Our top choices for Upstate South Carolina hotels

Suite, 1 King Bed with Sofa bed, Non Smoking (Efficiency) | Premium bedding, individually decorated, desk, laptop workspace

Comfort Inn & Suites Clemson - University Area

Clemson

HANS

3.081.270 ₫ total

includes taxes & fees

10 May - 11 May

Fairfield Inn & Suites by Marriott Greenville Simpsonville

Simpsonville

henry

2.388.634 ₫ total

includes taxes & fees

19 Apr - 20 Apr

La Quinta by Wyndham Haywood Mall-Near Greenville Downtown

Greenville

Cody

2.059.896 ₫ total

includes taxes & fees

19 Apr - 20 Apr

Woodspring Suites Greenville Airport

Greenville

Willie

1.945.382 ₫ total

includes taxes & fees

28 Apr - 29 Apr

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

Greenville

Alysha

2.930.498 ₫ total

includes taxes & fees

18 Apr - 19 Apr

Holiday Inn Express Gaffney by IHG

Gaffney

Kevin

2.325.381 ₫ total

includes taxes & fees

3 May - 4 May

Comfort Inn & Suites Greer - Greenville

Greer

susan

2.843.365 ₫ total

includes taxes & fees

18 May - 19 May

Best Western Plus Greenville I-385 Inn & Suites

Greenville

Karen

2.723.349 ₫ total

includes taxes & fees

19 Apr - 20 Apr

Courtyard Greenville-Spartanburg by Marriott

Greer

Heather

3.392.862 ₫ total

includes taxes & fees

26 Apr - 27 Apr

Lakeside Lodge Clemson

Seneca

Jeffrey

3.563.659 ₫ total

includes taxes & fees

28 Apr - 29 Apr

Hampton Inn Easley

Easley

Wesley

3.931.398 ₫ total

includes taxes & fees

28 Apr - 29 Apr

Best Western Greenville Airport Inn

Greenville

Jack

1.862.888 ₫ total

includes taxes & fees

19 Apr - 20 Apr

Drury Inn & Suites Greenville

Greenville

Karen

3.592.078 ₫ total

includes taxes & fees

28 Apr - 29 Apr

The Abernathy of Clemson

Clemson

Linda

4.446.503 ₫ total

includes taxes & fees

20 Apr - 21 Apr

The Inn at Patrick Square

Clemson

Eric

4.648.216 ₫ total

includes taxes & fees

3 May - 4 May

Holiday Inn Express Hotel & Suites Spartanburg-North by IHG

Spartanburg

Christine

2.867.972 ₫ total

includes taxes & fees

3 May - 4 May

Comfort Inn Greenville - Haywood Mall

Greenville

Noel

2.286.376 ₫ total

includes taxes & fees

17 May - 18 May

Best Western Plus Clemson Hotel & Conference Center

Clemson

Jeff

3.081.272 ₫ total

includes taxes & fees

21 Apr - 22 Apr

Fairfield Inn by Marriott Greenville-Spartanburg Airport

Greenville

Debra

3.033.813 ₫ total

includes taxes & fees

14 May - 15 May

Hilton Garden Inn Anderson

Anderson

Scott

2.903.819 ₫ total

includes taxes & fees

9 May - 10 May

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Holiday Rentals in Upstate South Carolina

Cabin

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Seneca

"Excellent stay."

Cottage

Deck, Grill & Dock Access: Lake Keowee Retreat!

Seneca

"The best, perfect "

Aparthotel

Full-sized fridge, microwave, oven, stovetop

stayAPT Suites Greenville-Haywood Mall

Greenville

"Nice gym, good breakfast and the rooms are clean and well appointed. Good hotel stayed one night with my family "

Mobile Home

Cabin, 2 Bedrooms, Non Smoking (No Pets, Linens Included) | In-room dining

Carolina Landing RV Resort - Caravan Park

Fair Play

"Very nice stay with friendly staff"

Apartment

Deluxe Two Bedroom (Self Check-in with Virtual Front Desk) | Living area | 55-inch flat-screen TV with digital channels, TV, streaming services

Mint House Greenville Downtown by Kasa

Greenville Downtown

"Very clean, nice amenities. Plenty of space and a great location. "

Cottage

Greer Guest House < 1 Mi to Park & Downtown Area!

Greer

"Nice place en Greenville area "

Cottage

8 Mi to Clemson: Peaceful Family Home w/ Yard

Seneca

"The place was all out perfect the owner was polite and perfect. It was a very peaceful place to stay thank you so much."

Cottage

Claires Cottage ~ 4 Mi to Downtown Greenville!

Greenville

"Great trip. The small cottage was perfect for my wife and I and the owner was very responsive."

Cottage

Wooded Cottage - 3 Mi to Clemson University

Clemson

Cottage

Stay at Jos Taylor Retreat: 9 Mi to Greenville!

Taylors

"This rental is a time capsule that takes you back to Grandma and Grandpa's home. The owner is great to communicate with, as well as their property manager. Quaint older furniture, complete with blankets on the couches. There's all you need to cook and even a great cast-iron frying pan. I wish we had stayed here longer."

Cottage

Cozy Greenville Bungalow ~ 2 Mi to Downtown!

Greenville

"Amazing place. Great host. "

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Stay near popular Southeastern United States attractions

Clemson University

4.8/5 (1,439 reviews)

Take a campus tour or just explore the area of Clemson University during your travels in Clemson. Experience the area's theatre scene or attend a football match.

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Falls Park on the Reedy

4.8/5 (2,661 reviews)

Falls Park on the Reedy is just one of the places to see in Greenville, so why not enjoy the other things to explore during your travels? Experience the acclaimed theatre scene or attend a sporting event in this family-friendly area.

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Learn more about Upstate South Carolina

Experience the family-friendly area of Upstate South Carolina—live music, sports teams and sights from Discovery Island Water Park to Frankie's Fun Park.

See all hotels in Upstate South Carolina

Top Upstate South Carolina Hotel Reviews

Best Western Plus Greenville I-385 Inn & Suites

6/10 Okay

"Room clean, staff nice, breakfast great, room temp working perfect. Sleep not much. Young kids somewhere near by slammed room doors, you could hear them jumping on beds and running down hall until 11pm. This made my well trained, quiet service dog bark a warning from 8-11pm. I did not call down to desk. "

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

6/10 Okay

"Overall the hotel was nice. We cam because it had an indoor pool. We went down several times with the kids but it was always ice cold. We generally pick hotels that out kids will like so we won't return here. Other than that it was a very nice place."