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21 Dec - 22 Dec
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22 Dec - 23 Dec
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26 Dec - 28 Dec
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Our top choices for Penn Center hotels

Exterior
607 Bay Inn Downtown Beaufort

607 Bay Inn Downtown Beaufort

607 Bay Inn Downtown Beaufort
2.5 star property
9.8 km from Penn Center
9.8 out of 10, Exceptional, (89)
"Great Inn! Location, view, cleanliness, friendly staff!"
United States
Nicole
607 Bay Inn Downtown Beaufort
View from property
City Loft Hotel

City Loft Hotel

City Loft Hotel
3.5 star property
9.9 km from Penn Center
9.4 out of 10, Exceptional, (759)
"Great place to stay in city center Beaufort. Easy free parking, friendly staff, comfy mattresses, nice bathroom and shower. Location was perfect for walking to shops and restaurants."
United States
Laura
The price is 3.756.203 ₫
4.131.718 ₫ total
includes taxes & fees
22 Dec - 23 Dec
City Loft Hotel
Porch
Circa 1785

Circa 1785

Circa 1785
4.0 star property
10.3 km from Penn Center
9.6 out of 10, Exceptional, (137)
"Very nice and charming boutique hotel"
United States
Grady
The price is 3.386.740 ₫
3.725.414 ₫ total
includes taxes & fees
22 Dec - 23 Dec
Circa 1785
Exterior
Best Western Sea Island Inn

Best Western Sea Island Inn

Best Western Sea Island Inn
2.5 star property
10.2 km from Penn Center
9.4 out of 10, Exceptional, (1002)
"Perfect spot!"
United States
Tricia
The price is 3.683.837 ₫
4.052.219 ₫ total
includes taxes & fees
22 Dec - 23 Dec
Best Western Sea Island Inn
Premier Room | Egyptian cotton sheets, premium bedding, pillow-top beds
The Emerald Boutique Stays

The Emerald Boutique Stays

The Emerald Boutique Stays
2.5 star property
10 km from Penn Center
9.2 out of 10, Wonderful, (220)
"Close to downtown shopping and restaurants. Nice room and helpful staff."
United States
Jeffrey
The price is 3.394.635 ₫
3.734.099 ₫ total
includes taxes & fees
22 Dec - 23 Dec
The Emerald Boutique Stays
Exterior
Rhett House Inn

Rhett House Inn

Rhett House Inn
4.0 star property
10.3 km from Penn Center
9.2 out of 10, Wonderful, (643)
"What a lovely stay. Beautiful, clean and friendly staff made this stay wonderful. Will stay again while in Beaufort."
United States
REBECCA
The price is 3.834.073 ₫
5.060.876 ₫ total
includes taxes & fees
3 Jan - 4 Jan 2026
Rhett House Inn
Premium bedding, individually decorated, individually furnished
Beaufort Inn

Beaufort Inn

Beaufort Inn
3.5 star property
10 km from Penn Center
9.0 out of 10, Wonderful, (1002)
"If you are looking for a unique place to stay, this would be it. Staff was great and the rooms were clean."
United States
Samantha
The price is 4.002.511 ₫
4.808.014 ₫ total
includes taxes & fees
22 Dec - 23 Dec
Beaufort Inn
Balcony
Anchorage 1770

Anchorage 1770

Anchorage 1770
5.0 star property
10.3 km from Penn Center
9.2 out of 10, Wonderful, (218)
"Great property at a wonderful location."
United States
Dave
Anchorage 1770
View from property
Cuthbert House

Cuthbert House

Cuthbert House
4.5 star property
10.4 km from Penn Center
9.2 out of 10, Wonderful, (951)
"Excellent accommodations. Staff was very friendly & helpful. Will definitely come back. The Inn is beautiful. "
United States
Melanie
The price is 9.911.545 ₫
10.902.699 ₫ total
includes taxes & fees
22 Dec - 23 Dec
Cuthbert House
Free daily buffet breakfast
SpringHill Suites by Marriott Beaufort

SpringHill Suites by Marriott Beaufort

SpringHill Suites by Marriott Beaufort
2.5 star property
12.7 km from Penn Center
9.4 out of 10, Exceptional, (1024)
"Breakfast menu was good and well stocked."
United States
Connie
The price is 2.710.445 ₫
2.981.490 ₫ total
includes taxes & fees
24 Dec - 25 Dec
SpringHill Suites by Marriott Beaufort
Exterior
Hilton Garden Inn Beaufort

Hilton Garden Inn Beaufort

Hilton Garden Inn Beaufort
3.0 star property
12 km from Penn Center
8.4 out of 10, Very good, (1002)
"Good hotel"
United States
joshua
The price is 2.617.027 ₫
2.878.730 ₫ total
includes taxes & fees
2 Jan - 3 Jan 2026
Hilton Garden Inn Beaufort
Terrace/patio
Holiday Inn Hotel & Suites Beaufort at Highway 21 by IHG

Holiday Inn Hotel & Suites Beaufort at Highway 21 by IHG

Holiday Inn Hotel & Suites Beaufort at Highway 21 by IHG
3.0 star property
12.7 km from Penn Center
8.2 out of 10, Very good, (1002)
"Stayed here about 4 times and each time room has been clean especially the bathroom. Staff is very friendly and professional."
United States
John
The price is 2.342.035 ₫
2.576.238 ₫ total
includes taxes & fees
1 Jan - 2 Jan 2026
Holiday Inn Hotel & Suites Beaufort at Highway 21 by IHG
Reception
Hampton Inn Beaufort

Hampton Inn Beaufort

Hampton Inn Beaufort
2.5 star property
13 km from Penn Center
8.4 out of 10, Very good, (1000)
"Room was spotless and staff very courtesy."
United States
Griselda
The price is 2.325.983 ₫
2.558.581 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Hampton Inn Beaufort
Outdoor pool
Home2 Suites BY Hilton Beaufort, SC

Home2 Suites BY Hilton Beaufort, SC

Home2 Suites BY Hilton Beaufort, SC
3.0 star property
15 km from Penn Center
9.2 out of 10, Wonderful, (722)
"Room was spotless and beds comfortable"
United States
Judy
The price is 2.924.912 ₫
3.217.404 ₫ total
includes taxes & fees
16 Jan - 17 Jan 2026
Home2 Suites BY Hilton Beaufort, SC
Snack bar
Tru by Hilton Beaufort, SC

Tru by Hilton Beaufort, SC

Tru by Hilton Beaufort, SC
2.5 star property
14.9 km from Penn Center
9.0 out of 10, Wonderful, (711)
"Awesome stay!!!"
United States
Michael
The price is 2.459.926 ₫
2.705.919 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Tru by Hilton Beaufort, SC
View from property
Newly Updated Poolside Studio Steps From Beach, Sandbar, & Tennis

Newly Updated Poolside Studio Steps From Beach, Sandbar, & Tennis

Newly Updated Poolside Studio Steps From Beach, Sandbar, & Tennis
2.5 star property
11 km from Penn Center
8.8 out of 10, Excellent, (3)
"Great stay with the family, great location"
United States
Troy
The price is 3.786.202 ₫
8.432.019 ₫ total
includes taxes & fees
23 Dec - 24 Dec
Newly Updated Poolside Studio Steps From Beach, Sandbar, & Tennis
Miscellaneous
Super 8 by Wyndham Port Royal/Beaufort

Super 8 by Wyndham Port Royal/Beaufort

Super 8 by Wyndham Port Royal/Beaufort
2.0 star property
10.2 km from Penn Center
6.0 out of 10, (906)
"The room could have been a little cleaner but all and all it was Great! "
United States
Gina
The price is 1.566.006 ₫
1.722.607 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Super 8 by Wyndham Port Royal/Beaufort
Room, 1 King Bed, Refrigerator & Microwave | Desk, iron/ironing board, free WiFi, bed sheets
Oasis Inn

Oasis Inn

Oasis Inn
2.5 star property
12.8 km from Penn Center
7.4 out of 10, Good, (596)
"Fantastic stay. The staff was very friendly and helpful and the rooms were what I needed. Thank you "
United States
Chris
The price is 2.368.113 ₫
2.604.925 ₫ total
includes taxes & fees
22 Dec - 23 Dec
Oasis Inn
Exterior
Sleep Inn Beaufort near MCAS

Sleep Inn Beaufort near MCAS

Sleep Inn Beaufort near MCAS
2.5 star property
13.7 km from Penn Center
7.4 out of 10, Good, (1001)
"Overall i would stay here again."
United States
Joshua
The price is 2.214.407 ₫
2.435.849 ₫ total
includes taxes & fees
11 Jan - 12 Jan 2026
Sleep Inn Beaufort near MCAS
Exterior
Country Inn & Suites by Radisson, Beaufort West, SC

Country Inn & Suites by Radisson, Beaufort West, SC

Country Inn & Suites by Radisson, Beaufort West, SC
2.5 star property
13.4 km from Penn Center
7.2 out of 10, Good, (1002)
"I enjoyed everything. Parking, breakfast, staff, and parking was good. "
United States
Deaven
The price is 2.344.667 ₫
2.579.134 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Country Inn & Suites by Radisson, Beaufort West, SC
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Penn Center Hotel Reviews

Hotels near other Penn Center attractions

Sanctuary Golf Club

Enjoy a round of golf in Beaufort at Sanctuary Golf Club. Wander the beautiful beaches in this family-friendly area.
See properties

York W. Bailey Museum

You can study the exhibits at York W. Bailey Museum, a museum with a storied past, during your trip to Saint Helena Island. Wander the waterfront in this trendy area.
See properties

Frequently asked questions

What's the area like around Penn Center?
Penn Center is located in a historic area of Saint Helena Island known for its beautiful island views. You'll find 63 hotels and other accommodations within a few miles for a convenient home base.
How many hotels can I expect to find close to Penn Center?
Expedia has 63 hotels and other accommodation options a few miles from Penn Center.
If I need to cancel the hotel reservation for my stay near Penn Center, will I receive a refund?
Yes, most hotel reservations are fully refundable provided that you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of check in. If you booked a non-refundable reservation, it might still be possible to cancel it and be given a refund within 24 hours of your booking. Plug in your dates, click on "Search", then you can use the "fully refundable" filter to review the top deals on offer near Penn Center.
What can I see and do near Penn Center?
Attractions like York W. Bailey Museum and Red Piano Too Gallery highlight the local culture. You can enjoy nature at Horse Island, Cherry Hill Knoll Island or Sheep Island. You might plan a visit to Cat Island Driving Range or Sanctuary Golf Club while you're in the area.

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