The Best Hotels Closest to Sioux Empire Medical Museum in Sioux Falls - 2026 Updated Prices

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Our top choices for Sioux Empire Medical Museum hotels

A large, two-story building with a stone facade and multiple windows, illuminated by warm lighting.

A spacious lobby with multiple seating areas, a fireplace, and large windows.

A stone pillar with a fire pit in the center, surrounded by blue chairs.

An indoor swimming pool with a water slide, a large umbrella structure, and a frog-shaped water feature.

1. Clubhouse Hotel Suites Sioux Falls

Mall District, 2.8 km from Sioux Empire Medical Museum

Jordyn

3.471.942 ₫

4.165.531 ₫ total

includes taxes & fees

25 Oct - 26 Oct

A spacious bar area with a large TV screen, a fireplace, and a wine rack.

A hotel room with a large bed, wooden wardrobe, a TV, and a kitchenette area.

A modern bar area with a black marble column, bar stools, and a view of the city through large windows.

A spacious living room with a fireplace, large windows, and modern furniture.

2. Highpoint Hotel

University Heights, 0.2 km from Sioux Empire Medical Museum

Randell J

3.155.841 ₫

3.513.906 ₫ total

includes taxes & fees

18 Oct - 19 Oct

A lobby with a large safe, a checkered floor, and a sofa with cushions.

A modern hotel room with a desk, chair, and bed. It features a large window with a city view, a flat-screen TV, and a wooden wardrobe.

A bar area with high stools and tables, a bar counter with bottles, and a seating area with cushioned chairs.

A lobby with a grand chandelier, blue curtains, and a round glass table with a vase of flowers.

3. Hotel On Phillips

Downtown Sioux Falls, 1.9 km from Sioux Empire Medical Museum

Frank

3.878.560 ₫

4.306.754 ₫ total

includes taxes & fees

4 Oct - 5 Oct

A patio with wicker chairs and a round table with a fire pit.

A modern hotel room with a bed, a sofa, a small table, a TV, and a bathroom visible through an open door.

An indoor swimming pool with two lanes, safety railings, and lounge chairs.

A modern hotel room with a dining area, a sofa, a desk, and a chair.

4. Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

University Heights, 0.2 km from Sioux Empire Medical Museum

Ross

3.175.092 ₫

3.535.050 ₫ total

includes taxes & fees

11 Oct - 12 Oct

A Hampton Inn hotel with a modern design, featuring a prominent red sign, a covered entrance, and stone pillars.

A hotel room with a desk, two beds, a TV, and a window with a striped blind.

A snack and beverage display area with various snacks and drinks.

A swimming pool with clear water, surrounded by a tiled deck and seating areas.

5. Hampton Inn Sioux Falls

Mall District, 3.1 km from Sioux Empire Medical Museum

Tami

2.791.166 ₫

3.113.857 ₫ total

includes taxes & fees

18 Oct - 19 Oct

A modern lobby with a glass fireplace, seating areas, and indoor plants.

A modern building with a sign reading "THE STEEL DISTRICT" and a covered walkway.

A bar area with a long counter, multiple stools, and shelves stocked with bottles.

A modern dining area with a large marble table, comfortable chairs, a built-in fireplace, and a large TV mounted on a dark wall.

6. Canopy By Hilton Sioux Falls Downtown

Downtown Sioux Falls, 2.5 km from Sioux Empire Medical Museum

Marnie

3.953.922 ₫

4.545.348 ₫ total

includes taxes & fees

1 Nov - 2 Nov

A long communal dining table with chairs, a bar area with shelves of bottles, and a brick wall with a mirror.

A spacious hallway with a patterned carpet, large windows, and seating areas.

A multi-story hotel with a modern design, featuring balconies on each floor and a visible restaurant named "CRAVE" at the ground level.

A modern lobby with seating areas, a large pillar, and a wall mural.

7. Hilton Garden Inn Sioux Falls Downtown

Downtown Sioux Falls, 2.1 km from Sioux Empire Medical Museum

Samuel

3.201.864 ₫

3.720.340 ₫ total

includes taxes & fees

1 Nov - 2 Nov

A buffet with labeled containers of omelets and other dishes.

A hotel room with a large bed, a small desk, a chair, a kitchenette, and a nightstand with a lamp.

A snack and beverage display with various brands and products.

A reception area with a glass door entrance, a reception desk, and a computer station.

8. Holiday Inn Express & Suites Sioux Falls At Empire Mall by IHG

Mall District, 3.1 km from Sioux Empire Medical Museum

Hagel

3.636.360 ₫

4.041.035 ₫ total

includes taxes & fees

15 Oct - 16 Oct

A multi-level hotel lobby with a central seating area, multiple floors, and a variety of amenities including a bar and dining space.

A multi-level hotel lobby with a central atrium, multiple floors, and a variety of seating areas.

A hotel room with a bed, a sofa, a TV, and a desk.

A multi-level hotel lobby with a central courtyard, featuring a patterned floor, multiple levels of balconies, and a rock formation.

9. Sheraton Sioux Falls Hotel & Convention Center

Northwest Sioux Falls, 2.9 km from Sioux Empire Medical Museum

Joan

2.739.030 ₫

3.056.689 ₫ total

includes taxes & fees

11 Oct - 12 Oct

A hotel room with two beds, a desk with a computer, a television, and a couch.

A black leather chair, a floor lamp, and a window with a view of parked cars.

A sign for Center Inn with a parking lot and buildings in the background.

A hotel reception area with a Christmas tree, a clock, and a sign indicating a non-smoking policy.

10. The Center Inn

All Saints, 2.4 km from Sioux Empire Medical Museum

Marissa

2.477.523 ₫

2.769.818 ₫ total

includes taxes & fees

9 Oct - 10 Oct

A spacious lobby with multiple seating areas, a bar, and a staircase leading to an upper level.

A modern hotel room with a large window, a round coffee table, a sofa, a chair, and a small table with a lamp.

A hotel room with a bed, a sofa, a chair, a desk, and a large window with a city view.

A modern hotel lobby with a bar area, seating arrangements, and a view of the lobby.

11. Holiday Inn Sioux Falls-City Centre by IHG

Downtown Sioux Falls, 1.9 km from Sioux Empire Medical Museum

Stacey

2.858.570 ₫

3.577.631 ₫ total

includes taxes & fees

11 Oct - 12 Oct

A multi-story hotel with a flat roof, a landscaped area with a water feature, and a bridge connecting to another building.

A restaurant with a long wooden table, multiple chairs, a bar area, and a stone wall.

A swimming pool with lounge chairs and umbrellas, a view of the outside, and a sign indicating the hotel name.

A hotel room with a wooden table, a laptop, a telephone, a glass of orange juice, a lamp, and a chair.

12. Country Inn & Suites by Radisson, Sioux Falls

Downtown Sioux Falls, 2 km from Sioux Empire Medical Museum

Hayley

2.370.014 ₫

2.651.880 ₫ total

includes taxes & fees

1 Nov - 2 Nov

A hotel room with a bed, two bedside lamps, a nightstand, a mirror, and a small desk with a telephone.

A small, cozy room with a sofa, two armchairs, a coffee table, and a desk with a lamp. There are two framed pictures on the wall.

A small cafe with a 'Good Morning' sign, a coffee machine, a microwave, and a refrigerator.

13. Valley Inn

University Heights, 0.2 km from Sioux Empire Medical Museum

Darrel

2.124.437 ₫

2.382.748 ₫ total

includes taxes & fees

4 Oct - 5 Oct

An indoor pool area with a slide, seating, and tropical decor.

A restaurant with booths and tables, a TV screen, and a view of the outdoors.

A lobby with a stone fire feature, seating area, and a reception desk.

A modern restaurant with a central bar, red cushioned chairs, and a 'TEAM ROOM' sign.

14. Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

Northwest Sioux Falls, 2.9 km from Sioux Empire Medical Museum

Sami

1.611.687 ₫

1.819.968 ₫ total

includes taxes & fees

18 Oct - 19 Oct

A living room with a fireplace, a television, a chandelier, a sofa, and a coffee table.

A cozy living room with a sectional sofa, a wooden coffee table, and a chandelier.

A two-story house with a steeply pitched roof, a front porch, and a brick entrance.

A wooden door with a glass panel, leading to a brick-paved entrance.

15. Historic Twin Tudors Inn

1.4 km from Sioux Empire Medical Museum

Anonymous traveller

6.604.596 ₫

7.503.813 ₫ total

includes taxes & fees

11 Oct - 12 Oct

16. Sioux Falls Inn

Northwest Sioux Falls, 3.1 km from Sioux Empire Medical Museum

Stephanie

1.423.115 ₫

1.613.105 ₫ total

includes taxes & fees

15 Oct - 16 Oct

A multi-story hotel with a modern design, featuring a central entrance and multiple balconies.

A hallway with a wooden floor, a small black desk with a mirror, and a door with a glass panel.

A hotel room with a bed, a window with blinds, a heater, a nightstand, and a painting on the wall.

A laundry room with multiple white washers and dryers, wooden flooring, and a door on the left.

17. WoodSpring Suites Sioux Falls

2.8 km from Sioux Empire Medical Museum

Catherine

2.052.973 ₫

2.304.086 ₫ total

includes taxes & fees

4 Oct - 5 Oct

A reception area with a counter, a food mart sign, and a security camera.

A swimming pool with a tiled floor, a poolside table, and chairs.

A breakfast bar with seating, a microwave, toaster, and a coffee maker.

A hotel room with two beds, a desk, a chair, and a TV.

18. Ramada by Wyndham Sioux Falls

2.6 km from Sioux Empire Medical Museum

Tiffany

1.413.693 ₫

1.602.795 ₫ total

includes taxes & fees

18 Oct - 19 Oct

A modern hotel room with a kitchenette, a bed, a desk, and a chair.

A modern kitchen with wooden cabinets, a marble countertop, and various appliances.

A modern living room with a flat-screen TV, a sofa, a coffee table, and a dining area with a table and chairs.

A modern hotel room with a kitchenette, a bed, a sofa, a dining area, and a view of the outdoors.

19. Staybridge Suites Sioux Falls Southwest by IHG

South Sioux Falls, 5.2 km from Sioux Empire Medical Museum

Bailey

3.144.427 ₫

3.501.488 ₫ total

includes taxes & fees

1 Nov - 2 Nov

A deck with outdoor furniture, a fire pit, and a view of a body of water.

A modern hotel lobby with a dining area, seating arrangements, and a kitchen in the background.

A reception area with a herringbone-patterned wall, a reception desk, and seating area with chairs and a table.

A modern Hyatt Place hotel with a glass entrance canopy and a brick facade.

20. Hyatt Place Sioux Falls South

Mall District, 3.8 km from Sioux Empire Medical Museum

Catherine

3.040.479 ₫

3.387.379 ₫ total

includes taxes & fees

11 Oct - 12 Oct

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Compare popular hotels close to Sioux Empire Medical Museum

Property	Property class	Guest rating
Clubhouse Hotel Suites Sioux Falls	9.6 Exceptional 1,227 reviews	View
Highpoint Hotel	9.8 Exceptional 349 reviews	View
Hotel On Phillips	9.6 Exceptional 1,603 reviews	View
Home2 Suites By Hilton Sioux Falls/Sanford Medical Center	9.4 Exceptional 676 reviews	View
Hampton Inn Sioux Falls	9.4 Exceptional 1,003 reviews	View

Top Sioux Empire Medical Museum Hotel Reviews

Days Inn by Wyndham Sioux Falls Empire

10/10 Excellent

"Alex was very kind during our late night check in."

Clubhouse Hotel Suites Sioux Falls

10/10 Excellent

"Great stay. Quiet room! Nice breakfast!"

Valley Inn

10/10 Excellent

"Everything was great"

Other attractions near Sioux Empire Medical Museum

University of Sioux Falls

8.0/10 (242 reviews)

Explore the campus of University of Sioux Falls during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Augustana College

8.2/10 (310 reviews)

Take a campus tour or just explore the area of Augustana College during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Center for Western Studies

You can spend time exploring the galleries in Center for Western Studies during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Delbridge Museum of Natural History

6.0/10 (1 review)

You can spend time browsing the exhibits at Delbridge Museum of Natural History during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Washington Pavilion

Washington Pavilion is just one of the places to see in Sioux Falls, so why not enjoy the other things to explore during your travels?

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Washington Pavilion of Arts and Science

9.0/10 (132 reviews)

You can make plans for a show at Washington Pavilion of Arts and Science during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Pettigrew Home and Museum

You can spend time studying the exhibits at Pettigrew Home and Museum during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Club David

After visiting Club David, make a plan to see the other sights and activities in Sioux Falls.

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Frequently asked questions

What's the area like around Sioux Empire Medical Museum?

Sioux Empire Medical Museum is located in a welcoming area of Sioux Falls known for its beautiful waterfalls and sporting events. If you're looking for a convenient place to stay, take a look at the 136 hotels and other accommodation options you'll find within a mile.

How many hotels are there close to Sioux Empire Medical Museum?

Expedia has 136 hotels and other accommodation options within a mile from Sioux Empire Medical Museum.

If I need to cancel the hotel reservation for my stay near Sioux Empire Medical Museum, will I receive a refund?

Yes, the majority of hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your check-in date. If you have a reservation that's non-refundable, you might still have the option to cancel and be given a refund within 24 hours of booking. Enter dates in and click on "Search", then use the "fully refundable" filter to view the best options available near Sioux Empire Medical Museum.

What can I see and do near Sioux Empire Medical Museum?

Washington Pavilion of Arts and Science, Old Courthouse Museum and Center for Western Studies feature a variety of fascinating exhibits to see while you're in town. Learn about local history at St. Joseph Cathedral and Pettigrew Home and Museum. You can enjoy live performances at Edith Mortenson Theatre Center and Orpheum Theatre Center.

Search Hotels Near Sioux Empire Medical Museum, Sioux Falls

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Treat yourself

Be picky

Check prices for these dates

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Our top choices for Sioux Empire Medical Museum hotels

1. Clubhouse Hotel Suites Sioux Falls

2. Highpoint Hotel

3. Hotel On Phillips

4. Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

5. Hampton Inn Sioux Falls

6. Canopy By Hilton Sioux Falls Downtown

7. Hilton Garden Inn Sioux Falls Downtown

8. Holiday Inn Express & Suites Sioux Falls At Empire Mall by IHG

9. Sheraton Sioux Falls Hotel & Convention Center

10. The Center Inn

11. Holiday Inn Sioux Falls-City Centre by IHG

12. Country Inn & Suites by Radisson, Sioux Falls

13. Valley Inn

14. Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

15. Historic Twin Tudors Inn

16. Sioux Falls Inn

17. WoodSpring Suites Sioux Falls

18. Ramada by Wyndham Sioux Falls

19. Staybridge Suites Sioux Falls Southwest by IHG

20. Hyatt Place Sioux Falls South

Compare popular hotels close to Sioux Empire Medical Museum

Top Sioux Empire Medical Museum Hotel Reviews

Days Inn by Wyndham Sioux Falls Empire

Clubhouse Hotel Suites Sioux Falls

Valley Inn

Other attractions near Sioux Empire Medical Museum

University of Sioux Falls

Augustana College

Center for Western Studies

Delbridge Museum of Natural History

Washington Pavilion

Washington Pavilion of Arts and Science

Pettigrew Home and Museum

Club David

Frequently asked questions