A bench, a bicycle, and a lake surrounded by trees.

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Check availability on Upstate South Carolina 4 Star Hotels

This weekend
30 Oct - 1 Nov
Next weekend
6 Nov - 8 Nov

Our top choices for Upstate South Carolina 4-star hotels

A large, multi-story house with a prominent waterfall in the foreground, surrounded by lush greenery.

1. Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection
4.0 star property
Greenville Downtown
9.6 out of 10, Exceptional, (570 reviews)
"Wonderful"
United States
colleen
The price is 9.047.150 ₫
10.250.421 ₫ total
includes taxes & fees
22 Nov - 23 Nov
Grand Bohemian Lodge Greenville, Autograph Collection
A dining area with a wooden table, chairs, and a vase of white flowers.

2. Hotel Hartness

Hotel Hartness
4.0 star property
Greenville
9.8 out of 10, Exceptional, (875 reviews)
"Beautiful property and very friendly staff! Highly recommend!"
United States
Nicole
The price is 4.248.490 ₫
5.666.557 ₫ total
includes taxes & fees
22 Nov - 23 Nov
Hotel Hartness
A hotel facade with arched windows, a fountain, and a sign for "The Westin."

3. The Westin Poinsett Greenville

The Westin Poinsett Greenville
4.0 star property
Greenville Downtown
9.4 out of 10, Exceptional, (1,000 reviews)
"This was our first stay and we were very impressed. Great location and helpful staff. Very nice room and comfy beds. Good restaurants within walking distance. Highly recommend."
United States
Mary C
The price is 4.109.991 ₫
4.734.168 ₫ total
includes taxes & fees
22 Nov - 23 Nov
The Westin Poinsett Greenville
A modern living room with a sofa, a coffee table, a TV, and a balcony with a view of buildings.

4. Mint House Greenville Downtown by Kasa

Mint House Greenville Downtown by Kasa
4.0 star property
Greenville Downtown
9.2 out of 10, Wonderful, (932 reviews)
"Great location, convenient!"
United States
Michelle
The price is 2.326.410 ₫
2.559.052 ₫ total
includes taxes & fees
24 Nov - 25 Nov
Mint House Greenville Downtown by Kasa
A modern lounge area with a brick accent wall, a fireplace, and comfortable seating.

5. The Abernathy of Clemson

The Abernathy of Clemson
4.0 star property
Clemson
9.6 out of 10, Exceptional, (657 reviews)
"Great place."
United States
John
The price is 3.931.633 ₫
4.364.113 ₫ total
includes taxes & fees
15 Nov - 16 Nov
The Abernathy of Clemson
A multi-level interior with a spiral staircase, wooden railings, and a seating area with tables and chairs.

6. The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
4.0 star property
Clemson
9.8 out of 10, Exceptional, (902 reviews)
"Always a wonderful stay!"
United States
Laurrie
The price is 5.402.441 ₫
5.996.709 ₫ total
includes taxes & fees
30 Oct - 31 Oct
The Shepherd Hotel Downtown Clemson
A white BMW with "BMW Performance Driving School" text on the side, driving on a road with a cloud-covered sky in the background.

7. Greenville Marriott

Greenville Marriott
4.0 star property
Greenville
8.6 out of 10, Excellent, (711 reviews)
"We had a great stay! Rooms were very clean and beds very comfortable!!"
United States
John
The price is 3.153.578 ₫
3.573.005 ₫ total
includes taxes & fees
29 Nov - 30 Nov
Greenville Marriott
Lobby

8. Doubletree By Hilton Greenville Airport

Doubletree By Hilton Greenville Airport
4.0 star property
Greer
9.2 out of 10, Wonderful, (30 reviews)
"Everything was great!"
United States
Stephanie
The price is 2.797.896 ₫
3.170.016 ₫ total
includes taxes & fees
29 Nov - 30 Nov
Doubletree By Hilton Greenville Airport
A white, two-story house with a front porch, surrounded by trees and shrubs.

9. Liberty Hall Bed and Breakfast

Liberty Hall Bed and Breakfast
4.0 star property
Pendleton
9.8 out of 10, Exceptional, (104 reviews)
"Excellent bed & breakfast! Beautiful and perfectly located. My daughter was visiting Clemson and it was the perfect location. Will definitely return!"
United States
Christine
The price is 2.359.497 ₫
2.619.021 ₫ total
includes taxes & fees
12 Nov - 13 Nov
Liberty Hall Bed and Breakfast
A modern building with outdoor seating and a garden.

10. The Station by Compo Hotels

The Station by Compo Hotels
4.0 star property
Travelers Rest
10.0 out of 10, Exceptional, (24 reviews)
"great place perfect for more privacy vs. a standard hotel"
United States
John
The price is 5.273.158 ₫
7.933.016 ₫ total
includes taxes & fees
29 Nov - 30 Nov
The Station by Compo Hotels
A two-story house with a tiled roof, a stone fire pit, and outdoor seating.

11. Hotel Domestique

Hotel Domestique
4.0 star property
Travelers Rest
9.8 out of 10, Exceptional, (37 reviews)
"Overall it was an exceptional experience and would highly recommend to anyone looking for a quiet get away."
United States
Chuck
The price is 10.830.731 ₫
11.913.804 ₫ total
includes taxes & fees
1 Nov - 2 Nov
Hotel Domestique
A spacious living room with a stone fireplace, wooden beams, and a chandelier.

12. Landing Apartments Greer - Sugar Creek

Landing Apartments Greer - Sugar Creek
4.0 star property
Greer
9.2 out of 10, Wonderful, (5 reviews)
"The apartment was clean. Excellent value for stay. Amenities were great. Will book again!"
United States
Amanda
Landing Apartments Greer - Sugar Creek
A bedroom with a bed, a chair, and a potted aloe plant on a table.

13. Landing Furnished Apartments - Spartanburg, SC

Landing Furnished Apartments - Spartanburg, SC
4.0 star property
Spartanburg
Landing Furnished Apartments - Spartanburg, SC
A cozy living room with a fireplace, leather armchair, and a large window.

14. Designer Retreat w/ Pool, Golf + Beach Access!

Designer Retreat w/ Pool, Golf + Beach Access!
4.0 star property
Salem
10.0 out of 10, Exceptional, (1 review)
"Property is in a great community, and it was very clean and beautifully decorated."
United States
Anonymous traveller
Designer Retreat w/ Pool, Golf + Beach Access!
A two-story yellow house with a front porch, a small garden, and a pathway leading to the entrance.

15. Wooded Keowee Key Retreat Near Golf & Trails

Wooded Keowee Key Retreat Near Golf & Trails
4.0 star property
Salem
Wooded Keowee Key Retreat Near Golf & Trails
A swimming pool with a view of a lake and docked boats.

16. Lake Keowee Condo: Resort Pools & Lake Access!

Lake Keowee Condo: Resort Pools & Lake Access!
4.0 star property
Salem
10.0 out of 10, Exceptional, (2 reviews)
"Wow!! Absolutely beautiful property. Recent remodel with beautiful and very tasteful design. Amazingly clean, organized and tidy. We are from Denver and did not have exposure to Lake Keowee. The lake was beautiful with great walking trails on the property. Special and spectacular spot! We will definitely go back. This is a gated community. Super comfortable king beds and nice linens."
United States
Shawn
Lake Keowee Condo: Resort Pools & Lake Access!
A swimming pool with a view of the lake and docked boats.

17. Keowee Key Condo w/ Lake Access & Community Pools!

Keowee Key Condo w/ Lake Access & Community Pools!
4.0 star property
Salem
Keowee Key Condo w/ Lake Access & Community Pools!
A wooden deck with a table and chairs, large windows, and a view of trees.

18. Salem Vacation Rental w/ Lake Keowee Access!

Salem Vacation Rental w/ Lake Keowee Access!
4.0 star property
Salem
Salem Vacation Rental w/ Lake Keowee Access!
A swimming pool with a view of the lake and docked boats.

19. Views, Pools & Marina: Lake Keowee Condo!

Views, Pools & Marina: Lake Keowee Condo!
4.0 star property
Salem
Views, Pools & Marina: Lake Keowee Condo!
A multi-story wooden building with balconies, large windows, and a landscaped area with trees.

20. Tee Times & Lake Days! Luxe Keowee Key Living

Tee Times & Lake Days! Luxe Keowee Key Living
4.0 star property
Salem
Tee Times & Lake Days! Luxe Keowee Key Living
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Learn more about Upstate South Carolina

Experience the family-friendly area of Upstate South Carolina—live music, sports teams and sights from Discovery Island Water Park to Frankie's Fun Park.

See all hotels in Upstate South Carolina
An aerial view of a park with a winding path, trees in autumn colors, and a bridge.
Photo by Visit Greenville, South Carolina
Open Photo by Visit Greenville, South Carolina

Top Upstate South Carolina Hotel Reviews

Frequently asked questions

What are the best 4-star hotels in Upstate South Carolina?
Stay at Greenville Marriott and get ready for upscale comfort and plenty of handy amenities. This 4-star hotel in Greer, Upstate South Carolina, is highly recommended by Expedia guests.
How much does it cost to stay in a 4-star hotel in Upstate South Carolina?
Expedia can help you quickly locate the perfect 4-star hotel for your getaway in Upstate South Carolina. Use our handy filter tool to tailor your search by things like amenities, budget and property star rating and get access to fabulous deals in a few clicks.

  • Search for the lowest price from 2.559.052 ₫

What's the difference between 5-star and 4-star hotels in Upstate South Carolina?
Offering a friendly guest experience and upmarket décor, 4-star hotels are a wonderful option for your Upstate South Carolina trip. These kinds of accommodation generally come with loads of handy amenities that make it simple to kick back and relax — think large beds, bathrobes, restaurants and pools. Or live the high life at a 5-star hotel designed to pamper with exclusive perks and amenities. Full-service health clubs, premium toiletries and fine dining are typically featured at these deluxe retreats.