Southeast Missouri Holidays
Book a Hotel + Flight or Car together to unlock savings
Top hotels in Southeast Missouri
Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St, Farmington, MO
Fully refundableReserve now, pay when you stay
The price is 1.433.494 ₫ per night from 31 Oct to 1 Nov
1.433.494 ₫
1.632.033 ₫ total
31 Oct - 1 Nov
includes taxes & fees
8/10 Very Good! (1,005 reviews)
"It was very nice. There was a problem with me being charge 2 times but that was fix right away"
Reviewed on 6 Oct 2025
Drury Plaza Hotel Cape Girardeau Conference Center
3351 Percy Drive, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
The price is 2.371.326 ₫ per night from 19 Oct to 20 Oct
2.371.326 ₫
2.674.890 ₫ total
19 Oct - 20 Oct
includes taxes & fees
9.4/10 Exceptional! (1,012 reviews)
"The lady that checked me in was amazing!"
Reviewed on 6 Oct 2025
The Riverview
777 Main St, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
The price is 3.011.919 ₫ per night from 19 Oct to 20 Oct
3.011.919 ₫
3.397.867 ₫ total
19 Oct - 20 Oct
includes taxes & fees
9.2/10 Wonderful! (431 reviews)
"The rooms are always amazing! When we go in its always so nice and cool. Loved having a k-cup in my room again. This is my favorite place in cape. My only complaint would be no microwave in the room for snacks and things."
Reviewed on 6 Oct 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Popular places to visit
Lake Wappapello
Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.
Southeast Missouri State University
Take a campus tour or just explore the area of Southeast Missouri State University during your trip to Cape Girardeau. While in this family-friendly area, you can savour the top-notch restaurants.
Current River State Park
Commune with nature and explore the great outdoors at Current River State Park during your travels in Salem. While you're in the area, stroll along the riverfront.
