Compare and book 5 Star hotels in Palo Alto, California

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Palo Alto 5 Star Hotels

Tonight
20 Dec - 21 Dec
Tomorrow
21 Dec - 22 Dec
Next weekend
26 Dec - 28 Dec
In two weeks
2 Jan - 4 Jan

Our top choices for Palo Alto 5-star hotels

Poolside bar
Shashi Hotel Mountain View Palo Alto

Shashi Hotel Mountain View Palo Alto

Shashi Hotel Mountain View Palo Alto
5.0 star property
Mountain View
9.4 out of 10, Exceptional, (1201)
"Perfect place to stay and enjoy "
United States
Ali
The price is 3.528.842 ₫
3.888.607 ₫ total
includes taxes & fees
10 Jan - 11 Jan 2026
Shashi Hotel Mountain View Palo Alto
Terrace/patio
Four Seasons Hotel Silicon Valley at East Palo Alto

Four Seasons Hotel Silicon Valley at East Palo Alto

Four Seasons Hotel Silicon Valley at East Palo Alto
5.0 star property
East Palo Alto
9.4 out of 10, Exceptional, (666)
"Wonderful stay "
United States
Cindy
The price is 9.473.400 ₫
10.770.782 ₫ total
includes taxes & fees
2 Jan - 3 Jan 2026
Four Seasons Hotel Silicon Valley at East Palo Alto
Exterior
Rosewood Sand Hill

Rosewood Sand Hill

Rosewood Sand Hill
5.0 star property
Menlo Park
9.4 out of 10, Exceptional, (276)
"Really great hotel and my go to place for anything in Palo Alto "
United States
Lisa
The price is 21.196.732 ₫
26.484.901 ₫ total
includes taxes & fees
16 Jan - 17 Jan 2026
Rosewood Sand Hill
Breakfast, lunch, dinner served; Japanese cuisine, al fresco dining
Nobu Hotel Palo Alto

Nobu Hotel Palo Alto

Nobu Hotel Palo Alto
5.0 star property
University South
9.2 out of 10, Wonderful, (434)
"Beautiful hotel. "
United States
Dianne
The price is 10.394.425 ₫
12.025.830 ₫ total
includes taxes & fees
26 Dec - 27 Dec
Nobu Hotel Palo Alto
Terrace/patio
Clement Palo Alto – All-Inclusive Urban Resort

Clement Palo Alto – All-Inclusive Urban Resort

Clement Palo Alto – All-Inclusive Urban Resort
5.0 star property
Palo Alto
10.0 out of 10, Exceptional, (112)
"Great hotel!!"
United States
Matthew
The price is 12.590.938 ₫
15.448.220 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Clement Palo Alto – All-Inclusive Urban Resort
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Palo Alto.
The Ameswell Hotel

The Ameswell Hotel

800 Moffett Blvd Mountain View CA
The price is 3.389.109 ₫ per night from 21 Dec to 22 Dec
3.389.109 ₫
3.785.465 ₫ total
21 Dec - 22 Dec
includes taxes & fees
9.6/10 Exceptional! (1,133 reviews)
Still don't see what you're looking for?
See all properties in Palo Alto.
You can also use these popular filters to refine your search.
PoolSpaHot tubBreakfast includedWaterpark
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Palo Alto

Silicon Valley's heart offers visitors the chance to tour Stanford's iconic campus and stroll University Avenue's tech-inspired shops. Bike the flat, tree-lined areas where garage startups became tech giants, then hike the rolling hills of Foothills Park when you need a break.

See all hotels in Palo Alto
F688EF PALO ALTO, USA - OCT 22 2014

Top Palo Alto Hotel Reviews

Frequently asked questions

What are the best 5-star hotels in Palo Alto?
Gear up for 5-star pampering at Nobu Hotel Palo Alto, Clement Palo Alto – All-Inclusive Urban Resort or Shashi Hotel Mountain View Palo Alto. These are among the best stays in Palo Alto according to Expedia traveller reviews. Pick one and enjoy a taste of the good life!
How much does it cost to stay in a 5-star hotel in Palo Alto?
How much you pay for a 5-star hotel in Palo Alto depends on factors like when you want to go and the length of your break. An insider tip for landing an awesome deal? Use our pricing filters to compare all of the available options for your preferred dates.

  • Search for the lowest price per night from 3.785.465 ₫

What makes a hotel 5 stars in Palo Alto?
In Palo Alto, a hotel must offer a certain number of high-end conveniences to be rated 5 stars. These can include on-site gyms, saunas and spas, gourmet restaurants, premium bedding, complimentary luxury toiletries and more. What also sets 5-star hotels apart is their outstanding service. You can expect things like in-room massages, concierge services and nightly turn-down services. Some may even offer special touches such as welcome gifts.