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Our top choices for Duke Regional Hospital hotels

Lobby
Hampton Inn & Suites Durham/North I-85

Hampton Inn & Suites Durham/North I-85

Hampton Inn & Suites Durham/North I-85
2.5 star property
2.2 km from Duke Regional Hospital
9.0 out of 10, Wonderful, (1004)
"Nice place to stay and close to everything. "
United States
Christy
The price is 2.715.398 ₫
3.081.924 ₫ total
includes taxes & fees
8 Jan - 9 Jan 2026
Hampton Inn & Suites Durham/North I-85
Free buffet breakfast
Holiday Inn Express Durham by IHG

Holiday Inn Express Durham by IHG

Holiday Inn Express Durham by IHG
2.5 star property
2.4 km from Duke Regional Hospital
8.8 out of 10, Excellent, (952)
"Room was great"
United States
Barbara
The price is 2.420.704 ₫
2.747.499 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Holiday Inn Express Durham by IHG
Lobby
Red Roof Inn Durham - Duke Univ Medical Center

Red Roof Inn Durham - Duke Univ Medical Center

Red Roof Inn Durham - Duke Univ Medical Center
2.0 star property
2.3 km from Duke Regional Hospital
6.8 out of 10, (1002)
"Good motel...clean, easy acess "
United States
Howard
The price is 1.527.175 ₫
1.778.139 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Red Roof Inn Durham - Duke Univ Medical Center
Miscellaneous
Super 8 by Wyndham Durham/University Area NC

Super 8 by Wyndham Durham/University Area NC

Super 8 by Wyndham Durham/University Area NC
2.0 star property
2.4 km from Duke Regional Hospital
5.0 out of 10, (344)
"The environment was not pleasant "
United States
Denise
The price is 1.677.390 ₫
1.903.838 ₫ total
includes taxes & fees
26 Dec - 27 Dec
Super 8 by Wyndham Durham/University Area NC
Premium bedding, desk, blackout curtains, iron/ironing board
Comfort Inn & Suites Durham near Duke University

Comfort Inn & Suites Durham near Duke University

Comfort Inn & Suites Durham near Duke University
2.5 star property
Croasdaile Farm Master, 3.3 km from Duke Regional Hospital
8.6 out of 10, Excellent, (1004)
"Loved our stay"
United States
Brian
The price is 2.487.010 ₫
2.822.757 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Comfort Inn & Suites Durham near Duke University
Meeting facility
Hilton Garden Inn Durham/University Medical Center

Hilton Garden Inn Durham/University Medical Center

Hilton Garden Inn Durham/University Medical Center
3.0 star property
9th Street District, 4.1 km from Duke Regional Hospital
9.2 out of 10, Wonderful, (1002)
"Clean rooms, nice staff. Clean hotel. Ample parking. "
United States
Emana
The price is 2.532.530 ₫
2.874.421 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Hilton Garden Inn Durham/University Medical Center
Courtyard
Residence Inn Durham McPherson/Duke University Medical Cntr

Residence Inn Durham McPherson/Duke University Medical Cntr

Residence Inn Durham McPherson/Duke University Medical Cntr
3.0 star property
Trinity Park, 4.1 km from Duke Regional Hospital
9.2 out of 10, Wonderful, (459)
"Hotel was great - very friendly staff."
United States
Lisa
The price is 3.681.575 ₫
4.178.587 ₫ total
includes taxes & fees
19 Dec - 20 Dec
Residence Inn Durham McPherson/Duke University Medical Cntr
Reception
Hampton Inn & Suites Durham University Medical Center

Hampton Inn & Suites Durham University Medical Center

Hampton Inn & Suites Durham University Medical Center
2.5 star property
5 km from Duke Regional Hospital
9.6 out of 10, Exceptional, (391)
"Great breakfast, clean rooms and beds "
United States
Fabiola B
The price is 2.862.746 ₫
3.249.217 ₫ total
includes taxes & fees
11 Jan - 12 Jan 2026
Hampton Inn & Suites Durham University Medical Center
BBQ/picnic Area
Courtyard Durham Near Duke University/Downtown

Courtyard Durham Near Duke University/Downtown

Courtyard Durham Near Duke University/Downtown
3.0 star property
Croasdaile Farm Master, 3.4 km from Duke Regional Hospital
8.2 out of 10, Very good, (1002)
"Great place "
United States
Silvia
The price is 2.773.285 ₫
3.147.679 ₫ total
includes taxes & fees
20 Dec - 21 Dec
Courtyard Durham Near Duke University/Downtown
Premium bedding, desk, blackout curtains, iron/ironing board
The Durham Hotel

The Durham Hotel

The Durham Hotel
4.0 star property
Downtown Durham, 4.5 km from Duke Regional Hospital
9.0 out of 10, Wonderful, (638)
"Perfect place to stay for an easy walk to see a show at the charming Carolina Theater. Food, service and atmosphere were outstanding. "
United States
Jo
The price is 4.894.295 ₫
5.555.025 ₫ total
includes taxes & fees
20 Dec - 21 Dec
The Durham Hotel
Front of property – evening/night
University Inn Durham next to Duke University Medical Center

University Inn Durham next to Duke University Medical Center

University Inn Durham next to Duke University Medical Center
2.0 star property
4.5 km from Duke Regional Hospital
8.8 out of 10, Excellent, (1003)
"Great place"
United States
Chase
The price is 2.818.015 ₫
3.198.750 ₫ total
includes taxes & fees
24 Dec - 25 Dec
University Inn Durham next to Duke University Medical Center
Daily cooked-to-order breakfast (USD 19.95 per person)
Durham Marriott City Center

Durham Marriott City Center

Durham Marriott City Center
3.5 star property
Downtown Durham, 4.5 km from Duke Regional Hospital
8.8 out of 10, Excellent, (823)
"The room was clean. The staff was very helpful and the food was good. "
United States
Tia
The price is 3.525.808 ₫
4.001.793 ₫ total
includes taxes & fees
23 Dec - 24 Dec
Durham Marriott City Center
Property amenity
Aloft Durham Downtown

Aloft Durham Downtown

Aloft Durham Downtown
3.0 star property
American Tobacco District, 4.9 km from Duke Regional Hospital
9.0 out of 10, Wonderful, (731)
"Very friendly staff, very clean and convenient location"
United States
Robert
The price is 4.446.728 ₫
5.047.035 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Aloft Durham Downtown
BBQ/picnic Area
AC Hotel Durham

AC Hotel Durham

AC Hotel Durham
3.0 star property
5.4 km from Duke Regional Hospital
9.2 out of 10, Wonderful, (614)
"Room was very clean, staff very helpful and nice. "
United States
Tia
The price is 3.108.763 ₫
3.528.444 ₫ total
includes taxes & fees
19 Dec - 20 Dec
AC Hotel Durham
Terrace/patio
SpringHill Suites by Marriott Durham City View

SpringHill Suites by Marriott Durham City View

SpringHill Suites by Marriott Durham City View
3.5 star property
5.4 km from Duke Regional Hospital
9.2 out of 10, Wonderful, (453)
"Great room, showers amazing, great staff. "
United States
Micah
The price is 2.710.136 ₫
3.076.005 ₫ total
includes taxes & fees
28 Dec - 29 Dec
SpringHill Suites by Marriott Durham City View
Front of property
The Lodge at Duke Medical Center

The Lodge at Duke Medical Center

The Lodge at Duke Medical Center
3.0 star property
4.6 km from Duke Regional Hospital
8.4 out of 10, Very good, (1005)
"Older property but very convenient and clean for our quick trip. "
United States
Stacie
The price is 3.394.248 ₫
3.852.472 ₫ total
includes taxes & fees
18 Dec - 19 Dec
The Lodge at Duke Medical Center
Interior entrance
21c Museum Hotel Durham

21c Museum Hotel Durham

21c Museum Hotel Durham
4.0 star property
Downtown Durham, 4.6 km from Duke Regional Hospital
8.4 out of 10, Very good, (1002)
"Overall good hotel and friendly staff. Building and rooms show some age but that is part of the charm. Enjoyable stay. "
United States
Lisa H
The price is 4.238.863 ₫
4.942.669 ₫ total
includes taxes & fees
23 Dec - 24 Dec
21c Museum Hotel Durham
Exterior
Unscripted Durham, Part of JDV by Hyatt

Unscripted Durham, Part of JDV by Hyatt

Unscripted Durham, Part of JDV by Hyatt
3.5 star property
Downtown Durham, 4.5 km from Duke Regional Hospital
8.2 out of 10, Very good, (1003)
"Staff was nice, room was large and very clean, location was excellent"
United States
Janice
The price is 3.341.624 ₫
4.240.311 ₫ total
includes taxes & fees
23 Dec - 24 Dec
Unscripted Durham, Part of JDV by Hyatt
Terrace/patio
JB Duke Hotel

JB Duke Hotel

JB Duke Hotel
4.0 star property
6.2 km from Duke Regional Hospital
9.4 out of 10, Exceptional, (539)
"Excellent on all levels! Will definitely stay here again!"
United States
Cherie Nan
The price is 3.916.764 ₫
4.445.527 ₫ total
includes taxes & fees
20 Dec - 21 Dec
JB Duke Hotel
Indoor pool
Washington Duke Inn & Golf Club

Washington Duke Inn & Golf Club

Washington Duke Inn & Golf Club
4.0 star property
6.6 km from Duke Regional Hospital
9.4 out of 10, Exceptional, (1002)
"Everything fabulous!"
United States
Terri
The price is 4.209.920 ₫
4.778.258 ₫ total
includes taxes & fees
18 Dec - 19 Dec
Washington Duke Inn & Golf Club
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Duke Regional Hospital Hotel Reviews

Hotels near other Duke Regional Hospital attractions

Sennett's hole is a swimming hole accessed from the west point outpost on the eno river. There are lots of rocks to lounge on on one side, and a rope swing on the other. It's great spot to hang out!
Photo by Nikki Benson
Open Photo by Nikki Benson

West Point on the Eno

Explore the great outdoors at West Point on the Eno, a lovely green space in Durham. Attend a sporting event or visit the stunning cathedral in this family-friendly area.
See properties
Brightleaf is part of downtown Durham, NC's renaissance. Old tobacco warehouses have found new life as shops and restaurants.
Photo by Jeff Bechtel
Open Photo by Jeff Bechtel

Brightleaf Square

You can do some window-shopping at Brightleaf Square during your visit to Durham. Discover the lively festivals and stunning cathedral in this family-friendly area.
See properties

Frequently asked questions

What's the area like around Duke Regional Hospital?
Duke Regional Hospital is located in an area of Durham known for its stunning cathedral. If you're looking for a convenient place to stay, take a look at the 10 hotels and other accommodation options you'll find within a mile.
How many hotels can I expect to find near Duke Regional Hospital?
Expedia has 10 hotels and other accommodation options within a mile from Duke Regional Hospital.
If I need to cancel the hotel reservation for my stay near Duke Regional Hospital, will I receive a refund?
Yes, you'll find most hotel reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of your arrival date. If your reservation is non-refundable, you may still be able to cancel and get a refund within a 24-hour period of booking. Add your dates and click on "Search", then use the filter option "fully refundable" to view the best deals near Duke Regional Hospital.
What can I see and do near Duke Regional Hospital?
You might want to spend some time browsing the exhibits at Museum of Life and Science, Nasher Museum of Art at Duke University or Bennett Place. While you're exploring, swing by American Tobacco Campus, Cameron Indoor Stadium and Wallace Wade Stadium to learn a bit about the area. You can watch performances at Carolina Theatre, Durham Performing Arts Center and Manbites Dog Theater if you're interested in local theatre.

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