A vineyard with rows of grapevines.

Compare and book 5 Star hotels in Santa Cruz, O'Higgins Region

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Check availability on Santa Cruz 5 Star Hotels

Tonight
13 Sep - 14 Sep
Tomorrow
14 Sep - 15 Sep
Next weekend
18 Sep - 20 Sep
In two weeks
25 Sep - 27 Sep

Our top choices for Santa Cruz 5-star hotels

A modern bathroom with a large window, a curved bathtub, and a view of a valley.
A modern bedroom with a large bed, a sofa, a small table, and a desk. The room has large windows offering a view of mountains and trees.
A bedroom with a large bed, a desk, and a chair, with a view of mountains and a lake.
A wooden deck with a pool, lounge chairs, and umbrellas overlooking a lake with mountains in the background.

1. Vik Chile

Vik Chile
San Vicente
United Kingdom
Andre
17.218.656 ₫
17.218.656 ₫ total
20 Sept - 21 Sept
Vik Chile
A modern, well-lit building with a glass facade, a wooden deck with lounge chairs, and a hanging light fixture.
A modern bathroom with a wooden vanity, a large mirror, and a hanging light fixture.
A modern bedroom with a bed, bedside table, and a glass table with two wine glasses and a bottle.
A vineyard with rows of grapevines, a swimming pool, and several modern buildings.

2. Vibo Wine Lodge

Vibo Wine Lodge
Santa Cruz
Vibo Wine Lodge
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Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Santa Cruz.
Santa Cruz Plaza

Santa Cruz Plaza

Plaza De Armas 286 Santa Cruz O'Higgins
2.643.840 ₫
2.643.840 ₫ total
20 Sept - 21 Sept
Santa Cruz Plaza
Hotel Cava Colchagua

Hotel Cava Colchagua

Barreales´s Way Santa Cruz O'Higgins
3.294.869 ₫
3.294.869 ₫ total
14 Sept - 15 Sept
9/10 Wonderful! (177 reviews)
Hotel Cava Colchagua
Barrica Lodge

Barrica Lodge

Ruta I-706 Santa Cruz
Get ratesBarrica Lodge
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Santa Cruz

Nestled in the heart of wine country, Santa Cruz invites visitors to taste world-class Colchagua Valley wines at family-owned vineyards. Museum of Colchagua showcases impressive pre-Columbian artefacts while the Plaza de Armas offers local crafts and regional foods on weekends.

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A vineyard with rows of grapevines.

Top Santa Cruz Hotel Reviews