Compare and book 5 Star hotels in Mendrisio, Canton of Ticino

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Check availability on Mendrisio 5 Star Hotels

Tonight
20 Dec - 21 Dec
Tomorrow
21 Dec - 22 Dec
Next weekend
26 Dec - 28 Dec
In two weeks
2 Jan - 4 Jan

Our top choices for Mendrisio 5-star hotels

Villa (Sola Cabiati) | Premium bedding, down duvets, minibar, in-room safe
Grand Hotel Tremezzo

Grand Hotel Tremezzo

Grand Hotel Tremezzo
5.0 star property
Tremezzina
9.8 out of 10, Exceptional, (87)
"Nicest hotel I’ve ever stayed in - unbelievable experience all around."
United States
Jordan
Grand Hotel Tremezzo
Indoor pool, open 8:00 AM to 8:00 PM, pool loungers
Hotel Splendide Royal

Hotel Splendide Royal

Hotel Splendide Royal
5.0 star property
Loreto
9.4 out of 10, Exceptional, (461)
"Great place to stay "
United States
carla
The price is 8.047.850 ₫
8.661.959 ₫ total
includes taxes & fees
5 Jan - 6 Jan 2026
Hotel Splendide Royal
2 restaurants, lunch served
Grand Hotel Villa Serbelloni

Grand Hotel Villa Serbelloni

Grand Hotel Villa Serbelloni
5.0 star property
Historic Center
9.2 out of 10, Wonderful, (550)
"The staff were wonderful and the hotel was impeccable. All amenities were extremely thoughtful."
United States
Brian
Grand Hotel Villa Serbelloni
Terrace/patio
Mandarin Oriental, Lago di Como

Mandarin Oriental, Lago di Como

Mandarin Oriental, Lago di Como
5.0 star property
Blevio
9.4 out of 10, Exceptional, (482)
"The staff was amazing "
United States
Maria
Mandarin Oriental, Lago di Como
Premium bedding, down duvets, minibar, in-room safe
Grand Hotel Villa Castagnola

Grand Hotel Villa Castagnola

Grand Hotel Villa Castagnola
5.0 star property
Cassarate
9.6 out of 10, Exceptional, (393)
"Amazing hotel and a truly special place."
United Kingdom
steve
The price is 14.657.810 ₫
15.522.410 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Grand Hotel Villa Castagnola
Suite | Down duvets, in-room safe, laptop workspace, soundproofing
Grand Hotel Campione

Grand Hotel Campione

Grand Hotel Campione
5.0 star property
Campione d'Italia
9.0 out of 10, Wonderful, (166)
"Very good breakfast and welcoming atmosphere "
United Kingdom
Ehab
Grand Hotel Campione
Front of property
Villa Principe Leopoldo

Villa Principe Leopoldo

Villa Principe Leopoldo
5.0 star property
Loreto
9.2 out of 10, Wonderful, (342)
"The breakfast served in the dining room is amazing, excellent selection of any kind of food you may eat. The service and staff are exquisite. Only the building needs to be refreshed and the rooms to be equipped with USB plugs or international plugs fur foreign travelers. "
United States
Alessandra
Villa Principe Leopoldo
Junior Suite, Terrace, Lake View | Minibar, in-room safe, blackout curtains, free WiFi
Swiss Diamond Boutique Hotel La Romantica

Swiss Diamond Boutique Hotel La Romantica

Swiss Diamond Boutique Hotel La Romantica
5.0 star property
Melide
9.8 out of 10, Exceptional, (17)
"Beautiful location and friendly staffs are impressive. Would love to visit again. "
United States
Susan
The price is 10.582.302 ₫
11.292.033 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Swiss Diamond Boutique Hotel La Romantica
Indoor pool, seasonal outdoor pool
Grand Hotel Victoria Concept & Spa, by R Collection Hotels

Grand Hotel Victoria Concept & Spa, by R Collection Hotels

Grand Hotel Victoria Concept & Spa, by R Collection Hotels
5.0 star property
Menaggio
9.8 out of 10, Exceptional, (95)
"Beautiful property with excellent service."
United States
Gabriel
Grand Hotel Victoria Concept & Spa, by R Collection Hotels
2 restaurants, breakfast served
Swiss Diamond Hotel & SPA

Swiss Diamond Hotel & SPA

Swiss Diamond Hotel & SPA
5.0 star property
Vico Morcote
9.0 out of 10, Wonderful, (435)
"Beautiful property, very friendly and helpful staff. The breakfast buffet was excellent! We had a wonderful time."
Canada
Sabrina
Swiss Diamond Hotel & SPA
Indoor pool, outdoor pool, pool loungers
ARIA Retreat & SPA - The Leading Hotels of the World

ARIA Retreat & SPA - The Leading Hotels of the World

ARIA Retreat & SPA - The Leading Hotels of the World
5.0 star property
Porlezza
9.8 out of 10, Exceptional, (78)
"This was the nicest hotel that we have ever stayed at, and the food was out of this world."
United States
Jeremy
The price is 27.732.436 ₫
30.505.680 ₫ total
includes taxes & fees
30 Dec - 31 Dec
ARIA Retreat & SPA - The Leading Hotels of the World
Rooftop bar
Palazzo Venezia

Palazzo Venezia

Palazzo Venezia
5.0 star property
Como City Centre
9.8 out of 10, Exceptional, (119)
"The hotel was in a perfect location. Next to the lake. Nice rooftop bar and dinner at the hotel restaurant was absolutely delicious. Super friendly staff. Easy access to ferries. Would definitely stay here again. "
United States
Susana
The price is 19.328.583 ₫
21.569.672 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Palazzo Venezia
Outdoor dining
Passalacqua

Passalacqua

Passalacqua
5.0 star property
Moltrasio
10.0 out of 10, Exceptional, (18)
"Entire hotel is a 12/10 but add in that they have ALL the Dyson products in each room!!! "
United States
bernard
Passalacqua
Front of property
Bianca Relais - by R Collection Hotels

Bianca Relais - by R Collection Hotels

Bianca Relais - by R Collection Hotels
5.0 star property
Oggiono
9.8 out of 10, Exceptional, (50)
"simple n modern design beautiful lakeview"
Hong Kong SAR China
Po Mei
The price is 9.526.652 ₫
10.479.317 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Bianca Relais - by R Collection Hotels
Indoor pool
The View Lugano

The View Lugano

The View Lugano
5.0 star property
Paradiso
9.6 out of 10, Exceptional, (157)
"Wonderful hotel, can’t praise it enough. Look forward to our next stay! "
United States
Jonathan
The price is 18.011.580 ₫
19.003.624 ₫ total
includes taxes & fees
21 Dec - 22 Dec
The View Lugano
3 restaurants, breakfast, lunch, dinner served; Italian cuisine
Nuvole Garden Hotel

Nuvole Garden Hotel

Nuvole Garden Hotel
5.0 star property
Brunate
8.4 out of 10, Very good, (8)
"Excellent service and environment. Such a resort on top of lake Como with full view. Highly recommended. "
Hong Kong SAR China
Tsun
The price is 12.933.456 ₫
14.534.939 ₫ total
includes taxes & fees
24 Dec - 25 Dec
Nuvole Garden Hotel
Terrace/patio
Hotel Eden Roc

Hotel Eden Roc

Hotel Eden Roc
5.0 star property
Ascona
9.4 out of 10, Exceptional, (129)
"Super Hotel! "
Germany
Stephan
Hotel Eden Roc
Junior Suite, Lake View, Annex Building (in grotta) | Lake view
Villa Lario Resort Mandello

Villa Lario Resort Mandello

Villa Lario Resort Mandello
5.0 star property
Mandello del Lario
9.8 out of 10, Exceptional, (38)
"Great well run resort"
United States
gordon
Villa Lario Resort Mandello
Exterior
Resort Collina d'Oro, Starhotels Collezione

Resort Collina d'Oro, Starhotels Collezione

Resort Collina d'Oro, Starhotels Collezione
5.0 star property
Collina d'Oro
9.2 out of 10, Wonderful, (163)
"Excellent resort"
United States
Gregory
Resort Collina d'Oro, Starhotels Collezione
Exterior
Giardino Ascona

Giardino Ascona

Giardino Ascona
5.0 star property
Ascona
9.6 out of 10, Exceptional, (75)
"We loved being there and being taken care of by amazing staff."
United States
Karin
Giardino Ascona
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Learn more about Mendrisio

Tucked between Lake Lugano and Generoso Mount, this charming town invites you to explore its cultural treasures at Museum d'Art and Galleria Baumgartner. Bargain hunters flock to FoxTown Factory Stores while nature lovers can discover the UNESCO-listed Monte San Giorgio with its remarkable fossil deposits.

See all hotels in Mendrisio
Panoramic aerial view of a Swiss city. Mendrisio with to the right the church of Saints Cosmas and Damian, Switzerland

Top Mendrisio Hotel Reviews

Grand Hotel Villa Serbelloni

Grand Hotel Villa Serbelloni

10/10 Excellent
"The staff were wonderful and the hotel was impeccable. All amenities were extremely thoughtful."
Brian 1-night trip
Posted 2 months ago
Grand Hotel Villa Serbelloni

Frequently asked questions

What are the best 5-star hotels in Mendrisio?
Get ready for 5-star luxuriousness at Swiss Diamond Hotel & SPA, Resort Collina d'Oro or The View Lugano. These are some of the leading properties in Mendrisio according to Expedia traveller reviews. Book your favourite and get a taste of the finer life!
How much does it cost to stay in a 5-star hotel in Mendrisio?
The amount you pay for a 5-star hotel in Mendrisio can vary depending on when you prefer to travel and how long you plan to be away, among several factors. Use our price per night filter and other search tools to score the best deal on a high-end stay.

  • Search for the lowest price per night

What makes a hotel 5 stars in Mendrisio?
Impeccable guest service is at the heart of every 5-star hotel in Mendrisio. From the instant you arrive, staff cater to your every whim, whether recommending activities and tours or providing in-room massages. Additionally, hotels have to offer top-rate conveniences to obtain a 5-star rating. These can include luxury bathrobes, spas or saunas, swimming pools, gourmet kitchens and knowledgeable concierge.