Southeast Missouri Holidays
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Top hotels in Southeast Missouri
Drury Plaza Hotel Cape Girardeau Conference Center
3351 Percy Drive Cape Girardeau MO
Fully refundableReserve now, pay when you stay
The price is 2.634.137 ₫ per night from 10 May to 11 May
2.634.137 ₫
2.971.675 ₫ total
10 May - 11 May
includes taxes & fees
9.6/10 Exceptional! (1,002 reviews)
This is my home away from home place! You get free dinner and the BEST breakfast buffet ever with your stay! Plus the indoor pool and hot tub! There is a thermostat in every room to control requirement. It’s just simply the best hotel ever seriously I absolutely love staying here!!!
Reviewed on 18 Apr 2026
Drury Inn & Suites Sikeston, MO
2608 East Malone Ave, Miner Sikeston MO
Fully refundableReserve now, pay when you stay
The price is 2.923.921 ₫ per night from 3 May to 4 May
2.923.921 ₫
3.361.779 ₫ total
3 May - 4 May
includes taxes & fees
9.6/10 Exceptional! (1,005 reviews)
👍
Reviewed on 19 Apr 2026
Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St Farmington MO
Fully refundableReserve now, pay when you stay
The price is 1.664.941 ₫ per night from 3 May to 4 May
1.664.941 ₫
1.812.288 ₫ total
3 May - 4 May
includes taxes & fees
8/10 Very Good! (1,005 reviews)
I get it is cheap, but It shouldn’t small like feet. The room smelled bad, the hallway also, the walls are thin u can hear any noise. Never again
Reviewed on 26 Apr 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Popular places to visit
Southeast Missouri State University
Take a campus tour or just explore the area of Southeast Missouri State University during your trip to Cape Girardeau. While in this family-friendly area, you can savour the top-notch restaurants.
Lake Wappapello
Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.
Current River State Park
Commune with nature and explore the great outdoors at Current River State Park during your travels in Salem. While you're in the area, stroll along the riverfront.
