The Best Hotels Closest to Lake Issaqueena in Central - 2026 Updated Prices

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Our top choices for Lake Issaqueena hotels

A cabin with a large window, surrounded by trees.

A wooden cabin bedroom with a large window, a bed, a bedside table with a lantern, and a heater.

A wooden interior with a table, chair, and a hanging lantern.

1. Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

15.8 km from Lake Issaqueena

Nirumol

2.416.590 ₫

3.805.902 ₫ total

includes taxes & fees

8 Sept - 9 Sept

A spacious indoor dining area with multiple tables and chairs, a food service counter, and a modern architectural design with balconies.

A spacious indoor area with multiple seating arrangements, a ping pong table, and a bar area with purple accents.

A hotel room with a bed, a desk, a TV, a mirror, and a nightstand with a lamp.

A lobby with seating areas, a reception desk, and a patterned wall.

2. Best Western Plus Clemson Hotel & Conference Center

6.8 km from Lake Issaqueena

Julio

2.638.295 ₫

2.928.507 ₫ total

includes taxes & fees

31 Aug - 1 Sept

A poolside area with outdoor seating and a view of a lake and forested hills.

A modern cafe interior with round tables and chairs, a counter with a beverage dispenser, and a wall-mounted TV.

A modern lounge area with a round table, two green armchairs, a sofa, and a TV mounted on the wall.

A deck with outdoor seating overlooking a body of water, adjacent to a building with multiple windows.

3. Fairfield Inn & Suites Seneca Clemson Univ Area

10.6 km from Lake Issaqueena

Ronald

3.129.178 ₫

3.442.097 ₫ total

includes taxes & fees

6 Sept - 7 Sept

A hotel dining area with a long table, multiple chairs, and a bar in the background.

A long, narrow hallway with white walls and a light-colored floor, leading to a door at the end.

A reception area with a counter, chairs, and a patterned rug.

A hotel pantry with shelves stocked with snacks, a microwave, and a refrigerator with beverages.

4. Hampton Inn & Suites Seneca-Clemson Area

8.6 km from Lake Issaqueena

Georgina

3.097.785 ₫

3.407.355 ₫ total

includes taxes & fees

3 Sept - 4 Sept

A modern kitchen with a microwave, coffee maker, and bar stools.

A hotel hallway with a carpeted floor, light-colored walls, and doors on both sides.

A Comfort Inn & Suites hotel with a modern design, featuring a prominent sign, well-maintained landscaping, and a clear view of the entrance.

A hotel room with a large flat-screen TV mounted on the wall, a desk with a chair, a bedside table, a lamp, and a wardrobe.

5. Comfort Inn & Suites Clemson - University Area

6.6 km from Lake Issaqueena

Anita

2.749.148 ₫

3.051.553 ₫ total

includes taxes & fees

27 Sept - 28 Sept

6. Holiday Inn Express & Suites Clemson by IHG

7.1 km from Lake Issaqueena

Angela

2.869.130 ₫

3.184.734 ₫ total

includes taxes & fees

7 Sept - 8 Sept

A hotel room with a bed, a desk, a chair, a large window with curtains, a bathroom with a bathtub, and a flat-screen TV.

A breakfast bar with waffle makers, coffee machines, and a clock on the wall.

A rectangular swimming pool with a metal ladder, surrounded by lounge chairs and tables, with a wooded area in the background.

A reception area with a brick wall, a reception desk, and a glass door leading outside.

7. Best Western Seneca-Clemson

9.7 km from Lake Issaqueena

Michelle

2.638.295 ₫

2.902.124 ₫ total

includes taxes & fees

31 Aug - 1 Sept

A spacious hallway with a wooden ceiling, a sofa, a chair, and a lamp.

A brick building with a sign reading "The Inn at Patrick Square".

A hotel with a brick facade, multiple windows, and a sign reading "The Inn at Patrick Square".

A hotel lobby with a long corridor, seating areas, and a reception desk.

8. The Inn at Patrick Square

9.2 km from Lake Issaqueena

Beatriz

3.886.367 ₫

4.313.865 ₫ total

includes taxes & fees

30 Aug - 31 Aug

A reception area with a reception desk, a sofa, a staircase, and a wall with artwork.

A wall with a decorative design featuring a building, trees, and a sky with clouds.

A dining area with a brick floor, wooden tables, and chairs, a kitchen counter with appliances, and large windows offering a view of the outside.

A hotel room with two beds, a desk, a television, and a clock on the wall.

9. Inn @ Clemson

6.5 km from Lake Issaqueena

Terry

2.089.248 ₫

2.319.066 ₫ total

includes taxes & fees

29 Aug - 30 Aug

A restaurant interior with a counter, seating area, and a TV mounted on the wall.

A hotel room with a TV on a wooden cabinet, a desk with a lamp, a framed picture, and a chair.

A multi-story motel with a central entrance, a flag, and a parking lot with several cars.

A spacious lobby with a high ceiling, a chandelier, framed artwork, a lamp, a sofa, and a view through large glass doors to an outdoor area.

10. Quality Inn Seneca US-123

13.5 km from Lake Issaqueena

Anthony

1.971.875 ₫

2.326.032 ₫ total

includes taxes & fees

6 Sept - 7 Sept

A modern bar area with a menu board, bar stools, and a countertop with various items.

A Courtyard Marriott hotel with a brick facade, multiple floors, and a covered entrance area.

An outdoor patio with a circular fire pit surrounded by wicker furniture and a pergola overhead.

A modern dining area with a bar, bar stools, and a patterned rug.

11. Courtyard Marriott Clemson

7.3 km from Lake Issaqueena

Gargi

3.081.706 ₫

3.420.693 ₫ total

includes taxes & fees

3 Sept - 4 Sept

A spacious porch with wooden flooring, a dining area with a table and chairs, and a view of the surrounding landscape.

A swimming pool with lounge chairs and a covered area with tables and chairs.

A spacious living room with a dark leather sofa, a wooden coffee table, and a dining area with a table and chairs. Large windows provide natural light and views of the outdoors.

A modern bedroom with a large bed, a ceiling fan, and a view of the outdoors through a window.

12. Carolina Camp Cedar

20.2 km from Lake Issaqueena

Katlynn

4.408.027 ₫

7.064.319 ₫ total

includes taxes & fees

30 Aug - 31 Aug

A dining area with a table and chairs, large windows with a view of the outside, and a green sofa.

A reception desk with a vase of flowers, framed pictures, and a printer.

A gazebo with a tiled roof and a surrounding gravel area.

A gazebo with a tiled roof and wooden pillars, surrounded by a fence and potted plants.

13. Days Inn by Wyndham Clemson

7.1 km from Lake Issaqueena

David

2.089.248 ₫

2.319.066 ₫ total

includes taxes & fees

29 Aug - 30 Aug

A modern kitchen area with a bar counter and seating.

A vending area with snacks and beverages, including chips and soda.

A modern living room with a grey sofa, purple and orange cushions, a coffee table with magazines, and a large window with patterned curtains.

A Hampton Inn with a modern design, featuring a prominent entrance and outdoor seating area.

14. Hampton Inn Clemson-University Area

5.5 km from Lake Issaqueena

DOUGLAS

2.759.060 ₫

3.062.557 ₫ total

includes taxes & fees

6 Sept - 7 Sept

A kitchen with a coffee maker, microwave, and refrigerator.

A hotel room with a bed, a desk with a chair, a television, a small table, and a microwave.

A reception area with a check-in desk, a seating area with a bench, and a wall-mounted display of postcards.

A red brick building with a white porch and columns, a door, and windows.

15. Rodeway Inn & Suites Walhalla

17.7 km from Lake Issaqueena

michael

1.995.089 ₫

2.224.525 ₫ total

includes taxes & fees

27 Sept - 28 Sept

A modern dining area with a high ceiling, large windows, and a buffet setup.

A swimming pool with lounge chairs and a fence, surrounded by trees.

A modern hotel room with a large bed, bedside tables with lamps, a wall-mounted air conditioner, and a large window with curtains.

A Days Inn reception area with a view of a parking lot and a grassy area.

16. Days Inn by Wyndham Seneca / Clemson Area

12.7 km from Lake Issaqueena

John

2.112.723 ₫

2.323.995 ₫ total

includes taxes & fees

30 Aug - 31 Aug

A green RV parked in a forest with a picnic table and a covered area.

A covered outdoor seating area with a table and chairs, large windows, and a wooden lattice fence.

A rectangular swimming pool with a tiled deck, surrounded by lounge chairs and umbrellas, and a covered seating area.

A covered outdoor seating area with wooden chairs and tables, a signboard, and a view of the surrounding forest.

17. The Point At Lake Hartwell

19.8 km from Lake Issaqueena

Douglas

2.816.964 ₫

3.126.831 ₫ total

includes taxes & fees

28 Sept - 29 Sept

A hotel lobby with a reception desk, seating area, and a view of the street outside.

A modern kitchen with wooden cabinets, a built-in dishwasher, a large window with a view of the outside, and a flat-screen TV mounted on the wall.

A compact bathroom with a white sink, a mirror, a black refrigerator, and a towel rack with wooden hangers.

A reception area with a desk, two chairs, a large water dispenser, and a painting on the wall.

18. Econo Lodge Clemson - University Area

7.6 km from Lake Issaqueena

2.194.884 ₫

2.480.220 ₫ total

includes taxes & fees

28 Sept - 29 Sept

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Compare popular hotels close to Lake Issaqueena

Property	Property class	Guest rating
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy	9.8 Exceptional 101 reviews	View
Best Western Plus Clemson Hotel & Conference Center	8.0 Very good 1,004 reviews	View
Fairfield Inn & Suites Seneca Clemson Univ Area	9.4 Exceptional 264 reviews	View
Hampton Inn & Suites Seneca-Clemson Area	9.2 Wonderful 738 reviews	View
Comfort Inn & Suites Clemson - University Area	8.4 Very good 1,002 reviews	View

Top Lake Issaqueena Hotel Reviews

The Shepherd Hotel Downtown Clemson

10/10 Excellent

"Fabulous stay. Beautiful room!!"

Inn @ Clemson

10/10 Excellent

"It’s"

Best Western Plus Clemson Hotel & Conference Center

8/10 Good

"The front desk woman was super sweet and welcoming. The hotel itself has a lot of character and is pretty cool, although it could definitely use some updating. Our room had a musty smell, and the bathroom floors—especially in the corners—could use a deeper cleaning. Overall, we just needed an affordable place to sleep for one night while visiting Clemson for a tour, and for around $100, it did the job. Not fancy, but perfectly fine for a quick overnight stay."

Comfort Inn & Suites Clemson - University Area

10/10 Excellent

"room was clean and modern, very nice"

The Abernathy of Clemson

10/10 Excellent

"The property was clean and had great access to Clemson University. The staff was very nice accommodating."

Courtyard Marriott Clemson

10/10 Excellent

"👍"

Hampton Inn Clemson-University Area

8/10 Good

"The hotel rooms need updating, but the hotel is clean, the breakfast is good, and the staff is very friendly."

Other attractions near Lake Issaqueena

Larry W. Abernathy Waterfront Park

8.6/10 (58 reviews)

Larry W. Abernathy Waterfront Park is just one of the places to see in Clemson, so why not enjoy the other things to explore during your travels? Experience the area's theatre scene or attend a football match.

See properties

Littlejohn Coliseum

9.4/10 (141 reviews)

Catch an event at Littlejohn Coliseum during your trip to Clemson. Amble around the area's lakeside or attend a football match.

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Sloan Tennis Center

Catch an event at Sloan Tennis Center during your trip to Clemson. You can attend a football match while in the area.

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Memorial Stadium

9.6/10 (410 reviews)

Catch an event at Memorial Stadium during your trip to Clemson. Experience the area's theatre scene or attend a football match.

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Clemson Area African American Museum

You can spend time exploring the galleries in Clemson Area African American Museum in Clemson. You can attend a football match while in the area.

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Wyndham Plaza

You can search for that perfect souvenir at Wyndham Plaza during your stay in Seneca. Stroll along the lakeside or attend a sporting event in this family-friendly area.

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World of Energy

You can spend an afternoon browsing the exhibits at World of Energy in Seneca. Amble around this family-friendly area's lakeside or attend a sporting event.

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Frequently asked questions

What's the area like around Lake Issaqueena?

Lake Issaqueena is located in Central. You'll find 206 hotels and other accommodations within a few miles for a convenient home base.

How many hotels will I find close to Lake Issaqueena?

Expedia has 206 hotels and other accommodation options a few miles from Lake Issaqueena.

If I need to cancel the hotel reservation for my stay near Lake Issaqueena, will I receive a refund?

Yes, most hotel room reservations are refundable if you cancel prior to the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of check in. If you have a reservation that's non-refundable, you might be able to cancel it and receive a refund within 24 hours of your booking. Plug in your dates, click on "Search", then filter by "fully refundable" to get the top deals on offer near Lake Issaqueena.

What can I see and do near Lake Issaqueena?

You'll want to browse the exhibits at Fort Hill and Clemson Area African American Museum. Explore nature at Keowee Reservoir and Larry W. Abernathy Waterfront Park. If you've got some time to explore the area around Lake Issaqueena, you may want to make a stop by Littlejohn Coliseum, Memorial Stadium and Sloan Tennis Center.

Search Hotels Near Lake Issaqueena, Central

Change your mind

Treat yourself

Be picky

Check prices for these dates

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Our top choices for Lake Issaqueena hotels

1. Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

2. Best Western Plus Clemson Hotel & Conference Center

3. Fairfield Inn & Suites Seneca Clemson Univ Area

4. Hampton Inn & Suites Seneca-Clemson Area

5. Comfort Inn & Suites Clemson - University Area

6. Holiday Inn Express & Suites Clemson by IHG

7. Best Western Seneca-Clemson

8. The Inn at Patrick Square

9. Inn @ Clemson

10. Quality Inn Seneca US-123

11. Courtyard Marriott Clemson

12. Carolina Camp Cedar

13. Days Inn by Wyndham Clemson

14. Hampton Inn Clemson-University Area

15. Rodeway Inn & Suites Walhalla

16. Days Inn by Wyndham Seneca / Clemson Area

17. The Point At Lake Hartwell

18. Econo Lodge Clemson - University Area

Compare popular hotels close to Lake Issaqueena

Top Lake Issaqueena Hotel Reviews

The Shepherd Hotel Downtown Clemson

Inn @ Clemson

Best Western Plus Clemson Hotel & Conference Center

Comfort Inn & Suites Clemson - University Area

The Abernathy of Clemson

Courtyard Marriott Clemson

Hampton Inn Clemson-University Area

Other attractions near Lake Issaqueena

Larry W. Abernathy Waterfront Park

Littlejohn Coliseum

Sloan Tennis Center

Memorial Stadium

Clemson Area African American Museum

Wyndham Plaza

World of Energy

Frequently asked questions