A pier extending into calm waters with a small boat docked at the end.

Find hotels in Panacea, FL from 2.710.423 ₫

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
27 Aug - 28 Aug
Tomorrow
28 Aug - 29 Aug
This weekend
28 Aug - 30 Aug
Next weekend
4 Sep - 6 Sep

Filter by

Star rating

Guest rating

Our top choices for Panacea hotels

1. The Panacea Motel

The Panacea Motel
Panacea
United States
Michelle
3.107.503 ₫
3.464.865 ₫ total
includes taxes & fees
2 Sept - 3 Sept
The Panacea Motel

2. The Lodge at Wakulla Springs

The Lodge at Wakulla Springs
Crawfordville
United States
Sherry
2.948.683 ₫
3.287.762 ₫ total
includes taxes & fees
30 Aug - 31 Aug
The Lodge at Wakulla Springs

3. Wildwood Inn

Wildwood Inn
Crawfordville
United States
Kizzy
3.126.444 ₫
3.590.316 ₫ total
includes taxes & fees
23 Sept - 24 Sept
Wildwood Inn

4. Best Western Wakulla Inn & Suites

Best Western Wakulla Inn & Suites
Crawfordville
United States
Lydia
2.900.430 ₫
3.233.979 ₫ total
includes taxes & fees
13 Sept - 14 Sept
Best Western Wakulla Inn & Suites

5. The Old Carrabelle Hotel

The Old Carrabelle Hotel
Carrabelle
United States
David
2.605.692 ₫
2.879.290 ₫ total
includes taxes & fees
1 Sept - 2 Sept
The Old Carrabelle Hotel

6. Franklin Inn

Franklin Inn
Carrabelle
United States
Jacorian
2.452.872 ₫
2.710.423 ₫ total
includes taxes & fees
1 Sept - 2 Sept
Franklin Inn

7. St James Bay Golf & Pickleball Resort

St James Bay Golf & Pickleball Resort
Carrabelle
United States
Mike
3.527.685 ₫
4.890.454 ₫ total
includes taxes & fees
29 Aug - 30 Aug
St James Bay Golf & Pickleball Resort

8. The Moorings Hotel and Marina

The Moorings Hotel and Marina
Carrabelle
United States
Tina
4.707.617 ₫
5.201.917 ₫ total
includes taxes & fees
1 Sept - 2 Sept
The Moorings Hotel and Marina
View all properties
Save an average of 15% on thousands of hotels when you're signed in

Stay near popular Panacea attractions

Alligator Point Beach

8.8/10 (10 reviews)
Escape to this pristine stretch of old coastal Florida with white sands and shallow, clear waters. Spot dolphins and sea turtles while enjoying the serenity of an undeveloped shoreline.
See properties

Bald Point State Park

8.6/10 (20 reviews)
Where Ochlockonee Bay meets Apalachee Bay, this coastal park showcases diverse ecosystems from beaches to pine flatwoods. Spot migrating raptors and monarch butterflies while hiking through pristine natural habitats.
See properties

Mashes Sand Beach

8.8/10 (3 reviews)
Mashes Sands Beach offers serene shallow waters and expansive sandbars perfect for peaceful exploration. Wade through the tea-colored Gulf waters while spotting hermit crabs and enjoying spectacular sunset views.
See properties

Wilson Beach

Wilson Beach offers a serene Gulf Coast escape with pristine shores and gentle waves far from tourist crowds. Bring supplies and enjoy peaceful beachcombing along this unspoiled natural sanctuary.
See properties

Panacea Springs

Once a popular health resort, these historic mineral springs were believed to possess healing properties in the early 1900s. Explore the remnants of spa structures while imagining the therapeutic rituals of a bygone era.
See properties

Public Beach Access

Mashes Sands Beach features tranquil white-sand shores and shallow waters ideal for families. Wade in the gentle surf, cast a fishing line, or enjoy a peaceful picnic away from tourist crowds.
See properties

Silver Lake

Swim in crystal-clear waters along a pristine 250-foot white sand beach surrounded by longleaf pines. The mile-long interpretive trail offers peaceful wildlife encounters with bald eagles and turtles.
See properties

Alligator Harbor Aquatic Preserve

Explore the great outdoors at Alligator Harbor Aquatic Preserve, a lovely green space in Panacea. Stroll along the beaches in this relaxing area or seek out the fishing spots.
See properties

Learn more about Panacea

Kayak through pristine coastal marshes at Panacea's Woolley Park, where fishing piers and boardwalks offer prime spots for catching redfish. Nearby St. Marks National Wildlife Refuge invites visitors to spot migratory birds and explore the historic lighthouse along scenic hiking trails.

See all hotels in Panacea
A sunset over a calm body of water with silhouettes of birds flying and a distant tree line.

Top Panacea Hotel Reviews

More cheap stays in Panacea

Franklin Inn

Franklin Inn

1589 US-98 Carrabelle FL
2.452.872 ₫
2.710.423 ₫ total
28 Sept - 29 Sept
includes taxes & fees
7.8/10 Good! (507 reviews)
Franklin Inn
Best Western Wakulla Inn & Suites

Best Western Wakulla Inn & Suites

3292 Coastal Hwy 98 Crawfordville FL
2.900.430 ₫
3.233.979 ₫ total
13 Sept - 14 Sept
includes taxes & fees
8.8/10 Excellent! (1,000 reviews)
Best Western Wakulla Inn & Suites
The Old Carrabelle Hotel

The Old Carrabelle Hotel

201 Tallahassee St Carrabelle FL
3.030.442 ₫
3.348.638 ₫ total
24 Sept - 25 Sept
includes taxes & fees
9.6/10 Exceptional! (44 reviews)
The Old Carrabelle Hotel
The Panacea Motel

The Panacea Motel

1545 Coastal Hwy Panacea FL
3.107.503 ₫
3.464.865 ₫ total
2 Sept - 3 Sept
includes taxes & fees
The Panacea Motel
The Moorings Hotel and Marina

The Moorings Hotel and Marina

1000 Hwy 98 Carrabelle FL
4.707.617 ₫
5.201.917 ₫ total
1 Sept - 2 Sept
includes taxes & fees
The Moorings Hotel and Marina
Cozy Waterfront 'island House' on Live Oak Island!

Cozy Waterfront 'island House' on Live Oak Island!

Crawfordville FL
Get ratesCozy Waterfront 'island House' on Live Oak Island!

Hotels in Panacea with star rating

Frequently asked questions

What's the seasonal weather in Panacea?
The hottest months are usually July and August, with an average temperature of 27°C, while the coldest months are January and February, with an average of 14°C. The rainiest months in Panacea are August, July, June and September, with each month seeing an average of 201 mm of rainfall.

Explore a world of travel with Expedia