Compare and book 4 Star hotels in Upstate South Carolina, South Carolina

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Check availability on Upstate South Carolina 4 Star Hotels

Our top choices for Upstate South Carolina 4-star hotels

Exterior
Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection
4.0 star property
Greenville Downtown
9.6 out of 10, Exceptional, (435 reviews)
"Awesome place."
United States
ailen
The price is 6.018.578 ₫
6.800.992 ₫ total
includes taxes & fees
8 Feb - 9 Feb
Grand Bohemian Lodge Greenville, Autograph Collection
Exterior
The Westin Poinsett Greenville

The Westin Poinsett Greenville

The Westin Poinsett Greenville
4.0 star property
Greenville Downtown
9.2 out of 10, Wonderful, (1,005 reviews)
"Great staff! Wonderful stay!"
United States
angela
The price is 4.702.151 ₫
5.172.366 ₫ total
includes taxes & fees
25 Jan - 26 Jan
The Westin Poinsett Greenville
Lobby
The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
4.0 star property
Clemson
9.8 out of 10, Exceptional, (747 reviews)
"Beautiful hotel. Great service. Delicious food. "
United States
Shannon
The price is 4.702.151 ₫
5.219.388 ₫ total
includes taxes & fees
18 Jan - 19 Jan
The Shepherd Hotel Downtown Clemson
Restaurant
Hotel Hartness

Hotel Hartness

Hotel Hartness
4.0 star property
Greenville
9.8 out of 10, Exceptional, (638 reviews)
"The hotel was clean staff was amazing room was outstanding."
United States
Clifford
The price is 4.212.978 ₫
5.522.646 ₫ total
includes taxes & fees
18 Jan - 19 Jan
Hotel Hartness
Bar (on property)
Greenville Marriott

Greenville Marriott

Greenville Marriott
4.0 star property
Greenville
8.6 out of 10, Excellent, (613 reviews)
"Bed was SO comfortable, I slept all through the night!!! Staff incredible especially the girls at breakfast and Adam at the bar. "
United States
LYNNE
The price is 2.994.666 ₫
3.294.133 ₫ total
includes taxes & fees
24 Jan - 25 Jan
Greenville Marriott
Meeting facility
Mint House Greenville - Downtown

Mint House Greenville - Downtown

Mint House Greenville - Downtown
4.0 star property
Greenville Downtown
9.2 out of 10, Wonderful, (785 reviews)
"Spotless wonderful stay"
United States
Tanganica
The price is 3.051.340 ₫
3.448.014 ₫ total
includes taxes & fees
8 Feb - 9 Feb
Mint House Greenville - Downtown
Lobby lounge
The Abernathy of Clemson

The Abernathy of Clemson

The Abernathy of Clemson
4.0 star property
Clemson
9.6 out of 10, Exceptional, (560 reviews)
"location is amazing! "
United States
colleen
The Abernathy of Clemson
Apartment, 1 Bedroom | Private kitchen | Full-sized fridge, microwave, oven, stovetop
Park Place Apartments by Landing

Park Place Apartments by Landing

Park Place Apartments by Landing
4.0 star property
Greenville
7.6 out of 10, Good, (44 reviews)
"Loved the apartment! Very spacious, clean, brand new. Access to bike paths. Seemed like a quirky location but everything is close by car or bike. "
United States
Kathie
Park Place Apartments by Landing
Trailside Wedge Cottage | Terrace/patio
The Station by Compo Hotels

The Station by Compo Hotels

The Station by Compo Hotels
4.0 star property
Travelers Rest
10.0 out of 10, Exceptional, (16 reviews)
"great place perfect for more privacy vs. a standard hotel"
United States
John
The Station by Compo Hotels
Courtyard
Hotel Domestique

Hotel Domestique

Hotel Domestique
4.0 star property
Travelers Rest
9.8 out of 10, Exceptional, (31 reviews)
"Overall it was an exceptional experience and would highly recommend to anyone looking for a quiet get away."
United States
Chuck
The price is 7.223.975 ₫
7.946.373 ₫ total
includes taxes & fees
15 Jan - 16 Jan
Hotel Domestique
Front of property
Liberty Hall Bed and Breakfast

Liberty Hall Bed and Breakfast

Liberty Hall Bed and Breakfast
4.0 star property
Pendleton
10.0 out of 10, Exceptional, (78 reviews)
"The owners are amazing. Comfy rooms, stellar breakfast and good people. "
United States
Renee
The price is 3.633.642 ₫
5.346.793 ₫ total
includes taxes & fees
17 Jan - 18 Jan
Liberty Hall Bed and Breakfast
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Learn more about Upstate South Carolina

Experience the family-friendly area of Upstate South Carolina—live music, sports teams and sights from Frankie's Fun Park to The Shops at Greenridge.

See all hotels in Upstate South Carolina
The view from Caesars Head after a storm
Photo by Michelle Hendrix
Open Photo by Michelle Hendrix

Top Upstate South Carolina Hotel Reviews

Frequently asked questions

What are the best 4-star hotels in Upstate South Carolina?
Stay at Greenville Marriott and get ready for upscale comfort and plenty of handy amenities. This 4-star hotel in Greer, Upstate South Carolina, is highly recommended by Expedia guests.
How much does it cost to stay in a 4-star hotel in Upstate South Carolina?
Expedia can help you quickly locate the perfect 4-star hotel for your getaway in Upstate South Carolina. Use our handy filter tool to tailor your search by things like amenities, budget and property star rating and get access to fabulous deals in a few clicks.

  • Search for the lowest price from 3.294.133 ₫

What's the difference between 5-star and 4-star hotels in Upstate South Carolina?
Offering a friendly guest experience and upmarket décor, 4-star hotels are a wonderful option for your Upstate South Carolina trip. These kinds of accommodation generally come with loads of handy amenities that make it simple to kick back and relax — think large beds, bathrobes, restaurants and pools. Or live the high life at a 5-star hotel designed to pamper with exclusive perks and amenities. Full-service health clubs, premium toiletries and fine dining are typically featured at these deluxe retreats.