Compare and book 4 Star hotels in Opelousas, Louisiana
- Change your mindBook hotels with free cancellation
- Be pickySearch almost a million properties worldwide
Check availability on Opelousas 4 Star Hotels
Top Opelousas 4 Star Hotels

DoubleTree by Hilton Hotel Lafayette
Lafayette
8.4 out of 10, Very good, (1013)
The price is 2.226.788 ₫
2.560.807 ₫ total
includes taxes & fees
28 Dec - 29 Dec

Maison D'Memoire Bed & Breakfast Cottages
Rayne
9.6 out of 10, Exceptional, (94)
The price is 5.246.635 ₫
5.941.815 ₫ total
includes taxes & fees
4 Dec - 5 Dec

Wyndham Garden Lafayette
Lafayette
5.4 out of 10, (548)
Save an average of 15% on thousands of hotels when you're signed in
Learn more about Opelousas
Spice up your visit to the Zydeco Capital with live music venues and the annual Zydeco Festival in late August. Explore Cajun food history at the Opelousas Museum, then sample authentic boudin and crawfish at family-owned restaurants locals recommend.

Top Opelousas Hotel Reviews
Frequently asked questions
Explore a world of travel with Expedia
Hotels in Opelousas by Star Rating
Accommodation near Opelousas attractions
Choose Your Opelousas Hotel Style
- Business Hotels in Opelousas
- Casino Hotels in Opelousas
- Cheap Hotels in Opelousas
- Family-Friendly Hotels in Opelousas
- Golf Hotels in Opelousas
- Historic Hotels in Opelousas
- Hotels with Air Conditioning in Opelousas
- Hotels with Breakfast in Opelousas
- Hotels with Connecting Rooms in Opelousas
- Hotels with Gym in Opelousas
- Hotels with Hot Tubs in Opelousas
- Hotels with Parking in Opelousas
- Hotels with Pool in Opelousas
- Hotels with Room Service in Opelousas
- Hotels with Wifi in Opelousas
- Hotels with a Bar in Opelousas
- Pet-Friendly Hotels in Opelousas
- Shopping Hotels in Opelousas
- Sports Hotels in Opelousas
- Wedding Hotels in Opelousas









