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Compare and book 4 Star hotels in Southeast Missouri, Missouri

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Check availability on Southeast Missouri 4 Star Hotels

This weekend
31 Jul - 2 Aug
Next weekend
7 Aug - 9 Aug

Our top choices for Southeast Missouri 4-star hotels

Lobby sitting area

The Riverview

The Riverview
4.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (635 reviews)
"Such a great place in fact it was so nice I stayed a few more nights, the casino is amazing"
United States
James
The price is 3.007.804 ₫
3.393.225 ₫ total
includes taxes & fees
4 Aug - 5 Aug
The Riverview
Street view

Urban Lofts

Urban Lofts
4.0 star property
Perryville
Urban Lofts
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Learn more about Southeast Missouri

Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from Crane Lake Recreation Area to K Bridge Recreation Area.

See all hotels in Southeast Missouri
A historical marker sign for the Frisco Depot, detailing its construction in 1928, architectural style, and historical significance.
Photo by Bill Dillard
Open Photo by Bill Dillard

Top Southeast Missouri Hotel Reviews

The Riverview

The Riverview

10/10 Excellent
"Very clean property all the way around!"
Michael 1-night trip
Posted 14 hours ago
The Riverview

Frequently asked questions

How much does it cost to stay in a 4-star hotel in Southeast Missouri?
To book a 4-star hotel in Southeast Missouri that matches your budget, take advantage of Expedia's handy search filters. Browse the available options during your chosen dates and use our pricing filter to set your limit. You can also list your results by the cheapest stay first.

  • Search for the lowest price from 3.393.225 ₫

What's the difference between 5-star and 4-star hotels in Southeast Missouri?
Treat yourself to refined living during your Southeast Missouri holiday by choosing a 4-star hotel. As well as featuring upmarket surroundings, these retreats are typically packed with amenities, including complimentary bathrobes, large beds and more. A 5-star hotel will go above and beyond to make your trip an even more lavish and memorable one. 24-hour front desk, on-site spas and gourmet dining are a few of the superior services and conveniences you'll likely have access to.
Does Southeast Missouri have any 4-star all-inclusive resorts?
Enjoy a stress-free holiday experience where everything is included in the upfront price by using our "All inclusive" filter. Budgeting is easy when your room, meals and many activities are already taken care of. Eager for more ideas? Check out the amazing deals on Expedia's standard 4-star hotels in and around Southeast Missouri too.