Mytilene Holidays

Book a Hotel + Flight or Car together to unlock savings

Photo by Jadranka Džepina

Top hotels in Mytilene

Mythical Coast Wellness Retreat

Mythical Coast Wellness Retreat

5 out of 5
Agrilia, Lesvos
8.8/10 Excellent! (36 reviews)
"Very average but nice and quiet. Would rate it a 3 star hotel. Service very bland. No smiles. Dinner overpriced, took a very long time and was underwhelming. We were put at a table in the lobby because the restaurant was closed for an event. Room was clean. But very cheap low grade 1 star hotel amenities ..."

Reviewed on 2 Nov 2024

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Mythical Coast Wellness Retreat
Heliotrope Hotels

Heliotrope Hotels

4 out of 5
Varia, Mytilene, Lesvos, Lesvos Island
Fully refundableReserve now, pay when you stay
The price is 4.263.389 ₫ per night from 5 Sept to 6 Sept
4.263.389 ₫
4.975.579 ₫ total
5 Sept - 6 Sept
includes taxes & fees
8.6/10 Excellent! (183 reviews)
"Great people. Beautiful island"

Reviewed on 21 Jul 2025

Heliotrope Hotels
The Loriet

The Loriet

4 out of 5
Vareia, Mitilene, Lesvos, Lesvos Island
The price is 4.003.930 ₫ per night from 14 Aug to 15 Aug
4.003.930 ₫
4.692.034 ₫ total
14 Aug - 15 Aug
includes taxes & fees
8.2/10 Very Good! (69 reviews)
"Lovey building."

Reviewed on 24 Jul 2025

The Loriet
See all 163 properties in Mytilene
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

Port of Mytilene

4.5/5(7 reviews)

Explore the waterfront in Mytilene with a trip to Port of Mytilene. While you're in the area, stroll along the seaside.

Port of Mytilene

Mytilini Castle

5/5(3 reviews)

Learn about the local history of Mytilene when you spend time at Mytilini Castle. While you're in the area, stroll along the seaside.

Mytilini Castle

Thermi Beach

5/5(2 reviews)

Why not spend a care-free afternoon at Thermi Beach during your travels in Mytilene? While you're in the area, stroll along the seaside.

Thermi Beach

Frequently asked questions

How much does a Mytilene holiday package cost?
You can grab a holiday package to this top destination on Expedia. But how much your holiday to Mytilene costs will depend on the season, length of stay and hotel choice.
What are the cheapest months to go to Mytilene?
If you're hoping to score a cheap Mytilene holiday package, consider visiting in February, March and December. You're likely to find lower prices on flights and accommodation during these months — ideal for budget-conscious travellers.
How many days is enough for Mytilene?
With a well-organised schedule, you can easily tick off the main Mytilene attractions in a few days. But if you'd like to discover lesser-known spots or go on day trips, think about booking your Mytilene holiday for longer.
Is it worth booking a holiday package to Mytilene?
Well known for its history, festivals and family-friendly attractions, a Mytilene holiday is a hit with all types of travellers. Be sure to check out top sights like Olive-press Museum of Archipelagos Society and Temple of Messon, and consider renting a set of wheels for day trips to discover even more.
How to find the best Mytilene package deals?
Use Expedia's handy filters to help you find some fabulous Mytilene package deals. When you start your search, just set your maximum budget and then order the results by "Price: low to high." If you want to save, plan your trip for midweek, or browse for Mytilene package deals in the off-season. Play around with your travel dates and you may score even better discounts. As a rule of thumb, it's usually best to book your holiday package well in advance.
Is it cheaper to book a Mytilene holiday as a package?
An Expedia holiday package could land you great savings when compared to booking stays and flights separately. Better still, you can personalise your Mytilene escape to match your exact needs. Pick your preferred flight time, select the hotel type and add a car rental. Check out our great deals to see how much you can save.
When to book a holiday package to Mytilene?
Land incredible discounts by reserving your flights ahead of time with Expedia. If being spontaneous is more your thing, snap up one of our last-minute deals for an impromptu Mytilene escape.
How to plan a trip to Mytilene?

  1. Pick your dates: The things you want to do in Mytilene and your preferred season can help you decide when to go.
  2. Set your budget: Factor in costs such as flights, food and transportation when calculating how much to save for your trip to Mytilene. Then, choose a hotel that suits your budget, whether that's a wallet-friendly stay or a high-end getaway.
  3. Decide your trip length: Think about how much time you'd like to spend discovering Mytilene. Plan your itinerary so you can get to all the experiences and attractions you're interested in at a leisurely pace.
  4. Bundle your bookings: With your travel dates in place, you can combine your flights, car rental, hotels and more into a customised Mytilene holiday package.