Seneca Holiday Rentals, South Carolina: Private House Rentals

A calm lake with mountains in the background.

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Our top choices for Seneca hotels

A multi-story hotel with a swimming pool, landscaped grounds, and a parking area.

An aerial view of a multi-story hotel with a central courtyard, outdoor pool, and lounge area.

A swimming pool with lounge chairs and a covered patio area, surrounded by trees and a view of a lake.

A spacious lobby with a stone fireplace, modern lighting fixtures, and a seating area with sofas and a coffee table.

1. Lakeside Lodge Clemson

Seneca

Laura

2.845.663 ₫

3.532.538 ₫ total

includes taxes & fees

26 Aug - 27 Aug

An outdoor patio area with a fire pit, seating, and string lights.

A modern restaurant with a central counter, seating area, and a TV displaying news.

A modern indoor space with a mix of seating options, including a sofa and tables, under stylish pendant lighting.

A modern hotel with a prominent 'tru by Hilton' sign, a well-lit entrance, and a parking area.

2. Tru by Hilton Seneca Clemson

Seneca

Susana

2.798.852 ₫

3.078.736 ₫ total

includes taxes & fees

13 Sept - 14 Sept

A poolside area with outdoor seating and a view of a lake and forested hills.

A modern lobby with a reception desk, seating area, and a vending machine.

A modern cafe interior with round tables and chairs, a counter with a beverage dispenser, and a wall-mounted TV.

A deck with outdoor seating overlooking a body of water, adjacent to a building with multiple windows.

3. Fairfield Inn & Suites Seneca Clemson Univ Area

Seneca

Ronald

3.132.057 ₫

3.445.263 ₫ total

includes taxes & fees

30 Aug - 31 Aug

A hotel dining area with a long table, multiple chairs, and a bar in the background.

A reception area with a counter, chairs, and a patterned rug.

A long, narrow hallway with white walls and a light-colored floor, leading to a door at the end.

A hotel pantry with shelves stocked with snacks, a microwave, and a refrigerator with beverages.

4. Hampton Inn & Suites Seneca-Clemson Area

Seneca

Georgina

3.099.447 ₫

3.409.183 ₫ total

includes taxes & fees

27 Aug - 28 Aug

A hotel room with a bed, a desk, a chair, a large window with curtains, a bathroom with a bathtub, and a flat-screen TV.

A multi-story hotel with a prominent entrance, parking area, and a car parked in front.

A reception area with a brick wall, a reception desk, and a glass door leading outside.

A breakfast bar with waffle makers, coffee machines, and a clock on the wall.

5. Best Western Seneca-Clemson

Seneca

Michelle

2.530.029 ₫

2.783.034 ₫ total

includes taxes & fees

25 Aug - 26 Aug

A restaurant interior with a counter, seating area, and a TV mounted on the wall.

A multi-story motel with a central entrance, a flag, and a parking lot with several cars.

A hotel room with a bed, desk, TV, and a bathroom visible through an open door.

A spacious lobby with a high ceiling, a chandelier, framed artwork, a lamp, a sofa, and a view through large glass doors to an outdoor area.

6. Quality Inn Seneca US-123

Seneca

Anthony

1.973.689 ₫

2.328.170 ₫ total

includes taxes & fees

30 Aug - 31 Aug

A modern dining area with a high ceiling, large windows, and a buffet setup.

A modern hotel lobby with a high ceiling, comfortable seating, large windows, and a view of the parking lot.

A swimming pool with lounge chairs and a fence, surrounded by trees.

A modern hotel room with a large bed, bedside tables with lamps, a wall-mounted air conditioner, and a large window with curtains.

7. Days Inn by Wyndham Seneca / Clemson Area

Seneca

John

2.114.667 ₫

2.326.134 ₫ total

includes taxes & fees

30 Aug - 31 Aug

A cabin with a large window, surrounded by trees.

A wooden interior with a table, chair, and a hanging lantern.

A wooden cabin bedroom with a large window, a bed, a bedside table with a lantern, and a heater.

8. Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Seneca

Nirumol

2.428.788 ₫

3.820.771 ₫ total

includes taxes & fees

21 Sept - 22 Sept

A lakeside patio with Adirondack chairs, a fire pit, and a dock extending into the water.

A modern building with a glass facade, outdoor seating area, and a flag.

A spacious kitchen with a large island, a dining area with white furniture, and a living room with a fireplace.

A spacious kitchen with wooden cabinets, a granite countertop, and a view of the lake through large windows.

9. Beautiful Lake Keowee Home w/ Boat Dock & Fire Pit

Seneca

10.159.124 ₫

20.488.002 ₫ total

includes taxes & fees

23 Aug - 24 Aug

A spacious hallway with a wooden ceiling, a sofa, a chair, and a lamp.

A hotel lobby with a long corridor, seating areas, and a reception desk.

A brick building with a sign reading "The Inn at Patrick Square".

A hotel with a brick facade, multiple windows, and a sign reading "The Inn at Patrick Square".

10. The Inn at Patrick Square

Clemson

Beatriz

3.889.943 ₫

4.317.838 ₫ total

includes taxes & fees

27 Aug - 28 Aug

A golf course with a water body, trees, and a distant view of a bridge.

A large, curved swimming pool with lounge chairs and umbrellas, surrounded by landscaped areas and a building in the background.

A golf course with a clubhouse, surrounded by dense trees and a large body of water.

A modern building with a central entrance, surrounded by a well-maintained lawn and trees.

11. Clemson University's James F. Martin Inn

Clemson

Bill

3.889.943 ₫

4.317.837 ₫ total

includes taxes & fees

1 Sept - 2 Sept

A poolside area with wicker furniture and a table, surrounded by a fence and greenery.

A modern lobby with a curved blue sofa, a reception desk, and a bar area.

A corner market with a wooden interior, a glass door entrance, and a refrigerator display.

A modern living room with a stone wall, a fireplace, and a large window. There are two sofas, a coffee table, and a dining area with a table and chairs.

12. Fairfield Inn & Suites by Marriott Anderson Clemson

Anderson

Mary

2.561.097 ₫

2.842.818 ₫ total

includes taxes & fees

30 Aug - 31 Aug

A modern lounge area with a brick accent wall, a fireplace, and comfortable seating.

A hotel room with a bed, a sofa, a dining table with chairs, a coffee machine, and a TV mounted on the wall.

A modern living room with a sofa, two armchairs, a coffee table, and a potted plant.

A bar area with a counter, multiple chairs, and a display of bottles and glasses.

13. The Abernathy of Clemson

Clemson

Robert

3.972.244 ₫

4.409.190 ₫ total

includes taxes & fees

7 Sept - 8 Sept

A modern kitchen with a microwave, coffee maker, and bar stools.

A hotel hallway with a carpeted floor, light-colored walls, and doors on both sides.

A Comfort Inn & Suites hotel with a modern design, featuring a prominent sign, well-maintained landscaping, and a clear view of the entrance.

A hotel lobby with a reception desk, a large tiger mural, a TV, and a seating area with a blue sofa.

14. Comfort Inn & Suites Clemson - University Area

Clemson

Anita

2.751.678 ₫

3.054.364 ₫ total

includes taxes & fees

13 Sept - 14 Sept

A spacious indoor dining area with multiple tables and chairs, a food service counter, and a modern architectural design with balconies.

A spacious indoor area with multiple levels of balconies, seating areas, and a central open space.

A hotel room with a bed, a desk, a TV, a mirror, and a nightstand with a lamp.

A spacious indoor area with multiple seating arrangements, a ping pong table, and a bar area with purple accents.

15. Best Western Plus Clemson Hotel & Conference Center

Clemson

Julio

2.640.723 ₫

2.931.203 ₫ total

includes taxes & fees

25 Aug - 26 Aug

A modern office space with desks, computers, and a large abstract art piece on the wall.

A reception area with a modern design, featuring a reception desk with illuminated panels, a wooden counter, and a wall-mounted digital display.

A modern hotel lobby with a bar area, seating arrangements, and a large TV screen.

A Holiday Inn Express hotel with a gas station, multiple floors, and a well-lit entrance.

16. Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG

Anderson

Merret

2.871.770 ₫

3.187.665 ₫ total

includes taxes & fees

30 Aug - 31 Aug

A spacious living room with a fireplace, large windows, and a flat-screen TV mounted above the mantel.

A multi-story hotel with a prominent entrance, a well-lit facade, and a parking area in front.

A hotel lobby with a reception desk, potted plants, and a tiled floor.

A seating area with wicker chairs, a coffee table, and a large floor lamp.

17. Hilton Garden Inn Anderson

Anderson

Holly

2.761.598 ₫

3.065.374 ₫ total

includes taxes & fees

7 Sept - 8 Sept

A reception area with a reception desk, a sofa, a staircase, and a wall with artwork.

A hotel room with two beds, a desk, a television, and a clock on the wall.

A dining area with a brick floor, wooden tables, and chairs, a kitchen counter with appliances, and large windows offering a view of the outside.

A tiger mascot holding a sign with "HOWARD'S ROCK" text, a staircase, and a desk with a computer.

18. Inn @ Clemson

Clemson

Terry

2.091.171 ₫

2.321.200 ₫ total

includes taxes & fees

23 Aug - 24 Aug

A compact bathroom with a sink, a microwave, and a small refrigerator.

A hotel room with a bed, a desk, a chair, a television, and a window.

A motel with a blue and white exterior, a parking lot, and a small garden area with shrubs and young trees.

A covered balcony with a view of buildings and a cloudy sky.

19. Carolina Inn Anderson Clemson Area

Anderson

Trevor

1.696.955 ₫

1.883.621 ₫ total

includes taxes & fees

2 Sept - 3 Sept

A modern living room with a sectional sofa, a coffee table, a fireplace, and a clock on the wall.

A spacious lobby with a reception desk, seating area, and a patterned rug.

A hotel room with a green sofa, a small table, a brown armchair, a bed with a red blanket, and a television on a wooden stand.

A kitchen area with blue cabinets, a countertop with various food items, and overhead lighting.

20. Country Inn & Suites by Radisson, Anderson, SC

Anderson

DOROTHY

2.751.678 ₫

3.054.364 ₫ total

includes taxes & fees

14 Sept - 15 Sept

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Where to stay in Seneca

Find the best Seneca areas for the activities you enjoy most.Learn more about Seneca

A large lake surrounded by dense forests.

A lakeside scene with autumn foliage, a clear sky, and a sunset.

Downtown

City centre Seneca captures the essence of small-town Southern charm with its well-preserved railway heritage and historic brick buildings. Tree-lined streets lead to charming shops and local eateries housed in structures dating back to the 1800s. Ram Cat Alley's colourful murals tell stories of local history while the old courthouse square hosts community gatherings. This walkable district offers a peaceful retreat from big city life. Visitors can browse antique stores for railway memorabilia, sample authentic Southern comfort food, or explore the cultural exhibits at the Bertha Lee Strickland Museum. The nearby Lake Keowee provides outdoor recreation just minutes away.

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A sunset over a lake surrounded by dense forests and residential areas.

Serenity Bay

Serenity Bay offers a peaceful retreat within Saxony Forest's coastal embrace. The quiet residential streets wind through mature trees, creating a tranquil atmosphere away from tourist crowds. Nature lovers can explore nearby Lake Keowee or enjoy the neighborhood's forest trails. The area perfectly balances woodland serenity with beach proximity. Visitors should plan for self-contained holiday rentals rather than hotels. While dining options are limited within the area, the natural surroundings provide ideal conditions for relaxation and outdoor recreation.

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A sunset over a calm lake with a kayaker and a large tree on the shore.

Pine Ridge Point

Lake Keowee's serene waters lap against the shores of Pine Ridge Point, a tranquil residential haven in Seneca. Private docks stretch into crystal-clear waters where boats gently bob. Towering pines create natural privacy between lakefront homes. Visitors enjoy peaceful mornings watching mist rise over the water. This area offers an authentic lakeside living experience without tourist crowds. Holiday rentals range from cosy cabins to luxury estates with private boat slips. Days revolve around swimming, fishing, and water sports on Lake Keowee. Nature trails wind through mature forests for hiking and birdwatching.

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Indian Oaks

Indian Oaks offers a tranquil retreat in suburban Seneca where mature oak trees create natural canopies over peaceful residential streets. This family-oriented community provides an authentic glimpse into American suburban living without tourist crowds. Landscaped yards and community green spaces showcase South Carolina's native beauty. Visitors can enjoy quiet morning walks on spacious pavements while listening to birdsong. Lake Keowee lies just beyond the area boundaries for those seeking water activities. With minimal commercial presence, Indian Oaks delivers a genuinely restful experience away from urban bustle.

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Stay near popular Seneca attractions

A waterfall surrounded by autumn foliage.

High Falls County Park

Nestled along Lake Keowee with the Blue Ridge Mountains as backdrop, High Falls County Park offers pristine swimming and camping spots. Reserve waterfront campsites early to enjoy the park's serene natural setting.

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A grassy field with yellow flowers and trees in the foreground, with mountains in the background.

Blue Ridge Field

This historic park honours African-American education in Oconee County on the former Blue Ridge High School football grounds. Stroll the paved loop trail and explore community gardens in this peaceful green space.

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Oconee County Library Seneca Branch

This welcoming community hub offers reading materials, digital resources, and programmes for all ages. Explore seasonal events like storytimes, trivia contests, and craft workshops in a tranquil learning environment.

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South Cove Park

This lakeside retreat on Lake Keowee offers pristine beaches, boat ramps, and scenic picnic spots. Enjoy fishing, swimming, or simply relaxing amid the natural beauty of upstate South Carolina.

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Friendship Recreation Area

After visiting Friendship Recreation Area, make a plan to see the other sights and activities in Seneca. Stroll along the lakeside or attend a sporting event in this family-friendly area.

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Seneca City Hall

Seneca City Hall is just one of the places to see in Seneca, so why not enjoy the other things to explore during your travels?

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The Gauntlet

You can make plans for a show at The Gauntlet during your trip to Seneca.

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Seneca Historic District

Stroll through Seneca Historic District's charming streets with Victorian and Classical Revival architecture. Ram Cat Alley offers boutique shopping and restaurants, especially vibrant during Thursday jazz performances.

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Learn more about Seneca

Nestled along Lake Keowee's shoreline, this charming town offers spectacular waterfront activities from kayaking to fishing at South Cove County Park. Nearby Stumphouse Tunnel and Issaqueena Falls provide fascinating historical exploration and refreshing natural beauty, especially during summer's humid afternoons.

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Top Seneca Hotel Reviews

Courtyard Marriott Clemson

10/10 Excellent

"👍"

Lakeside Lodge Clemson

10/10 Excellent

"No one under 25 allowed to check In should be changed to 21"

Clemson University's James F. Martin Inn

10/10 Excellent

"everything was amazing. Just the air-conditioning was really loud. Probably could use an update or repair."

Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG

10/10 Excellent

"Great stay! Staff was friendly and property was clean! Close to son’s apartment!"

The Abernathy of Clemson

10/10 Excellent

"Outstanding customer service! I will definitely recommend this property."

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

10/10 Excellent

"Me and my family had a great time"

Comfort Inn & Suites Clemson - University Area

10/10 Excellent

"Good"

Fairfield Inn & Suites Seneca Clemson Univ Area

10/10 Excellent

"This is the cleanest hotel I’ve ever been to. It’s very new. We had a room with a very nice view of the lake. Glad I found this hotel."

Best Western Plus Clemson Hotel & Conference Center

10/10 Excellent

"This was the most enjoyable stay I’ve had in Clemson! Everything was great. I will stay here again next year!"

More cheap stays in Seneca

Days Inn by Wyndham Anderson

1007 George Smith Mill Rd Anderson SC

1.531.176 ₫

1.699.605 ₫ total

2 Sept - 3 Sept

includes taxes & fees

8.2/10 Very good! (1,013 reviews)

Inn @ Clemson

1303 Tiger Blvd Clemson SC

2.091.171 ₫

2.321.200 ₫ total

23 Aug - 24 Aug

includes taxes & fees

Best Western Plus Clemson Hotel & Conference Center

1310 Tiger Blvd Clemson SC

2.640.723 ₫

2.931.203 ₫ total

25 Aug - 26 Aug

includes taxes & fees

8/10 Very good! (1,037 reviews)

Comfort Inn & Suites Clemson - University Area

1305 Tiger Blvd Clemson SC

2.751.678 ₫

3.054.364 ₫ total

13 Sept - 14 Sept

includes taxes & fees

8.4/10 Very good! (1,012 reviews)

Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG

107 Interstate Blvd Anderson SC

2.871.770 ₫

3.187.665 ₫ total

30 Aug - 31 Aug

includes taxes & fees

9.2/10 Wonderful! (650 reviews)

Lakeside Lodge Clemson

13500 Clemson Blvd Seneca SC

2.845.663 ₫

3.532.538 ₫ total

26 Aug - 27 Aug

includes taxes & fees

9/10 Wonderful! (1,008 reviews)

Hotels in Seneca with star rating

Frequently asked questions

What's the seasonal weather in Seneca?

The hottest months are usually July and August, with an average temperature of 25°C, while the coldest months are January and February, with an average of 8°C. Average annual precipitation for Seneca is 1565 mm.

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Find hotels in Seneca, SC from 1.699.605 ₫

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Seneca

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Seneca hotels

1. Lakeside Lodge Clemson

2. Tru by Hilton Seneca Clemson

3. Fairfield Inn & Suites Seneca Clemson Univ Area

4. Hampton Inn & Suites Seneca-Clemson Area

5. Best Western Seneca-Clemson

6. Quality Inn Seneca US-123

7. Days Inn by Wyndham Seneca / Clemson Area

8. Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

9. Beautiful Lake Keowee Home w/ Boat Dock & Fire Pit

10. The Inn at Patrick Square

11. Clemson University's James F. Martin Inn

12. Fairfield Inn & Suites by Marriott Anderson Clemson

13. The Abernathy of Clemson

14. Comfort Inn & Suites Clemson - University Area

15. Best Western Plus Clemson Hotel & Conference Center

16. Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG

17. Hilton Garden Inn Anderson

18. Inn @ Clemson

19. Carolina Inn Anderson Clemson Area

20. Country Inn & Suites by Radisson, Anderson, SC

Where to stay in Seneca

Downtown

Serenity Bay

Pine Ridge Point

Indian Oaks

Stay near popular Seneca attractions

High Falls County Park

Blue Ridge Field

Oconee County Library Seneca Branch

South Cove Park

Friendship Recreation Area

Seneca City Hall

The Gauntlet

Seneca Historic District

Learn more about Seneca

Top Seneca Hotel Reviews

Courtyard Marriott Clemson

Lakeside Lodge Clemson

Clemson University's James F. Martin Inn

Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG

The Abernathy of Clemson

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Comfort Inn & Suites Clemson - University Area

Fairfield Inn & Suites Seneca Clemson Univ Area

Best Western Plus Clemson Hotel & Conference Center

More cheap stays in Seneca

Days Inn by Wyndham Anderson

Inn @ Clemson

Best Western Plus Clemson Hotel & Conference Center

Comfort Inn & Suites Clemson - University Area

Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG

Lakeside Lodge Clemson

Hotels in Seneca with star rating

Frequently asked questions

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