Southeast Missouri Holidays
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Top hotels in Southeast Missouri
Drury Plaza Hotel Cape Girardeau Conference Center
3351 Percy Drive Cape Girardeau MO
Fully refundableReserve now, pay when you stay
The price is 2.618.038 ₫ per night from 18 Mar to 19 Mar
2.618.038 ₫
2.953.513 ₫ total
18 Mar - 19 Mar
includes taxes & fees
9.6/10 Exceptional! (1,013 reviews)
This was our first time staying at a Drury Hotel. The room was clean and comfortable! We missed the evening snack, but breakfast was awesome! So many options. Would definitely stay again!
Reviewed on 4 Mar 2026
Drury Inn & Suites Cape Girardeau
3303 Campster Drive Cape Girardeau MO
Fully refundableReserve now, pay when you stay
The price is 2.356.208 ₫ per night from 5 Apr to 6 Apr
2.356.208 ₫
2.658.132 ₫ total
5 Apr - 6 Apr
includes taxes & fees
9.4/10 Exceptional! (1,006 reviews)
Great as all Drury’s
Reviewed on 4 Mar 2026
The Riverview
777 Main St Cape Girardeau MO
Fully refundableReserve now, pay when you stay
The price is 2.522.386 ₫ per night from 8 Mar to 9 Mar
2.522.386 ₫
2.845.604 ₫ total
8 Mar - 9 Mar
includes taxes & fees
9.4/10 Exceptional! (516 reviews)
Run very well—check in great
Reviewed on 2 Mar 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Popular places to visit
Southeast Missouri State University
Take a campus tour or just explore the area of Southeast Missouri State University during your trip to Cape Girardeau. While in this family-friendly area, you can savour the top-notch restaurants.
Lake Wappapello
Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.
Current River State Park
Commune with nature and explore the great outdoors at Current River State Park during your travels in Salem. While you're in the area, stroll along the riverfront.
