Compare and book 5 Star hotels in Knoxville, Tennessee

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Knoxville 5 Star Hotels

Tonight
20 Dec - 21 Dec
Tomorrow
21 Dec - 22 Dec
Next weekend
26 Dec - 28 Dec
In two weeks
2 Jan - 4 Jan
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Knoxville and related destinations

Nestled along the Tennessee River, this vibrant city blends Appalachian charm with a thriving arts scene at the historic Market Square. Outdoor enthusiasts can hike nearby Smoky Mountain trails, then return for live music and Southern comfort food at locally-owned city centre restaurants.

See all hotels in Knoxville
Skyline of downtown Knoxville, Tennessee, USA

Top Knoxville Hotel Reviews

Frequently asked questions

How much does it cost to stay in a 5-star hotel in Knoxville?
The amount you pay for a 5-star hotel in Knoxville depends on things like when you plan to go and the length of your escape. An insider tip for scoring the best deal? Use our pricing filters to compare all of the available accommodation for your preferred dates.

  • Search for the lowest price per night

What makes a hotel 5 stars in Knoxville?
From gourmet dining venues and all-day gyms to pools and the finest bedding, the 5-star experience in Knoxville is all about comfort and luxury. But it calls for more than just top-notch perks to get a 5-star rating. Hotels must also provide superb services like massage treatments, dry cleaning and laundry and a nightly turn-down service.
Are there any 5-star all-inclusive resorts in Knoxville?
Our handy filters are the quickest way to narrow down what you want. Select "5-star" and "All inclusive" to see the most upscale resorts in Knoxville where your lodging, meals, entertainment and activities are included in the price. At these retreats, your holiday is pure extravagance from the moment you pull up to the entrance.