Search Hotels in Sanibel Isles, Sanibel

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
23 Dec - 24 Dec
Tomorrow
24 Dec - 25 Dec
This weekend
26 Dec - 28 Dec
Next weekend
2 Jan - 4 Jan

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Sanibel Isles hotels

Lobby
Days Inn & Suites by Wyndham Fort Myers Near JetBlue Park

Days Inn & Suites by Wyndham Fort Myers Near JetBlue Park

Days Inn & Suites by Wyndham Fort Myers Near JetBlue Park
2.0 star property
28 km from Sanibel Isles
8.0 out of 10, Very good, (1513)
"Nice and beautiful place to stay "
United States
Maguenne
The price is 1.966.926 ₫
2.193.121 ₫ total
includes taxes & fees
31 Dec - 1 Jan 2026
Days Inn & Suites by Wyndham Fort Myers Near JetBlue Park
Suite with King Bed, Beachfront, Balcony | Terrace/patio
Lani Kai Beachfront Resort

Lani Kai Beachfront Resort

Lani Kai Beachfront Resort
3.5 star property
10.3 km from Sanibel Isles
9.0 out of 10, Wonderful, (1032)
"Clean rooms lovely view of Beach and pool area."
United States
Laurice-Larry
The price is 4.976.937 ₫
6.136.642 ₫ total
includes taxes & fees
6 Jan - 7 Jan 2026
Lani Kai Beachfront Resort
Indoor pool
Comfort Inn & Suites Fort Myers Airport

Comfort Inn & Suites Fort Myers Airport

Comfort Inn & Suites Fort Myers Airport
2.5 star property
27.7 km from Sanibel Isles
8.8 out of 10, Excellent, (1120)
"Great staff"
United States
Alison
The price is 2.476.619 ₫
2.761.430 ₫ total
includes taxes & fees
25 Dec - 26 Dec
Comfort Inn & Suites Fort Myers Airport
Front of property – evening/night
Trianon Bonita Bay

Trianon Bonita Bay

Trianon Bonita Bay
3.5 star property
27.6 km from Sanibel Isles
9.2 out of 10, Wonderful, (1712)
"The room was great as well as the amenities!!!"
United States
Fernando
The price is 3.768.252 ₫
4.201.601 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Trianon Bonita Bay
Free daily buffet breakfast
Holiday Inn Express & Suites Fort Myers Airport by IHG

Holiday Inn Express & Suites Fort Myers Airport by IHG

Holiday Inn Express & Suites Fort Myers Airport by IHG
2.5 star property
27.6 km from Sanibel Isles
9.6 out of 10, Exceptional, (1004)
"Clean rooms and wonderful breakfast. Appreciated the airport shuttle as well."
United States
Susan
The price is 3.554.685 ₫
3.963.473 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Holiday Inn Express & Suites Fort Myers Airport by IHG
Lobby
La Quinta Inn & Suites by Wyndham Bonita Springs Naples N.

La Quinta Inn & Suites by Wyndham Bonita Springs Naples N.

La Quinta Inn & Suites by Wyndham Bonita Springs Naples N.
3.0 star property
29.4 km from Sanibel Isles
9.0 out of 10, Wonderful, (1223)
"Will stay again"
United States
joseph
The price is 3.111.244 ₫
3.469.036 ₫ total
includes taxes & fees
2 Jan - 3 Jan 2026
La Quinta Inn & Suites by Wyndham Bonita Springs Naples N.
Exterior
Best Western Fort Myers Waterfront

Best Western Fort Myers Waterfront

Best Western Fort Myers Waterfront
3.0 star property
27.5 km from Sanibel Isles
7.4 out of 10, Good, (1004)
"Breakfast, and room better than expected "
United States
Brandi
The price is 2.887.413 ₫
3.219.465 ₫ total
includes taxes & fees
27 Dec - 28 Dec
Best Western Fort Myers Waterfront
Terrace/patio
Hilton Garden Inn Ft Myers

Hilton Garden Inn Ft Myers

Hilton Garden Inn Ft Myers
3.0 star property
19.9 km from Sanibel Isles
8.8 out of 10, Excellent, (1002)
"Great amenities, pool and spa, clean room, beautiful lobby and good on site restaurant "
United States
Aleksandar
The price is 2.942.713 ₫
3.281.125 ₫ total
includes taxes & fees
31 Dec - 1 Jan 2026
Hilton Garden Inn Ft Myers
Outdoor pool
Sanibel Island Beach Resort

Sanibel Island Beach Resort

Sanibel Island Beach Resort
3.0 star property
Mid Island, 3.2 km from Sanibel Isles
9.2 out of 10, Wonderful, (1481)
"Great place."
United States
Michael
The price is 6.820.247 ₫
8.262.901 ₫ total
includes taxes & fees
7 Jan - 8 Jan 2026
Sanibel Island Beach Resort
View from room
Courtyard by Marriott Fort Myers Cape Coral

Courtyard by Marriott Fort Myers Cape Coral

Courtyard by Marriott Fort Myers Cape Coral
3.0 star property
25.2 km from Sanibel Isles
8.2 out of 10, Very good, (1013)
"Very friendly staff, super comfortable room"
United States
Rocio
The price is 2.820.264 ₫
3.144.594 ₫ total
includes taxes & fees
2 Jan - 3 Jan 2026
Courtyard by Marriott Fort Myers Cape Coral
Exterior
Woodspring Suites Fort Myers - Cape Coral

Woodspring Suites Fort Myers - Cape Coral

Woodspring Suites Fort Myers - Cape Coral
2.5 star property
23.4 km from Sanibel Isles
7.2 out of 10, Good, (147)
"For the price, the sheets were clean. "
United States
Dairon
The price is 1.948.642 ₫
2.172.735 ₫ total
includes taxes & fees
25 Dec - 26 Dec
Woodspring Suites Fort Myers - Cape Coral
Terrace/patio
Dolphin Key Resort

Dolphin Key Resort

Dolphin Key Resort
3.0 star property
15.3 km from Sanibel Isles
8.8 out of 10, Excellent, (1212)
"Nice room, helpful staff, nice heated pool, bar/restaurant on site has good prices and live entertainment most nights. Overall, a fun place to stay."
United States
Jacob
The price is 2.106.640 ₫
2.348.904 ₫ total
includes taxes & fees
30 Dec - 31 Dec
Dolphin Key Resort
Lobby
Quality Inn Fort Myers Cape Coral

Quality Inn Fort Myers Cape Coral

Quality Inn Fort Myers Cape Coral
2.0 star property
23 km from Sanibel Isles
7.6 out of 10, Good, (199)
"Microwave made an explosion when tried to use it. The rest amazing"
United States
Alain
The price is 1.872.276 ₫
2.420.712 ₫ total
includes taxes & fees
30 Dec - 31 Dec
Quality Inn Fort Myers Cape Coral
Lobby lounge
Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral

Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral

Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral
3.0 star property
20.1 km from Sanibel Isles
8.6 out of 10, Excellent, (790)
"A great location. Staff was very helpful. Pool was heated!"
United States
FRED
The price is 2.817.631 ₫
3.141.659 ₫ total
includes taxes & fees
30 Dec - 31 Dec
Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral
Exterior
Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG
2.5 star property
12.1 km from Sanibel Isles
9.4 out of 10, Exceptional, (1002)
"Great rooms, good staff"
United States
Dedan
The price is 3.607.347 ₫
4.022.192 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG
Reception
Americas Best Value Inn Ft. Myers

Americas Best Value Inn Ft. Myers

Americas Best Value Inn Ft. Myers
3.0 star property
21.9 km from Sanibel Isles
7.6 out of 10, Good, (1126)
"Loved it. The staff was great rooms were clean. "
United States
Austin
The price is 1.804.600 ₫
2.012.129 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Americas Best Value Inn Ft. Myers
Lobby
Best Western Fort Myers Inn & Suites

Best Western Fort Myers Inn & Suites

Best Western Fort Myers Inn & Suites
2.5 star property
25.5 km from Sanibel Isles
8.8 out of 10, Excellent, (1114)
"Clean room, old property and fresh, varied options for breakfast"
Canada
supriya
The price is 2.299.134 ₫
2.563.535 ₫ total
includes taxes & fees
25 Dec - 26 Dec
Best Western Fort Myers Inn & Suites
Outdoor pool, pool loungers
Doubletree by Hilton Fort Myers at Bell Tower Shops

Doubletree by Hilton Fort Myers at Bell Tower Shops

Doubletree by Hilton Fort Myers at Bell Tower Shops
4.0 star property
20.9 km from Sanibel Isles
8.8 out of 10, Excellent, (1000)
"Great hotel and location and good value. "
United States
Amy
The price is 3.325.331 ₫
3.707.745 ₫ total
includes taxes & fees
1 Jan - 2 Jan 2026
Doubletree by Hilton Fort Myers at Bell Tower Shops
Outdoor pool
Residence Inn by Marriott Fort Myers Sanibel

Residence Inn by Marriott Fort Myers Sanibel

Residence Inn by Marriott Fort Myers Sanibel
3.0 star property
8.5 km from Sanibel Isles
8.6 out of 10, Excellent, (1004)
"The property was clean and the breakfast was excellent the staff was friendly and convenient to Sanibel Island"
United States
robert
The price is 3.554.955 ₫
3.963.775 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Residence Inn by Marriott Fort Myers Sanibel
Deluxe Studio, 1 King Bed, Marina View | View from room
Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

Latitude 26 Waterfront Boutique Resort - Fort Myers Beach
2.5 star property
10.3 km from Sanibel Isles
8.8 out of 10, Excellent, (1001)
"Great Place to Stay!"
United States
JUDY
The price is 3.436.457 ₫
3.831.715 ₫ total
includes taxes & fees
25 Dec - 26 Dec
Latitude 26 Waterfront Boutique Resort - Fort Myers Beach
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Sanibel Isles

Find the best Sanibel Isles areas for the activities you enjoy most.
Fort Myers featuring a beach
Photo by Sanibel Captiva Chamber of Commerce/Milissa Sprecher Photography
Open Photo by Sanibel Captiva Chamber of Commerce/Milissa Sprecher Photography

West End

If you're spending some time in West End, J. N. Ding Darling National Wildlife Refuge and Bowman's Beach are top sights worth seeing.

Mid Island

If you're spending some time in Mid Island, Periwinkle Way and Sanibel Island Southern Beach are top sights worth seeing.

East End

While visiting East End, you might make a stop by sights like Sanibel Island Northern Beach and Sanibel Island Lighthouse.

Beachview Country Club Estates

While visiting Beachview Country Club Estates, you might make a stop by sights like Periwinkle Way and Sanibel Island Golf Club.

Sanctuary

While there might not be top attractions in Sanctuary, you can explore the larger area and discover places like Blind Pass Beach and Turner Beach.

Top Sanibel Isles Hotel Reviews

Hyatt Vacation Club at Coconut Cove, Bonita Springs

Hyatt Vacation Club at Coconut Cove, Bonita Springs

10/10 Excellent
"Clean grounds and very quiet. Friendly staff. "
Elise 4-night trip
Posted 3 days ago
Hyatt Vacation Club at Coconut Cove, Bonita Springs

Frequently asked questions

What's it like in Sanibel Isles?
Travellers to the Sanibel Isles neighbourhood in Sanibel will be sure to enjoy their stay.
How many hotels should I expect to find in the Sanibel Isles area?
When you want to find places to stay in Sanibel, start by booking one of Expedia's 7 hotels and other accommodation options in Sanibel Isles.
If I need to cancel my hotel reservation in Sanibel Isles, will I receive a refund?
Yes! The majority of hotel room reservations are refundable if you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If you have a reservation that's non-refundable, you might still have the option to cancel and receive a refund within 24 hours of booking. Put your dates in and click on "Search", then filter by "fully refundable" to view top deals in Sanibel Isles.
What is there to do in this Sanibel neighbourhood?
Woodring Point, Woodring Beach and Dunes Golf and Tennis Club are just a few of the places to visit in and around Sanibel Isles. Bailey's Beach and Periwinkle Way are also worth a visit when you're out sightseeing in Sanibel.