The Best Hotels Closest to Byron Town Square in Byron - 2026 Updated Prices

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Our top choices for Byron Town Square hotels

A modern hotel lobby with a reception desk, seating area, and a kitchenette.

A small, well-organized pantry with shelves stocked with snacks and beverages.

A hotel room with a large bed, a desk, a chair, and a kitchenette.

A modern hotel lobby with a reception desk, seating area, and a large window providing natural light.

1. Spark by Hilton Rochester South

15.8 km from Byron Town Square

Stanton

2.258.790 ₫

2.600.431 ₫ total

includes taxes & fees

1 Nov - 2 Nov

An outdoor seating area with wooden pillars, colorful striped cushions, and potted plants.

A modern hotel room with a bed, desk, and kitchenette.

A modern restaurant with a counter, seating area, and a TV screen.

An indoor swimming pool with wooden ceiling beams, yellow chairs, and tables along the sides.

2. Home2 Suites by Hilton Rochester Mayo Clinic Area

12.6 km from Byron Town Square

Vickie

3.175.092 ₫

3.655.324 ₫ total

includes taxes & fees

24 Oct - 25 Oct

A modern indoor patio with a fire feature, seating, and large windows.

A modern interior with a seating area, a bookshelf, and a window with a view of trees.

A reception area with a curved reception desk, wooden shelving, and a green moss wall with the text "I ♥ EVEN".

A modern hotel lobby with a large glass wall, a green wall mural, and a seating area with sofas and chairs.

3. EVEN Hotel Rochester - Mayo Clinic Area by IHG

11.9 km from Byron Town Square

Rici

3.170.414 ₫

4.001.218 ₫ total

includes taxes & fees

23 Oct - 24 Oct

A self-service breakfast station with a waffle maker, coffee machines, and a variety of condiments.

A compact laundry area with a washing machine, dryer, and a water fountain.

A hotel room with a large bed, a desk, a chair, a television, and a window with curtains.

A hotel lobby with leather sofas, a stone fireplace, and a patterned carpet.

4. Econo Lodge Mayo Clinic Area

13.8 km from Byron Town Square

Ashley

1.830.005 ₫

2.106.794 ₫ total

includes taxes & fees

1 Nov - 2 Nov

A reception area with a wooden reception desk, a "Welcome to the Bread & Butter State" sign, and a "Please Center" sign.

A coffee station with four coffee dispensers, a stack of disposable cups, and a tray with various coffee-related items.

A modern lounge area with seating arrangements, a reception desk, and a patterned wall.

A pool area with a table and chairs, a lifeguard chair, and a pool lift.

5. Hampton Inn Rochester-South

13.6 km from Byron Town Square

dennis

2.748.905 ₫

3.164.677 ₫ total

includes taxes & fees

11 Oct - 12 Oct

A hotel room with a large bed, a desk with a chair, a window with a view of the outdoors, and two bedside lamps.

A modern living room with a sofa, two armchairs, a coffee table, and a large window offering a view of the outdoors.

A laundry area with two Whirlpool washers and a dryer, a wooden shelf above, and a white ceiling.

A gym with treadmills, elliptical machines, and a stationary bike.

6. Comfort Inn & Suites Rochester South Mayo Clinic

17.4 km from Byron Town Square

Phil

2.167.316 ₫

2.495.122 ₫ total

includes taxes & fees

2 Nov - 3 Nov

An outdoor patio area with a concrete floor, wooden fence, and string lights.

A modern living room with a stone fireplace, a blue armchair, a round coffee table, and a large window offering a view of the outdoors.

A Fairfield Inn & Suites hotel with a modern design, featuring a prominent entrance and a parking area.

A breakfast bar with a wooden counter, a coffee machine, and a refrigerator.

7. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

11.2 km from Byron Town Square

Jon

2.900.149 ₫

3.338.796 ₫ total

includes taxes & fees

17 Oct - 18 Oct

A modern outdoor seating area with a built-in fireplace, two wooden chairs, a table, and a sofa.

A modern kitchen with a central island, bar stools, and pendant lighting. A living area with a sofa, ottoman, and a view of the outdoors is visible.

A gym with various exercise equipment, including treadmills, stationary bikes, and weight machines.

A modern urban street with tall buildings, a pedestrian walkway, and a parking area.

8. Staybridge Suites Rochester - Mayo Clinic Area by IHG

11.9 km from Byron Town Square

Sheri

2.780.609 ₫

3.253.149 ₫ total

includes taxes & fees

1 Nov - 2 Nov

A swimming pool with clear blue water, surrounded by lounge chairs and a view of residential buildings through large windows.

A modern reception area with a brick-patterned wall, two reception desks, a flat-screen TV, and seating arrangements including a sofa and chairs.

An outdoor patio area with wicker furniture, a central fire feature, and a stone building in the background.

A modern lounge area with seating, a fireplace, and a bar area.

9. Residence Inn by Marriott Rochester Mayo Clinic Area South

12.7 km from Byron Town Square

Chee

3.560.219 ₫

4.098.701 ₫ total

includes taxes & fees

17 Oct - 18 Oct

A modern hotel lobby with a reception desk, seating area, and a dining space.

A modern breakfast area with a counter displaying various food items, a water dispenser, and a sign indicating a bakery section.

A Holiday Inn Express building with a stone facade and illuminated signage.

A hotel room with a bed, desk, chair, and a bathroom.

10. Holiday Inn Express Rochester South - Mayo Area by IHG

15.8 km from Byron Town Square

Melissa

2.598.700 ₫

2.991.753 ₫ total

includes taxes & fees

18 Oct - 19 Oct

An outdoor seating area with a fire feature, blue cushioned chairs, and a modern building with large windows in the background.

A modern Hyatt House hotel with a prominent 'Hyatt House' sign, multiple floors, and a parking garage.

A modern bar area with seating and a counter.

A modern dining area with round tables and chairs, a large painting on the wall, and a flat-screen TV mounted above a geometric-patterned wall.

11. Hyatt House Rochester/Mayo Clinic Area

13 km from Byron Town Square

Kathy

3.066.466 ₫

3.530.268 ₫ total

includes taxes & fees

17 Oct - 18 Oct

An outdoor patio area with yellow umbrellas, wicker furniture, and a sign for Centerstone Plaza Hotel.

A garden with a water feature, rocks, and yellow umbrellas.

A restaurant interior with wooden tables, chairs, and a stone wall.

A modern reception area with a wooden reception desk, glass pendant lights, and a long hallway with seating.

12. Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

12.8 km from Byron Town Square

Van

2.802.866 ₫

3.226.801 ₫ total

includes taxes & fees

10 Oct - 11 Oct

A room with a fireplace, two leather armchairs, a sofa, and a large window providing a view of the outdoors.

A hotel room with a bed, a sink, a microwave, and a window with curtains.

A paved garden area with two benches, a potted plant with yellow flowers, and a variety of greenery.

A reception area with a curved counter, ceiling lights, and a potted plant.

13. Brentwood Inn & Suites

12.7 km from Byron Town Square

Daniel

2.436.281 ₫

2.804.777 ₫ total

includes taxes & fees

29 Oct - 30 Oct

A coffee shop interior with a wooden counter, menu boards, and seating area.

An outdoor seating area with tables and chairs, a neon sign, and flower arrangements.

A hotel room with a bed, bedside table, and a window with curtains.

14. TownePlace Suites by Marriott Rochester Mayo Clinic Area

12.5 km from Byron Town Square

Hafsa

3.560.219 ₫

4.098.701 ₫ total

includes taxes & fees

17 Oct - 18 Oct

A modern dining area with high tables, chairs, and pendant lighting.

A reception desk with a large digital screen displaying a cityscape and the word "happy."

A multi-story hotel with a modern design, featuring a prominent entrance with a covered area and a parking lot in front.

A hotel room with two beds, a desk with a computer, a chair, and a window with a view.

15. Hampton Inn & Suites Rochester-North

11.2 km from Byron Town Square

Dr. Tim

2.535.811 ₫

2.919.353 ₫ total

includes taxes & fees

24 Oct - 25 Oct

A spacious living area with a modern staircase, leather sofas, and contemporary lighting.

A rooftop pool area with lounge chairs and umbrellas, surrounded by a modern building with a brick facade.

A modern pool table in a spacious, well-lit room with large windows and a bar area.

An outdoor seating area with blue sofas and wicker chairs, a wooden table, and green ottomans on a tiled patio.

16. The Berkman

11.5 km from Byron Town Square

Suzette

4.312.023 ₫

5.013.932 ₫ total

includes taxes & fees

1 Nov - 2 Nov

A restaurant with wooden tables and bar stools, a bar area with a counter, and multiple televisions mounted on the walls.

A modern kitchen with wooden cabinets, a microwave, an oven, and a dishwasher.

A hotel room with two beds, a desk, a chair, and a mirror.

An indoor swimming pool with a slide, seating area, and a large frog statue.

17. AmericInn by Wyndham Rochester Near Mayo Clinic

13.5 km from Byron Town Square

Jeanne

1.896.531 ₫

2.183.381 ₫ total

includes taxes & fees

25 Oct - 26 Oct

A hotel breakfast area with a self-serve station, including a waffle maker, toaster, and various food items.

A modern living room with a sofa, coffee table, and a TV mounted on a stone wall.

A hotel lobby with a patterned carpet, two beige armchairs, a small table, a clock, a fire extinguisher, and a staircase.

A compact kitchen with a microwave, refrigerator, and coffee maker. A small bar stool is near the counter.

18. Quality Inn & Suites Mayo Clinic Area

13.7 km from Byron Town Square

Edward

1.965.917 ₫

2.291.327 ₫ total

includes taxes & fees

24 Oct - 25 Oct

A modern kitchen with a dark countertop, black cabinets, a microwave, and a refrigerator. There are two pendant lights above the counter.

A hotel room with a large round table, two sofas, a TV, and a bed.

A hotel lobby with a reception desk, seating area, and a large window.

A hotel gym with treadmills, elliptical machines, and free weights.

19. Candlewood Suites Rochester Mayo Clinic Area by IHG

13.6 km from Byron Town Square

Sean

3.014.492 ₫

3.470.432 ₫ total

includes taxes & fees

9 Oct - 10 Oct

A Comfort Inn hotel with a stone facade, a covered entrance, and a parking area.

A spacious living room with a stone fireplace, blue sofas, and a flat-screen TV.

A spacious lobby with a central seating area, a reception desk, and a fireplace.

A modern dining area with wooden tables and chairs, a kitchen with granite countertops, and a view of the outdoors through large windows.

20. Comfort Inn & Suites West - Medical Center

8.8 km from Byron Town Square

yuan

2.124.957 ₫

2.446.357 ₫ total

includes taxes & fees

10 Oct - 11 Oct

View all properties

Compare popular hotels close to Byron Town Square

Property	Property class	Guest rating
Spark by Hilton Rochester South	9.2 Wonderful 588 reviews	View
Home2 Suites by Hilton Rochester Mayo Clinic Area	9.6 Exceptional 1,000 reviews	View
EVEN Hotel Rochester - Mayo Clinic Area by IHG	9.4 Exceptional 1,002 reviews	View
Econo Lodge Mayo Clinic Area	9.0 Wonderful 1,000 reviews	View
Hampton Inn Rochester-South	9.0 Wonderful 1,001 reviews	View

Top Byron Town Square Hotel Reviews

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

10/10 Excellent

"Nice rooms, very comfortable beds. Pool area looked fun for kids. We didn't have time to use the pool. Good breakfast. Courteous staff. Free shuttle to the Clinics. They made our first visit to the Mayo Clinic far less stressful."

Quality Inn near Medical Center

10/10 Excellent

"I had a nice room, although it was rather hot. But it has everything I needed, including quiet and privacy which really matter to me. Breakfast is good, but I don't eat pork so I do wish there was an alternative meat there. But the eggs were good and there was coffee, yogurt, muffins etc we which is really nice They were very accommodating and helpful too Yes I highly recommend them."

Aspen Select

10/10 Excellent

"Its location from St Mary's hospital in Rochester was wonderful! The walk to hospital was literally across the street. Continental breakfast was served till 9:30 and was a large enough room. Staff was easy to work with and very helpful. Good experience."

Kahler Grand Hotel

10/10 Excellent

"This is a grand hotel - stately, convenient and a delightful place to stay. Loved the walkable "subway" connecting the hotel to restaurants and Mayo Clinic. Enjoyed the Architecture and history of the Plummer Bldg."

Kahler Inn and Suites - Mayo Clinic Area

8/10 Good

"Overall it was a good stay. Pros: this hotel has the underground tunnel connected to the hospital so it was easy walking over, expecially since there is massive construction going on right there. Hotel was clean, staff was wonderful, breakfast was a good variety and good. Rooms were quiet, never heard any of the construction! A detail I may have missed or it wasn’t added in the description was if you parked in there ramp it was 17 dollars a night. Cons: defiantly needs some updating, but biggest con was the room we had was definitely not handicap accessible at all for the bathroom. Being “connect” to the hospital and the amount of the elderly I would think it would have something there. Toilet was so low almost ment for a child, and extremely tiny room, no grab bars, and step in shower/tub. I would stay here again, most definitely but not if I had elderly with me again"

Brentwood Inn & Suites

10/10 Excellent

"Staff was very helpful and kind. Desk chair worn and could use a replacement-normally would not care but was working remote while there. Wi-Fi great"

Sleep Inn & Suites West-Near Medical Center

10/10 Excellent

"Nice breakfast and staff. Good pricing"

Comfort Inn & Suites West - Medical Center

8/10 Good

"Everything was very good!"

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

10/10 Excellent

"Had great help from staff."

Other attractions near Byron Town Square

High Point Shopping Center

You can do some window-shopping at High Point Shopping Center during your trip to Byron. Amble around the area's parks or experience its art scene.

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Valley View Park

Valley View Park is just one of the places to see in Byron, so why not enjoy the other things to explore during your travels? Amble around the area's parks or experience its art scene.

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Somerby Park

Somerby Park is just one of the places to see in Byron, so why not enjoy the other things to explore during your travels? Amble around the area's parks or experience its art scene.

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Community Center Park

Community Center Park is just one of the places to see in Byron, so why not enjoy the other things to explore during your travels? Amble around the area's parks or experience its art scene.

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East Brookfield Park

After visiting East Brookfield Park, make a plan to see the other sights and activities in Byron. Amble around the area's parks or experience its art scene.

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Links of Byron Mini Golf

Enjoy a round of golf in Byron at Links of Byron Mini Golf. Amble around the area's parks or experience its art scene.

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Brook Lawn Park

After visiting Brook Lawn Park, make a plan to see the other sights and activities in Byron. Amble around the area's parks or experience its art scene.

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Somerby Golf Club

Enjoy a round of golf in Byron at Somerby Golf Club. Amble around the area's parks or experience its art scene.

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Frequently asked questions

What's the area like around Byron Town Square?

Byron Town Square is located in Byron. You'll find 9 hotels and other accommodations within a few miles for a convenient home base.

How many hotels should I expect to find near Byron Town Square?

Expedia has 9 hotels and other accommodation options a few miles from Byron Town Square.

If I need to cancel the hotel reservation for my stay near Byron Town Square, will I receive a refund?

Yes! Most hotel bookings are refundable if you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your scheduled arrival. If you have a reservation that's non-refundable, you may still be able to cancel and receive a refund within 24 hours of booking. Add dates, click "Search", then use the "fully refundable" filter to get the best deals available near Byron Town Square.

What can I see and do near Byron Town Square?

Explore nature at Oxbow Park and Douglas Trail. A trip to High Point Shopping Center and Cheery Meadows Center might be just the ticket for souvenir shopping. If you're looking for something to do, plan a visit to Links of Byron Mini Golf, Somerby Golf Club and Putting Green while you're in the area.

Search Hotels Near Byron Town Square, Byron

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Treat yourself

Be picky

Check prices for these dates

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Our top choices for Byron Town Square hotels

1. Spark by Hilton Rochester South

2. Home2 Suites by Hilton Rochester Mayo Clinic Area

3. EVEN Hotel Rochester - Mayo Clinic Area by IHG

4. Econo Lodge Mayo Clinic Area

5. Hampton Inn Rochester-South

6. Comfort Inn & Suites Rochester South Mayo Clinic

7. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

8. Staybridge Suites Rochester - Mayo Clinic Area by IHG

9. Residence Inn by Marriott Rochester Mayo Clinic Area South

10. Holiday Inn Express Rochester South - Mayo Area by IHG

11. Hyatt House Rochester/Mayo Clinic Area

12. Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

13. Brentwood Inn & Suites

14. TownePlace Suites by Marriott Rochester Mayo Clinic Area

15. Hampton Inn & Suites Rochester-North

16. The Berkman

17. AmericInn by Wyndham Rochester Near Mayo Clinic

18. Quality Inn & Suites Mayo Clinic Area

19. Candlewood Suites Rochester Mayo Clinic Area by IHG

20. Comfort Inn & Suites West - Medical Center

Compare popular hotels close to Byron Town Square

Top Byron Town Square Hotel Reviews

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Quality Inn near Medical Center

Aspen Select

Kahler Grand Hotel

Kahler Inn and Suites - Mayo Clinic Area

Brentwood Inn & Suites

Sleep Inn & Suites West-Near Medical Center

Comfort Inn & Suites West - Medical Center

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

Other attractions near Byron Town Square

High Point Shopping Center

Valley View Park

Somerby Park

Community Center Park

East Brookfield Park

Links of Byron Mini Golf

Brook Lawn Park

Somerby Golf Club

Frequently asked questions