Sanibel Isles Holidays

Book a Hotel + Flight or Car together to unlock savings

Where to stay in Sanibel Isles

Find the best Sanibel Isles areas and neighborhoods for the activities you enjoy most. Learn more about Sanibel Isles
Fort Myers featuring a beach

West End

3 out of top 10 points of interest in this area

If you're spending some time in West End, J. N. Ding Darling National Wildlife Refuge and Bowman's Beach are top sights worth seeing.

Find hotels in West End

Top hotels in Sanibel Isles

Margaritaville Beach Resort Fort Myers

Margaritaville Beach Resort Fort Myers

4 out of 5
251 Crescent Street Fort Myers Beach FL
The price is 4.482.645 ₫ per night from 30 Nov to 1 Dec
4.482.645 ₫
6.320.544 ₫ total
30 Nov - 1 Dec
includes taxes & fees
8.8/10 Excellent! (1,631 reviews)
Yes very much so.

Reviewed on 14 Nov 2025

Margaritaville Beach Resort Fort Myers
Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Holiday Inn Express Cape Coral-Fort Myers Area by IHG

2.5 out of 5
1538 Cape Coral Pkwy E Cape Coral FL
Fully refundableReserve now, pay when you stay
The price is 2.195.205 ₫ per night from 25 Nov to 26 Nov
2.195.205 ₫
2.447.930 ₫ total
25 Nov - 26 Nov
includes taxes & fees
9.2/10 Wonderful! (1,012 reviews)
Room was very clean, the staff were outstanding

Reviewed on 17 Nov 2025

Holiday Inn Express Cape Coral-Fort Myers Area by IHG
Lani Kai Beachfront Resort

Lani Kai Beachfront Resort

3.5 out of 5
1400 Estero Blvd Fort Myers Beach FL
Fully refundableReserve now, pay when you stay
The price is 5.777.001 ₫ per night from 20 Nov to 21 Nov
5.777.001 ₫
7.029.608 ₫ total
20 Nov - 21 Nov
includes taxes & fees
8.8/10 Excellent! (1,002 reviews)
Courteous staff. Rooms were clean. Some

Reviewed on 13 Nov 2025

Lani Kai Beachfront Resort
See all 15,106 properties in Sanibel Isles
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Sanibel Isles holiday package cost?
Discover the best of Sanibel Isles from as low as . We offer a great selection of rental cars, hotels and flights to suit your travel style. You can pick up even better deals when you add a few tours or experiences to your holiday package.
How do I get a cheap travel package to Sanibel Isles?
If you love landing a bargain, bundle your bookings into a Sanibel Isles holiday package. Whether you need hotels, flights, rental cars or activities, you can browse and book everything in one place. You'll have ample choice at your fingertips as well. Expedia has over 550 partner airlines and 1null000null000 hotels across the globe to select from. Fly with who you want, stay where you like and save your hard-earned money — now that's the ideal getaway!
Where should I stay in Sanibel Isles?
With interesting attractions like Sanibel Island Lighthouse and Sanibel and Captiva Island Visitors Centre in this neighbourhood, see if you can find a hotel near either of them. Sanibel Island Northern Beach is another sight in Sanibel Isles that people flock to.
What are the top hotels in Sanibel Isles?
When it comes to comfortable places to stay in Sanibel Isles, you can't beat Post Hurricane Update. Take a look at our offers and land a bargain.
How far in advance should I book my Sanibel Isles holiday?
Be rewarded with the biggest variety and the cheapest prices by booking your trip to Sanibel Isles nice and early. Air carriers typically sell flights around 12 months before departure, so secure your spot as soon as you can. That said, Expedia is committed to giving you the best deals around, so it's always a good time to book your dream holiday!
What does an Expedia Sanibel Isles travel package include?
It comes down to what sort of trip you're thinking about. Sanibel Isles travel deals can include flights, hotels and car rentals. You can mix and match to find the bundle that suits you. You can also add on activities and experiences after you've booked to score even bigger discounts.
What should I know before booking a Sanibel Isles travel package?
A travel package can be more affordable than individually booking everything you need for your escape. For example, bundle your hotels, flights and rental cars and save a tidy sum. Whatever your holiday goals are, you're bound to find a package that's right for you.
Can I choose my airline with a Sanibel Isles Expedia holiday package?
Yes, the choice is yours. Expedia has access to more than 550 partner airlines across the globe, so you can tailor your Sanibel Isles escape according to your needs and budget.
If I'm not able to travel, can I cancel my Sanibel Isles holiday package?
You can. We totally understand that life happens, so we're here to help if you need to make changes to your Sanibel Isles holiday package. It may be possible to cancel or change your itinerary for free if you've booked in the last 24 hours. Your airline, hotel or car rental company may impose a fee if your booking was made more than 24 hours ago. Visit our Customer Service Portal for more information. Also, be sure to check your itinerary for the finer details on change fees.

Popular places to visit

Bowman's Beach

Bowman's Beach

4.5/5(5 reviews)

Why not spend a care-free afternoon at Bowman's Beach during your travels in Sanibel? Stroll along the seaside or discover the area's sunsets.

Bowman's Beach
Sanibel Island Lighthouse

Sanibel Island Lighthouse

4/5(23 reviews)

You can find out about the history of Sanibel with a trip to Sanibel Island Lighthouse. Wander through the beautiful beaches and seaside in this family-friendly area.

Sanibel Island Lighthouse
Periwinkle Way

Periwinkle Way

During your trip to Sanibel, you can do some window-shopping at Periwinkle Way. Wander the beautiful beaches in this family-friendly area.

Periwinkle Way