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Check availability on San Sisto 4 Star Hotels

Our top choices for San Sisto 4-star hotels

Front of property – evening/night
TH Assisi - Hotel Cenacolo

TH Assisi - Hotel Cenacolo

TH Assisi - Hotel Cenacolo
4.0 star property
Assisi
9.2 out of 10, Wonderful, (610)
"Nice place to stay"
United States
José Felipe Casillas
The price is 1.923.513 ₫
2.300.912 ₫ total
includes taxes & fees
11 Jan - 12 Jan 2026
TH Assisi - Hotel Cenacolo
Garden
La Meridiana Bleisure Hotel

La Meridiana Bleisure Hotel

La Meridiana Bleisure Hotel
4.0 star property
Perugia
8.4 out of 10, Very good, (337)
"The best hotel and seevices u can ever have. Definitely recommend!!"
United States
Tahmina
The price is 2.719.588 ₫
3.114.974 ₫ total
includes taxes & fees
21 Dec - 22 Dec
La Meridiana Bleisure Hotel
Front of property – evening/night
Giotto Hotel & Spa

Giotto Hotel & Spa

Giotto Hotel & Spa
4.0 star property
Assisi Historic Center
8.8 out of 10, Excellent, (762)
"Very relaxing & restful hotel "
United States
Mary Davis
Giotto Hotel & Spa
Front of property – evening/night
Hotel Fontebella

Hotel Fontebella

Hotel Fontebella
4.0 star property
Assisi Historic Center
8.6 out of 10, Excellent, (631)
"Fantastic views and staff"
United States
Nancy
Hotel Fontebella
Daily buffet breakfast (EUR 10 per person)
Best Western Hotel Quattrotorri Perugia

Best Western Hotel Quattrotorri Perugia

Best Western Hotel Quattrotorri Perugia
4.0 star property
Perugia
8.6 out of 10, Excellent, (350)
"Great stay "
United States
temi
The price is 2.425.530 ₫
2.791.448 ₫ total
includes taxes & fees
9 Jan - 10 Jan 2026
Best Western Hotel Quattrotorri Perugia
View from property
Hotel Sangallo Palace

Hotel Sangallo Palace

Hotel Sangallo Palace
4.0 star property
Perugia
8.8 out of 10, Excellent, (617)
"Great hotel with a fantastic staff and great accomodations"
United States
Steven
The price is 2.669.799 ₫
3.060.433 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Hotel Sangallo Palace
Poolside bar
Hotel Perugia Plaza

Hotel Perugia Plaza

Hotel Perugia Plaza
4.0 star property
Perugia
8.2 out of 10, Very good, (205)
"Very clean but few amenities limited dining no bar"
Canada
leonard
The price is 3.414.976 ₫
3.879.838 ₫ total
includes taxes & fees
11 Jan - 12 Jan 2026
Hotel Perugia Plaza
Indoor pool
Perugia Park Hotel

Perugia Park Hotel

Perugia Park Hotel
4.0 star property
Perugia
8.4 out of 10, Very good, (380)
"Beautiful safe but u need to taxi to go into town centre "
United Kingdom
Roy
The price is 2.933.688 ₫
3.350.711 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Perugia Park Hotel
Garden
BV Grand Hotel Assisi

BV Grand Hotel Assisi

BV Grand Hotel Assisi
4.0 star property
Assisi Historic Center
8.6 out of 10, Excellent, (314)
"Great if you have a car. Easy drive to Assisi. Good breakfast and large rooms and facilities. Indoor pool. Really comfortable. Easy drive to historic Assisi, there are 2 large parking lots with great access. Larger than hotels close "
United States
Jose F
The price is 2.518.082 ₫
2.954.938 ₫ total
includes taxes & fees
12 Jan - 13 Jan 2026
BV Grand Hotel Assisi
Interior
Hotel Giò Wine e Jazz Area

Hotel Giò Wine e Jazz Area

Hotel Giò Wine e Jazz Area
4.0 star property
Perugia
8.6 out of 10, Excellent, (569)
"Great stay"
United States
Wendy
Hotel Giò Wine e Jazz Area
Terrace/patio
Hotel Priori Secret Garden

Hotel Priori Secret Garden

Hotel Priori Secret Garden
4.0 star property
Old Town Perugia
9.6 out of 10, Exceptional, (176)
"The staff and location were incredible "
Canada
Dominica
The price is 3.976.034 ₫
4.497.292 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Hotel Priori Secret Garden
Reception
Asisium Boutique Hotel

Asisium Boutique Hotel

Asisium Boutique Hotel
4.0 star property
Assisi Historic Center
9.2 out of 10, Wonderful, (127)
"Very modern and up to date with comfortable bed and large shower with excellent water pressure"
United States
Adam
The price is 3.842.544 ₫
4.412.279 ₫ total
includes taxes & fees
9 Jan - 10 Jan 2026
Asisium Boutique Hotel
Spa
Abbazia Collemedio Resort & Spa

Abbazia Collemedio Resort & Spa

Abbazia Collemedio Resort & Spa
4.0 star property
Collazzone
9.2 out of 10, Wonderful, (69)
"Lovely stay for a few days to relax before a family wedding. "
United Kingdom
Richard
The price is 2.669.687 ₫
3.029.519 ₫ total
includes taxes & fees
23 Dec - 24 Dec
Abbazia Collemedio Resort & Spa
Deluxe Double Room, Hot Tub | Room amenity
Locanda della Posta Boutique Hotel

Locanda della Posta Boutique Hotel

Locanda della Posta Boutique Hotel
4.0 star property
Old Town Perugia
9.6 out of 10, Exceptional, (184)
"Superb hotel"
United States
Angel Raul
Locanda della Posta Boutique Hotel
View from property
Relais dell'Olmo

Relais dell'Olmo

Relais dell'Olmo
4.0 star property
Perugia
9.2 out of 10, Wonderful, (210)
"A great place to stay, quiet and charming, a short distance from Perugia."
Canada
Gabriella
The price is 2.859.832 ₫
3.269.180 ₫ total
includes taxes & fees
11 Jan - 12 Jan 2026
Relais dell'Olmo
Aerial view
Hotel Lidò

Hotel Lidò

Hotel Lidò
4.0 star property
Passignano sul Trasimeno
8.0 out of 10, Very good, (144)
"Great visit "
Mexico
Francisco
Hotel Lidò
Terrace/patio
Relais Il Canalicchio

Relais Il Canalicchio

Relais Il Canalicchio
4.0 star property
Collazzone
8.6 out of 10, Excellent, (121)
"A tiny medieval village restored back into a beautiful hotel. Staff was awesome. Loved it and will be back. "
United States
Nicole
Relais Il Canalicchio
Seasonal outdoor pool, pool umbrellas, pool loungers
Posta Donini 1579 UNA Esperienze

Posta Donini 1579 UNA Esperienze

Posta Donini 1579 UNA Esperienze
4.0 star property
Perugia
9.2 out of 10, Wonderful, (252)
"Great grounds, lovely bedroom with character. Very peaceful also"
United Kingdom
Erika
Posta Donini 1579 UNA Esperienze
Exterior
Hotel Valle di Assisi Spa & Golf

Hotel Valle di Assisi Spa & Golf

Hotel Valle di Assisi Spa & Golf
4.0 star property
Assisi
9.2 out of 10, Wonderful, (202)
"Our second 14 nights stay. We had deluxe room. It is spacious, excellent bed and big flat-tv. Everything is so easy and relax in this hotel. The only wish is that the breakfast would be better. The proberty is large and beautiful. You can easily make a long walk in the hotel area. Coming again."
Finland
SARI
The price is 3.214.214 ₫
3.721.117 ₫ total
includes taxes & fees
7 Jan - 8 Jan 2026
Hotel Valle di Assisi Spa & Golf
Seasonal outdoor pool, pool umbrellas, pool loungers
Hotel Ristorante La Bastiglia

Hotel Ristorante La Bastiglia

Hotel Ristorante La Bastiglia
4.0 star property
Spello
8.0 out of 10, Very good, (79)
"Clean rooms great views. Make sure you check in early since a parking permit is necessary. "
United States
Gennaro
The price is 2.048.719 ₫
2.469.985 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Hotel Ristorante La Bastiglia
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Explore similar 5-star hotels

Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in San Sisto.
Sina Brufani

Sina Brufani

Piazza Italia, 12 Perugia PG
The price is 6.308.902 ₫ per night from 17 Dec to 18 Dec
6.308.902 ₫
7.094.123 ₫ total
17 Dec - 18 Dec
includes taxes & fees
9.2/10 Wonderful! (619 reviews)
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top San Sisto Hotel Reviews

Frequently asked questions

What are the best 4-star hotels in San Sisto?
Kick back in 4-star hotel comfort at Hotel La Meridiana. Highly recommended by many of our guests, it comes with concierge services and a terrace. Also take a look at Arte Hotel Perugia. Concierge services and complimentary breakfast help make this escape another sought-after choice in San Sisto.
How much does it cost to stay in a 4-star hotel in San Sisto?
To find a 4-star hotel in San Sisto that fits your budget, take advantage of Expedia's handy filters. Check out the available options during your chosen dates and use our pricing filter to set your maximum rate. You can also sort your results by the most affordable escape first.

  • Search for the lowest price from 7.094.123 ₫

What's the difference between 5-star and 4-star hotels in San Sisto?
If you decide to stay at a 4-star hotel in San Sisto, you'll typically find lots of conveniences to keep you relaxed, such as a restaurant, gym and pool. You can experience excellent service and upscale accommodation. Pick a 5-star hotel and you'll get a few extra bells and whistles — think on-site spas, concierge assistance and indulgent turndown services. You're likely to get more amenities and premium services at a 5-star retreat, but both are awesome options for luxury travellers.

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