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Our top choices for Upstate South Carolina hotels

A modern restaurant interior with round tables and chairs, a kitchen area, and large windows offering a view of parked cars outside.

1. Best Western Plus Greenville I-385 Inn & Suites

Greenville

Rubin

2.160.976 ₫ total

includes taxes & fees

1 Nov - 2 Nov

A multi-level hotel lobby with a central atrium, multiple dining areas, and a reception desk.

2. Embassy Suites Greenville Golf Resort & Conference Center

Greenville

Shirleen

2.962.957 ₫ total

includes taxes & fees

25 Nov - 26 Nov

A spacious lobby with a modern design, featuring a reception desk, seating area with sofas and armchairs, and a large chandelier.

3. Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

Greenville

Taleigha

2.547.962 ₫ total

includes taxes & fees

29 Nov - 30 Nov

A modern indoor fire feature with a stone border, surrounded by seating areas and a glass wall in the background.

4. SpringHill Suites by Marriott Greenville Downtown

Greenville Downtown

Deborah

4.144.390 ₫ total

includes taxes & fees

22 Nov - 23 Nov

A hotel patio with outdoor seating, stone pillars, and a modern building in the background.

5. DoubleTree by Hilton Greenville Woodruff Road

Greenville

Jamie

3.256.404 ₫ total

includes taxes & fees

24 Nov - 25 Nov

A spacious lobby with modern furniture, a chandelier, and potted plants.

6. Hilton Greenville

Greenville

William

3.097.969 ₫ total

includes taxes & fees

22 Nov - 23 Nov

A dining area with a wooden table, chairs, and a vase of white flowers.

7. Hotel Hartness

Greenville

Nicole

5.666.557 ₫ total

includes taxes & fees

22 Nov - 23 Nov

An indoor swimming pool with a tiled floor, a covered area, and a seating area with chairs.

8. Drury Inn & Suites Greenville

Greenville

Jamie

3.269.614 ₫ total

includes taxes & fees

5 Nov - 6 Nov

A modern hotel room with a large bed, a desk, and a kitchenette.

9. Microtel Inn & Suites by Wyndham Greenville / Woodruff Rd

Greenville

Maclin

2.030.181 ₫ total

includes taxes & fees

15 Nov - 16 Nov

A Comfort Inn hotel with a stone facade, a clear sign indicating a 12'6" clearance, and a well-lit entrance.

10. Comfort Inn Greenville - Haywood Mall

Greenville

Paul

2.516.891 ₫ total

includes taxes & fees

1 Nov - 2 Nov

A multi-story hotel with a stone facade, large windows, and outdoor seating areas.

11. Hampton Inn & Suites Greenville-Downtown-RiverPlace

Greenville Downtown

Cindy

4.298.733 ₫ total

includes taxes & fees

22 Nov - 23 Nov

A covered outdoor area with a grill and seating, surrounded by brick walls and windows.

12. Homewood Suites by Hilton Greenville Downtown

Greenville Downtown

Cyrus

3.938.505 ₫ total

includes taxes & fees

23 Nov - 24 Nov

A hotel lobby with round tables and chairs, a TV mounted on the wall, and a reception desk.

13. Hyatt Place Greenville Downtown

Greenville Downtown

Tamara

3.719.438 ₫ total

includes taxes & fees

29 Nov - 30 Nov

A modern hotel lobby with a bar area, seating, and a reception desk.

14. Holiday Inn Greenville - Woodruff Road by IHG

Greenville

Rick

2.870.158 ₫ total

includes taxes & fees

1 Nov - 2 Nov

A spacious lobby with a large beige sofa, a fireplace, and a modern chandelier.

15. Hilton Garden Inn Greenville

Greenville

Valerie

2.617.666 ₫ total

includes taxes & fees

22 Nov - 23 Nov

A modern outdoor seating area with a glass-top coffee table, blue sofas, and orange patterned cushions.

16. Tru by Hilton Greenville Woodruff Road

Greenville

Amy

3.105.655 ₫ total

includes taxes & fees

23 Nov - 24 Nov

A circular outdoor seating area with a fire pit, surrounded by sofas and chairs, in front of a multi-story building.

17. Courtyard by Marriott Greenville Haywood Mall

Greenville

alejandro

3.206.333 ₫ total

includes taxes & fees

23 Nov - 24 Nov

A hotel entrance with a covered walkway, a reception desk, and a parking area.

18. Holiday Inn Express & Suites Greenville S- Piedmont by IHG

Piedmont

STEPHEN

3.184.857 ₫ total

includes taxes & fees

29 Nov - 30 Nov

A multi-story hotel with a modern design, featuring a prominent 'La Quinta' sign, a parking lot, and a landscaped entrance area.

19. La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.

Greenville

Sam

2.862.796 ₫ total

includes taxes & fees

1 Nov - 2 Nov

A modern lobby with a reception desk, seating area, and a kitchen in the background.

20. Courtyard by Marriott Greenville Downtown

Greenville Downtown

Ray

4.190.958 ₫ total

includes taxes & fees

8 Nov - 9 Nov

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Holiday Rentals in Upstate South Carolina

Aparthotel

stayAPT Suites Greenville-Haywood Mall

Greenville

"The kitchen was nice and came with basic utensils which was helpful"

Apartment

A modern living room with a sofa, a coffee table, a TV, and a balcony with a view of buildings.

Mint House Greenville Downtown by Kasa

Greenville Downtown

"Great location, convenient!"

Cottage

A living room with a blue sofa, a round coffee table with a vase of flowers, a patterned rug, and a chair. There are paintings on the walls and a window with curtains.

Claires Cottage ~ 4 Mi to Downtown Greenville!

Greenville

"Great trip. The small cottage was perfect for my wife and I and the owner was very responsive."

Cabin

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Seneca

"My wife and I enjoyed our stay here. 10/10 experience."

Mobile Home

A wooden dining table with green placemats, surrounded by chairs, in a cabin with large windows and wooden walls.

Carolina Landing RV Resort - Caravan Park

Fair Play

"Very nice stay with friendly staff"

Cottage

A modern living room with a ceiling fan, a sofa, a chair, and a coffee table. There is a kitchen in the background with cabinets and a countertop.

< 3 Mi to Dtwn: Modern Cottage in Greenville!

Greenville

Apartment

A large house with a spacious driveway and a pond in the background.

Serene Travelers Rest Apartment: 7 Mi to Downtown!

Travelers Rest

"The best time ever. My wife and I enjoyed our Honeymoon and stay here. We will come back every year for our Anniversary now and also to vacation here. The area was beautiful, quiet, and safe. We had everything we needed. No other vacation spot in South Carolina can compete. Thank you for our wonderful stay and perfect memories! "

Cottage

A spacious living room with a large sofa, a kitchen area with a bar, and a view of the outdoors through the windows.

Waterfront Cabin w/ Private Dock on Lake Hartwell!

Townville

"We booked last minute for Clemson parents weekend. It worked out fine, it is really in the middle of no where. There are no outlets in the bathroom you have to use the kitchen mirror and outlets to get ready. There was a coffee machine but no coffee. It was very clean. The deck needs some work."

Apartment

A swimming pool with a view of a lake and docked boats.

Lake Keowee Condo: Resort Pools & Lake Access!

Salem

"Wow!! Absolutely beautiful property. Recent remodel with beautiful and very tasteful design. Amazingly clean, organized and tidy. We are from Denver and did not have exposure to Lake Keowee. The lake was beautiful with great walking trails on the property. Special and spectacular spot! We will definitely go back. This is a gated community. Super comfortable king beds and nice linens."

Cottage

A covered porch with wooden railings and a table with chairs.

Fish, Hike & Explore! Family Tamassee Getaway

Tamassee

"Fall weekend getaway and this was perfect location. Loved the back porch for coffee and views of the sun through all the colorful leaves. Felt like we were away from it all but just a short drive to restaurants, stores, lakes and parks!!!"

Cottage

A balcony with wicker chairs, a white railing, and a view of a forest.

Waterfront Lake Hartwell Vacation Rental w/ Dock!

Townville

Cottage

Mountain Rest Cottage w/ Gas Fireplace!

Mountain Rest

"Unit is attached to the owners house. The drive way leading up to the apartment is loose gravel. Not safe for a heavy motorcycle. "

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Stay near popular Upstate South Carolina attractions

A historic building with a clock tower, surrounded by a well-maintained lawn with a paw print design.

Clemson University

9.6/10 (1,439 reviews)

Take a campus tour or just explore the area of Clemson University during your travels in Clemson. Experience the area's theatre scene or attend a football match.

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Learn more about Upstate South Carolina

Experience the family-friendly area of Upstate South Carolina—live music, sports teams and sights from Discovery Island Water Park to Frankie's Fun Park.

See all hotels in Upstate South Carolina

An aerial view of a park with a winding path, trees in autumn colors, and a bridge.

Top Upstate South Carolina Hotel Reviews

Comfort Inn Greenville - Haywood Mall

10/10 Excellent

"Plenty of restaurants nearby...easy access to I85. We had a little trouble finding the hotel entrance (hotel sits back from main road). Otherwise very pleasant and helpful staff."