Compare and book 4 Star hotels in Upstate South Carolina, South Carolina

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Check availability on Upstate South Carolina 4 Star Hotels

Our top choices for Upstate South Carolina 4-star hotels

Exterior

Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection
4.0 star property
Greenville Downtown
9.6 out of 10, Exceptional, (472 reviews)
"Beautiful and comfortable! We loved it and wish we could have stayed longer than one night!"
United States
Nancy
The price is 8.928.582 ₫
10.089.298 ₫ total
includes taxes & fees
27 Apr - 28 Apr
Grand Bohemian Lodge Greenville, Autograph Collection
Restaurant

Hotel Hartness

Hotel Hartness
4.0 star property
Greenville
9.8 out of 10, Exceptional, (698 reviews)
"Great place"
United States
Helen
The price is 4.221.955 ₫
5.534.415 ₫ total
includes taxes & fees
26 Apr - 27 Apr
Hotel Hartness
Lobby

The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
4.0 star property
Clemson
9.8 out of 10, Exceptional, (785 reviews)
"Excellent stay, I highly recommend! Accommodations, location, overall vibe, great food and drinks! "
United States
Julie
The price is 5.241.262 ₫
5.817.801 ₫ total
includes taxes & fees
20 Apr - 21 Apr
The Shepherd Hotel Downtown Clemson
Deluxe Two Bedroom (Self Check-in with Virtual Front Desk) | Living area | 55-inch flat-screen TV with digital channels, TV, streaming services

Mint House Greenville Downtown by Kasa

Mint House Greenville Downtown by Kasa
4.0 star property
Greenville Downtown
9.2 out of 10, Wonderful, (811 reviews)
"Very clean, nice amenities. Plenty of space and a great location. "
United States
Dawn
The price is 2.820.800 ₫
3.102.880 ₫ total
includes taxes & fees
4 May - 5 May
Mint House Greenville Downtown by Kasa
Exterior

The Westin Poinsett Greenville

The Westin Poinsett Greenville
4.0 star property
Greenville Downtown
9.2 out of 10, Wonderful, (1,000 reviews)
"Great hotel Great location Great room Friendly and courteous staff"
United States
Charles
The price is 6.294.543 ₫
6.923.997 ₫ total
includes taxes & fees
19 Apr - 20 Apr
The Westin Poinsett Greenville
Bar (on property)

Greenville Marriott

Greenville Marriott
4.0 star property
Greenville
8.6 out of 10, Excellent, (637 reviews)
"The airport shuttle arrived within 10 minutes of dispatch and the hotel and restaurant staff were very friendly and accommodating. "
United States
Leslie
The price is 3.371.264 ₫
3.830.598 ₫ total
includes taxes & fees
10 May - 11 May
Greenville Marriott
Lobby lounge

The Abernathy of Clemson

The Abernathy of Clemson
4.0 star property
Clemson
9.6 out of 10, Exceptional, (587 reviews)
"Excellent location to visit Clemson. Staff is very friendly. Rooms are clean spacious. "
United States
Linda
The price is 4.005.858 ₫
4.446.503 ₫ total
includes taxes & fees
20 Apr - 21 Apr
The Abernathy of Clemson
Trailside Wedge Cottage | Terrace/patio

The Station by Compo Hotels

The Station by Compo Hotels
4.0 star property
Travelers Rest
10.0 out of 10, Exceptional, (19 reviews)
"great place perfect for more privacy vs. a standard hotel"
United States
John
The price is 6.787.440 ₫
9.638.987 ₫ total
includes taxes & fees
19 Apr - 20 Apr
The Station by Compo Hotels
Front of property

Liberty Hall Bed and Breakfast

Liberty Hall Bed and Breakfast
4.0 star property
Pendleton
10.0 out of 10, Exceptional, (87 reviews)
"The was by far one of the best bed and breakfast places that I have ever stayed in. The house is beautiful, the rooms and spotless and the breakfast is amazing. "
United States
Jennifer Ann
The price is 3.138.963 ₫
4.801.154 ₫ total
includes taxes & fees
10 May - 11 May
Liberty Hall Bed and Breakfast
Courtyard

Hotel Domestique

Hotel Domestique
4.0 star property
Travelers Rest
9.8 out of 10, Exceptional, (33 reviews)
"Overall it was an exceptional experience and would highly recommend to anyone looking for a quiet get away."
United States
Chuck
The price is 10.772.242 ₫
11.849.466 ₫ total
includes taxes & fees
17 May - 18 May
Hotel Domestique
Lobby

Landing Apartments Greer - Sugar Creek

Landing Apartments Greer - Sugar Creek
4.0 star property
Greer
Landing Apartments Greer - Sugar Creek
Studio, 1 Queen Bed (0 Bedroom) | Individually decorated, individually furnished, iron/ironing board

Landing Furnished Apartments - Spartanburg, SC

Landing Furnished Apartments - Spartanburg, SC
4.0 star property
Spartanburg
Landing Furnished Apartments - Spartanburg, SC
Apartment (2 Bedrooms) | Interior

Tee Times & Lake Days! Luxe Keowee Key Living

Tee Times & Lake Days! Luxe Keowee Key Living
4.0 star property
Salem
Tee Times & Lake Days! Luxe Keowee Key Living
Apartment (2 Bedrooms) | Interior

Private Balcony: Lake Keowee Home w/ Pool Access

Private Balcony: Lake Keowee Home w/ Pool Access
4.0 star property
Salem
Private Balcony: Lake Keowee Home w/ Pool Access
Apartment (1 Bedroom) | Interior

Designer Retreat w/ Pool, Golf + Beach Access!

Designer Retreat w/ Pool, Golf + Beach Access!
4.0 star property
Salem
10.0 out of 10, Exceptional, (1 review)
"Property is in a great community, and it was very clean and beautifully decorated."
United States
Anonymous traveller
Designer Retreat w/ Pool, Golf + Beach Access!
Apartment, 1 Bedroom | Private kitchen | Full-sized fridge, microwave, oven, stovetop

Park Place Apartments by Landing

Park Place Apartments by Landing
4.0 star property
Greenville
7.6 out of 10, Good, (46 reviews)
"Loved the apartment! Very spacious, clean, brand new. Access to bike paths. Seemed like a quirky location but everything is close by car or bike. "
United States
Kathie
Park Place Apartments by Landing
Apartment (2 Bedrooms) | Interior

Views, Pools & Marina: Lake Keowee Condo!

Views, Pools & Marina: Lake Keowee Condo!
4.0 star property
Salem
Views, Pools & Marina: Lake Keowee Condo!
Apartment (3 Bedrooms) | Interior

5 Mi to Memorial Stadium & Beach: Modern Townhome

5 Mi to Memorial Stadium & Beach: Modern Townhome
4.0 star property
Central
5 Mi to Memorial Stadium & Beach: Modern Townhome
Apartment (3 Bedrooms) | Interior

Keowee Key Condo w/ Lake Access & Community Pools!

Keowee Key Condo w/ Lake Access & Community Pools!
4.0 star property
Salem
Keowee Key Condo w/ Lake Access & Community Pools!
Apartment (4 Bedrooms) | Interior

Salem Vacation Rental w/ Lake Keowee Access!

Salem Vacation Rental w/ Lake Keowee Access!
4.0 star property
Salem
Salem Vacation Rental w/ Lake Keowee Access!
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Learn more about Upstate South Carolina

Experience the family-friendly area of Upstate South Carolina—live music, sports teams and sights from Discovery Island Water Park to Frankie's Fun Park.

See all hotels in Upstate South Carolina
Photo by Visit Greenville, South Carolina
Open Photo by Visit Greenville, South Carolina

Top Upstate South Carolina Hotel Reviews

Hotel Hartness

Hotel Hartness

10/10 Excellent
"Beautiful property. Almost hate to give a great review since it’s a hidden gem that I selfishly want to keep that way. "
Carl 2-night trip
Posted 3 days ago
Hotel Hartness

Frequently asked questions

What are the best 4-star hotels in Upstate South Carolina?
Stay at Greenville Marriott and get ready for upscale comfort and plenty of handy amenities. This 4-star hotel in Greer, Upstate South Carolina, is highly recommended by Expedia guests.
How much does it cost to stay in a 4-star hotel in Upstate South Carolina?
Expedia can help you quickly locate the perfect 4-star hotel for your getaway in Upstate South Carolina. Use our handy filter tool to tailor your search by things like amenities, budget and property star rating and get access to fabulous deals in a few clicks.

  • Search for the lowest price from 3.102.880 ₫

What's the difference between 5-star and 4-star hotels in Upstate South Carolina?
Offering a friendly guest experience and upmarket décor, 4-star hotels are a wonderful option for your Upstate South Carolina trip. These kinds of accommodation generally come with loads of handy amenities that make it simple to kick back and relax — think large beds, bathrobes, restaurants and pools. Or live the high life at a 5-star hotel designed to pamper with exclusive perks and amenities. Full-service health clubs, premium toiletries and fine dining are typically featured at these deluxe retreats.