Compare and book 4 Star hotels in Upstate South Carolina, South Carolina

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Check availability on Upstate South Carolina 4 Star Hotels

Tonight
28 Feb - 1 Mar
Tomorrow
1 Mar - 2 Mar
Next weekend
6 Mar - 8 Mar
In two weeks
13 Mar - 15 Mar

Our top choices for Upstate South Carolina 4-star hotels

Exterior

Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection
4.0 star property
Greenville Downtown
9.6 out of 10, Exceptional, (457 reviews)
"The room was very clean, the food amazing, and the staff was efficient and friendly.Will definitely be back."
United States
Sharlene
The price is 7.530.762 ₫
8.509.762 ₫ total
includes taxes & fees
1 Mar - 2 Mar
Grand Bohemian Lodge Greenville, Autograph Collection
Exterior

The Westin Poinsett Greenville

The Westin Poinsett Greenville
4.0 star property
Greenville Downtown
9.2 out of 10, Wonderful, (1,000 reviews)
"Great hotel Great location Great room Friendly and courteous staff"
United States
Charles
The price is 4.927.797 ₫
5.420.577 ₫ total
includes taxes & fees
1 Mar - 2 Mar
The Westin Poinsett Greenville
Lobby

The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
4.0 star property
Clemson
9.8 out of 10, Exceptional, (763 reviews)
"Awesome hotel and very convenient for visiting Clemson."
United States
Nina
The price is 6.492.177 ₫
7.206.316 ₫ total
includes taxes & fees
3 Mar - 4 Mar
The Shepherd Hotel Downtown Clemson
Restaurant

Hotel Hartness

Hotel Hartness
4.0 star property
Greenville
9.8 out of 10, Exceptional, (659 reviews)
"The hotel was clean staff was amazing room was outstanding."
United States
Clifford
The price is 3.944.921 ₫
5.219.157 ₫ total
includes taxes & fees
8 Mar - 9 Mar
Hotel Hartness
Bar (on property)

Greenville Marriott

Greenville Marriott
4.0 star property
Greenville
8.6 out of 10, Excellent, (628 reviews)
"Stay here often. Always great service. "
United States
Andrea
The price is 3.179.076 ₫
3.496.984 ₫ total
includes taxes & fees
8 Mar - 9 Mar
Greenville Marriott
Deluxe Two Bedroom (Self Check-in with Virtual Front Desk) | Living area | 55-inch flat-screen TV with digital channels, TV, streaming services

Mint House Greenville Downtown by Kasa

Mint House Greenville Downtown by Kasa
4.0 star property
Greenville Downtown
9.2 out of 10, Wonderful, (797 reviews)
"Spotless wonderful stay"
United States
Tanganica
The price is 2.790.812 ₫
3.069.892 ₫ total
includes taxes & fees
23 Mar - 24 Mar
Mint House Greenville Downtown by Kasa
Lobby lounge

The Abernathy of Clemson

The Abernathy of Clemson
4.0 star property
Clemson
9.6 out of 10, Exceptional, (566 reviews)
"Great stay"
United States
Megan
The Abernathy of Clemson
Apartment, 1 Bedroom | Private kitchen | Full-sized fridge, microwave, oven, stovetop

Park Place Apartments by Landing

Park Place Apartments by Landing
4.0 star property
Greenville
7.6 out of 10, Good, (46 reviews)
"Loved the apartment! Very spacious, clean, brand new. Access to bike paths. Seemed like a quirky location but everything is close by car or bike. "
United States
Kathie
Park Place Apartments by Landing
Trailside Wedge Cottage | Terrace/patio

The Station by Compo Hotels

The Station by Compo Hotels
4.0 star property
Travelers Rest
10.0 out of 10, Exceptional, (17 reviews)
"great place perfect for more privacy vs. a standard hotel"
United States
John
The price is 5.636.736 ₫
8.350.195 ₫ total
includes taxes & fees
3 Mar - 4 Mar
The Station by Compo Hotels
Courtyard

Hotel Domestique

Hotel Domestique
4.0 star property
Travelers Rest
9.8 out of 10, Exceptional, (31 reviews)
"Overall it was an exceptional experience and would highly recommend to anyone looking for a quiet get away."
United States
Chuck
The price is 9.826.472 ₫
10.809.119 ₫ total
includes taxes & fees
1 Mar - 2 Mar
Hotel Domestique
Front of property

Liberty Hall Bed and Breakfast

Liberty Hall Bed and Breakfast
4.0 star property
Pendleton
10.0 out of 10, Exceptional, (82 reviews)
"The owners are amazing. Comfy rooms, stellar breakfast and good people. "
United States
Renee
Liberty Hall Bed and Breakfast
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Learn more about Upstate South Carolina

Experience the family-friendly area of Upstate South Carolina—live music, sports teams and sights from Discovery Island Water Park to Frankie's Fun Park.

See all hotels in Upstate South Carolina
Greenville - Spartanburg
Photo by Visit Greenville, South Carolina
Open Photo by Visit Greenville, South Carolina

Top Upstate South Carolina Hotel Reviews

The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson

10/10 Excellent
"All was excellent"
Hazel 2-night trip
Posted 5 days ago
The Shepherd Hotel Downtown Clemson
Hotel Hartness

Hotel Hartness

10/10 Excellent
"The room was really clean, staff very helpful and friendly. The hotel itself was really beautiful. Fitness center had nice equipment (only wish they also had a fan!) but it was well air-conditioned. Illy coffee/espresso in the room - was a plus! Really nice looking restaurant within a quick stroll from restaurant that we would have loved to check out if we had more time. Would stay again in a heartbeat and have recommended to family/friends already! "
Ashina 1-night trip
Posted 7 days ago
Hotel Hartness

Frequently asked questions

What are the best 4-star hotels in Upstate South Carolina?
Stay at Greenville Marriott and get ready for upscale comfort and plenty of handy amenities. This 4-star hotel in Greer, Upstate South Carolina, is highly recommended by Expedia guests.
How much does it cost to stay in a 4-star hotel in Upstate South Carolina?
Expedia can help you quickly locate the perfect 4-star hotel for your getaway in Upstate South Carolina. Use our handy filter tool to tailor your search by things like amenities, budget and property star rating and get access to fabulous deals in a few clicks.

  • Search for the lowest price from 3.069.892 ₫

What's the difference between 5-star and 4-star hotels in Upstate South Carolina?
Offering a friendly guest experience and upmarket décor, 4-star hotels are a wonderful option for your Upstate South Carolina trip. These kinds of accommodation generally come with loads of handy amenities that make it simple to kick back and relax — think large beds, bathrobes, restaurants and pools. Or live the high life at a 5-star hotel designed to pamper with exclusive perks and amenities. Full-service health clubs, premium toiletries and fine dining are typically featured at these deluxe retreats.