San Francisco Holidays

Book a Hotel + Flight or Car together to unlock savings

Where to stay in San Francisco

Find the best San Francisco areas and neighborhoods for the activities you enjoy most. Learn more about San Francisco
View of the Panama City Old Town

Casco Viejo

3.5/5(3 area reviews)

Unique features of Casco Viejo include the historical sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

Find hotels in Casco Viejo

Top hotels in San Francisco

Sheraton Grand Panama

Sheraton Grand Panama

4 out of 5
Via Israel And 77th Street Panama City Panama
Fully refundableReserve now, pay when you stay
The price is 3.335.581 ₫ per night from 1 May to 2 May
3.335.581 ₫
3.669.139 ₫ total
1 May - 2 May
includes taxes & fees
8.6/10 Excellent! (1,001 reviews)
The hotel needs urgently a renovation. The staff is poorly trained

Reviewed on 12 Apr 2026

Sheraton Grand Panama
Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica

4 out of 5
Via Israel y Calle 71, San Francisco Panama City Panama
The price is 2.731.147 ₫ per night from 27 Apr to 28 Apr
2.731.147 ₫
3.004.262 ₫ total
27 Apr - 28 Apr
includes taxes & fees
9.6/10 Exceptional! (1,174 reviews)
Everything was great

Reviewed on 14 Apr 2026

Ramada Plaza by Wyndham Panama Punta Pacifica
Courtyard by Marriott Panama Multiplaza Mall

Courtyard by Marriott Panama Multiplaza Mall

4 out of 5
Via Israel Multiplaza Pacific Mall Panama City Panama
The price is 2.887.852 ₫ per night from 16 May to 17 May
2.887.852 ₫
3.176.637 ₫ total
16 May - 17 May
includes taxes & fees
9/10 Wonderful! (1,003 reviews)
Shopped nearby

Reviewed on 13 Apr 2026

Courtyard by Marriott Panama Multiplaza Mall
See all 1,522 properties in San Francisco
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a San Francisco holiday package cost?
Much less than you might think — from a low , in fact! By bundling hotels, flights and car rentals into a custom-built holiday package, your San Francisco escape is only clicks away.
How do I get a cheap travel package to San Francisco?
Lock in flights that suit your schedule, add a hotel to your booking and watch how much you save with a San Francisco holiday package. It's that easy! From flights and hotels to rental cars and activities, Expedia makes travelling on the cheap easy. And with more than 550 partner airlines and 1null000null000 hotel options around the globe to pick from, you'll never be short of choice.
Where should I stay in San Francisco?
Make sightseeing easy by staying near San Francisco's main attractions. Miraflores Locks and Metropolitan Cathedral of Panama are two which top many visitors' bucket lists.
What are the top hotels in San Francisco?
If this will be your first visit to San Francisco, secure a room at Sublime Apartment City Centre. Ph Boutique Quartier Atlapa or New Cosy Apartment Ocean View. Quartier Del Mar. Both hotels will make you feel at home and are popular options with lots of travellers.
How far in advance should I book my San Francisco holiday?
It can be hard to know when is the ideal time to book your trip to San Francisco. But typically the earlier you book, the lower the prices. Sometimes, you can reserve your flights and hotels up to a year prior to your departure date. If you're eager to escape on a last-minute getaway, no need to fret! There are unbeatable deals announced on Expedia every day.
What does an Expedia San Francisco travel package include?
That mostly depends on you. You can choose from a range of San Francisco packages, such as a hotel, rental car and flight. You can also book a hotel and a flight, or a flight and a rental car. Once you've made your booking, you can add the fun stuff like experiences and tours. Whatever your ideal San Francisco holiday looks like, you're sure to save!
What should I know before booking a San Francisco travel package?
So many places to go, so many things to see and do. With a travel package, you'll be able to afford more of them. Bundle your hotels, flights and rental cars and land big savings.
Can I choose my airline with a San Francisco Expedia holiday package?
Yes, definitely. Expedia has more than 550 airline partners to choose from worldwide. With such a huge range of choice, finding the ideal carrier to whisk you off to San Francisco won't be difficult.
If I'm not able to travel, can I cancel my San Francisco holiday package?
Your situation can change in a flash, so yes, you can. You may be able to amend or cancel your San Francisco holiday package for free if you've booked in the last 24 hours. For older bookings, you can still make changes, but your car rental company, airline or hotel may charge a fee. Need more information? Look up our Customer Service Portal. We'll help make sure your trip goes off without a hitch.

Popular places to visit

Multiplaza Pacific Mall

Multiplaza Pacific Mall

During your trip to Panama City, you can search for that perfect souvenir at Multiplaza Pacific Mall. You can enjoy the restaurants while in the area.

Multiplaza Pacific Mall
Causeway, Amador, Panama

Amador Causeway

You can learn about the history of Ancon with a visit to Amador Causeway. Stroll along the seaside or visit the shops in this vibrant area.

Amador Causeway
Panama City night skyline

Avenida Balboa

You can browse for the perfect souvenirs at Avenida Balboa during your stay in Panama City. While you're in the area, wander around the natural setting.

Avenida Balboa