Search Hotels in Medical Center District, San Antonio

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26 Dec - 27 Dec
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Our top choices for Medical Center District hotels

Lobby
San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center
3.5 star property
Medical Center District
8.6 out of 10, Excellent, (1003)
"Best hotel!"
United States
Valeria
The price is 2.881.821 ₫
3.424.444 ₫ total
includes taxes & fees
2 Jan - 3 Jan 2026
San Antonio Marriott Northwest Medical Center
Front of property
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
3.0 star property
Medical Center District
8.4 out of 10, Very good, (3120)
"Great place "
United States
Amado
The price is 2.333.842 ₫
2.758.559 ₫ total
includes taxes & fees
28 Dec - 29 Dec
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
Pool
Fairfield Inn & Suites by Marriott San Antonio Medical Center

Fairfield Inn & Suites by Marriott San Antonio Medical Center

Fairfield Inn & Suites by Marriott San Antonio Medical Center
2.5 star property
Medical Center District
9.0 out of 10, Wonderful, (1001)
"Everything was great, staff really kind ..."
United States
traci
The price is 2.181.406 ₫
2.546.791 ₫ total
includes taxes & fees
31 Dec - 1 Jan 2026
Fairfield Inn & Suites by Marriott San Antonio Medical Center
Exterior
Courtyard by Marriott Medical Center San Antonio

Courtyard by Marriott Medical Center San Antonio

Courtyard by Marriott Medical Center San Antonio
3.0 star property
Medical Center District
8.8 out of 10, Excellent, (1004)
"Clean room, very close to medical center, and personnel at check in were very friendly."
United States
Melinda
The price is 2.339.098 ₫
2.765.024 ₫ total
includes taxes & fees
2 Jan - 3 Jan 2026
Courtyard by Marriott Medical Center San Antonio
Premium bedding, pillow-top beds, in-room safe, desk
SpringHill Suites by Marriott San Antonio Medical Center/NW

SpringHill Suites by Marriott San Antonio Medical Center/NW

SpringHill Suites by Marriott San Antonio Medical Center/NW
3.0 star property
Medical Center District
8.8 out of 10, Excellent, (1000)
"good staff. good stay"
United States
Divya
The price is 2.654.482 ₫
3.137.808 ₫ total
includes taxes & fees
2 Jan - 3 Jan 2026
SpringHill Suites by Marriott San Antonio Medical Center/NW
Lobby
Drury Inn & Suites San Antonio Northwest Medical Center

Drury Inn & Suites San Antonio Northwest Medical Center

Drury Inn & Suites San Antonio Northwest Medical Center
3.0 star property
Medical Center District
9.2 out of 10, Wonderful, (1285)
"Great place to stay and visit "
United States
Harry
The price is 2.365.117 ₫
2.795.616 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Drury Inn & Suites San Antonio Northwest Medical Center
Exterior
OYO Inn & Suites Medical Center San Antonio

OYO Inn & Suites Medical Center San Antonio

OYO Inn & Suites Medical Center San Antonio
2.0 star property
Medical Center District
7.2 out of 10, Good, (225)
"Always great stay"
United States
Juan
The price is 1.419.228 ₫
1.748.936 ₫ total
includes taxes & fees
12 Jan - 13 Jan 2026
OYO Inn & Suites Medical Center San Antonio
Free daily on-the-go breakfast
Country Inn & Suites by Radisson, San Antonio Medical Center, TX

Country Inn & Suites by Radisson, San Antonio Medical Center, TX

Country Inn & Suites by Radisson, San Antonio Medical Center, TX
3.0 star property
Medical Center District
6.8 out of 10, (1000)
"Easy and convenient location "
United States
Monique
The price is 1.541.439 ₫
1.799.630 ₫ total
includes taxes & fees
18 Jan - 19 Jan 2026
Country Inn & Suites by Radisson, San Antonio Medical Center, TX
Reception
Park Inn by Radisson

Park Inn by Radisson

Park Inn by Radisson
2.0 star property
Medical Center District
7.2 out of 10, Good, (1000)
"Staff were amazing, and everything else was great too. "
United States
Maximilian
The price is 1.586.119 ₫
1.851.794 ₫ total
includes taxes & fees
23 Jan - 24 Jan 2026
Park Inn by Radisson
Desk, laptop workspace, blackout curtains, free WiFi
Studio 6 San Antonio, Tx - Northwest Medical Center

Studio 6 San Antonio, Tx - Northwest Medical Center

Studio 6 San Antonio, Tx - Northwest Medical Center
2.0 star property
Medical Center District
7.2 out of 10, Good, (222)
"Clean, and accommodating room was very a very good Choice!!"
United States
Jessica
The price is 1.392.683 ₫
1.625.958 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Studio 6 San Antonio, Tx - Northwest Medical Center
Desk, laptop workspace, free WiFi, bed sheets
Studio 6 San Antonio, TX - Medical Center

Studio 6 San Antonio, TX - Medical Center

Studio 6 San Antonio, TX - Medical Center
2.0 star property
Medical Center District
6.6 out of 10, (795)
"Staff and amenities "
United States
Keyshia
The price is 1.250.760 ₫
1.530.926 ₫ total
includes taxes & fees
31 Dec - 1 Jan 2026
Studio 6 San Antonio, TX - Medical Center
Front of property
Atria Inn & Suites

Atria Inn & Suites

Atria Inn & Suites
2.0 star property
Medical Center District
7.4 out of 10, Good, (273)
"Nice, comfortable space for a reasonable price. "
United States
Cynthia
Atria Inn & Suites
Free WiFi, bed sheets
Motel 6 San Antonio, TX - Northwest Medical Center

Motel 6 San Antonio, TX - Northwest Medical Center

Motel 6 San Antonio, TX - Northwest Medical Center
2.0 star property
Medical Center District
6.0 out of 10, (999)
"Great experience "
United States
John
The price is 1.123.556 ₫
1.328.143 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Motel 6 San Antonio, TX - Northwest Medical Center
Basic Room, Multiple Beds, Non Smoking | Desk, iron/ironing board, free WiFi, bed sheets
Flex Studios

Flex Studios

Flex Studios
2.5 star property
Medical Center District
6.0 out of 10, (498)
"heb is nearby. "
United States
Sayeed
The price is 1.088.075 ₫
1.286.203 ₫ total
includes taxes & fees
31 Dec - 1 Jan 2026
Flex Studios
Premium bedding, down duvets, individually decorated
La Quinta Inn and Suites by Wyndham Schertz-San Antonio-Selma

La Quinta Inn and Suites by Wyndham Schertz-San Antonio-Selma

La Quinta Inn and Suites by Wyndham Schertz-San Antonio-Selma
3.0 star property
31 km from Medical Center District
7.8 out of 10, Good, (1002)
"Great service rooms were clean. Food was great."
United States
Cassandra
The price is 2.147.386 ₫
2.469.494 ₫ total
includes taxes & fees
28 Dec - 29 Dec
La Quinta Inn and Suites by Wyndham Schertz-San Antonio-Selma
Courtyard
stayAPT Suites San Antonio-Randolph

stayAPT Suites San Antonio-Randolph

stayAPT Suites San Antonio-Randolph
2.5 star property
Live Oak, 24.4 km from Medical Center District
8.8 out of 10, Excellent, (457)
"Parking was easy and just overall enjoyed my stay. Nice and quiet "
United States
Jennifer
stayAPT Suites San Antonio-Randolph
Reception
Best Western Garden Inn

Best Western Garden Inn

Best Western Garden Inn
2.5 star property
Uptown, 21.2 km from Medical Center District
8.2 out of 10, Very good, (1003)
"Clean room, friendly and helpful staff."
United States
Robyn
The price is 1.786.913 ₫
2.086.222 ₫ total
includes taxes & fees
9 Jan - 10 Jan 2026
Best Western Garden Inn
Exterior
Holiday Inn Express & Suites San Antonio North - Windcrest by IHG

Holiday Inn Express & Suites San Antonio North - Windcrest by IHG

Holiday Inn Express & Suites San Antonio North - Windcrest by IHG
2.5 star property
17.5 km from Medical Center District
9.0 out of 10, Wonderful, (1001)
"The Rooms were clean and bed was comfortable "
United States
Sonal
The price is 2.500.020 ₫
2.895.813 ₫ total
includes taxes & fees
2 Jan - 3 Jan 2026
Holiday Inn Express & Suites San Antonio North - Windcrest by IHG
Exterior
Comfort Suites San Antonio Ft. Sam Houston/SAMMC Area

Comfort Suites San Antonio Ft. Sam Houston/SAMMC Area

Comfort Suites San Antonio Ft. Sam Houston/SAMMC Area
2.5 star property
17.2 km from Medical Center District
9.2 out of 10, Wonderful, (831)
"Very nice accommodations"
United States
Sandy
The price is 1.976.406 ₫
2.307.454 ₫ total
includes taxes & fees
30 Dec - 31 Dec
Comfort Suites San Antonio Ft. Sam Houston/SAMMC Area
Room, 1 King Bed, Accessible, Non Smoking | Pillow-top beds, desk, blackout curtains, iron/ironing board
Days Inn & Suites by Wyndham San Antonio near Frost Bank Center

Days Inn & Suites by Wyndham San Antonio near Frost Bank Center

Days Inn & Suites by Wyndham San Antonio near Frost Bank Center
2.5 star property
Arena District, 17.8 km from Medical Center District
8.6 out of 10, Excellent, (1003)
"Room was clean, mattress firm and not saggy, and front desk staff very friendly and kind."
United States
Ashley
The price is 1.720.157 ₫
2.008.283 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Days Inn & Suites by Wyndham San Antonio near Frost Bank Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Medical Center District

Find the best Medical Center District areas for the activities you enjoy most.
Downtown - Riverwalk showing a river or creek, a bridge and boating

Downtown San Antonio

A scenic riverfront great entertainment and top sights from San Antonio River to Aztec Theater – discover Downtown San Antonio, a destination also famous for its historic sites.

Uptown

If you're spending some time in Uptown, San Antonio River and Marion Koogler McNay Art Museum are top sights worth seeing.

Far West Side

While visiting Far West Side, you might make a stop by sights like Aquatica San Antonio Waterpark and Hill Country Golf Club.

Stone Oak

Stone Oak is known for its abundant dining options, and you can plan a trip to Shops at Hardy Oak and Alta Vista while you're in town.

Near East Side

If you're spending some time in Near East Side, Alamodome and Carver Community Cultural Center are top sights worth seeing.

Top Medical Center District Hotel Reviews

Hyatt Vacation Club at Wild Oak Ranch, San Antonio

Hyatt Vacation Club at Wild Oak Ranch, San Antonio

10/10 Excellent
"they were amazing, helped us out throughout and made our big moment even better "
Aahil 1-night trip
Posted 8 days ago
Hyatt Vacation Club at Wild Oak Ranch, San Antonio

Frequently asked questions

What is Medical Center District like?
Travellers are sure to enjoy a stay in San Antonio's Medical Center District neighbourhood. Are you looking for Medical Center District travel tips? Make sure that you visit USAA Corporate Office Headquarters and The San Antonio Art Institute while you're in the neighbourhood.
How many hotels will I be able to find in Medical Center District?
Expedia has 123 hotels and other accommodation options in Medical Center District to choose from, making this an ideal home base for exploring the greater San Antonio area.
If I need to cancel my hotel reservation in Medical Center District, will I receive a refund?
Yes, you'll find most hotel reservations are fully refundable if you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, you may still be able to cancel and receive a refund within a 24-hour period of your booking. Add your dates and click on "Search", then use the "fully refundable" filter to review the top deals on offer in Medical Center District.
What can I see and do in this San Antonio neighbourhood?
USAA Corporate Office Headquarters, The San Antonio Art Institute and Cinemark San Antonio 16 are just a few attractions to check out in Medical Center District. Wonderland of the Americas Mall and Regal Huebner Oaks are also worth a visit when you're out sightseeing in San Antonio.