Our top choices for Upstate South Carolina hotels

Premium bedding, in-room safe, individually furnished, laptop workspace

Carolina Camp Cedar

Pickens

Katlynn

5.062.975 ₫ total

includes taxes & fees

10 Mar - 11 Mar

The Abernathy of Clemson

Clemson

Megan

Hampton Inn Easley

Easley

Thomas

4.032.337 ₫ total

includes taxes & fees

15 Mar - 16 Mar

SUN AND SAND MOTEL

Spartanburg

Tracy

2.065.925 ₫ total

includes taxes & fees

13 Mar - 14 Mar

The Inn at Patrick Square

Clemson

Joyce

4.626.509 ₫ total

includes taxes & fees

10 Mar - 11 Mar

Inn @ Clemson

Clemson

Keren

Clemson University's James F. Martin Inn

Clemson

Paige

4.335.533 ₫ total

includes taxes & fees

12 Mar - 13 Mar

Tru by Hilton Seneca Clemson

Seneca

Cindy

3.123.162 ₫ total

includes taxes & fees

16 Mar - 17 Mar

Holiday Inn Express & Suites Clemson by IHG

Clemson

Rishandrea

3.578.996 ₫ total

includes taxes & fees

15 Mar - 16 Mar

Urban Boutique Hotel, BW Signature Collection

Greenville

cyndi

1.859.596 ₫ total

includes taxes & fees

29 Mar - 30 Mar

Suite, 1 King Bed with Sofa bed, Non Smoking (Efficiency) | Premium bedding, individually decorated, desk, laptop workspace

Comfort Inn & Suites Clemson - University Area

Clemson

Delaney

3.066.881 ₫ total

includes taxes & fees

15 Mar - 16 Mar

Lakeside Lodge Clemson

Seneca

Jeffrey

3.547.016 ₫ total

includes taxes & fees

10 Mar - 11 Mar

Home2 Suites by Hilton Greenville Downtown

Greenville Downtown

Robert

3.996.010 ₫ total

includes taxes & fees

5 Apr - 6 Apr

Hampton Inn & Suites Seneca-Clemson Area

Seneca

Debby

3.475.452 ₫ total

includes taxes & fees

22 Mar - 23 Mar

Woodspring Suites Greenville Airport

Greenville

Makiya

2.277.997 ₫ total

includes taxes & fees

10 Mar - 11 Mar

Holiday Inn Spartanburg Northwest by IHG

Spartanburg

Jennifer

2.997.046 ₫ total

includes taxes & fees

22 Mar - 23 Mar

Aloft Greenville Downtown

Greenville Downtown

Mike

3.897.104 ₫ total

includes taxes & fees

15 Mar - 16 Mar

Tru by Hilton Greenville Woodruff Road

Greenville

Christopher

2.889.911 ₫ total

includes taxes & fees

5 Apr - 6 Apr

Standard Room, 1 King Bed, Non Smoking, Jetted Tub | Desk, laptop workspace, blackout curtains, iron/ironing board

Best Western Seneca-Clemson

Seneca

Tabatha

2.916.700 ₫ total

includes taxes & fees

3 Apr - 4 Apr

Best Western Plus Clemson Hotel & Conference Center

Clemson

Tina

2.770.088 ₫ total

includes taxes & fees

10 Mar - 11 Mar

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Holiday Rentals in Upstate South Carolina

Cabin

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Seneca

"Excellent stay."

Apartment

Serene Travelers Rest Apartment: 7 Mi to Downtown!

Travelers Rest

"The best time ever. My wife and I enjoyed our Honeymoon and stay here. We will come back every year for our Anniversary now and also to vacation here. The area was beautiful, quiet, and safe. We had everything we needed. No other vacation spot in South Carolina can compete. Thank you for our wonderful stay and perfect memories! "

Aparthotel

Full-sized fridge, microwave, oven, stovetop

stayAPT Suites Greenville-Haywood Mall

Greenville

"Room was very clean and welcoming. The only staff we met was Mark, and he was absolutely wonderful and friendly. "

Apartment

Deluxe Two Bedroom (Self Check-in with Virtual Front Desk) | Living area | 55-inch flat-screen TV with digital channels, TV, streaming services

Mint House Greenville Downtown by Kasa

Greenville Downtown

"Spotless wonderful stay"

Mobile Home

Cabin, 2 Bedrooms, Non Smoking (No Pets, Linens Included) | In-room dining

Carolina Landing RV Resort - Caravan Park

Fair Play

"Lake "

Cottage

Wooded Cottage - 3 Mi to Clemson University

Clemson

Cottage

Stay at Jos Taylor Retreat: 9 Mi to Greenville!

Taylors

"This rental is a time capsule that takes you back to Grandma and Grandpa's home. The owner is great to communicate with, as well as their property manager. Quaint older furniture, complete with blankets on the couches. There's all you need to cook and even a great cast-iron frying pan. I wish we had stayed here longer."

Cottage

Waterfront Lake Hartwell Vacation Rental w/ Dock!

Townville

Cottage

8 Mi to Clemson: Peaceful Family Home w/ Yard

Seneca

"The place was all out perfect the owner was polite and perfect. It was a very peaceful place to stay thank you so much."

Cottage

Waterfront Seneca Cabin ~ 4 Mi to Boat Launch!

Seneca

"Beautiful and quaint cabin! Highly recommend, great view of the lake."

Cottage

Deck, Grill & Dock Access: Lake Keowee Retreat!

Seneca

"The best, perfect "

Cottage

Claires Cottage ~ 4 Mi to Downtown Greenville!

Greenville

"Great trip. The small cottage was perfect for my wife and I and the owner was very responsive."

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Stay near popular Southeastern United States attractions

Clemson University

4.7/5 (738 reviews)

Take a campus tour or just explore the area of Clemson University during your travels in Clemson. Experience the area's theatre scene or attend a football match.

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Nice little church with a beautiful Mountain view

Fred W. Symmes Chapel

4.8/5 (13 reviews)

You can find out about the history of Cleveland with a visit to Fred W. Symmes Chapel. Wander the lakeside and forests in this relaxing area.

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Learn more about Upstate South Carolina

Experience the family-friendly area of Upstate South Carolina—live music, sports teams and sights from Discovery Island Water Park to Frankie's Fun Park.

See all hotels in Upstate South Carolina

Top Upstate South Carolina Hotel Reviews

Hotel Hartness

10/10 Excellent

"relaxing"

Hyatt Place Greenville Downtown

2/10 Terrible

"Blood stain on bedspread. No housekeeping to change beds. We had to remove blood stain spread ourselves. Only gave a top sheet and blanket to make our own bed.Daughter was locked in restroom. She did not lock it herself. We had to call front desk to get her out. No maintenance was available to fix door from locking again."