Compare and book 5 Star hotels in Santa Cruz, Santa Cruz

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Check availability on Santa Cruz 5 Star Hotels

Tonight
20 Dec - 21 Dec
Tomorrow
21 Dec - 22 Dec
Next weekend
26 Dec - 28 Dec
In two weeks
2 Jan - 4 Jan

Our top choices for Santa Cruz 5-star hotels

Outdoor pool, pool umbrellas, pool loungers
Marriott Santa Cruz de la Sierra Hotel

Marriott Santa Cruz de la Sierra Hotel

Marriott Santa Cruz de la Sierra Hotel
5.0 star property
Santa Cruz
9.0 out of 10, Wonderful, (211)
"Great hotel, food and location albeit a little expensive "
United States
Reinaldo
The price is 2.926.228 ₫
2.926.228 ₫ total
16 Jan - 17 Jan 2026
Marriott Santa Cruz de la Sierra Hotel
Lobby sitting area
Novotel Santa Cruz De La Sierra

Novotel Santa Cruz De La Sierra

Novotel Santa Cruz De La Sierra
5.0 star property
Santa Cruz
9.2 out of 10, Wonderful, (104)
"Luxurious hotel,very chic and beautiful."
United States
Cristhian
The price is 2.631.500 ₫
2.631.500 ₫ total
15 Jan - 16 Jan 2026
Novotel Santa Cruz De La Sierra
Outdoor pool
Radisson Hotel Santa Cruz

Radisson Hotel Santa Cruz

Radisson Hotel Santa Cruz
5.0 star property
Santa Cruz
8.8 out of 10, Excellent, (237)
"Great experience! Great place to stay! "
United States
Anonymous traveller
Radisson Hotel Santa Cruz
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Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Santa Cruz.
Camino Real Hotel

Camino Real Hotel

Av. San Martín y 4to. Anillo Santa Cruz
The price is 4.736.700 ₫ per night from 25 Dec to 26 Dec
4.736.700 ₫
4.736.700 ₫ total
25 Dec - 26 Dec
8.8/10 Excellent! (407 reviews)
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Santa Cruz

Tropical energy pulses through Plaza 24 de Septiembre, where locals gather under palm trees and the Metropolitan Cathedral's twin towers stand watch. Biocentro Güembé offers rainforest trails with butterfly gardens, while the massive Ventura Mall provides air-conditioned shopping when afternoon temperatures climb.

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San Lorenzo Cathedral showing a garden

Top Santa Cruz Hotel Reviews

Frequently asked questions

What are the best 5-star hotels in Santa Cruz?
Novotel Santa Cruz De La Sierra, Marriott Santa Cruz de la Sierra Hotel and Radisson Hotel Santa Cruz are some of the leading 5-star hotels in Santa Cruz, according to reviews by our customers. These upscale hotels rate highly for things like their amenities, location and guest service standards. Choose your favourite and enjoy the best of it all.
How much does it cost to stay in a 5-star hotel in Santa Cruz?
The amount you pay for a 5-star hotel in Santa Cruz can vary based on the time of year you travel and how long you plan to stay, among several factors. Take advantage of our price per night filter and other search tools to land the best rate on a high-end getaway.

  • Search for the lowest price per night from 1.936.784 ₫

What makes a hotel 5 stars in Santa Cruz?
Outstanding guest service is the defining feature of every 5-star hotel in Santa Cruz. From the minute you arrive, staff cater to your every whim, whether recommending activities and tours or providing a turn-down service. Also, hotels must offer upscale amenities to qualify for a 5-star rating. These can include luxury bathrobes, on-site spa facilities, pools, gastronomic kitchens and knowledgeable concierge.