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Our top choices for Sanctuary hotels

OYO Waterfront Hotel - Cape Coral/Fort Myers, FL

OYO Waterfront Hotel - Cape Coral/Fort Myers, FL
2.5 star property
25.2 km from Sanctuary
5.8 out of 10, (1,004 reviews)
"It was perfect for my one night stay definitely will be coming back "
United States
Marice
The price is 1.869.107 ₫
2.387.011 ₫ total
includes taxes & fees
12 Apr - 13 Apr
OYO Waterfront Hotel - Cape Coral/Fort Myers, FL

Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral

Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral
3.0 star property
30.1 km from Sanctuary
8.6 out of 10, Excellent, (845 reviews)
"Nice place "
United States
Vyacheslav
The price is 2.584.248 ₫
2.881.437 ₫ total
includes taxes & fees
3 Apr - 4 Apr
Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral

Allure Suites

Allure Suites
3.0 star property
27.2 km from Sanctuary
7.6 out of 10, Good, (1,001 reviews)
"Everything was great and wonderful next time i go to cape coral we will stay there "
United States
Alejandro
The price is 2.252.412 ₫
2.511.439 ₫ total
includes taxes & fees
1 Apr - 2 Apr
Allure Suites

Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Holiday Inn Express Cape Coral-Fort Myers Area by IHG
2.5 star property
23.9 km from Sanctuary
9.2 out of 10, Wonderful, (1,337 reviews)
"Great location, clean rooms, wonderful basic breakfast and coffee, I will be back again."
United States
Eduardo
The price is 2.660.744 ₫
2.966.861 ₫ total
includes taxes & fees
26 Apr - 27 Apr
Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Homewood Suites by Hilton - Fort Myers

Homewood Suites by Hilton - Fort Myers
3.0 star property
30.9 km from Sanctuary
9.2 out of 10, Wonderful, (1,000 reviews)
"Room and the property are very nice. "
United States
Sherri
The price is 3.110.700 ₫
3.468.431 ₫ total
includes taxes & fees
27 Apr - 28 Apr
Homewood Suites by Hilton - Fort Myers

Dolphin Key Resort

Dolphin Key Resort
3.0 star property
23.8 km from Sanctuary
8.8 out of 10, Excellent, (1,238 reviews)
"Pool area is great. Restaurant attached is a bonus."
United States
Barbara
The price is 2.370.960 ₫
2.643.620 ₫ total
includes taxes & fees
1 Apr - 2 Apr
Dolphin Key Resort

La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway
3.0 star property
19.9 km from Sanctuary
8.2 out of 10, Very good, (1,065 reviews)
"Rooms were perfect, bigger than most and very comfortable. Staff was incredibly friendly and the breakfast had a waffle maker! "
United States
Emily
The price is 3.698.698 ₫
4.123.890 ₫ total
includes taxes & fees
6 Apr - 7 Apr
La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL

Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL
2.5 star property
22.6 km from Sanctuary
8.8 out of 10, Excellent, (1,003 reviews)
"Room was clean and staff was fantastic "
United States
Wayne
The price is 3.002.689 ₫
3.347.998 ₫ total
includes taxes & fees
26 Apr - 27 Apr
Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL

Hilton Garden Inn Ft Myers

Hilton Garden Inn Ft Myers
3.0 star property
29.5 km from Sanctuary
8.8 out of 10, Excellent, (1,004 reviews)
"Great quick stay"
United States
Jason R
The price is 3.368.871 ₫
3.756.291 ₫ total
includes taxes & fees
19 Apr - 20 Apr
Hilton Garden Inn Ft Myers

Lazy Cuckoo Inn

Lazy Cuckoo Inn
2.0 star property
22.1 km from Sanctuary
8.8 out of 10, Excellent, (272 reviews)
"Great location just a couple miles from the beach, close to stores and restaurants"
United States
Kayla
The price is 2.370.960 ₫
3.495.454 ₫ total
includes taxes & fees
7 Apr - 8 Apr
Lazy Cuckoo Inn

Doubletree by Hilton Fort Myers at Bell Tower Shops

Doubletree by Hilton Fort Myers at Bell Tower Shops
4.0 star property
30.8 km from Sanctuary
8.8 out of 10, Excellent, (1,051 reviews)
"Wonderful staff, pool and on site restaurant "
United States
Lori
The price is 3.611.236 ₫
4.026.529 ₫ total
includes taxes & fees
19 Apr - 20 Apr
Doubletree by Hilton Fort Myers at Bell Tower Shops

Candlewood Suites Fort Myers Sanibel Gateway by IHG

Candlewood Suites Fort Myers Sanibel Gateway by IHG
3.0 star property
25.4 km from Sanctuary
7.6 out of 10, Good, (1,000 reviews)
"The location was great for access to beaches"
United States
Shelly
The price is 2.449.899 ₫
2.731.769 ₫ total
includes taxes & fees
12 Apr - 13 Apr
Candlewood Suites Fort Myers Sanibel Gateway by IHG

TriLuxe Inn & Studios

TriLuxe Inn & Studios
2.0 star property
22.7 km from Sanctuary
8.0 out of 10, Very good, (20 reviews)
"We arrived after dark. And the neighborhood seemed sketchy."
United States
Laurie
The price is 2.370.870 ₫
3.495.322 ₫ total
includes taxes & fees
1 Apr - 2 Apr
TriLuxe Inn & Studios

Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG
2.5 star property
23.1 km from Sanctuary
9.2 out of 10, Wonderful, (1,000 reviews)
"everything was great! "
United States
Olivia
The price is 3.055.904 ₫
3.407.333 ₫ total
includes taxes & fees
6 Apr - 7 Apr
Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

Matlacha on Shoreview

Matlacha on Shoreview
2.0 star property
20.2 km from Sanctuary
9.6 out of 10, Exceptional, (245 reviews)
"Great place with comfy beds. "
United States
Rebecca
The price is 2.239.155 ₫
4.259.005 ₫ total
includes taxes & fees
18 Apr - 19 Apr
Matlacha on Shoreview

White Orchid Apartments

White Orchid Apartments
2.0 star property
20 km from Sanctuary
8.4 out of 10, Very good, (56 reviews)
"Clean, easy access, quiet, best bed and sheets ever!!!"
United States
Brooke
The price is 2.423.556 ₫
3.554.067 ₫ total
includes taxes & fees
1 Apr - 2 Apr
White Orchid Apartments

Residence Inn by Marriott Fort Myers Sanibel

Residence Inn by Marriott Fort Myers Sanibel
3.0 star property
19.3 km from Sanctuary
8.8 out of 10, Excellent, (1,000 reviews)
"Everything was nice in room. & clean. Nice place to stay"
United States
Laura
The price is 3.345.688 ₫
3.730.442 ₫ total
includes taxes & fees
27 Apr - 28 Apr
Residence Inn by Marriott Fort Myers Sanibel

Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway

Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway
3.0 star property
22.9 km from Sanctuary
8.6 out of 10, Excellent, (1,000 reviews)
"This hotel was super clean and the staff was so friendly, I would absolutely stay here again!!"
United States
Abigail
The price is 3.194.473 ₫
3.561.972 ₫ total
includes taxes & fees
6 Apr - 7 Apr
Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway

Pink Shell Beach Resort and Marina

Pink Shell Beach Resort and Marina
4.0 star property
20.4 km from Sanctuary
9.4 out of 10, Exceptional, (1,306 reviews)
"Incredible beach view, staff, and the facilities were extremely clean"
United States
Kelly
The price is 16.572.381 ₫
20.211.666 ₫ total
includes taxes & fees
3 Apr - 4 Apr
Pink Shell Beach Resort and Marina

Heated Pool, 3 Mi to Dtwn: Cape Coral Escape!

Heated Pool, 3 Mi to Dtwn: Cape Coral Escape!
3.0 star property
20.2 km from Sanctuary
The price is 2.054.754 ₫
9.124.425 ₫ total
includes taxes & fees
31 Mar - 1 Apr
Heated Pool, 3 Mi to Dtwn: Cape Coral Escape!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Sanctuary

Find the best Sanctuary areas for the activities you enjoy most.

Mid Island

If you're spending some time in Mid Island, Periwinkle Way and Sanibel Island Southern Beach are top sights worth seeing.

West End

If you're spending some time in West End, J. N. Ding Darling National Wildlife Refuge and Bowman's Beach are top sights worth seeing.

East End

While visiting East End, you might make a stop by sights like Sanibel Island Northern Beach and Sanibel Island Lighthouse.

Beachview Country Club Estates

While visiting Beachview Country Club Estates, you might make a stop by sights like Periwinkle Way and Sanibel Island Golf Club.

Shell Harbor

While Shell Harbor isn't home to many top sights, Sanibel Moorings Botanical Gardens and Sanibel Sea School are some notable places to visit nearby.

Top Sanctuary Hotel Reviews

Frequently asked questions

What is Sanctuary like?
Travellers are sure to enjoy a stay in Sanibel's Sanctuary neighbourhood. Consider a visit to J. N. Ding Darling National Wildlife Refuge as part of your Sanctuary travel plans.
How many hotels will I be able to find in the Sanctuary area?
With 10 Expedia hotels and other accommodation options in Sanctuary to choose from, this is a good starting point for exploring the greater Sanibel area.
If I need to cancel my hotel reservation in Sanctuary, will I receive a refund?
Yes, the majority of hotel room reservations are fully refundable if you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and receive a refund within a 24-hour period of booking. Enter dates in and click on "Search", then you can filter by "fully refundable" to get the best deals available in Sanctuary.
What is there to do around this Sanibel neighbourhood?
J. N. Ding Darling National Wildlife Refuge is an attraction you might want to check out while you're in Sanctuary. Castaways Marina and Blind Pass Beach are also worth a visit when you're out sightseeing in Sanibel.