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15 Dec - 16 Dec
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16 Dec - 17 Dec
This weekend
19 Dec - 21 Dec
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26 Dec - 28 Dec

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Our top choices for La Guillotière hotels

Property amenity
Hotel de Noailles

Hotel de Noailles

Hotel de Noailles
3.0 star property
La Guillotière
7.4 out of 10, Good, (117)
"Beautiful property right next to dining and shopping. Highly recommended!"
United States
John
Hotel de Noailles
Front of property – evening/night
Ibis Lyon Centre

Ibis Lyon Centre

Ibis Lyon Centre
3.0 star property
La Guillotière
7.8 out of 10, Good, (175)
"nice place to stay "
France
lahouari
The price is 2.171.707 ₫
2.504.384 ₫ total
includes taxes & fees
2 Jan - 3 Jan 2026
Ibis Lyon Centre
Terrace/patio
Ho36 hostels

Ho36 hostels

Ho36 hostels
La Guillotière
8.0 out of 10, Very good, (159)
"Great value hostel, safe comfortable and convenient "
United Kingdom
David
The price is 2.122.349 ₫
2.388.878 ₫ total
includes taxes & fees
1 Jan - 2 Jan 2026
Ho36 hostels
Daily buffet breakfast (EUR 14.5 per person)
Best Western Hotel Saint Antoine

Best Western Hotel Saint Antoine

Best Western Hotel Saint Antoine
3.0 star property
Les Cordeliers, 1.8 km from La Guillotière
8.2 out of 10, Very good, (434)
"Really great location and helpful staff. Really cramped room, though one of the two the best showers we have had of 20 different hotel rooms on this trip. "
United States
Fred
The price is 1.906.947 ₫
2.213.148 ₫ total
includes taxes & fees
11 Jan - 12 Jan 2026
Best Western Hotel Saint Antoine
Breakfast, lunch, dinner served; Regional cuisine
Radisson Blu Hotel Lyon

Radisson Blu Hotel Lyon

Radisson Blu Hotel Lyon
4.0 star property
Part Dieu - Bir Hakeim, 1.2 km from La Guillotière
8.4 out of 10, Very good, (1002)
"It was great. The room was clean and comfortable. The staff were helpful and friendly"
United States
Glenn
The price is 3.425.317 ₫
3.944.506 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Radisson Blu Hotel Lyon
Lobby
Campanile Lyon Centre-Berges du Rhône

Campanile Lyon Centre-Berges du Rhône

Campanile Lyon Centre-Berges du Rhône
3.0 star property
3rd Arrondissement, 1 km from La Guillotière
7.8 out of 10, Good, (1003)
"Good stay for one night in Lyon. Good basic hotel. "
United Kingdom
Olivia
The price is 1.853.041 ₫
2.153.851 ₫ total
includes taxes & fees
11 Jan - 12 Jan 2026
Campanile Lyon Centre-Berges du Rhône
View from property
Fourvière Hôtel Lyon

Fourvière Hôtel Lyon

Fourvière Hôtel Lyon
4.0 star property
Fourvière, 2.8 km from La Guillotière
9.2 out of 10, Wonderful, (1004)
"This property was excellent "
United States
Ed
Fourvière Hôtel Lyon
Exterior
Le Phenix Hotel

Le Phenix Hotel

Le Phenix Hotel
4.0 star property
Old Lyon, 2.5 km from La Guillotière
9.2 out of 10, Wonderful, (1001)
"Fantastic location with excellent rooms"
United States
Hudson
The price is 3.144.301 ₫
3.635.357 ₫ total
includes taxes & fees
18 Dec - 19 Dec
Le Phenix Hotel
Premium Double Room | In-room safe, individually decorated, individually furnished, desk
Globe et Cecil Hôtel

Globe et Cecil Hôtel

Globe et Cecil Hôtel
4.0 star property
Bellecour - Hôtel Dieu, 1.6 km from La Guillotière
8.4 out of 10, Very good, (528)
"Very nice stay, loved the location and the hotel! "
Sweden
Sandra
The price is 3.596.443 ₫
4.132.899 ₫ total
includes taxes & fees
18 Dec - 19 Dec
Globe et Cecil Hôtel
Front of property
Mercure Lyon Centre Beaux Arts

Mercure Lyon Centre Beaux Arts

Mercure Lyon Centre Beaux Arts
4.0 star property
Les Cordeliers, 1.7 km from La Guillotière
9.0 out of 10, Wonderful, (1000)
"Relatively basic hotel in a great location with excellent staff."
United Kingdom
Ian
The price is 3.187.230 ₫
3.682.610 ₫ total
includes taxes & fees
11 Jan - 12 Jan 2026
Mercure Lyon Centre Beaux Arts
Exterior
Mercure Lyon Centre Château Perrache

Mercure Lyon Centre Château Perrache

Mercure Lyon Centre Château Perrache
4.0 star property
Perrache, 1.9 km from La Guillotière
8.2 out of 10, Very good, (822)
"Hotel is dated and could use remodeling. Staff was good."
United States
Rene
The price is 2.637.214 ₫
3.077.592 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Mercure Lyon Centre Château Perrache
Restaurant
Bikube Lyon

Bikube Lyon

Bikube Lyon
4.0 star property
3rd Arrondissement, 1.1 km from La Guillotière
9.0 out of 10, Wonderful, (189)
"Everything was great! Staff were alway friendly and helpful! Room was immaculate. Shared living space was cool. Close to Metro. Highly recommend!"
United States
Kathleen
The price is 2.268.121 ₫
2.671.590 ₫ total
includes taxes & fees
2 Jan - 3 Jan 2026
Bikube Lyon
View from property
Hotel du Theatre

Hotel du Theatre

Hotel du Theatre
2.0 star property
Bellecour - Hôtel Dieu, 1.8 km from La Guillotière
8.2 out of 10, Very good, (576)
"Great location, walkable to everything we wanted to see."
United States
Alison
The price is 2.428.045 ₫
2.738.795 ₫ total
includes taxes & fees
16 Dec - 17 Dec
Hotel du Theatre
Classic Room with balcony including self-service snacks and drinks at the Club | Premium bedding, in-room safe, desk, soundproofing
OKKO Hotels Lyon Centre

OKKO Hotels Lyon Centre

OKKO Hotels Lyon Centre
4.0 star property
1.7 km from La Guillotière
9.0 out of 10, Wonderful, (1008)
"Fantastic hotel, welcoming staff. "
Canada
Carol
The price is 2.900.525 ₫
3.367.235 ₫ total
includes taxes & fees
19 Dec - 20 Dec
OKKO Hotels Lyon Centre
Daily buffet breakfast (EUR 10 per person)
Premiere Classe Lyon Centre - Gare Part Dieu

Premiere Classe Lyon Centre - Gare Part Dieu

Premiere Classe Lyon Centre - Gare Part Dieu
2.0 star property
Part Dieu - Bir Hakeim, 1 km from La Guillotière
8.0 out of 10, Very good, (1002)
"Excellent stay , clean tiny hotel , excellent service , thank you"
Canada
Dorin
The price is 1.443.687 ₫
1.656.001 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Premiere Classe Lyon Centre - Gare Part Dieu
Exterior
Campanile PRIME - Lyon Centre Gare Part Dieu

Campanile PRIME - Lyon Centre Gare Part Dieu

Campanile PRIME - Lyon Centre Gare Part Dieu
3.0 star property
1.5 km from La Guillotière
9.0 out of 10, Wonderful, (1198)
"Nice place to stay."
United States
Yuanmei
The price is 2.147.843 ₫
2.478.134 ₫ total
includes taxes & fees
19 Dec - 20 Dec
Campanile PRIME - Lyon Centre Gare Part Dieu
Terrace/patio
Collège Hôtel

Collège Hôtel

Collège Hôtel
4.0 star property
Old Lyon, 2.4 km from La Guillotière
8.4 out of 10, Very good, (764)
"Loved it"
United States
Steven
Collège Hôtel
Garden
Appart'hôtel Odalys City - Lyon Centre Confluence

Appart'hôtel Odalys City - Lyon Centre Confluence

Appart'hôtel Odalys City - Lyon Centre Confluence
2.4 km from La Guillotière
8.0 out of 10, Very good, (794)
"The property was good and well maintained but the homeless people camped nearby felt unsafe."
United Kingdom
Elaine
The price is 2.066.421 ₫
2.386.716 ₫ total
includes taxes & fees
14 Jan - 15 Jan 2026
Appart'hôtel Odalys City - Lyon Centre Confluence
Indoor pool
Grand Hotel Des Terreaux

Grand Hotel Des Terreaux

Grand Hotel Des Terreaux
4.0 star property
2.3 km from La Guillotière
8.8 out of 10, Excellent, (1002)
"helpful staff, hotel location, amenities"
Canada
Rick
The price is 2.912.251 ₫
3.380.134 ₫ total
includes taxes & fees
19 Dec - 20 Dec
Grand Hotel Des Terreaux
Terrace/patio
Hôtel Mercure Lyon Centre Plaza République

Hôtel Mercure Lyon Centre Plaza République

Hôtel Mercure Lyon Centre Plaza République
4.0 star property
Les Cordeliers, 1.6 km from La Guillotière
8.4 out of 10, Very good, (684)
"Location excellent"
United States
DIDEM
The price is 2.839.644 ₫
3.300.265 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Hôtel Mercure Lyon Centre Plaza République
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in La Guillotière

Find the best La Guillotière areas for the activities you enjoy most.

Lyon City Centre

Gourmet restaurants interesting history and top sights from Bellecour Square to Place Carnot – discover Lyon City Centre, a destination also famous for its shopping.

Lyon showing a city, a river or creek and a statue or sculpture

Old Lyon

If you're spending time in Old Lyon, you might enjoy attractions like Lyon Cathedral and Palais de Justice de Lyon. You might also enjoy the neighbourhood's ample dining options before hopping on the metro at Vieux Lyon Station to see more of the city.

Bellecour Square which includes a statue or sculpture, a river or creek and a bridge

Bellecour - Hôtel Dieu

While you're in Bellecour - Hôtel Dieu, take in top sights like Bellecour Square and jump on the metro at Bellecour Station to see more of the city.

3rd Arrondissement

Noted for its shopping and river views, there's plenty to explore in 3rd Arrondissement. Top attractions like Part Dieu Mall and Halles de Lyon - Paul Bocuse are major draws, and you can hop on the metro at Dauphine - Lacassagne Tram Stop or Archives Départementales Tram Stop to see more of the city.

2nd Arrondissement

Travellers love 2nd Arrondissement for its popular shops, and you can see more of Lyon by jumping on the metro at Place des Archives or Sainte-Blandine Tram Stop. You might spend time checking out top sights like Place Carnot and Lyon Confluence Shopping Center.

Top La Guillotière Hotel Reviews

Explore a world of travel with Expedia

Frequently asked questions

What is La Guillotière like?
La Guillotière is a neighbourhood that travellers like for its riverfront, shopping and restaurants.
How many hotels should I expect to find in the La Guillotière area?
If you're searching for places to stay in Lyon, Expedia has something to meet your needs with 42 La Guillotière hotels and other accommodation options to choose from.
If I need to cancel my hotel reservation in La Guillotière, will I receive a refund?
Yes, you'll find most room reservations are fully refundable as long as you cancel before the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your scheduled arrival. If you have a non-refundable reservation, you might be able to cancel it and get a refund within a 24-hour period of booking. Add your dates and click on "Search", then you can filter by "fully refundable" to review top deals in La Guillotière.
What is there to do around this Lyon neighbourhood?
Carrousel du Pont de la Guillotière, Museum of the Resistance and Centre d'Histoire de la Resistance et de la Deportation are just a few of the places to visit in and around La Guillotière. La Part-Dieu Business District and Tour Part-Dieu are also worth a visit when you're out sightseeing in Lyon.
How can I get around La Guillotière and the greater Lyon area?
For a quick way to explore the city, catch a ride on metro transit at Garibaldi Station, Saxe-Gambetta Station or Saint-André Tram Stop.