Compare and book 4 Star hotels in Pickens, South Carolina

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Check availability on Pickens 4 Star Hotels

Tonight
20 Dec - 21 Dec
Tomorrow
21 Dec - 22 Dec
Next weekend
26 Dec - 28 Dec
In two weeks
2 Jan - 4 Jan

Our top choices for Pickens 4-star hotels

Lobby
Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection
4.0 star property
Greenville Downtown
9.6 out of 10, Exceptional, (421)
"Absolutely one of the best hotels to stay at. "
United States
stephen
The price is 8.394.485 ₫
9.485.767 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Grand Bohemian Lodge Greenville, Autograph Collection
Meeting facility
The Westin Poinsett Greenville

The Westin Poinsett Greenville

The Westin Poinsett Greenville
4.0 star property
Greenville Downtown
9.2 out of 10, Wonderful, (1001)
"Awesome place "
United States
Dominick
The price is 3.780.150 ₫
4.158.166 ₫ total
includes taxes & fees
25 Dec - 26 Dec
The Westin Poinsett Greenville
In-room safe, blackout curtains, soundproofing, iron/ironing board
The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
4.0 star property
Clemson
9.8 out of 10, Exceptional, (742)
"Staff was amazing and our room was clean and comfortable. "
United States
Amanda R
The price is 4.447.235 ₫
4.936.431 ₫ total
includes taxes & fees
21 Dec - 22 Dec
The Shepherd Hotel Downtown Clemson
Two Bedroom Suite | Laptop workspace, iron/ironing board, free WiFi, bed sheets
Mint House Greenville - Downtown

Mint House Greenville - Downtown

Mint House Greenville - Downtown
4.0 star property
Greenville Downtown
9.2 out of 10, Wonderful, (777)
"Spotless wonderful stay"
United States
Tanganica
The price is 3.528.841 ₫
3.987.592 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Mint House Greenville - Downtown
Meeting facility
The Abernathy of Clemson

The Abernathy of Clemson

The Abernathy of Clemson
4.0 star property
Clemson
9.6 out of 10, Exceptional, (557)
"location is amazing! "
United States
colleen
The Abernathy of Clemson
Apartment, 2 Bedrooms | Living area | 40-inch TV with digital channels
Park Place Apartments by Landing

Park Place Apartments by Landing

Park Place Apartments by Landing
4.0 star property
Greenville
7.6 out of 10, Good, (43)
"Loved the apartment! Very spacious, clean, brand new. Access to bike paths. Seemed like a quirky location but everything is close by car or bike. "
United States
Kathie
Park Place Apartments by Landing
Trailside Wedge Cottage | Terrace/patio
The Station by Compo Hotels

The Station by Compo Hotels

The Station by Compo Hotels
4.0 star property
Travelers Rest
10.0 out of 10, Exceptional, (15)
"great place perfect for more privacy vs. a standard hotel"
United States
John
The price is 4.713.016 ₫
7.355.305 ₫ total
includes taxes & fees
18 Jan - 19 Jan 2026
The Station by Compo Hotels
Bar (on property)
Hotel Domestique

Hotel Domestique

Hotel Domestique
4.0 star property
Travelers Rest
9.8 out of 10, Exceptional, (31)
"Overall it was an exceptional experience and would highly recommend to anyone looking for a quiet get away."
United States
Chuck
The price is 7.236.625 ₫
7.960.288 ₫ total
includes taxes & fees
8 Jan - 9 Jan 2026
Hotel Domestique
Tree House, Mountain View | Laptop workspace, free WiFi
Tuxedo Falls

Tuxedo Falls

Tuxedo Falls
4.0 star property
Zirconia
10.0 out of 10, Exceptional, (3)
"This is, by far, one of the greatest stays we have ever had! The cabin was brand new and was impeccable from the bathroom to the living space, to the pizza grill. The mini kitchenette was stocked with everything we would need, including beautiful local pottery and glassware. The porch was so spacious, and our girls (12 & 13) deemed this the best place to stay EVER. The hiking trails along the creeks and waterfalls were so beautiful! The owners were so responsive to any of our requests, including...
United States
rebecca
Tuxedo Falls
Restaurant
Liberty Hall Bed and Breakfast

Liberty Hall Bed and Breakfast

Liberty Hall Bed and Breakfast
4.0 star property
Pendleton
10.0 out of 10, Exceptional, (78)
"The owners are amazing. Comfy rooms, stellar breakfast and good people. "
United States
Renee
The price is 3.487.527 ₫
5.187.213 ₫ total
includes taxes & fees
3 Jan - 4 Jan 2026
Liberty Hall Bed and Breakfast
42-inch flat-screen TV with digital channels
Southern Sunshine Retreat

Southern Sunshine Retreat

Southern Sunshine Retreat
4.0 star property
Easley
Southern Sunshine Retreat
Signature House, 4 Bedrooms, Patio | Living room | 43-inch Smart TV with cable channels, TV, fireplace
Lake Hartwell Frank Howard Home Clemson

Lake Hartwell Frank Howard Home Clemson

Lake Hartwell Frank Howard Home Clemson
4.0 star property
Anderson
The price is 3.237.852 ₫
7.976.962 ₫ total
includes taxes & fees
1 Jan - 2 Jan 2026
Lake Hartwell Frank Howard Home Clemson
Family House, 4 Bedrooms, Patio, Courtyard View | Terrace/patio
Belvedere

Belvedere

Belvedere
4.0 star property
Anderson
8.0 out of 10, Very good, (1)
"Bring everything. Including hangers for your clothes, salt and pepper, etc. it is like staying at a place that has one purpose, to rent out. Beds are uncomfortable. Nice big closets with one wire hanger. Why??? "
United States
CANDACE
Belvedere
Comfort House, 3 Bedrooms, Non Smoking, Fireplace | Living room | 65-inch Smart TV with cable channels, fireplace, Netflix
Pendleton

Pendleton

Pendleton
4.0 star property
Pendleton
Pendleton
House (202 / 204 Randall St Full Duplex) | Private kitchen | Coffee/tea maker, high chair, blender, cookware/dishes/utensils
Randall St , 202/204

Randall St , 202/204

Randall St , 202/204
4.0 star property
Greenville
Randall St , 202/204
House | Exterior
140 Catlin Circle

140 Catlin Circle

140 Catlin Circle
4.0 star property
Greenville
140 Catlin Circle
Stovetop, dishwasher, coffee/tea maker, toaster
34 Allen St

34 Allen St

34 Allen St
4.0 star property
Greenville
34 Allen St
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Learn more about Pickens

Nestled in the foothills of the Blue Ridge Mountains, this charming town offers a slice of small-town Americana. Hike the trails at Table Rock State Park, then explore the Hagood Mill Historic Site to experience local heritage and traditional bluegrass music.

See all hotels in Pickens
Table Rock State Park South Carolina Blue Ridge Mountains Landscape sunrise morning scenic photography

Top Pickens Hotel Reviews

Frequently asked questions

How much does it cost to stay in a 4-star hotel in Pickens?
To book a 4-star hotel in Pickens that fits your budget, make use of Expedia's filters. Check out the availability during your preferred dates and use our pricing filter to set your limit. You can also list your results by the cheapest option first.

  • Search for the lowest price from 3.987.592 ₫

What's the difference between 5-star and 4-star hotels in Pickens?
Offering a welcoming guest experience and upmarket surroundings, 4-star hotels are a terrific option for your Pickens break. These types of accommodation generally come with lots of useful amenities that make it simple to unpack and recharge — think 24-hour room service, pools and gyms. Or live the high life at a 5-star hotel designed to indulge you in exclusive perks and amenities. On-site health clubs, premium toiletries and world-class dining are typically included at these plush retreats.
Does Pickens have any 4-star all-inclusive resorts?
Use our "All inclusive" filter to search for your next getaway in Pickens where everything is taken care of, from your room to your food, activities and entertainment. We can also help you find standard 4-star stays in and around this amazing destination.