New Madrid Holidays
Book a Hotel + Flight or Car together to unlock savings
Top hotels in New Madrid
Hampton Inn Sikeston
1240 Commerce Drive, Sikeston, MO
Fully refundableReserve now, pay when you stay
The price is 2.667.932 ₫ per night from 12 Oct to 13 Oct
2.667.932 ₫
3.020.765 ₫ total
12 Oct - 13 Oct
includes taxes & fees
8.8/10 Excellent! (401 reviews)
"Everything was enjoyable and the staff was top notch."
Reviewed on 30 Sept 2025
New Orleans Inn Portageville
600 US-61, Portageville, MO
Fully refundableReserve now, pay when you stay
8/10 Very Good! (700 reviews)
"The staff was wonderful"
Reviewed on 30 Sept 2025
Fairfield Inn & Suites by Marriott Sikeston
1239 Commerce Drive, Sikeston, MO
Fully refundableReserve now, pay when you stay
The price is 2.663.976 ₫ per night from 12 Oct to 13 Oct
2.663.976 ₫
3.016.286 ₫ total
12 Oct - 13 Oct
includes taxes & fees
9.4/10 Exceptional! (26 reviews)
"Very clean and comfortable room."
Reviewed on 4 Oct 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Popular places to visit
New Madrid Historical Museum
You can study the exhibits at New Madrid Historical Museum, a museum with a storied past, during your travels to New Madrid. Amble around the area's parks or experience its museums.
Hunter-Dawson State Historic Site
You can browse the exhibits at Hunter-Dawson State Historic Site, a museum with a story of its own, during your trip to New Madrid. Amble around the area's parks or experience its museums.
River Ridge Winery
You can enjoy a tasting or tour at River Ridge Winery during your travels to New Madrid. Amble around the area's parks or experience its museums.
