A calm lake with mountains in the background.

Find hotels in Seneca, SC from 1.692.248 ₫

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Check prices for these dates

Tonight
6 Oct - 7 Oct
Tomorrow
7 Oct - 8 Oct
This weekend
9 Oct - 11 Oct
Next weekend
16 Oct - 18 Oct

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Our top choices for Seneca hotels

1. Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
Seneca
United States
Angela
3.118.500 ₫
3.430.351 ₫ total
includes taxes & fees
11 Oct - 12 Oct
Fairfield Inn & Suites Seneca Clemson Univ Area

2. Lakeside Lodge Clemson

Lakeside Lodge Clemson
Seneca
United States
Lori
2.832.583 ₫
3.516.301 ₫ total
includes taxes & fees
12 Oct - 13 Oct
Lakeside Lodge Clemson

3. Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
Seneca
United States
Gretchen
2.748.905 ₫
3.023.796 ₫ total
includes taxes & fees
18 Oct - 19 Oct
Tru by Hilton Seneca Clemson

4. Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
Seneca
United States
Lloyd
3.108.882 ₫
3.419.770 ₫ total
includes taxes & fees
11 Oct - 12 Oct
Hampton Inn & Suites Seneca-Clemson Area

5. Best Western Seneca-Clemson

Best Western Seneca-Clemson
Seneca
United States
Michelle
2.430.699 ₫
2.673.768 ₫ total
includes taxes & fees
28 Oct - 29 Oct
Best Western Seneca-Clemson

6. Quality Inn Seneca US-123

Quality Inn Seneca US-123
Seneca
United States
Julie
1.965.146 ₫
2.318.092 ₫ total
includes taxes & fees
18 Oct - 19 Oct
Quality Inn Seneca US-123

7. Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
Seneca
United States
Rosario
2.157.502 ₫
2.373.252 ₫ total
includes taxes & fees
11 Oct - 12 Oct
Days Inn by Wyndham Seneca / Clemson Area

8. Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Seneca
United States
Nirumol
2.417.442 ₫
3.802.922 ₫ total
includes taxes & fees
4 Nov - 5 Nov
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

9. Clemson University's James F. Martin Inn

Clemson University's James F. Martin Inn
Clemson
United States
Lilllian
3.872.063 ₫
4.297.990 ₫ total
includes taxes & fees
19 Oct - 20 Oct
Clemson University's James F. Martin Inn

10. The Abernathy of Clemson

The Abernathy of Clemson
Clemson
United States
Robert
4.187.633 ₫
4.648.273 ₫ total
includes taxes & fees
18 Oct - 19 Oct
The Abernathy of Clemson

11. The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
Clemson
United States
Laurrie
5.432.746 ₫
6.030.350 ₫ total
includes taxes & fees
13 Oct - 14 Oct
The Shepherd Hotel Downtown Clemson

12. Hampton Inn Clemson-University Area

Hampton Inn Clemson-University Area
Clemson
United States
Blaise
2.849.475 ₫
3.162.916 ₫ total
includes taxes & fees
19 Oct - 20 Oct
Hampton Inn Clemson-University Area

13. The Inn at Patrick Square

The Inn at Patrick Square
Clemson
United States
Jennifer
3.872.063 ₫
4.297.991 ₫ total
includes taxes & fees
19 Oct - 20 Oct
The Inn at Patrick Square

14. Comfort Inn & Suites Clemson - University Area

Comfort Inn & Suites Clemson - University Area
Clemson
United States
Yvette
2.783.957 ₫
3.090.193 ₫ total
includes taxes & fees
18 Oct - 19 Oct
Comfort Inn & Suites Clemson - University Area

15. Holiday Inn Express & Suites Clemson by IHG

Holiday Inn Express & Suites Clemson by IHG
Clemson
United States
John
3.352.323 ₫
3.721.079 ₫ total
includes taxes & fees
18 Oct - 19 Oct
Holiday Inn Express & Suites Clemson by IHG

16. Inn @ Clemson

Inn @ Clemson
Clemson
United States
Heather
2.081.559 ₫
2.310.533 ₫ total
includes taxes & fees
7 Oct - 8 Oct
Inn @ Clemson

17. Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center
Clemson
United States
David
2.739.030 ₫
3.040.326 ₫ total
includes taxes & fees
12 Oct - 13 Oct
Best Western Plus Clemson Hotel & Conference Center

18. Courtyard Marriott Clemson

Courtyard Marriott Clemson
Clemson
United States
kim
2.786.557 ₫
3.093.077 ₫ total
includes taxes & fees
18 Oct - 19 Oct
Courtyard Marriott Clemson

19. Rodeway Inn & Suites Walhalla

Rodeway Inn & Suites Walhalla
Walhalla
United States
Richard
1.988.281 ₫
2.216.932 ₫ total
includes taxes & fees
5 Nov - 6 Nov
Rodeway Inn & Suites Walhalla

20. Liberty Hall Bed and Breakfast

Liberty Hall Bed and Breakfast
Pendleton
United States
Christine
2.965.839 ₫
3.292.082 ₫ total
includes taxes & fees
9 Oct - 10 Oct
Liberty Hall Bed and Breakfast
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Holiday Rentals in Seneca

Cabin

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Seneca
"Me and my family had a great time"
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Cottage

8 Mi to Clemson: Peaceful Family Home w/ Yard

8 Mi to Clemson: Peaceful Family Home w/ Yard
Seneca
"The place was all out perfect the owner was polite and perfect. It was a very peaceful place to stay thank you so much."
8 Mi to Clemson: Peaceful Family Home w/ Yard
Cottage

Home w/ Lake Keowee Access: Sleeps 7, Coffee Bar

Home w/ Lake Keowee Access: Sleeps 7, Coffee Bar
Seneca
"The best, perfect "
Home w/ Lake Keowee Access: Sleeps 7, Coffee Bar
Apartment

Screened Patio & Yard: Clemson Weekends/lakes Stay

Screened Patio & Yard: Clemson Weekends/lakes Stay
Seneca
"The townhome was perfect for our son’s graduation weekend. Very easy ride to Clemson campus. The kitchen was well appointed with what u need to cook. The place was clean and well cared for. Hosts were very helpful and responded quickly to questions. Thanks for a great stay!"
Screened Patio & Yard: Clemson Weekends/lakes Stay
Cottage

Waterfront Seneca Cabin ~ 4 Mi to Boat Launch!

Waterfront Seneca Cabin ~ 4 Mi to Boat Launch!
Seneca
"Beautiful and quaint cabin! Highly recommend, great view of the lake."
Waterfront Seneca Cabin ~ 4 Mi to Boat Launch!
Cottage

Lake Hartwell Home w/ Dock < 10 Miles to Clemson!

Lake Hartwell Home w/ Dock < 10 Miles to Clemson!
Seneca
"The home was adorable and served its purpose for our trip. We will definitely book again."
Lake Hartwell Home w/ Dock < 10 Miles to Clemson!
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Where to stay in Seneca

Find the best Seneca areas for the activities you enjoy most.

Downtown

City centre Seneca captures the essence of small-town Southern charm with its well-preserved railway heritage and historic brick buildings. Tree-lined streets lead to charming shops and local eateries housed in structures dating back to the 1800s. Ram Cat Alley's colourful murals tell stories of local history while the old courthouse square hosts community gatherings. This walkable district offers a peaceful retreat from big city life. Visitors can browse antique stores for railway memorabilia, sample authentic Southern comfort food, or explore the cultural exhibits at the Bertha Lee Strickland Museum. The nearby Lake Keowee provides outdoor recreation just minutes away.

Serenity Bay

Serenity Bay offers a peaceful retreat within Saxony Forest's coastal embrace. The quiet residential streets wind through mature trees, creating a tranquil atmosphere away from tourist crowds. Nature lovers can explore nearby Lake Keowee or enjoy the neighborhood's forest trails. The area perfectly balances woodland serenity with beach proximity. Visitors should plan for self-contained holiday rentals rather than hotels. While dining options are limited within the area, the natural surroundings provide ideal conditions for relaxation and outdoor recreation.

Pine Ridge Point

Lake Keowee's serene waters lap against the shores of Pine Ridge Point, a tranquil residential haven in Seneca. Private docks stretch into crystal-clear waters where boats gently bob. Towering pines create natural privacy between lakefront homes. Visitors enjoy peaceful mornings watching mist rise over the water. This area offers an authentic lakeside living experience without tourist crowds. Holiday rentals range from cosy cabins to luxury estates with private boat slips. Days revolve around swimming, fishing, and water sports on Lake Keowee. Nature trails wind through mature forests for hiking and birdwatching.

Indian Oaks

Indian Oaks offers a tranquil retreat in suburban Seneca where mature oak trees create natural canopies over peaceful residential streets. This family-oriented community provides an authentic glimpse into American suburban living without tourist crowds. Landscaped yards and community green spaces showcase South Carolina's native beauty. Visitors can enjoy quiet morning walks on spacious pavements while listening to birdsong. Lake Keowee lies just beyond the area boundaries for those seeking water activities. With minimal commercial presence, Indian Oaks delivers a genuinely restful experience away from urban bustle.

Stay near popular Seneca attractions

A waterfall surrounded by autumn foliage.

High Falls County Park

Nestled along Lake Keowee with the Blue Ridge Mountains as backdrop, High Falls County Park offers pristine swimming and camping spots. Reserve waterfront campsites early to enjoy the park's serene natural setting.
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A grassy field with yellow flowers and trees in the foreground, with mountains in the background.

Blue Ridge Field

This historic park honours African-American education in Oconee County on the former Blue Ridge High School football grounds. Stroll the paved loop trail and explore community gardens in this peaceful green space.
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Friendship Recreation Area

After visiting Friendship Recreation Area, make a plan to see the other sights and activities in Seneca. Stroll along the lakeside or attend a sporting event in this family-friendly area.
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Toy Train Park

After visiting Toy Train Park, make a plan to see the other sights and activities in Seneca.
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Highpointe Field

After visiting Highpointe Field, make a plan to see the other sights and activities in Seneca. Stroll along the lakeside or attend a sporting event in this family-friendly area.
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Oconee County Library Seneca Branch

This welcoming community hub offers reading materials, digital resources, and programmes for all ages. Explore seasonal events like storytimes, trivia contests, and craft workshops in a tranquil learning environment.
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South Cove Park

This lakeside retreat on Lake Keowee offers pristine beaches, boat ramps, and scenic picnic spots. Enjoy fishing, swimming, or simply relaxing amid the natural beauty of upstate South Carolina.
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World of Energy

This free educational centre reveals the science of nuclear power through interactive exhibits and engaging displays. Explore the outdoor nature trail and butterfly garden for a complete energy learning experience.
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Learn more about Seneca

Nestled along Lake Keowee's shoreline, this charming town offers spectacular waterfront activities from kayaking to fishing at South Cove County Park. Nearby Stumphouse Tunnel and Issaqueena Falls provide fascinating historical exploration and refreshing natural beauty, especially during summer's humid afternoons.

See all hotels in Seneca
A sunset over a lake surrounded by dense forests and residential areas.

Top Seneca Hotel Reviews

The Abernathy of Clemson

The Abernathy of Clemson

10/10 Excellent
"Very conveniently located to Clemson and well maintained. We enjoyed having an afternoon beverage at the bar and grabbing a quick bite to eat in the morning. Hallways were quiet and I appreciated the bathroom amenities and robes too. I would definitely recommend staying here."
Amy 1-night trip
Posted 1 hour ago
The Abernathy of Clemson
Comfort Inn & Suites Clemson - University Area

Comfort Inn & Suites Clemson - University Area

10/10 Excellent
"room was clean and comfortable. bathywas a bit on the small size but doable. breakfast was normal and ok. staff was very friendly and accommodating."
Julene 1-night trip
Posted 4 hours ago
Comfort Inn & Suites Clemson - University Area
Quality Inn Seneca US-123

Quality Inn Seneca US-123

8/10 Good
"Second time here! Staff great! This time my room smelled of smoke as a non smoking room! Comforter was clean but from a smoking room and smelled despite it being clean!"
Gina 2-night trip
Posted 17 hours ago
Quality Inn Seneca US-123
Inn @ Clemson

Inn @ Clemson

8/10 Good
"I didn't get up for the breakfast, but the room was clean. Everything you should expect. The price was lower than others in the area. I was pleasantly surprised."
Kevin 1-night trip
Posted 18 hours ago
Inn @ Clemson
Woodspring Suites Anderson North I-85

Woodspring Suites Anderson North I-85

8/10 Good
"Everything was great only thing I would make note of is the shower curtain had mold on it."
Jessica 2-night trip
Posted 2 days ago
Woodspring Suites Anderson North I-85
Horizon Inn & Suites

Horizon Inn & Suites

10/10 Excellent
"The pretty lady at the front desk is absolutely fabulous."
Sean 1-night trip
Posted 2 days ago
Horizon Inn & Suites
The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson

10/10 Excellent
"It was a lovely from beginning to end. The staff is amazing."
Alethea 2-night trip
Posted 3 days ago
The Shepherd Hotel Downtown Clemson
Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area

10/10 Excellent
"Great place to stay when visiting Clemson!"
Lloyd 1-night trip
Posted 4 days ago
Hampton Inn & Suites Seneca-Clemson Area
Best Western Seneca-Clemson

Best Western Seneca-Clemson

8/10 Good
"Stayed @ hotel for a football weekend. Hotel was awesome...one of the cleanest I've ever stayed in regardless of hotels' star ratings. The only reason I gave it 4 stars was two things....#1 The bed was a bit too hard for me. I'm used to softer mattresses, but these were a little too hard for me. #2....There was one staff person that was just not very friendly @ the front desk for part of my stay. She wasn't rude & she fulfilled my requests, but she just was not as outgoing as other team members & that stuck out to me. Would I stay at this hotel again? Absolutely...it's been many yrs since I've stayed in a BW...I tend to stay in the upper crust hotels, so I was very pleasantly surprised! Great job Best Western!!"
Susan 2-night trip
Posted 4 days ago
Best Western Seneca-Clemson

More cheap stays in Seneca

Days Inn by Wyndham Anderson

Days Inn by Wyndham Anderson

1007 George Smith Mill Rd Anderson SC
1.524.548 ₫
1.692.248 ₫ total
11 Oct - 12 Oct
includes taxes & fees
Days Inn by Wyndham Anderson
Horizon Inn & Suites

Horizon Inn & Suites

3025 N Main Street Anderson SC
1.575.826 ₫
1.853.114 ₫ total
14 Oct - 15 Oct
includes taxes & fees
4.6/10 (367 reviews)
Horizon Inn & Suites
Quality Inn Seneca US-123

Quality Inn Seneca US-123

226 Hi Tech Rd Seneca SC
1.965.146 ₫
2.318.092 ₫ total
18 Oct - 19 Oct
includes taxes & fees
8/10 Very good! (756 reviews)
Quality Inn Seneca US-123
Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center

1310 Tiger Blvd Clemson SC
2.739.030 ₫
3.040.326 ₫ total
12 Oct - 13 Oct
includes taxes & fees
Best Western Plus Clemson Hotel & Conference Center
Comfort Inn & Suites Clemson - University Area

Comfort Inn & Suites Clemson - University Area

1305 Tiger Blvd Clemson SC
2.783.957 ₫
3.090.193 ₫ total
18 Oct - 19 Oct
includes taxes & fees
8.4/10 Very good! (1,009 reviews)
Comfort Inn & Suites Clemson - University Area
Lakeside Lodge Clemson

Lakeside Lodge Clemson

13500 Clemson Blvd Seneca SC
2.832.583 ₫
3.516.301 ₫ total
12 Oct - 13 Oct
includes taxes & fees
Lakeside Lodge Clemson

Hotels in Seneca with star rating

Frequently asked questions

What's the seasonal weather in Seneca?
The hottest months are usually July and August, with an average temperature of 25°C, while the coldest months are January and February, with an average of 8°C. Average annual precipitation for Seneca is 1565 mm.

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