Find hotels in Southeast Missouri, MO from 1.579.857 ₫
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18 Sep - 20 SepOur top choices for Southeast Missouri hotels
1. Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference CenterCape Girardeau
Sandra
2.591.541 ₫
2.923.621 ₫ total
includes taxes & fees
17 Sept - 18 Sept
2. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHGCape Girardeau
ELAINE
2.617.718 ₫
2.979.330 ₫ total
includes taxes & fees
20 Sept - 21 Sept
3. Super 8 by Wyndham Potosi
Super 8 by Wyndham PotosiPotosi
Ross
1.508.946 ₫
1.648.146 ₫ total
includes taxes & fees
15 Sept - 16 Sept
4. Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MOSikeston
Scott Andrew
2.644.805 ₫
3.040.865 ₫ total
includes taxes & fees
17 Sept - 18 Sept
5. Fairfield Inn & Suites by Marriott Sikeston
Fairfield Inn & Suites by Marriott SikestonSikeston
Allen
2.617.718 ₫
2.963.912 ₫ total
includes taxes & fees
11 Oct - 12 Oct
6. Courtyard by Marriott Cape Girardeau Downtown
Courtyard by Marriott Cape Girardeau DowntownCape Girardeau
Kristin
3.242.342 ₫
3.674.029 ₫ total
includes taxes & fees
20 Sept - 21 Sept
7. Pear Tree Inn Cape Girardeau West
Pear Tree Inn Cape Girardeau WestCape Girardeau
Raidas
1.865.837 ₫
2.104.924 ₫ total
includes taxes & fees
20 Sept - 21 Sept
8. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape GirardeauJackson
Andrew
2.401.303 ₫
2.598.811 ₫ total
includes taxes & fees
14 Sept - 15 Sept
9. Madison Inn Lodge
Madison Inn LodgeFredericktown
Bawan
2.268.084 ₫
2.477.501 ₫ total
includes taxes & fees
14 Sept - 15 Sept
10. The Riverview
The RiverviewCape Girardeau
Alyssa
2.962.427 ₫
3.341.867 ₫ total
includes taxes & fees
13 Sept - 14 Sept
11. Honeysuckle Inn - Mountain View
Honeysuckle Inn - Mountain ViewMountain View
JOAQUIN
2.565.882 ₫
2.781.725 ₫ total
includes taxes & fees
12 Sept - 13 Sept
12. Holiday Inn Express & Suites Perryville by IHG
Holiday Inn Express & Suites Perryville by IHGPerryville
David
2.515.404 ₫
2.879.509 ₫ total
includes taxes & fees
4 Oct - 5 Oct
13. Super 8 by Wyndham Perryville
Super 8 by Wyndham PerryvillePerryville
paulette
1.828.515 ₫
2.093.192 ₫ total
includes taxes & fees
24 Sept - 25 Sept
14. Drury Inn & Suites Jackson MO
Drury Inn & Suites Jackson MOJackson
William
2.125.017 ₫
2.246.674 ₫ total
includes taxes & fees
20 Sept - 21 Sept
15. Crown Pointe Lodge, BW Signature Collection
Crown Pointe Lodge, BW Signature CollectionFarmington
Susan
2.841.909 ₫
3.093.418 ₫ total
includes taxes & fees
4 Oct - 5 Oct
16. Hampton Inn Poplar Bluff
Hampton Inn Poplar BluffPoplar Bluff
Theresa
2.422.815 ₫
2.712.947 ₫ total
includes taxes & fees
20 Sept - 21 Sept
17. Hampton Inn Cape Girardeau I 55 East
Hampton Inn Cape Girardeau I 55 EastCape Girardeau
Rebekah
2.741.606 ₫
3.092.915 ₫ total
includes taxes & fees
11 Oct - 12 Oct
18. Hampton Inn & Suites By Hilton Festus
Hampton Inn & Suites By Hilton FestusFestus
Linda
2.445.388 ₫
2.796.300 ₫ total
includes taxes & fees
8 Oct - 9 Oct
19. Best Western Plus Sikeston I-55
Best Western Plus Sikeston I-55Sikeston
Bernice
2.261.011 ₫
2.576.987 ₫ total
includes taxes & fees
20 Sept - 21 Sept
20. Baymont Inn and Suites by Wyndham Farmington, MO
Baymont Inn and Suites by Wyndham Farmington, MOFarmington
ILUNGA
1.451.408 ₫
1.579.857 ₫ total
includes taxes & fees
11 Oct - 12 Oct
Holiday Rentals in Southeast Missouri
Cabin
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Postcard Cabins St Francois, Outdoor Collection by Marriott BonvoyFrench Village
"I really enjoyed my time at the stay !"
Cottage
'turtle Rock' - Ironton Cabin w/ Furnished Patio!
'turtle Rock' - Ironton Cabin w/ Furnished Patio!Ironton
"Stroller, pack n play and high chair. This was amazing "
Aparthotel
The Atrium - A Boutique Hotel
The Atrium - A Boutique HotelPerryville
"What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor items…all was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. It was a great getaway."
Holiday Home
Tiny Houses of French Village
Tiny Houses of French VillageFrench Village
"Very nice place very clean well kept inside an out it's a nice little romantic getaway they have it set up so great its a must see sunset very relaxing "
Cottage
Walk to Current River: Ozarks Adventure Home!
Walk to Current River: Ozarks Adventure Home!Van Buren
"Teresa & Chuck went out of their way to make the stay EXCELENT. Teresa is a great cook and shared some of her creations with me, again EXCELENT. The lodging was comfortable and easy to access. Next time in town that will be the place for me."
Cottage
Cozy Belgrade Cottage w/ Wood-burning Stove!
Cozy Belgrade Cottage w/ Wood-burning Stove!Belgrade
Cottage
Cottage w/ Yard, Walk to Historic Attractions
Cottage w/ Yard, Walk to Historic AttractionsSte Genevieve
"The little blue cottage was very comfortable, clean and close to everything downtown. We parked the car and walked everywhere. It was on a quiet street. The bed was comfy, clean kitchen. We liked the little back yard, for relaxing. "
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Stay near popular Southeast Missouri attractions
Photo by Pat Long
Elephant Rocks State Park
9.6/10 (98 reviews)
You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.
Southeast Missouri State University
8.8/10 (248 reviews)
Take a campus tour or just explore the area of Southeast Missouri State University during your trip to Cape Girardeau. While in this family-friendly area, you can savour the top-notch restaurants.
Big Spring
9.8/10 (19 reviews)
Enjoy an outing to Big Spring during your stay in Van Buren. Wander the forests and riverfront while you're in the area.
Current River State Park
9.2/10 (20 reviews)
Commune with nature and explore the great outdoors at Current River State Park during your travels in Salem. While you're in the area, stroll along the riverfront.
Century Casino & Hotel Cape Girardeau
8.4/10 (176 reviews)
Why not roll the dice with a visit to Century Casino & Hotel Cape Girardeau during your time in Cape Girardeau? While in this family-friendly area, you can savour the top-notch restaurants.
Century Casino Caruthersville
7.0/10 (57 reviews)
Why not try your luck with a visit to Century Casino Caruthersville during your visit to Caruthersville? While in this family-friendly area, you can enjoy the restaurants.
Learn more about Southeast Missouri
Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from K Bridge Recreation Area to Lake Wappapello State Park.
See all hotels in Southeast Missouri
Photo by Bill Dillard
Top Southeast Missouri Hotel Reviews
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
10/10 Excellent
"Perfect trip!!! I can’t wait to go back when it gets colder outside :)"
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
10/10 Excellent
"Great"
Drury Inn & Suites Sikeston, MO
10/10 Excellent
"All good, staff friendly and helpful! Breakfast was great and kick back dinner was good!"
The Riverview
10/10 Excellent
"Very clean They need a fitness center !"
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
10/10 Excellent
"."
Motel 6 Poplar Bluff, MO
10/10 Excellent
"Nice"
Best Western Plus Sikeston I-55
8/10 Good
"Great location, nice, clean and well maintained, Hotel employees were very helpful great customer service,"
More cheap stays in Southeast Missouri
Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St Farmington MO
1.451.408 ₫
1.579.857 ₫ total
11 Oct - 12 Oct
includes taxes & fees
8/10 Very good! (1,006 reviews)
Days Inn and Suites by Wyndham Sikeston
220 S Interstate Dr Sikeston MO
1.696.333 ₫
1.933.397 ₫ total
13 Sept - 14 Sept
includes taxes & fees
Pear Tree Inn Cape Girardeau West
103 Cape West Pkwy Cape Girardeau MO
1.865.837 ₫
2.104.924 ₫ total
20 Sept - 21 Sept
includes taxes & fees
Comfort Inn Festus - St Louis South
1303 Veterans Blvd Festus MO
1.845.362 ₫
2.156.306 ₫ total
11 Oct - 12 Oct
includes taxes & fees
7.8/10 Good! (1,000 reviews)
The Farmstead Hotel
778 E 3rd St Caruthersville MO
2.462.210 ₫
2.800.147 ₫ total
13 Sept - 14 Sept
includes taxes & fees
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
3253 William Street Cape Girardeau MO
2.617.718 ₫
2.979.330 ₫ total
20 Sept - 21 Sept
includes taxes & fees
9.4/10 Exceptional! (1,001 reviews)
Hotels in Southeast Missouri with star rating
4 Star Hotels
2 properties
3 Star Hotels
70 properties
