Search Hotels in Clayton, St. Louis
Change your mind
Be picky
Go beyond your typical stay in Clayton
Check prices for these dates
Top Trending Hotels Near Clayton, St. Louis

Hyatt Regency St. Louis at The Arch
Hyatt Regency St. Louis at The Arch

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

21C Museum Hotel St Louis
21C Museum Hotel St Louis

Clayton Plaza Hotel & Extended Stay
Clayton Plaza Hotel & Extended Stay

Residence Inn By Marriott St. Louis Clayton
Residence Inn By Marriott St. Louis Clayton

Seven Gables, St. Louis West, a Tribute Portfolio Hotel
Seven Gables, St. Louis West, a Tribute Portfolio Hotel
Where to stay in Clayton

Downtown St. Louis
Gourmet restaurants beloved sports teams and top sights from Gateway Arch to Busch Stadium – discover Downtown St. Louis, a destination also famous for its historic sites.

Central West End
The abundant dining options and forests are just a few top-rate features of the neighbourhood. Make a stop by Cathedral Basilica of St. Louis or World Chess Hall of Fame while you're visiting, and jump aboard the metro at Central West End Station to get around town.
Creve Coeur
Travellers come to Creve Coeur for its abundant dining options, and you can see top attractions like Creve Coeur Golf Club and Saint Louis Abbey while you're in town.

Downtown West
While visiting Downtown West, you might make a stop by sights like St. Louis Union Station and St. Louis Aquarium at Union Station.
St. Charles Historic District
St. Charles Historic District is known for its ample dining options, and you can make a stop by Historic Main Street and Lewis & Clark Boathouse and Nature Center while in the area.
Top Clayton Hotel Reviews
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Hotels in top St. Louis neighborhoods
- Hotels in Downtown St. Louis
- Hotels in Clayton
- Hotels in Central West End
- Hotels in Creve Coeur
- Hotels in Downtown West
- Hotels in St. Charles Historic District
- Hotels in Soulard
- Hotels in The Hill
- Hotels in Ladue
- Hotels in Midtown
- Hotels in University City
- Hotels in Tower Grove South
- Hotels in Dogtown
- Hotels in The Grove
- Hotels in Shaw
- Hotels in Lafayette Square
- Hotels in The Gate
- Hotels in Benton Park
- Hotels in Southwest Garden
- Hotels in LaSalle Park
Hotels near popular St. Louis Attractions
- Hotels near Busch Stadium
- Hotels near St. Louis Union Station
- Hotels near Gateway Arch
- Hotels near Washington University in St. Louis
- Hotels near St. Louis Zoo
- Hotels near Enterprise Center
- Hotels near Dome at America’s Center
- Hotels near City Museum
- Hotels near St. Louis University
- Hotels near Mississippi River
Choose Your Clayton Hotel Style
- Boutique Hotels in Clayton
- Business Hotels in Clayton
- Family-Friendly Hotels in Clayton
- Golf Hotels in Clayton
- Historic Hotels in Clayton
- Hotels near Museums in Clayton
- Hotels with Airport Transfers in Clayton
- Hotels with Babysitting Services in Clayton
- Hotels with Breakfast in Clayton
- Hotels with Connecting Rooms in Clayton
- Hotels with Entertainment in Clayton
- Hotels with Gym in Clayton
- Hotels with Hot Tubs in Clayton
- Hotels with Indoor Pools in Clayton
- Hotels with Laundry Service in Clayton
- Hotels with Parking in Clayton
- Hotels with Restaurant in Clayton
- Hotels with Room Service in Clayton
- Hotels with a Bar in Clayton
- Hotels with a View in Clayton
- Luxury Hotels in Clayton
- Pet-Friendly Hotels in Clayton
- Romantic Hotels in Clayton
- Shopping Hotels in Clayton
- Spa Hotels in Clayton
- Sports Hotels in Clayton
- Wedding Hotels in Clayton