Compare and book 4 Star hotels in Santa Fe, Santa Fe Province

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Santa Fe 4 Star Hotels

Tonight
20 Dec - 21 Dec
Tomorrow
21 Dec - 22 Dec
Next weekend
26 Dec - 28 Dec
In two weeks
2 Jan - 4 Jan

Our top choices for Santa Fe 4-star hotels

Outdoor pool, pool loungers
InterTower Hotel

InterTower Hotel

InterTower Hotel
4.0 star property
Santa Fe
8.8 out of 10, Excellent, (212)
"Excelent place to stay."
United States
Angel
The price is 2.522.293 ₫
2.522.293 ₫ total
21 Dec - 22 Dec
InterTower Hotel
Rooftop terrace
Los Silos Hotel

Los Silos Hotel

Los Silos Hotel
4.0 star property
Santa Fe
9.2 out of 10, Wonderful, (28)
"Unique, interesting, and very nice. Staff was outstanding. We will be back soon"
United States
Russell
The price is 2.840.704 ₫
2.840.704 ₫ total
4 Jan - 5 Jan 2026
Los Silos Hotel
Premium bedding, pillow-top beds, individually decorated
Agustín 1 Apart

Agustín 1 Apart

Agustín 1 Apart
4.0 star property
Parana
9.0 out of 10, Wonderful, (4)
"Meu problema foi só a garagem, o apartamento é ótimo, limpeza estava impecável."
Brazil
Jose rodrigo kallas
The price is 1.421.010 ₫
1.421.010 ₫ total
21 Dec - 22 Dec
Agustín 1 Apart
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Learn more about Santa Fe

Discover colonial architecture and vibrant history at Plaza 25 de Mayo, where the Metropolitan Cathedral stands as a stunning centrepiece. Kayak along the Paraná River or visit the riverside Parque del Sur for sunset views across the water.

See all hotels in Santa Fe
Adobe

Top Santa Fe Hotel Reviews

Frequently asked questions

What are the best 4-star hotels in Santa Fe?
Relax in comfort at InterTower Hotel. According to reviews by our guests, this is one of Santa Fe's best 4-star hotels.
How much does it cost to stay in a 4-star hotel in Santa Fe?
Expedia can help you easily track down the perfect 4-star hotel for your stay in Santa Fe. Use our handy filter tool to tailor your search by things like budget, conveniences and star rating and get access to fantastic deals in a few clicks.

  • Search for the lowest price from 1.421.010 ₫

What's the difference between 5-star and 4-star hotels in Santa Fe?
Offering a friendly guest experience and upscale surroundings, 4-star hotels are an excellent option for your Santa Fe trip. These kinds of accommodation generally feature lots of useful amenities that make it a breeze to unpack and relax — think pillowtop mattresses, gyms and restaurants. Or live in the lap of luxury at a 5-star hotel designed to pamper with high-end perks and amenities. 24-hour front desk, complimentary toiletries and fine dining are typically featured at these plush properties.