Southeast Missouri Holidays
Book a Hotel + Flight or Car together to unlock savings
Photo by JG Morris
Top hotels in Southeast Missouri
Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St Farmington MO
Fully refundableReserve now, pay when you stay
The price is 1.408.018 ₫ per night from 1 Feb to 2 Feb
1.408.018 ₫
1.603.029 ₫ total
1 Feb - 2 Feb
includes taxes & fees
7.8/10 Good! (1,004 reviews)
The King Suite is huge!
Reviewed on 10 Jan 2026
Drury Plaza Hotel Cape Girardeau Conference Center
3351 Percy Drive Cape Girardeau MO
Fully refundableReserve now, pay when you stay
The price is 2.363.677 ₫ per night from 22 Jan to 23 Jan
2.363.677 ₫
2.666.261 ₫ total
22 Jan - 23 Jan
includes taxes & fees
9.4/10 Exceptional! (1,004 reviews)
Clean
Reviewed on 8 Jan 2026
The Riverview
777 Main St Cape Girardeau MO
Fully refundableReserve now, pay when you stay
The price is 2.529.416 ₫ per night from 14 Jan to 15 Jan
2.529.416 ₫
2.853.535 ₫ total
14 Jan - 15 Jan
includes taxes & fees
9.2/10 Wonderful! (488 reviews)
Room was spotless. The whole hotel was clean and the staff were very kind.
Reviewed on 9 Jan 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Popular places to visit
Lake Wappapello
Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.
Southeast Missouri State University
Take a campus tour or just explore the area of Southeast Missouri State University during your trip to Cape Girardeau. While in this family-friendly area, you can savour the top-notch restaurants.
Bonne Terre Mine
Commune with nature and explore the great outdoors at Bonne Terre Mine during your travels in Bonne Terre. You can seek out the golf courses while in the area.
