excellent
"Beautiful"
jennifer 2-night trip
Posted less than an hour ago
Drury Plaza Hotel San Antonio Riverwalk

Frequently asked questions

What is Medical Center District like?
Travellers are sure to enjoy a stay in San Antonio's Medical Center District neighbourhood. Consider a visit to Cinemark San Antonio 16 as part of your Medical Center District travel plans.
How many hotels will I be able to find in Medical Center District?
Expedia has 124 hotels and other accommodation options in Medical Center District to choose from, making this an ideal home base for exploring the greater San Antonio area.
If I need to cancel my hotel reservation in Medical Center District, will I receive a refund?
Yes, you'll find most hotel reservations are fully refundable if you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, you may still be able to cancel and receive a refund within a 24-hour period of your booking. Add your dates and click on "Search", then use the "fully refundable" filter to review the top deals on offer in Medical Center District.
What can I see and do in this San Antonio neighbourhood?
Cinemark San Antonio 16 is an attraction you might want to check out while you're in Medical Center District. Wonderland of the Americas Mall and Regal Huebner Oaks are also worth a visit when you're out sightseeing in San Antonio.