A bench, a bicycle, and a lake surrounded by trees.

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Go beyond your typical stay in Upstate South Carolina

Pet friendly

Apartment

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for Upstate South Carolina hotels

Clemson University's James F. Martin Inn

Clemson

4.196.280 ₫ total

includes taxes & fees

23 Jul - 24 Jul

Fairfield Inn & Suites by Marriott Greenville Simpsonville

Simpsonville

Carole

2.429.978 ₫ total

includes taxes & fees

26 Jul - 27 Jul

Best Western Plus Clemson Hotel & Conference Center

Clemson

Tammy

3.071.795 ₫ total

includes taxes & fees

19 Jul - 20 Jul

Suite, 1 King Bed with Sofa bed, Non Smoking (Efficiency) | Premium bedding, desk, laptop workspace, blackout curtains

Comfort Inn & Suites Clemson - University Area

Clemson

Lon

3.071.441 ₫ total

includes taxes & fees

16 Aug - 17 Aug

Lakeside Lodge Clemson

Seneca

JEFFREY

3.552.293 ₫ total

includes taxes & fees

26 Jul - 27 Jul

The Inn at Patrick Square

Clemson

Karyn

4.341.984 ₫ total

includes taxes & fees

19 Jul - 20 Jul

Comfort Inn & Suites Greer - Greenville

Greer

ANTHONY

3.016.785 ₫ total

includes taxes & fees

16 Aug - 17 Aug

Outdoor pool, open 9:00 AM to 9:00 PM, pool loungers

Fairfield Inn & Suites by Marriott Anderson Clemson

Anderson

Malerion

2.858.715 ₫ total

includes taxes & fees

16 Aug - 17 Aug

Hampton Inn & Suites Greenville Airport, SC

Greenville

Dianna

3.055.097 ₫ total

includes taxes & fees

2 Aug - 3 Aug

Drury Inn & Suites Greenville

Greenville

Aaron

3.320.716 ₫ total

includes taxes & fees

16 Aug - 17 Aug

Courtyard by Marriott Greenville Mauldin

Greenville

Jonathan

3.147.735 ₫ total

includes taxes & fees

26 Jul - 27 Jul

Clarion Greenville Airport Inn

Greenville

Gladys

2.012.817 ₫ total

includes taxes & fees

16 Aug - 17 Aug

Best Western Plus Greenville I-385 Inn & Suites

Greenville

Shabana

2.974.465 ₫ total

includes taxes & fees

19 Jul - 20 Jul

Hampton Inn Anderson/ Alliance Business Park

Anderson

meagan

3.308.067 ₫ total

includes taxes & fees

16 Aug - 17 Aug

Holiday Inn Express Gaffney by IHG

Gaffney

melvin

2.564.161 ₫ total

includes taxes & fees

2 Aug - 3 Aug

Hilton Garden Inn Anderson

Anderson

Gina

3.082.516 ₫ total

includes taxes & fees

7 Aug - 8 Aug

Comfort Suites Piedmont - Greenville South

Piedmont

Michelle

3.147.569 ₫ total

includes taxes & fees

23 Jul - 24 Jul

Best Western Spartanburg I-26

Spartanburg

Daniel

2.452.201 ₫ total

includes taxes & fees

31 Jul - 1 Aug

Fairfield Inn by Marriott Greenville-Spartanburg Airport

Greenville

Brian

2.591.512 ₫ total

includes taxes & fees

30 Jul - 31 Jul

The Abernathy of Clemson

Clemson

Robert

4.432.827 ₫ total

includes taxes & fees

2 Aug - 3 Aug

View all properties

Holiday Rentals in Upstate South Carolina

Cabin

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Seneca

"Awesome place "

Cottage

< 3 Mi to Dtwn: Modern Cottage in Greenville!

Greenville

Apartment

Deluxe Two Bedroom (Self Check-in with Virtual Front Desk) | Living area | 55-inch flat-screen TV with digital channels, TV, streaming services

Mint House Greenville Downtown by Kasa

Greenville Downtown

"Love the location. Room was great."

Aparthotel

Coffee/tea maker, full-sized fridge, microwave, oven

stayAPT Suites Greenville-Haywood Mall

Greenville

"This is a great hotel for the price!!"

Mobile Home

Cabin, 2 Bedrooms, Non Smoking (No Pets, Linens Included) | In-room dining

Carolina Landing RV Resort - Caravan Park

Fair Play

"Very nice stay with friendly staff"

Cottage

2 Mi to Downtown: Luxe Greenville Retreat!

Greenville

"Great house! Very clean and comfortable. Outstanding amenities. Conveniently located. "

Cottage

Claires Cottage ~ 4 Mi to Downtown Greenville!

Greenville

"Great trip. The small cottage was perfect for my wife and I and the owner was very responsive."

Cottage

Stay at Jos Taylor Retreat: 9 Mi to Greenville!

Taylors

"This rental is a time capsule that takes you back to Grandma and Grandpa's home. The owner is great to communicate with, as well as their property manager. Quaint older furniture, complete with blankets on the couches. There's all you need to cook and even a great cast-iron frying pan. I wish we had stayed here longer."

Apartment

Serene Travelers Rest Apartment: 7 Mi to Downtown!

Travelers Rest

"The best time ever. My wife and I enjoyed our Honeymoon and stay here. We will come back every year for our Anniversary now and also to vacation here. The area was beautiful, quiet, and safe. We had everything we needed. No other vacation spot in South Carolina can compete. Thank you for our wonderful stay and perfect memories! "

Cottage

Cozy Home in Historic Area ~ 2 Mi to Main St!

Greenville

"Absolutely adorable property. Little bit of an interesting part of town. We weren’t spending a bunch of time on property so it didn’t mater. Super close to down town and the house is well kept. "

Cottage

Serene Cabin w/ Pond & Creek on South Saluda River

Cleveland

"I chose this cabin due to its close proximity to the pretty place chapel. The property was BEAUTIFUL and tucked away. The silence and change of scenery was well needed and felt like we were at home. I honestly don’t have enough good things to say about the host Mr. Steve and his generosity and professionalism!"

Cottage

Waterfront Seneca Cabin ~ 4 Mi to Boat Launch!

Seneca

"Beautiful and quaint cabin! Highly recommend, great view of the lake."

See all holiday rentals

Save an average of 15% on thousands of hotels when you're signed in

Stay near popular Upstate South Carolina attractions

A historic building with a clock tower, surrounded by a well-maintained lawn with a paw print design.

Clemson University

9.6/10 (1,439 reviews)

Enjoy the student vibe around Clemson University, a top university in Clemson. Experience the area's theatre scene or attend a football match.

See properties

Learn more about Upstate South Carolina

Experience the family-friendly area of Upstate South Carolina—live music, sports teams and sights from Discovery Island Water Park to Frankie's Fun Park.

See all hotels in Upstate South Carolina

An aerial view of a park with a winding path, trees in autumn colors, and a bridge.

Top Upstate South Carolina Hotel Reviews

La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.

10/10 Excellent

"Clean room, helpful staff, okay breakfast, and close to everything in town"

Days Inn by Wyndham Greenville

8/10 Good

"We were on the 2nd floor and had a brand new TV! However we only got about 20 stations as all the others had no signal. Our door did not have a bar to so it never closed by itself and when it did close the dead bolt wouldn't work because the door was not fully flush at the bottom. The ac did not work well and did this high pitch squeal all night so I turned it off only to hear traffic and ambulance and police sirens all night."

Courtyard by Marriott Greenville Haywood Mall

8/10 Good

"The hotel is nice, not the top notch Marriott. Since they don't offer breakfast, they should at least have free coffee in the lounge. It's crazy to pay $10 a night for self-parking in their lot. We didn't see any sign of security around. Room was comfortable."

Hyatt Regency Greenville

10/10 Excellent

"We really enjoyed our stay at this hotel! The hotel has a restaurant, café, and bar, which was very convenient. The staff at check-in were very kind and helpful, and the room was nice as well! I do wish breakfast had been included in the room rate, but otherwise, it was a great place to stay!"