Southeast Missouri Holidays
Book a Hotel + Flight or Car together to unlock savings
Photo by JG Morris
Top hotels in Southeast Missouri
Drury Plaza Hotel Cape Girardeau Conference Center
3351 Percy Drive Cape Girardeau MO
Fully refundableReserve now, pay when you stay
The price is 2.373.216 ₫ per night from 4 Dec to 5 Dec
2.373.216 ₫
per night
4 Dec - 5 Dec
9.4/10 Exceptional! (1,002 reviews)
Breakfast and super Kickoff was AWESOME? love this hotel!!!
Reviewed on 23 Nov 2025
Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St Farmington MO
Fully refundableReserve now, pay when you stay
The price is 1.392.547 ₫ per night from 6 Dec to 7 Dec
1.392.547 ₫
per night
6 Dec - 7 Dec
8/10 Very Good! (1,005 reviews)
Great room, only problem is I thought I was getting a king and I had 2 queens.
Reviewed on 24 Nov 2025
Motel 6 Poplar Bluff, MO
4101 Highway 67 N Poplar Bluff MO
Fully refundableReserve now, pay when you stay
The price is 2.004.272 ₫ per night from 11 Dec to 12 Dec
2.004.272 ₫
per night
11 Dec - 12 Dec
7.8/10 Good! (1,004 reviews)
Staff was nice, rooms are small but comfortable
Reviewed on 24 Nov 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Popular places to visit
Lake Wappapello
Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.
Southeast Missouri State University
Take a campus tour or just explore the area of Southeast Missouri State University during your trip to Cape Girardeau. While in this family-friendly area, you can savour the top-notch restaurants.
Alley Spring & Mill
Learn about the local history of Eminence with a stop at Alley Spring & Mill. While you're in the area, stroll along the riverfront.
