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Our top choices for Southeast Missouri hotels

A kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, a stove, and a granite countertop.

1. Shepherd Mountain Inn

Ironton

Jonathan

3.480.266 ₫ total

includes taxes & fees

29 Oct - 30 Oct

A motel with a covered entrance, a flag, and a phone number.

2. Madison Inn Lodge

Fredericktown

Bawan

2.399.337 ₫ total

includes taxes & fees

2 Nov - 3 Nov

A modern kitchen with a central island, built-in appliances, and a view into the dining area.

3. Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

Festus

Terry

2.718.524 ₫ total

includes taxes & fees

1 Nov - 2 Nov

A hotel room with a bed, bedside tables, a desk, a chair, a lamp, and a window.

4. Hampton Inn & Suites By Hilton Festus

Festus

Misty

2.988.770 ₫ total

includes taxes & fees

1 Nov - 2 Nov

A modern lounge area with a stone fireplace, blue seating, a round coffee table, and a large window offering a view.

5. Fairfield Inn & Suites by Marriott Poplar Bluff

Poplar Bluff

ELAINE

2.828.886 ₫ total

includes taxes & fees

8 Nov - 9 Nov

A modern kitchen with a coffee machine, a refrigerator, and a microwave.

6. Super 8 by Wyndham Farmington

Farmington

Marisa

1.758.471 ₫ total

includes taxes & fees

3 Nov - 4 Nov

A dining area with tables and chairs, a kitchen area, and a TV mounted on the wall.

7. Baymont Inn and Suites by Wyndham Farmington, MO

Farmington

Kim

1.607.474 ₫ total

includes taxes & fees

2 Nov - 3 Nov

A spacious lobby with a reception desk, seating area, and large windows.

8. Drury Inn & Suites Poplar Bluff

Poplar Bluff

Dean

2.627.155 ₫ total

includes taxes & fees

8 Nov - 9 Nov

A hotel room with two beds, a desk, a chair, a TV, and a lamp.

9. Fort Davidson Hotel

Ironton

richard

3.528.330 ₫ total

includes taxes & fees

28 Oct - 29 Oct

An indoor swimming pool with clear water, surrounded by lounge chairs and a tiled floor.

10. Hampton Inn Farmington

Farmington

Charlie

2.925.664 ₫ total

includes taxes & fees

19 Nov - 20 Nov

A living room with a blue wall, a fireplace, a sofa, and a chair.

11. EC Reed's Mercantile and Hotel

Marble Hill

Jan

2.957.887 ₫ total

includes taxes & fees

28 Oct - 29 Oct

A modern lobby with seating areas, a patterned carpet, and a cityscape mural on the wall.

12. La Quinta Inn & Suites by Wyndham Festus - St. Louis South

Festus

Debra S

2.486.564 ₫ total

includes taxes & fees

1 Nov - 2 Nov

A Holiday Inn Express & Suites building with a covered entrance and multiple windows.

13. Holiday Inn Express & Suites Perryville by IHG

Perryville

Perry

2.987.729 ₫ total

includes taxes & fees

1 Nov - 2 Nov

A row of single-story houses with attached garages, a paved driveway, and a clear sky.

14. Microtel Inn & Suites by Wyndham Sainte Genevieve

Ste Genevieve

Samantha

2.628.347 ₫ total

includes taxes & fees

15 Nov - 16 Nov

A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.

15. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Jackson

J

2.234.517 ₫ total

includes taxes & fees

1 Nov - 2 Nov

A hotel room with a large bathtub, a sofa, a small table, a TV, and a window with curtains.

16. Super 8 by Wyndham Perryville

Perryville

Matthew

2.011.541 ₫ total

includes taxes & fees

8 Nov - 9 Nov

A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.

17. Fairfield Inn & Suites by Marriott Cape Girardeau

Cape Girardeau

Carlos

2.948.752 ₫ total

includes taxes & fees

1 Nov - 2 Nov

A spacious lobby with a modern design, featuring a seating area with patterned armchairs and a round table, a large window, and a fireplace with decorative wall art.

18. Drury Inn & Suites Hayti Caruthersville

Hayti

Philip

2.886.030 ₫ total

includes taxes & fees

8 Nov - 9 Nov

An indoor swimming pool with a brick border, wooden walls, and a view of the outdoors.

19. Crown Pointe Lodge, BW Signature Collection

Farmington

CURTIS

2.988.898 ₫ total

includes taxes & fees

19 Nov - 20 Nov

A spacious dining area with multiple tables and chairs, a flat-screen TV mounted on the wall, and large windows providing natural light.

20. Hampton Inn Poplar Bluff

Poplar Bluff

Denise

2.607.085 ₫ total

includes taxes & fees

8 Nov - 9 Nov

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Holiday Rentals in Southeast Missouri

Cabin

Sam A Baker State Park

Patterson

"Pet friendly, great staff. "

Cabin

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

French Village

"Recomend this location"

Aparthotel

A rustic interior with exposed brick walls, wooden railings, and a hanging floral chandelier.

The Atrium - A Boutique Hotel

Perryville

"What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor items…all was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. It was a great getaway."

Holiday Home

A wooden deck with two Adirondack chairs and a hammock.

Tiny Houses of French Village

French Village

"Very nice place very clean well kept inside an out it's a nice little romantic getaway they have it set up so great its a must see sunset very relaxing "

Cottage

A log cabin with a glass door leading to an outdoor patio, a grill, and a table with chairs.

Peaceful 2-cabin Property: 1 Mi to Current River!

Van Buren

"We had the best time. We had plenty of room for our families that were in town for a wedding. The rental had everything we needed."

Cottage

A bedroom with a bed, nightstand, lamp, and curtains.

Cottage w/ Yard, Walk to Historic Attractions

Ste Genevieve

"The little blue cottage was very comfortable, clean and close to everything downtown. We parked the car and walked everywhere. It was on a quiet street. The bed was comfy, clean kitchen. We liked the little back yard, for relaxing. "

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Stay near popular Southeast Missouri attractions

A large, reddish-brown rock formation with a smooth, rounded surface and a unique, intertwined shape.

Elephant Rocks State Park

9.6/10 (98 reviews)

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

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Learn more about Southeast Missouri

Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from K Bridge Recreation Area to Lake Wappapello State Park.

See all hotels in Southeast Missouri

A historical marker sign for the Frisco Depot, detailing its construction in 1928, architectural style, and historical significance.

Top Southeast Missouri Hotel Reviews

Drury Inn & Suites Cape Girardeau

10/10 Excellent

"Clean, spacious suite, enjoyable kick back and breakfast!"

Drury Inn & Suites Sikeston, MO

8/10 Good

"We had a two-room room king suite. The only complaint I had was that it took 5-10 minutes for the hot water to get hot. They did offer to give me points for a free stay if I wanted to sign-up for their rewards program. We will there next year when we go through Sikeston MO."