Our top choices for Upstate South Carolina hotels

Spa

Egyptian cotton sheets, premium bedding, pillow-top beds, in-room safe

1. Days Inn by Wyndham Greenville South/Mauldin

Mauldin

Scott

2.116.712 ₫ total

includes taxes & fees

2 Aug - 3 Aug

2. Best Western Plus Greenville I-385 Inn & Suites

Greenville

Terri

3.011.466 ₫ total

includes taxes & fees

2 Aug - 3 Aug

3. Clemson University's James F. Martin Inn

Clemson

Jesse

4.207.628 ₫ total

includes taxes & fees

27 Jul - 28 Jul

Single Room, 1 King Bed, Non Smoking | Desk, laptop workspace, free WiFi

4. Deluxe Inn

Mauldin

Diane

1.954.820 ₫ total

includes taxes & fees

27 Jul - 28 Jul

5. Drury Inn & Suites Greenville

Greenville

Aaron

3.387.609 ₫ total

includes taxes & fees

25 Aug - 26 Aug

6. The Inn at Patrick Square

Clemson

april

4.353.725 ₫ total

includes taxes & fees

27 Jul - 28 Jul

7. Fairfield Inn & Suites by Marriott Greenville Simpsonville

Simpsonville

Carole

2.436.550 ₫ total

includes taxes & fees

3 Aug - 4 Aug

8. Lakeside Lodge Clemson

Seneca

JEFFREY

3.561.900 ₫ total

includes taxes & fees

28 Jul - 29 Jul

9. Clarion Greenville Airport Inn

Greenville

Gladys

2.018.261 ₫ total

includes taxes & fees

16 Aug - 17 Aug

10. La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.

Greenville

Kelley

2.501.834 ₫ total

includes taxes & fees

11 Aug - 12 Aug

11. La Quinta by Wyndham Haywood Mall-Near Greenville Downtown

Greenville

Wade

2.215.165 ₫ total

includes taxes & fees

30 Jul - 31 Jul

12. Best Western Plus Clemson Hotel & Conference Center

Clemson

Steve

3.203.934 ₫ total

includes taxes & fees

31 Jul - 1 Aug

13. SpringHill Suites by Marriott Greenville Downtown

Greenville Downtown

Robert

3.581.907 ₫ total

includes taxes & fees

9 Aug - 10 Aug

14. Comfort Suites Greenville Airport

Greenville

Chandler

2.931.182 ₫ total

includes taxes & fees

23 Aug - 24 Aug

15. Staybridge Suites Greenville I-85 Woodruff Road by IHG

Greenville

Dean B.

3.648.506 ₫ total

includes taxes & fees

23 Aug - 24 Aug

16. Holiday Inn Express & Suites Greenville - Downtown by IHG

Greenville Downtown

SEAN

2.972.506 ₫ total

includes taxes & fees

9 Aug - 10 Aug

17. Fairfield Inn by Marriott Greenville-Spartanburg Airport

Greenville

Brian

2.522.971 ₫ total

includes taxes & fees

9 Aug - 10 Aug

18. Microtel Inn & Suites by Wyndham Greenville / Woodruff Rd

Greenville

Steven

2.215.164 ₫ total

includes taxes & fees

11 Aug - 12 Aug

19. The Abernathy of Clemson

Clemson

Robert

4.707.284 ₫ total

includes taxes & fees

28 Jul - 29 Jul

20. Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

Greenville

Ashli

2.351.259 ₫ total

includes taxes & fees

23 Aug - 24 Aug

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Holiday Rentals in Upstate South Carolina

Aparthotel

Coffee/tea maker, full-sized fridge, microwave, oven

stayAPT Suites Greenville-Haywood Mall

Greenville

"This is a great hotel for the price!!"

Apartment

Deluxe Two Bedroom (Self Check-in with Virtual Front Desk) | Living area | 55-inch flat-screen TV with digital channels, TV, streaming services

Mint House Greenville Downtown by Kasa

Greenville Downtown

"Love the location. Room was great."

Cottage

< 3 Mi to Dtwn: Modern Cottage in Greenville!

Greenville

Apartment

Landing Apartments Greer - Sugar Creek

Greer

"Very good check in instructions. Very roomy and very quiet. Much more relaxing than a hotel room. Worth every penny."

Cabin

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Seneca

"Cabin very cozy, pet friendly… great place to be disconnected for a couple days!! "

Mobile Home

Cabin, 2 Bedrooms, Non Smoking (No Pets, Linens Included) | In-room dining

Carolina Landing RV Resort - Caravan Park

Fair Play

"Very nice stay with friendly staff"

Cottage

Cozy Home in Historic Area ~ 2 Mi to Main St!

Greenville

"Absolutely adorable property. Little bit of an interesting part of town. We weren’t spending a bunch of time on property so it didn’t mater. Super close to down town and the house is well kept. "

Cottage

2 Mi to Downtown: Luxe Greenville Retreat!

Greenville

"Great house! Very clean and comfortable. Outstanding amenities. Conveniently located. "

Cottage

Claires Cottage ~ 4 Mi to Downtown Greenville!

Greenville

"Great trip. The small cottage was perfect for my wife and I and the owner was very responsive."

Cottage

Cozy Greenville Bungalow ~ 2 Mi to Downtown!

Greenville

"Amazing place. Great host. "

Cottage

Stay at Jos Taylor Retreat: 9 Mi to Greenville!

Taylors

"This rental is a time capsule that takes you back to Grandma and Grandpa's home. The owner is great to communicate with, as well as their property manager. Quaint older furniture, complete with blankets on the couches. There's all you need to cook and even a great cast-iron frying pan. I wish we had stayed here longer."

Apartment

Serene Travelers Rest Apartment: 7 Mi to Downtown!

Travelers Rest

"The best time ever. My wife and I enjoyed our Honeymoon and stay here. We will come back every year for our Anniversary now and also to vacation here. The area was beautiful, quiet, and safe. We had everything we needed. No other vacation spot in South Carolina can compete. Thank you for our wonderful stay and perfect memories! "

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Stay near popular Upstate South Carolina attractions

A historic building with a clock tower, surrounded by a well-maintained lawn with a paw print design.

Clemson University

9.6/10 (1,439 reviews)

Enjoy the student vibe around Clemson University, a top university in Clemson. Experience the area's theatre scene or attend a football match.

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Learn more about Upstate South Carolina

Experience the family-friendly area of Upstate South Carolina—live music, sports teams and sights from Discovery Island Water Park to Frankie's Fun Park.

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An aerial view of a park with a winding path, trees in autumn colors, and a bridge.

Top Upstate South Carolina Hotel Reviews

La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.

10/10 Excellent

"Todo estaba nuevo en el hotel, las instalaciones y habitaciones son bonitas y el desayuno está bien."

Embassy Suites by Hilton Greenville Downtown Riverplace

10/10 Excellent

"We stayed in a room with a balcony facing the water. There’s a large parking deck and it’s not crazy expensive (we paid $10 for an overnight stay). The hotel is in an excellent location and offers quite a few amenities. For example, you are offered two free drinks and snacks each evening. The complimentary breakfast includes an omelette bar, as well as other hot and cold options. There are a couple of restaurants right in the building- a steakhouse and a rooftop restaurant with great views. Beds are comfortable with decent pillows. Very walkable location near Falls Park and the suspension bridge. Couple small cons- the water pressure in the shower left a bit to be desired, and it’s a bit expensive given where it’s located and the amenities that are offered The water pressure in the showers"

Hilton Greenville

10/10 Excellent

"Hilton Greenville was excellent! The room was clean, comfortable and accessible. The hotel itself was clean, looked expensive and was in a nice area. I will say, there was only 1 of 3 elevators working at the time and it was incredibly slow. The hotel was allowing customers to use the service elevator at the time which was nice, but also slow due to so many people using it. We went up and down the stairs which was totally fine with us tho! Overall, we had a wonderful experience. We will definitely be staying here more in the future. 9/10 recommend!"