Photo by Bill Dillard

Find hotels in Southeast Missouri, MO from 1.500.899 ₫
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Our top choices for Southeast Missouri hotels

Drury Inn & Suites Jackson MO
Drury Inn & Suites Jackson MOJackson
9.6 out of 10, Exceptional, (1,009 reviews)
The price is 2.096.858 ₫
2.216.904 ₫ total
includes taxes & fees
12 Mar - 13 Mar

The Riverview
The RiverviewCape Girardeau
9.4 out of 10, Exceptional, (523 reviews)
The price is 2.524.408 ₫
2.847.885 ₫ total
includes taxes & fees
9 Mar - 10 Mar

Fairfield Inn & Suites by Marriott Sikeston
Fairfield Inn & Suites by Marriott SikestonSikeston
9.4 out of 10, Exceptional, (62 reviews)
The price is 2.647.614 ₫
2.997.762 ₫ total
includes taxes & fees
14 Mar - 15 Mar

Echo Bluff State Park
Echo Bluff State ParkEminence
9.4 out of 10, Exceptional, (227 reviews)
The price is 4.823.376 ₫
5.099.515 ₫ total
includes taxes & fees
9 Mar - 10 Mar

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape GirardeauJackson
9.0 out of 10, Wonderful, (719 reviews)
The price is 2.205.908 ₫
2.387.343 ₫ total
includes taxes & fees
15 Mar - 16 Mar

Drury Inn & Suites Poplar Bluff
Drury Inn & Suites Poplar BluffPoplar Bluff
9.2 out of 10, Wonderful, (1,003 reviews)
The price is 2.463.854 ₫
2.783.537 ₫ total
includes taxes & fees
15 Mar - 16 Mar

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHGCape Girardeau
9.4 out of 10, Exceptional, (1,006 reviews)
The price is 2.490.330 ₫
2.809.441 ₫ total
includes taxes & fees
15 Mar - 16 Mar

Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference CenterCape Girardeau
9.6 out of 10, Exceptional, (1,016 reviews)
The price is 2.621.138 ₫
2.957.010 ₫ total
includes taxes & fees
15 Mar - 16 Mar

Century Casino & Hotel Caruthersville
Century Casino & Hotel CaruthersvilleCaruthersville
8.6 out of 10, Excellent, (126 reviews)
The price is 3.185.001 ₫
3.622.251 ₫ total
includes taxes & fees
9 Mar - 10 Mar

The Farmstead Hotel
The Farmstead HotelCaruthersville
8.6 out of 10, Excellent, (506 reviews)
The price is 1.992.264 ₫
2.265.702 ₫ total
includes taxes & fees
9 Mar - 10 Mar

Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MOSikeston
9.4 out of 10, Exceptional, (1,012 reviews)
The price is 2.463.854 ₫
2.832.816 ₫ total
includes taxes & fees
15 Mar - 16 Mar

Crown Pointe Lodge, BW Signature Collection
Crown Pointe Lodge, BW Signature CollectionFarmington
9.0 out of 10, Wonderful, (592 reviews)
The price is 2.428.727 ₫
2.765.107 ₫ total
includes taxes & fees
9 Mar - 10 Mar

Fairfield Inn & Suites by Marriott Cape Girardeau
Fairfield Inn & Suites by Marriott Cape GirardeauCape Girardeau
9.4 out of 10, Exceptional, (162 reviews)
The price is 2.651.546 ₫
2.991.316 ₫ total
includes taxes & fees
19 Mar - 20 Mar

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Postcard Cabins St Francois, Outdoor Collection by Marriott BonvoyFrench Village
9.8 out of 10, Exceptional, (56 reviews)
The price is 2.464.116 ₫
3.779.639 ₫ total
includes taxes & fees
16 Mar - 17 Mar

Days Inn & Suites By Wyndham Festus
Days Inn & Suites By Wyndham FestusFestus
The price is 2.477.223 ₫
2.832.704 ₫ total
includes taxes & fees
12 Mar - 13 Mar

Fairfield Inn & Suites by Marriott Poplar Bluff
Fairfield Inn & Suites by Marriott Poplar BluffPoplar Bluff
9.4 out of 10, Exceptional, (876 reviews)
The price is 2.883.540 ₫
3.257.680 ₫ total
includes taxes & fees
15 Mar - 16 Mar

Holiday Inn Express & Suites Perryville by IHG
Holiday Inn Express & Suites Perryville by IHGPerryville
9.2 out of 10, Wonderful, (562 reviews)
The price is 2.700.042 ₫
3.090.873 ₫ total
includes taxes & fees
5 Apr - 6 Apr

Tru By Hilton Cape Girardeau
Tru By Hilton Cape GirardeauCape Girardeau
9.6 out of 10, Exceptional, (114 reviews)
The price is 2.557.962 ₫
2.911.319 ₫ total
includes taxes & fees
15 Mar - 16 Mar

Hampton Inn Poplar Bluff
Hampton Inn Poplar BluffPoplar Bluff
9.4 out of 10, Exceptional, (805 reviews)
The price is 2.450.485 ₫
2.743.931 ₫ total
includes taxes & fees
15 Mar - 16 Mar

Super 8 by Wyndham Perryville
Super 8 by Wyndham PerryvillePerryville
8.4 out of 10, Very good, (960 reviews)
The price is 1.782.552 ₫
2.040.576 ₫ total
includes taxes & fees
15 Mar - 16 Mar
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Holiday Rentals in Southeast Missouri
Cabin

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Postcard Cabins St Francois, Outdoor Collection by Marriott BonvoyFrench Village
9.8 out of 10, Exceptional, (56 reviews)
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Stay near popular Central United States attractions
Learn more about Southeast Missouri
Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from Sam A. Baker State Park to K Bridge Recreation Area.

Photo by Bill Dillard
Open Photo by Bill Dillard
Top Southeast Missouri Hotel Reviews

Drury Inn & Suites Poplar Bluff
10/10 Excellent
More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St Farmington MO
The price is 1.509.926 ₫ per night from 15 Mar to 16 Mar
1.509.926 ₫
1.719.051 ₫ total
15 Mar - 16 Mar
includes taxes & fees
8/10 Very Good! (1,010 reviews)
Hotels in Southeast Missouri with star rating

4 Star Hotels
2 properties

3 Star Hotels
52 properties

















































































































