Search Hotels Near Big Bend Regional Medical Center, Alpine

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
23 Dec - 24 Dec
Tomorrow
24 Dec - 25 Dec
This weekend
26 Dec - 28 Dec
Next weekend
2 Jan - 4 Jan

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Big Bend Regional Medical Center hotels

Interior detail
Alpine Bed and Breakfast

Alpine Bed and Breakfast

Alpine Bed and Breakfast
4.0 star property
0.3 km from Big Bend Regional Medical Center
10.0 out of 10, Exceptional, (90)
"Awesome place to stay! "
United States
Isabel
The price is 5.020.902 ₫
5.673.777 ₫ total
includes taxes & fees
5 Jan - 6 Jan 2026
Alpine Bed and Breakfast
House | 1 bedroom, iron/ironing board, Internet
New The Buffalo -shipping Container in Alpine

New The Buffalo -shipping Container in Alpine

New The Buffalo -shipping Container in Alpine
3.0 star property
2 km from Big Bend Regional Medical Center
10.0 out of 10, Exceptional, (9)
"Cozy and nice little stay. Great view of night sky for star gazing. Close to Big Bend for hiking. Definitely recommend. "
United States
Luke
The price is 2.915.739 ₫
5.222.992 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
New The Buffalo -shipping Container in Alpine
Lobby sitting area
The Holland Hotel

The Holland Hotel

The Holland Hotel
3.0 star property
< 0.1 km from Big Bend Regional Medical Center
8.6 out of 10, Excellent, (550)
"Everything --- absolutely excellent. "
United States
Tarai
The price is 2.920.965 ₫
3.498.053 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
The Holland Hotel
Restaurant
Hampton Inn Alpine

Hampton Inn Alpine

Hampton Inn Alpine
2.5 star property
2.4 km from Big Bend Regional Medical Center
9.2 out of 10, Wonderful, (1002)
"Very friendly staff, comfortable bed "
United States
Omar
The price is 3.223.686 ₫
3.642.766 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Hampton Inn Alpine
Lunch and dinner served, American cuisine
Alpine City Place

Alpine City Place

Alpine City Place
3.0 star property
0.1 km from Big Bend Regional Medical Center
8.0 out of 10, Very good, (80)
"All was good. Except that there is no office, this is kind of "Air B& B, but the place is awesome"
United States
JUAN
Alpine City Place
Courtyard
The Maverick Inn

The Maverick Inn

The Maverick Inn
3.0 star property
1.3 km from Big Bend Regional Medical Center
8.2 out of 10, Very good, (450)
"Looks a little dated, but the rooms are comfortable and well furnished "
United States
steve
The price is 2.343.637 ₫
2.845.808 ₫ total
includes taxes & fees
7 Jan - 8 Jan 2026
The Maverick Inn
Deluxe Single Room, 1 Queen Bed, Courtyard View, Courtyard Area | Terrace/patio
Antelope Lodge

Antelope Lodge

Antelope Lodge
3.5 star property
2.4 km from Big Bend Regional Medical Center
8.6 out of 10, Excellent, (586)
"Staff was very friendly!"
United States
Diane
The price is 2.995.963 ₫
3.385.425 ₫ total
includes taxes & fees
25 Dec - 26 Dec
Antelope Lodge
Pillow-top beds, desk, laptop workspace, blackout curtains
Quality Inn Alpine

Quality Inn Alpine

Quality Inn Alpine
2.5 star property
2.5 km from Big Bend Regional Medical Center
8.4 out of 10, Very good, (850)
"We enjoyed our stay very much and would definitely stay again"
United States
kerry
The price is 3.055.172 ₫
3.452.345 ₫ total
includes taxes & fees
9 Jan - 10 Jan 2026
Quality Inn Alpine
Restaurant
Value Lodge

Value Lodge

Value Lodge
2.0 star property
2.3 km from Big Bend Regional Medical Center
7.4 out of 10, Good, (355)
"Friendly staff, great price, clean room, good location for the area. My 3 day stay was peaceful and enjoyable. "
United States
Clint
The price is 2.324.667 ₫
2.696.498 ₫ total
includes taxes & fees
3 Jan - 4 Jan 2026
Value Lodge
Lobby
Americas Best Value Inn Alpine

Americas Best Value Inn Alpine

Americas Best Value Inn Alpine
2.5 star property
2.3 km from Big Bend Regional Medical Center
7.4 out of 10, Good, (570)
"Lighting is dim and the are no charging outlets for phones. Staff should have more knowledge of local restaurants."
United States
Nancy
The price is 2.894.650 ₫
3.270.955 ₫ total
includes taxes & fees
1 Jan - 2 Jan 2026
Americas Best Value Inn Alpine
Desk, iron/ironing board, free cots/infant beds, free WiFi
Travelodge by Wyndham Alpine

Travelodge by Wyndham Alpine

Travelodge by Wyndham Alpine
2.0 star property
3 km from Big Bend Regional Medical Center
6.6 out of 10, (604)
"Need lots of improvement "
United States
Ashish
The price is 2.999.910 ₫
3.389.898 ₫ total
includes taxes & fees
9 Jan - 10 Jan 2026
Travelodge by Wyndham Alpine
House | 1 bedroom, Internet, bed sheets
New The Cowboy Boots-shipping Container Home

New The Cowboy Boots-shipping Container Home

New The Cowboy Boots-shipping Container Home
2.0 star property
1.7 km from Big Bend Regional Medical Center
10.0 out of 10, Exceptional, (3)
"Good communication b4 and during stay. Very clean and on our way to natl park.."
United States
David
The price is 2.668.527 ₫
4.942.325 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
New The Cowboy Boots-shipping Container Home
Lobby
OYO Alpine TX near Big Bend National Park

OYO Alpine TX near Big Bend National Park

OYO Alpine TX near Big Bend National Park
2.5 star property
0.9 km from Big Bend Regional Medical Center
4.8 out of 10, (492)
"Good experience at this property, clean and comfortable rooms, well maintained properly."
United States
Mallory
The price is 1.313.227 ₫
1.668.196 ₫ total
includes taxes & fees
7 Jan - 8 Jan 2026
OYO Alpine TX near Big Bend National Park
House | 1 bedroom, bed sheets
New The Wild West Cozy Container Home

New The Wild West Cozy Container Home

New The Wild West Cozy Container Home
2.0 star property
1.9 km from Big Bend Regional Medical Center
10.0 out of 10, Exceptional, (3)
"5 Stars all the way. Highly recommend and would stay here again. The rooftop access was perfect for stargazing."
United States
Brenda
The price is 3.097.718 ₫
5.587.886 ₫ total
includes taxes & fees
13 Jan - 14 Jan 2026
New The Wild West Cozy Container Home
House | 1 bedroom, iron/ironing board, Internet
New Longhorn Stunning Container Home-in Alpine

New Longhorn Stunning Container Home-in Alpine

New Longhorn Stunning Container Home-in Alpine
3.0 star property
2 km from Big Bend Regional Medical Center
10.0 out of 10, Exceptional, (2)
The price is 3.376.217 ₫
6.289.658 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
New Longhorn Stunning Container Home-in Alpine
House | 1 bedroom, iron/ironing board, Internet
New Southwest Shipping Container-in Alpine

New Southwest Shipping Container-in Alpine

New Southwest Shipping Container-in Alpine
3.0 star property
2 km from Big Bend Regional Medical Center
9.0 out of 10, Wonderful, (2)
"Everything we needed was provided. Coffee, shampoo, soap and lotions. Enjoyed the rooftop deck at night for star gazing."
United States
Jay
The price is 3.376.217 ₫
6.289.658 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
New Southwest Shipping Container-in Alpine
House | 1 bedroom, iron/ironing board, Internet
New Moonlight Ridge-shipping Container Home

New Moonlight Ridge-shipping Container Home

New Moonlight Ridge-shipping Container Home
3.0 star property
1.8 km from Big Bend Regional Medical Center
10.0 out of 10, Exceptional, (1)
The price is 2.823.690 ₫
5.761.713 ₫ total
includes taxes & fees
13 Jan - 14 Jan 2026
New Moonlight Ridge-shipping Container Home
House | 2 bedrooms, Internet
Somewhere in Texas Container Home

Somewhere in Texas Container Home

Somewhere in Texas Container Home
2.0 star property
1.7 km from Big Bend Regional Medical Center
8.0 out of 10, Very good, (2)
"We really enjoyed our stay. We found the container home very comfortable, clean with everything we needed. We liked the observation deck only thing there is that the light from Alpine took away from our ability to view the stars.in every direction. Its still a good deal."
United States
Kimberly
The price is 3.499.026 ₫
7.006.895 ₫ total
includes taxes & fees
13 Jan - 14 Jan 2026
Somewhere in Texas Container Home
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Big Bend Regional Medical Center Hotel Reviews

Alpine City Place

Alpine City Place

10/10 Excellent
"Nice spot in town to stay at. Room was clean and comfortable. The noise from the band below didn't bother me and was over around 11pm. Would stay here again. "
Sheldon 3-night trip
Posted 3 weeks ago
Alpine City Place

Hotels near other Big Bend Regional Medical Center attractions

Kiowa Gallery

3.8/5 (19 reviews)
You can spend an afternoon exploring the galleries in Kiowa Gallery in Alpine. Wander around the parks or enjoy the area's restaurants.
See properties

Museum of the Big Bend

4.5/5 (95 reviews)
You can spend an afternoon browsing the exhibits at Museum of the Big Bend in Alpine. Wander around the parks or enjoy the area's restaurants.
See properties

Frequently asked questions

What's the area like around Big Bend Regional Medical Center?
Big Bend Regional Medical Center is located in Alpine. Travellers like the surrounding area for its parks. If you're looking for a convenient place to stay, take a look at the 50 hotels and other accommodation options you'll find within a mile.
How many hotels should I expect to find near Big Bend Regional Medical Center?
Expedia has 50 hotels and other accommodation options within a mile from Big Bend Regional Medical Center.
If I need to cancel the hotel reservation for my stay near Big Bend Regional Medical Center, will I receive a refund?
Yes! The majority of room reservations are fully refundable provided that you cancel before the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you booked a non-refundable reservation, it might still be possible to cancel it and be given a refund within 24 hours of your booking. Put your dates in and click on "Search", then use the filter option "fully refundable" to review the top deals on offer near Big Bend Regional Medical Center.
What can I see and do near Big Bend Regional Medical Center?
You might spend a leisurely day outdoors at Kokernot Municipal Park and Shipman Park. Attractions like Kiowa Gallery and Museum of the Big Bend highlight the local culture. You might plan a visit to Kokernot Field or Alpine Municipal Pool while you're in the area.