A coastal town with terracotta-roofed houses, a beach, and a castle on a hill.

Compare and book 4 Star hotels in Mytilene, Lesvos

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Mytilene 4 Star Hotels

Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Explore similar 5-star hotels

Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Mytilene.
Mythical Coast Wellness Retreat

Mythical Coast Wellness Retreat

Agrilia Lesvos
The price is 3.715.678 ₫ per night from 27 Jul to 28 Jul
3.715.678 ₫
4.520.151 ₫ total
27 Jul - 28 Jul
includes taxes & fees
Still don't see what you're looking for?
See all properties in Mytilene.
You can also use these popular filters to refine your search.
PoolSpaHot tubBreakfast includedWaterpark
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Mytilene

The harbour city's neoclassical mansions and Byzantine castle offer glimpses into its rich past as a trading centre. Explore the Archaeological Museum's ancient artefacts, then enjoy fresh seafood at tavernas along the waterfront promenade.

See all hotels in Mytilene
A coastal town with terracotta-roofed houses, a beach, and a castle on a hill.

Top Mytilene Hotel Reviews

Loriet Hotel

Loriet Hotel

10/10 Excellent
"Our vacation at the Loriet Hotel in Mithilini was amazing. Everything was perfect. We really had very good time in there. Thanks for the hospitality and the hygiene conditions. Having new plans for coming back again."
Melisa 1-night trip
Posted 2 weeks ago
Loriet Hotel

Frequently asked questions

What are the best 4-star hotels in Mytilene?
If you're seeking luxury comfort and plenty of amenities during your Mytilene getaway, check out Theofilos Paradise Boutique Hotel. This leading 4-star hotel comes with premium bedding and mineral springs in spa. Porto Lesvos also gets rave reviews from Expedia travellers. Concierge services and complimentary breakfast are among its conveniences.
How much does it cost to stay in a 4-star hotel in Mytilene?
Expedia can help you easily track down the ideal 4-star hotel for your stay in Mytilene. Use our handy filter tool to fine-tune your search by things like budget, amenities and star rating and get access to awesome deals in a couple of clicks.

  • Search for the lowest price from 4.520.151 ₫

What's the difference between 5-star and 4-star hotels in Mytilene?
Treat yourself to luxury during your Mytilene holiday by checking in to a 4-star hotel. As well as featuring upmarket surroundings, these properties are typically filled with amenities, including large beds, bathrobes and more. A 5-star hotel will go the extra mile to make your stay an even more indulgent and memorable one. 24-hour concierge assistance, on-site spas and world-class dining are only the start of the superior conveniences and services you'll likely have access to.