Search Hotels Near South Main, Vancouver

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
23 Dec - 24 Dec
Tomorrow
24 Dec - 25 Dec
This weekend
26 Dec - 28 Dec
Next weekend
2 Jan - 4 Jan

Filter by

Guest rating
Guest rating
Star rating

Our top choices for South Main hotels

Premium bedding, pillow-top beds, blackout curtains, soundproofing
Smithe House

Smithe House

Smithe House
4.0 star property
Yaletown, 2.7 km from South Main
10.0 out of 10, Exceptional, (351)
"Everything was perfect staff were amazing location perfect apartment was spotless "
Australia
Andrea
The price is 4.688.231 ₫
5.587.199 ₫ total
includes taxes & fees
25 Dec - 26 Dec
Smithe House
Dining
L'Hermitage Hotel

L'Hermitage Hotel

L'Hermitage Hotel
4.0 star property
Downtown Vancouver, 3 km from South Main
9.8 out of 10, Exceptional, (1011)
"Great stay"
Canada
Edwin
The price is 4.309.036 ₫
5.135.294 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
L'Hermitage Hotel
Terrace Apartment | Living area | 50-inch Smart TV with cable channels, streaming services
Keefer House

Keefer House

Keefer House
4.0 star property
Chinatown, 2.7 km from South Main
9.8 out of 10, Exceptional, (42)
"Great spot to stay! "
Canada
Armann
The price is 4.294.634 ₫
5.118.130 ₫ total
includes taxes & fees
22 Jan - 23 Jan 2026
Keefer House
Breakfast area
Windsor Guest House

Windsor Guest House

Windsor Guest House
2.5 star property
Mount Pleasant, 1 km from South Main
9.2 out of 10, Wonderful, (283)
"Very good location, clean, nice breakfast, good value for the cost!"
Canada
Diana R
The price is 2.499.241 ₫
2.978.597 ₫ total
includes taxes & fees
2 Jan - 3 Jan 2026
Windsor Guest House
Executive Suite, 1 King Bed | Egyptian cotton sheets, premium bedding, down duvets, pillow-top beds
OPUS Hotel Vancouver

OPUS Hotel Vancouver

OPUS Hotel Vancouver
4.0 star property
Yaletown, 2.6 km from South Main
9.6 out of 10, Exceptional, (1060)
"Room, service, amenities, and location were all excellent"
Canada
Matt
OPUS Hotel Vancouver
Front of property – evening/night
Hotel Blu Vancouver

Hotel Blu Vancouver

Hotel Blu Vancouver
4.0 star property
Downtown Vancouver, 2.7 km from South Main
9.6 out of 10, Exceptional, (3481)
"Nice clean rooms, great location."
Canada
Halyna
The price is 4.002.616 ₫
4.830.142 ₫ total
includes taxes & fees
1 Jan - 2 Jan 2026
Hotel Blu Vancouver
Exterior
Georgian Court Hotel, WorldHotels Elite

Georgian Court Hotel, WorldHotels Elite

Georgian Court Hotel, WorldHotels Elite
4.0 star property
Downtown Vancouver, 2.7 km from South Main
9.4 out of 10, Exceptional, (3769)
"Friendly staff, great location, and the room were very clean and quiet. Would definitely stay again when in the area."
Canada
Nicki
The price is 3.428.078 ₫
4.136.867 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Georgian Court Hotel, WorldHotels Elite
Terrace/patio
Granville Island Hotel

Granville Island Hotel

Granville Island Hotel
3.5 star property
Granville Island, 2.7 km from South Main
9.4 out of 10, Exceptional, (1242)
"Very nice hotel, I really love the location. "
Canada
Gary
The price is 4.813.481 ₫
5.808.390 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Granville Island Hotel
Couples treatment room(s), steam room, body treatments, body wraps
JW Marriott Parq Vancouver

JW Marriott Parq Vancouver

JW Marriott Parq Vancouver
5.0 star property
Downtown Vancouver, 2.3 km from South Main
9.2 out of 10, Wonderful, (1001)
"Nice rooms, quiet & clean"
Canada
Thomas
The price is 5.362.356 ₫
6.390.587 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
JW Marriott Parq Vancouver
Exterior
the DOUGLAS, Autograph Collection

the DOUGLAS, Autograph Collection

the DOUGLAS, Autograph Collection
5.0 star property
Downtown Vancouver, 2.4 km from South Main
9.2 out of 10, Wonderful, (845)
"Clean room, quick check-in, great location, and friendly staff. "
United States
Tyler
The price is 5.151.692 ₫
6.139.528 ₫ total
includes taxes & fees
29 Dec - 30 Dec
the DOUGLAS, Autograph Collection
Garden
Cambie Lodge B&B

Cambie Lodge B&B

Cambie Lodge B&B
3.0 star property
Mount Pleasant, 1 km from South Main
8.8 out of 10, Excellent, (354)
"Check-in was easy, staff were friendly, breakfast was good, and rooms were clean. I would stay again."
Canada
Estefania
The price is 2.930.145 ₫
3.492.043 ₫ total
includes taxes & fees
29 Dec - 30 Dec
Cambie Lodge B&B
View from property
Rosedale On Robson Suite Hotel

Rosedale On Robson Suite Hotel

Rosedale On Robson Suite Hotel
3.5 star property
Downtown Vancouver, 2.8 km from South Main
9.2 out of 10, Wonderful, (3178)
"We really enjoyed our stay and the location was very convenient."
Canada
Raylene
The price is 3.794.149 ₫
4.521.901 ₫ total
includes taxes & fees
24 Dec - 25 Dec
Rosedale On Robson Suite Hotel
Dining
Douglas Guest House

Douglas Guest House

Douglas Guest House
2.5 star property
Mount Pleasant, 1 km from South Main
8.8 out of 10, Excellent, (336)
"Parking was convenient and safe! "
Canada
Sheila
The price is 3.016.325 ₫
3.595.076 ₫ total
includes taxes & fees
11 Jan - 12 Jan 2026
Douglas Guest House
Exterior
Holiday Inn Vancouver Centre by IHG

Holiday Inn Vancouver Centre by IHG

Holiday Inn Vancouver Centre by IHG
3.0 star property
Fairview, 1.6 km from South Main
8.8 out of 10, Excellent, (1005)
"Great hotel , staff were excellent "
Canada
Darrell
The price is 3.408.927 ₫
4.062.587 ₫ total
includes taxes & fees
11 Jan - 12 Jan 2026
Holiday Inn Vancouver Centre by IHG
Exterior
Hilton Vancouver Downtown

Hilton Vancouver Downtown

Hilton Vancouver Downtown
4.5 star property
Downtown Vancouver, 2.9 km from South Main
9.2 out of 10, Wonderful, (1007)
"Great location, our plan had breakfast included that really worth it, staff very friendly "
United States
Silvia
The price is 3.910.307 ₫
4.718.777 ₫ total
includes taxes & fees
3 Jan - 4 Jan 2026
Hilton Vancouver Downtown
Property amenity
Residence Inn by Marriott Vancouver Downtown

Residence Inn by Marriott Vancouver Downtown

Residence Inn by Marriott Vancouver Downtown
3.0 star property
Downtown Vancouver, 3.2 km from South Main
9.2 out of 10, Wonderful, (1129)
"It was a lovely hotel"
Canada
Emily
The price is 3.202.093 ₫
3.816.095 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Residence Inn by Marriott Vancouver Downtown
Outdoor pool, a heated pool
Level Vancouver - Yaletown Seymour

Level Vancouver - Yaletown Seymour

Level Vancouver - Yaletown Seymour
4.0 star property
Downtown Vancouver, 2.9 km from South Main
9.2 out of 10, Wonderful, (551)
"Very nice hotel in a great location. Will definitely being staying here again "
Canada
Rory
The price is 4.410.155 ₫
5.321.756 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Level Vancouver - Yaletown Seymour
Exterior
Hampton Inn and Suites by Hilton, Downtown Vancouver

Hampton Inn and Suites by Hilton, Downtown Vancouver

Hampton Inn and Suites by Hilton, Downtown Vancouver
3.5 star property
Downtown Vancouver, 2.6 km from South Main
9.0 out of 10, Wonderful, (1700)
"Friendly staff, clean rooms and a great breakfast!"
Canada
Mark
The price is 3.423.886 ₫
4.131.790 ₫ total
includes taxes & fees
5 Jan - 6 Jan 2026
Hampton Inn and Suites by Hilton, Downtown Vancouver
Exterior
Best Western Premier Chateau Granville Hotel & Suites & Conf. Centre

Best Western Premier Chateau Granville Hotel & Suites & Conf. Centre

Best Western Premier Chateau Granville Hotel & Suites & Conf. Centre
3.5 star property
Downtown Vancouver, 3 km from South Main
9.0 out of 10, Wonderful, (1013)
"Had a very pleasant stay! All staff was kind and helpful "
Canada
Aleksandra
The price is 3.001.962 ₫
3.577.588 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Best Western Premier Chateau Granville Hotel & Suites & Conf. Centre
Superior Room, 2 Queen Beds, City View | Premium bedding, pillow-top beds, in-room safe, individually decorated
Hotel Belmont Vancouver - MGallery Collection

Hotel Belmont Vancouver - MGallery Collection

Hotel Belmont Vancouver - MGallery Collection
4.0 star property
Downtown Vancouver, 3 km from South Main
9.0 out of 10, Wonderful, (1674)
"Great place to stay"
Canada
annette
The price is 3.257.631 ₫
4.018.492 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Hotel Belmont Vancouver - MGallery Collection
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top South Main Hotel Reviews

Windsor Guest House

Windsor Guest House

10/10 Excellent
"Clean room, very welcoming, personal touches liked text and calls for PIN and directives. Wonderful friendly staff. Very quiet house."
Johanne 1-night trip
Posted 6 days ago
Windsor Guest House

Hotels near other South Main attractions

Olympic Village - Aqua Bus in Vancouver, BC. The view on the public transport boat with passengers on. Cityscape - Downtown and mountains in the background.

Olympic Village

You can find out about the history of Vancouver with a trip to Olympic Village. Attend a sporting event or visit the shops in this vibrant area.
See properties
ancouver, British Columbia / CANADA - Jul 25 2014: False Creek in a sunny summer day

Science World

4.4/5 (266 reviews)
You can spend time browsing the exhibits at Science World during your trip to Vancouver. Discover the top-notch restaurants and fascinating museums in this vibrant area.
See properties

Frequently asked questions

What's the area like around South Main?
South Main is located in Vancouver. If you're looking for a convenient place to stay, take a look at the 91 hotels and other accommodation options you'll find within a mile.
How many hotels will I be able to find near South Main?
Expedia has 91 hotels and other accommodation options within a mile from South Main.
If I need to cancel the hotel reservation for my stay near South Main, will I receive a refund?
Yes, most hotel room reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your scheduled arrival. If your reservation is non-refundable, it might still be possible to cancel it and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then you can use the "fully refundable" filter to review the best deals near South Main.
What can I see and do near South Main?
Science World, Vancouver Art Gallery and Museum of Vancouver feature captivating exhibits. Hotel Europe, Engine 374 Pavilion and Chinatown Millennium Gate are monuments to see when you're exploring the area around South Main. You can catch a show at Rickshaw Theatre, Queen Elizabeth Theatre and Orpheum Theater.
How can I get to South Main?
With so many ways to get around, seeing the area around South Main is a breeze. Nearby metro stations include Nanaimo Station, 29th Avenue Station and Commercial-Broadway Station. If you're hopping a train into town, Vancouver Rocky Mountaineer Station, Vancouver, BC (XEA-Vancouver Pacific Central Station) and Pacific Central Station are the closest train stations to East Vancouver.