A city skyline with a prominent arch bridge over a river, featuring several high-rise buildings and boats on the water.

Compare and book 4 Star hotels in Affton, St. Louis

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Affton 4 Star Hotels

Tonight
7 Oct - 8 Oct
Tomorrow
8 Oct - 9 Oct
This weekend
9 Oct - 11 Oct
Next weekend
16 Oct - 18 Oct

Our top choices for Affton 4-star hotels

A buffet with fruits, pastries, and beverages.
The Renaissance Hotel with a modern architectural design, featuring a prominent central entrance and a symmetrical facade.
A modern living room with a flat-screen TV, comfortable seating, and decorative items on shelves.
A modern bar area with a long counter, white bar stools, and a mix of bar and dining tables.

1. Renaissance St. Louis Airport Hotel

Renaissance St. Louis Airport Hotel
Berkeley
United States
Anthony
3.071.191 ₫
3.592.925 ₫ total
includes taxes & fees
29 Oct - 30 Oct
Renaissance St. Louis Airport Hotel
A lobby with a sofa, two armchairs, a coffee table, and a staircase.
A park with a pathway, trees, and a modern sculpture.
A spacious lobby with a sectional sofa, a white armchair, and a glass coffee table. There is a dining area in the background with a chandelier.
A rooftop lounge with large windows, red seating, and a view of the cityscape.

2. Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch
Downtown St. Louis
United States
David
3.485.795 ₫
4.110.762 ₫ total
includes taxes & fees
30 Oct - 31 Oct
Hyatt Regency St. Louis at The Arch
A multi-story building with a symmetrical facade, large windows, and a central entrance with a canopy.
A spacious lobby with multiple seating areas, a pool table, and artwork on the walls.
A reception desk with a wooden finish and the name "IDOL WOLF" on it.
A spacious lobby with a large spherical sculpture, a seating area, and a view of the outside through a large window.

3. 21C Museum Hotel St Louis

21C Museum Hotel St Louis
Downtown West
United States
Zane
3.734.038 ₫
4.496.143 ₫ total
includes taxes & fees
1 Nov - 2 Nov
21C Museum Hotel St Louis
A cozy lounge area with leather sofas, a fireplace, and a bar counter.
An outdoor patio area with a pool, red umbrellas, and seating arrangements.
A traditional building with a stone facade, large windows, and outdoor seating area with wicker furniture.
A restaurant with a central bar area, seating arrangements, and a fireplace.

4. The Cheshire

The Cheshire
Richmond Heights
United States
Matthew
3.857.769 ₫
4.580.637 ₫ total
includes taxes & fees
25 Oct - 26 Oct
The Cheshire
A modern outdoor lounge area with seating, a bar, and a view of a cityscape.
A modern bar area with a central fire feature, bar stools, and seating.
A restaurant with tables set for dining, a kitchen in the background, and hanging light fixtures.
The exterior of the Clark & Bourbon hotel with a well-lit entrance, a marquee sign, and a landscaped planter area.

5. Live by Loews - St.Louis

Live by Loews - St.Louis
Downtown St. Louis
United States
Molly
4.133.046 ₫
4.915.390 ₫ total
includes taxes & fees
18 Oct - 19 Oct
Live by Loews - St.Louis
A modern hotel room with a large bed, a nightstand, a mirror, and a view of the city through arched windows.
A modern living room with a grey sofa, a round wooden coffee table, and a large window with a city view.
A lobby with wooden paneling, a green wall, and two armchairs.
A modern restaurant interior with high tables, chairs, and a central bar area.

6. The Westin St. Louis

The Westin St. Louis
Downtown St. Louis
United States
Stacy
3.408.593 ₫
3.985.635 ₫ total
includes taxes & fees
18 Oct - 19 Oct
The Westin St. Louis
A hotel with a swimming pool, lounge chairs, and a courtyard with palm trees.
A bar area with a marble counter, bar stools, and a variety of liquor bottles.
An outdoor patio with a brick fireplace, wicker furniture, and a dining table set with food and drinks.
A restaurant with multiple dining tables and chairs, a bar area with shelves of bottles, and a large mirror above the bar.

7. The Royal Sonesta Chase Park Plaza St. Louis

The Royal Sonesta Chase Park Plaza St. Louis
Central West End
United States
Tosha
4.185.034 ₫
5.701.673 ₫ total
includes taxes & fees
1 Nov - 2 Nov
The Royal Sonesta Chase Park Plaza St. Louis
A long bar with multiple tables and chairs, wooden floors, and ornate chandeliers.
A luxurious hotel lobby with a grand stage, elegant seating, and a large chandelier.
A casino with multiple gaming tables and slot machines.
A large hotel with a prominent "RIVER CITY" sign.

8. River City Casino & Hotel

River City Casino & Hotel
St. Louis
United States
jodi
2.525.159 ₫
3.342.708 ₫ total
includes taxes & fees
25 Oct - 26 Oct
River City Casino & Hotel
A rooftop terrace with outdoor seating, string lights, and a city skyline view.
A modern hotel room with a large window, a bathtub, and a unique eye-themed pillow.
A modern lounge area with a central cylindrical light fixture, white seating, and artwork on the walls.
A multi-story hotel with a classic architectural style, featuring a prominent entrance and a series of uniformly lit windows.

9. Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton
Grand Center
United States
Skylee
3.175.947 ₫
3.745.363 ₫ total
includes taxes & fees
11 Oct - 12 Oct
Angad Arts Hotel St. Louis, Tapestry Collection by Hilton
An indoor swimming pool with clear glass walls, metal railings, and a tiled floor.
A grand lobby with a central chandelier, multiple levels, and rows of liquor bottles.
A bar area with multiple seating arrangements, a stage, and a chandelier.
A bakery display case with various pastries and cakes.

10. Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa
St. Charles
United States
Laura
4.396.885 ₫
5.570.047 ₫ total
includes taxes & fees
12 Oct - 13 Oct
Ameristar Casino Resort and Spa
A multi-story hotel with a prominent 'Marriott' sign, featuring a classic architectural style with a red brick facade and large windows.
Lobby
A spacious interior with a central staircase, large windows, and hanging chandeliers.
A spacious lobby with a high ceiling, a bar area, multiple seating arrangements, and a large screen displaying a sports event.

11. Marriott St. Louis Grand

Marriott St. Louis Grand
Downtown St. Louis
United States
Andrew
3.951.088 ₫
4.698.990 ₫ total
includes taxes & fees
20 Oct - 21 Oct
Marriott St. Louis Grand
A rooftop restaurant with round tables, chairs, and a view of the city.
A rooftop terrace with seating areas, a decorative moon sculpture, and string lights.
A modern lobby with a staircase, seating area, and wall-mounted artwork.
A hotel with a prominent sign reading "MOONRISE."

12. Moonrise Hotel

Moonrise Hotel
Delmar Loop
United States
Katherine
3.430.948 ₫
4.080.538 ₫ total
includes taxes & fees
19 Oct - 20 Oct
Moonrise Hotel
A restaurant with round tables and chairs, a bar area, and a patterned ceiling.
A Drury Plaza Hotel with a large parking lot and multiple cars parked in front.
An indoor swimming pool with clear glass walls, a tiled floor, and a 'Step Down' sign.
A spa bath with a sign indicating a capacity of 8 persons.

13. Drury Plaza Hotel St. Louis Brentwood

Drury Plaza Hotel St. Louis Brentwood
Brentwood
United States
Janell
3.534.924 ₫
4.196.781 ₫ total
includes taxes & fees
18 Oct - 19 Oct
Drury Plaza Hotel St. Louis Brentwood
A bar area with a long counter, multiple stools, and a television mounted on the wall.
A buffet area with various food items and a self-service station.
A multi-story hotel with a prominent corner location, large windows, and a well-lit facade.
A spacious lobby with striped chairs, a central coffee table, and large potted plants.

14. Embassy Suites by Hilton St. Louis Downtown

Embassy Suites by Hilton St. Louis Downtown
Downtown St. Louis
United States
Karen
2.962.796 ₫
3.523.623 ₫ total
includes taxes & fees
18 Oct - 19 Oct
Embassy Suites by Hilton St. Louis Downtown
A modern lounge with a central fire feature, comfortable seating, and large windows offering a city view.
A modern bar area with high tables and stools, large windows with city views, and green chandeliers.
A bar area with wooden bar stools, a high counter, and a seating area with cushioned sofas and tables.
A rooftop terrace with a glass table, cushioned seating, and a view of the cityscape.

15. Hilton St. Louis at the Ballpark

Hilton St. Louis at the Ballpark
Downtown St. Louis
United States
kristen
3.815.399 ₫
4.537.616 ₫ total
includes taxes & fees
15 Oct - 16 Oct
Hilton St. Louis at the Ballpark
A hotel bathroom with a shower, a sink, a mirror, and a towel rack.
A spacious lobby with a chandelier, seating area, and a central table with a vase of flowers.
A grand staircase with a curved design, leading to an upper floor.
A brick building with a tower, large windows, and a fountain in the garden.

16. Hilton St. Louis Frontenac

Hilton St. Louis Frontenac
Frontenac
United States
Linda L
3.602.249 ₫
4.196.187 ₫ total
includes taxes & fees
1 Nov - 2 Nov
Hilton St. Louis Frontenac
A rooftop pool area with multiple lounge chairs and umbrellas, surrounded by a modern building with large windows.
An outdoor seating area with modern furniture, a metal railing, and a view of surrounding buildings.
A bar area with a round table, ice-filled glasses, bottles of champagne, and decorative plants.
A cozy living room with a large TV, a fireplace, a Christmas tree, and a view of the city.

17. Le Méridien St. Louis Clayton

Le Méridien St. Louis Clayton
Clayton
United States
Steven
3.954.987 ₫
4.656.522 ₫ total
includes taxes & fees
11 Oct - 12 Oct
Le Méridien St. Louis Clayton
A modern dining area with round tables, orange chairs, and a decorative wall with pottery.
A modern lobby with seating areas, a reception desk, and a bar area.
A Marriott hotel with a large building, multiple flags, and a well-lit entrance area.
A modern hotel lobby with a bar area, seating arrangements, and decorative lighting.

18. Marriott St. Louis Airport

Marriott St. Louis Airport
Edmundson
United States
Sha
3.706.744 ₫
4.460.624 ₫ total
includes taxes & fees
30 Oct - 31 Oct
Marriott St. Louis Airport
A bar area with a central bar, multiple stools, and a chandelier.
A grand lobby with a bar area, ornate chandeliers, and a staircase.
A grand lobby with a bar area, chandeliers, and seating.
A spacious lobby with a high ceiling, ornate chandeliers, and a seating area with sofas and armchairs.

19. Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
Downtown St. Louis
United States
Carol
2.885.334 ₫
3.431.499 ₫ total
includes taxes & fees
11 Oct - 12 Oct
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
A spacious lobby with high arched ceilings, ornate columns, and a central fountain.
A spacious lobby with a high arched ceiling, multiple seating areas, and a central decorative column.
A spacious lobby with high ceilings, ornate green and gold detailing, and a central bar area.
A multi-level hotel lobby with a grand staircase, a reception desk, and a seating area.

20. St. Louis Union Station Hotel, Curio Collection by Hilton

St. Louis Union Station Hotel, Curio Collection by Hilton
Downtown West
United States
Maryann
4.241.701 ₫
5.044.614 ₫ total
includes taxes & fees
30 Oct - 31 Oct
St. Louis Union Station Hotel, Curio Collection by Hilton
Save an average of 15% on thousands of hotels when you're signed in

Explore similar 5-star hotels

Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Affton.
Four Seasons Hotel St Louis

Four Seasons Hotel St Louis

999 North Second Street St. Louis MO
9.747.750 ₫
11.397.947 ₫ total
8 Oct - 9 Oct
includes taxes & fees
9.4/10 Exceptional! (1,005 reviews)
Four Seasons Hotel St Louis
The Ritz-Carlton, St. Louis

The Ritz-Carlton, St. Louis

100 Carondelet Plaza St. Louis MO
15.050.526 ₫
17.569.605 ₫ total
1 Nov - 2 Nov
includes taxes & fees
9.2/10 Wonderful! (586 reviews)
The Ritz-Carlton, St. Louis
Still don't see what you're looking for?
See all properties in Affton.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Affton

This small St. Louis suburb offers family fun at Affton Plaza Bowl and Grant's Farm with its Budweiser Clydesdales. Grab a slice at local favourite Pirrone's Pizzeria, then catch a Cardinals game or visit the Gateway Arch in nearby St. Louis.

See all hotels in Affton
A city skyline with a prominent arch bridge over a river, featuring several high-rise buildings and boats on the water.

Top Affton Hotel Reviews

Moonrise Hotel

Moonrise Hotel

10/10 Excellent
"Great family trip great business trip whatever the occasion is it’s amazing"
Denise 1-night trip
Posted 1 day ago
Moonrise Hotel

Frequently asked questions

What are the best 4-star hotels in Affton?
River City Casino & Hotel is a 4-star hotel in Affton that rates highly among Expedia guests. A pillowtop mattress and shopping are just a couple of its amenities. Travellers also recommend The Cheshire. From a swimming pool to concierge services, it offers conveniences that cater to all aspects of your entertainment and relaxation.
How much does it cost to stay in a 4-star hotel in Affton?
With Expedia's sort and search filters, bagging a great deal on a 4-star hotel in Affton just got easier. Start by entering your chosen arrival date and length of your trip. Then sort the results by price and pick a property that best matches your style and budget.
  • Search for the lowest price from 11.397.947 ₫
What's the difference between 5-star and 4-star hotels in Affton?
Treat yourself to luxury living during your Affton getaway by choosing a 4-star hotel. As well as featuring upmarket surroundings, these properties are usually packed with amenities such as bathrobes, large beds and plenty more. A 5-star hotel will go the extra mile to make your stay an even more lavish and memorable one. 24-hour front desk, luxurious spas and gourmet dining are only the start of the first-rate services and conveniences you'll likely have access to.

Explore a world of travel with Expedia