Search Hotels in Isle of Palms South, Jacksonville

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Our top choices for Isle of Palms South hotels

Lobby lounge
Wyndham Garden Jacksonville

Wyndham Garden Jacksonville

Wyndham Garden Jacksonville
3.0 star property
15.3 km from Isle of Palms South
7.8 out of 10, Good, (1771)
"Quick check in, clean room, accessible to all the highways ! "
United States
Megan Rose
The price is 1.837.083 ₫
2.085.089 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Wyndham Garden Jacksonville
Property amenity
Days Inn by Wyndham Orange Park/Jacksonville

Days Inn by Wyndham Orange Park/Jacksonville

Days Inn by Wyndham Orange Park/Jacksonville
2.0 star property
27.6 km from Isle of Palms South
7.6 out of 10, Good, (1001)
"Friendly and courteous staff, clean room, very good dining options around."
United States
Ben Jasad
The price is 1.748.595 ₫
1.967.169 ₫ total
includes taxes & fees
10 Jan - 11 Jan 2026
Days Inn by Wyndham Orange Park/Jacksonville
Standard Double Room, 2 Double Beds, Smoking | Premium bedding, down duvets, in-room safe, blackout curtains
San Marco Inn East

San Marco Inn East

San Marco Inn East
3.0 star property
19.5 km from Isle of Palms South
8.4 out of 10, Very good, (1256)
"Nice clean rooms, safe environment and very friendly staff."
United States
Parry J
San Marco Inn East
Property amenity
WaterWalk Extended Stay by Wyndham Jacksonville Deerwood Pk

WaterWalk Extended Stay by Wyndham Jacksonville Deerwood Pk

WaterWalk Extended Stay by Wyndham Jacksonville Deerwood Pk
2.0 star property
12.3 km from Isle of Palms South
8.8 out of 10, Excellent, (743)
"Staff were great an accommodating. Room was nice and clean. Already booked another stay in January."
United States
Derek
The price is 3.136.483 ₫
3.559.909 ₫ total
includes taxes & fees
21 Dec - 22 Dec
WaterWalk Extended Stay by Wyndham Jacksonville Deerwood Pk
View from property
DoubleTree by Hilton Hotel Jacksonville Riverfront

DoubleTree by Hilton Hotel Jacksonville Riverfront

DoubleTree by Hilton Hotel Jacksonville Riverfront
4.0 star property
22.2 km from Isle of Palms South
6.8 out of 10, (1472)
"Loved the hotel "
United States
lucy
The price is 2.399.014 ₫
2.722.881 ₫ total
includes taxes & fees
21 Dec - 22 Dec
DoubleTree by Hilton Hotel Jacksonville Riverfront
Free daily buffet breakfast
La Quinta Inn & Suites by Wyndham Jacksonville Mandarin

La Quinta Inn & Suites by Wyndham Jacksonville Mandarin

La Quinta Inn & Suites by Wyndham Jacksonville Mandarin
3.0 star property
21.1 km from Isle of Palms South
7.4 out of 10, Good, (355)
"Clean room, nice staff "
United States
Dalsi
The price is 1.926.697 ₫
2.186.801 ₫ total
includes taxes & fees
14 Dec - 15 Dec
La Quinta Inn & Suites by Wyndham Jacksonville Mandarin
Lobby
Hilton Jacksonville At Mayo Clinic

Hilton Jacksonville At Mayo Clinic

Hilton Jacksonville At Mayo Clinic
4.5 star property
1.9 km from Isle of Palms South
9.2 out of 10, Wonderful, (53)
"Beautiful hotel. Close to Mayo Clinic."
United States
Patty
The price is 3.220.298 ₫
3.655.039 ₫ total
includes taxes & fees
20 Dec - 21 Dec
Hilton Jacksonville At Mayo Clinic
Exterior
WoodSpring Suites Jacksonville - South

WoodSpring Suites Jacksonville - South

WoodSpring Suites Jacksonville - South
2.5 star property
15.9 km from Isle of Palms South
7.6 out of 10, Good, (647)
"I love the hotel and enjoyed my stay."
United States
Marcus
The price is 1.686.848 ₫
1.914.572 ₫ total
includes taxes & fees
14 Dec - 15 Dec
WoodSpring Suites Jacksonville - South
Daily buffet breakfast (USD 26.95 per person)
Hyatt Regency Jacksonville

Hyatt Regency Jacksonville

Hyatt Regency Jacksonville
4.0 star property
22.1 km from Isle of Palms South
9.0 out of 10, Wonderful, (1381)
"Nice stay"
United States
April
The price is 3.795.408 ₫
4.350.867 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Hyatt Regency Jacksonville
Lobby sitting area
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
2.5 star property
3.8 km from Isle of Palms South
8.6 out of 10, Excellent, (1004)
"Good location for a family vacation "
United States
Angel
The price is 2.767.485 ₫
3.141.095 ₫ total
includes taxes & fees
19 Dec - 20 Dec
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
BBQ/picnic Area
Residence Inn by Marriott Jacksonville Butler Boulevard

Residence Inn by Marriott Jacksonville Butler Boulevard

Residence Inn by Marriott Jacksonville Butler Boulevard
3.0 star property
10.8 km from Isle of Palms South
8.8 out of 10, Excellent, (1004)
"The two bedroom/two bath suite with kitchen was absolutely perfect and the staff was friendly and helpful."
United States
Shauna
The price is 2.503.915 ₫
2.841.944 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Residence Inn by Marriott Jacksonville Butler Boulevard
Exterior
Hotel Indigo Jacksonville-Deerwood Park by IHG

Hotel Indigo Jacksonville-Deerwood Park by IHG

Hotel Indigo Jacksonville-Deerwood Park by IHG
3.5 star property
11.6 km from Isle of Palms South
9.2 out of 10, Wonderful, (1002)
"Very nice stay "
United States
Timmothy
The price is 3.004.698 ₫
3.410.333 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Hotel Indigo Jacksonville-Deerwood Park by IHG
Free daily buffet breakfast
Comfort Suites Baymeadows Near Butler Blvd

Comfort Suites Baymeadows Near Butler Blvd

Comfort Suites Baymeadows Near Butler Blvd
3.0 star property
14.3 km from Isle of Palms South
8.2 out of 10, Very good, (1001)
"Enjoyed our stay! Staff was awesome....very clean and quiet stay."
United States
Rita
The price is 2.557.420 ₫
2.902.672 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Comfort Suites Baymeadows Near Butler Blvd
Lobby
Southbank Hotel by Marriott Jacksonville Riverwalk

Southbank Hotel by Marriott Jacksonville Riverwalk

Southbank Hotel by Marriott Jacksonville Riverwalk
3.5 star property
21.9 km from Isle of Palms South
8.2 out of 10, Very good, (1606)
"We liked our stay"
United States
Lorie
The price is 2.585.622 ₫
2.934.681 ₫ total
includes taxes & fees
2 Jan - 3 Jan 2026
Southbank Hotel by Marriott Jacksonville Riverwalk
Property amenity
Sheraton Jacksonville Hotel

Sheraton Jacksonville Hotel

Sheraton Jacksonville Hotel
4.0 star property
10.5 km from Isle of Palms South
9.2 out of 10, Wonderful, (1001)
"Good hotel!"
United States
Charlie
The price is 2.352.362 ₫
2.669.932 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Sheraton Jacksonville Hotel
Studio, 2 Queen Beds, Accessible, Non Smoking | Living area | 43-inch LCD TV with satellite channels, TV
Hampton Inn & Suites Jacksonville Deerwood Park

Hampton Inn & Suites Jacksonville Deerwood Park

Hampton Inn & Suites Jacksonville Deerwood Park
2.5 star property
11.9 km from Isle of Palms South
9.4 out of 10, Exceptional, (1002)
"Great stay"
United States
Mary Jean
The price is 2.382.673 ₫
2.704.334 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Hampton Inn & Suites Jacksonville Deerwood Park
On the beach, white sand, surfing, kayaking
Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach
2.5 star property
4.8 km from Isle of Palms South
9.0 out of 10, Wonderful, (3426)
"Excellent location & property "
United States
Doris
The price is 3.771.687 ₫
4.280.865 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Margaritaville Jacksonville Beach
Desk, laptop workspace, blackout curtains, iron/ironing board
Candlewood Suites Jacksonville Southpoint by IHG

Candlewood Suites Jacksonville Southpoint by IHG

Candlewood Suites Jacksonville Southpoint by IHG
2.5 star property
16.2 km from Isle of Palms South
9.0 out of 10, Wonderful, (288)
"Had a good stay ! "
United States
Martiyanna
The price is 2.441.976 ₫
2.771.643 ₫ total
includes taxes & fees
12 Dec - 13 Dec
Candlewood Suites Jacksonville Southpoint by IHG
Indoor pool, 2 outdoor pools, open 8:00 AM to 10:00 PM, pool umbrellas
The Villas of Amelia Island

The Villas of Amelia Island

The Villas of Amelia Island
4.0 star property
29.5 km from Isle of Palms South
8.4 out of 10, Very good, (1127)
"We have stayed at this property every year for the past decade. We have always enjoyed our time out here with family. Highly recommend catching morning sunrise from the beach. The vibe is very pleasant and accommodating, you will not be disapppointed. "
United States
Harsha
The price is 4.196.246 ₫
5.880.590 ₫ total
includes taxes & fees
12 Dec - 13 Dec
The Villas of Amelia Island
Meeting facility
Delta Hotels by Marriott™ Jacksonville Deerwood

Delta Hotels by Marriott™ Jacksonville Deerwood

Delta Hotels by Marriott™ Jacksonville Deerwood
4.0 star property
15.2 km from Isle of Palms South
8.6 out of 10, Excellent, (463)
"Loved our stay, staff were nice and hotel was clean. "
United States
Wilfredo
The price is 2.523.946 ₫
2.864.680 ₫ total
includes taxes & fees
1 Jan - 2 Jan 2026
Delta Hotels by Marriott™ Jacksonville Deerwood
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Isle of Palms South

Find the best Isle of Palms South areas for the activities you enjoy most.
Photo by Ryan Ketterman
Open Photo by Ryan Ketterman

Downtown Jacksonville

Florida Theatre and Jacksonville Museum of Modern Art are top sights in Downtown Jacksonville, and you should be sure to explore the stunning river views. Hop aboard the metro at Riverplace Station or Kings Avenue Station to see more sights in the area.

Amelia City

While visiting Amelia City, you might make a stop by sights like American Beach and Fernandina Beach.

Southside

If you're spending some time in Southside, St. Johns Town Center and Merill Road Shopping Center are top sights worth seeing.

Sawgrass

Beaches and riverfront are just a few things travellers like about Sawgrass. A stop by Mickler Beach is also recommended if you've got time to explore the area.

Cummer Museum of Art and Gardens featuring art and interior views as well as a couple
Photo by Visit Jacksonville
Open Photo by Visit Jacksonville

Northwest

While visiting Northwest, you might make a stop by sights like Cummer Museum of Art and Gardens and Jacksonville-Baldwin Rail Trail.

Top Isle of Palms South Hotel Reviews

Weekly Inn

Weekly Inn

10/10 Excellent
"Very clean rooms and friendly staff, would recommend to anyone! 🙏"
Dournell 1-night trip
Posted 4 days ago
Weekly Inn
Hilton Jacksonville At Mayo Clinic

Hilton Jacksonville At Mayo Clinic

10/10 Excellent
"Clean. Very friendly staff."
Mark 1-night trip
Posted 10 days ago
Hilton Jacksonville At Mayo Clinic

Explore a world of travel with Expedia

Frequently asked questions

What is Isle of Palms South like?
Travellers will be sure to find plenty to entertain them in Jacksonville Beach's Isle of Palms South neighbourhood.
How many hotels can I expect to find in Isle of Palms South?
Expedia has 7 Isle of Palms South hotels and other accommodation options, and one might make a good home base for venturing out into the greater Jacksonville Beach area.
If I need to cancel my hotel reservation in Isle of Palms South, will I receive a refund?
Yes, the majority of hotel reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If you have a non-refundable reservation, you might be able to still cancel and receive a refund within a 24-hour period of booking. Enter dates in and click on "Search", then you can filter by "fully refundable" to view the best deals in Isle of Palms South.
What are the top things to see and do in Isle of Palms South?
Adventure Landing, Cradle Creek Preserve and Windsor Parke Golf Club are just a few of the places to visit in and around Isle of Palms South. Jacksonville Beach Golf Club and Windsor Commons Shopping Center are also worth a visit when you're out sightseeing in Jacksonville Beach.