Search Business Hotels in Little Italy

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Check availability on Little Italy Business Hotels

Tonight
20 Dec - 21 Dec
Tomorrow
21 Dec - 22 Dec
Next weekend
26 Dec - 28 Dec
In two weeks
2 Jan - 4 Jan

Our top choices for Little Italy business-friendly hotels

Suite, 1 Bedroom, Non Smoking | Living area | 32-inch LCD TV with premium TV channels, TV
Hampton Inn San Diego-Downtown

Hampton Inn San Diego-Downtown

Hampton Inn San Diego-Downtown
2.5 star property
Downtown San Diego
8.2 out of 10, Very good, (2292)
"Nice and convenient place to stay!"
United States
Esperanza
The price is 2.635.329 ₫
3.055.533 ₫ total
includes taxes & fees
18 Jan - 19 Jan 2026
Hampton Inn San Diego-Downtown
View from room
Courtyard by Marriott San Diego Downtown Little Italy

Courtyard by Marriott San Diego Downtown Little Italy

Courtyard by Marriott San Diego Downtown Little Italy
4.0 star property
Downtown San Diego
9.0 out of 10, Wonderful, (119)
"It was a nice place to stay at"
United States
Eric
The price is 3.110.181 ₫
3.606.099 ₫ total
includes taxes & fees
24 Dec - 25 Dec
Courtyard by Marriott San Diego Downtown Little Italy
Street view
Urban Boutique Hotel

Urban Boutique Hotel

Urban Boutique Hotel
3.0 star property
Downtown San Diego
8.6 out of 10, Excellent, (1267)
"Locations is excellent and the front desk lady was friendly "
Canada
Ju
Urban Boutique Hotel
Outdoor pool, open 7:00 AM to 10:00 PM, free pool cabanas, pool loungers
Hilton Garden Inn San Diego Downtown/Bayside

Hilton Garden Inn San Diego Downtown/Bayside

Hilton Garden Inn San Diego Downtown/Bayside
3.5 star property
Downtown San Diego
8.6 out of 10, Excellent, (1225)
"Staff was excellent and informative about local restaurants."
United States
Linda
The price is 3.405.009 ₫
3.947.938 ₫ total
includes taxes & fees
23 Dec - 24 Dec
Hilton Garden Inn San Diego Downtown/Bayside
Exterior
La Pensione Hotel

La Pensione Hotel

La Pensione Hotel
3.0 star property
Downtown San Diego
8.6 out of 10, Excellent, (1891)
"Great check-in experience, convenient parking, the room was clean and bed was comfortable. The city view option was exceptionally pleasant. Will stay again! "
United States
Mike
La Pensione Hotel
Standard Room, 2 Queen Beds | In-room safe, desk, blackout curtains, iron/ironing board
Harborview Inn & Suites San Diego Harbor

Harborview Inn & Suites San Diego Harbor

Harborview Inn & Suites San Diego Harbor
2.0 star property
Downtown San Diego
7.2 out of 10, Good, (1006)
"Room.was great and clean. It also a good view it was a great stay after all "
United States
Elsa
The price is 1.447.325 ₫
2.095.331 ₫ total
includes taxes & fees
22 Dec - 23 Dec
Harborview Inn & Suites San Diego Harbor
Food and drink
Porto Vista Hotel Downtown

Porto Vista Hotel Downtown

Porto Vista Hotel Downtown
3.5 star property
Downtown San Diego
6.8 out of 10, (1199)
"Nice stay, staff excellent, friendly, helpful and great customer service. Hotel ok older"
United States
Mizael
Porto Vista Hotel Downtown
Property amenity
Residence Inn by Marriott San Diego Downtown

Residence Inn by Marriott San Diego Downtown

Residence Inn by Marriott San Diego Downtown
3.0 star property
Downtown San Diego
8.6 out of 10, Excellent, (1001)
"Close to the harbor."
United States
Evelyn
The price is 3.844.634 ₫
4.460.161 ₫ total
includes taxes & fees
6 Jan - 7 Jan 2026
Residence Inn by Marriott San Diego Downtown
3 outdoor pools, pool cabanas (surcharge), pool umbrellas
Hyatt Regency Mission Bay Spa and Marina

Hyatt Regency Mission Bay Spa and Marina

Hyatt Regency Mission Bay Spa and Marina
4.0 star property
Mission Bay
8.4 out of 10, Very good, (1571)
"Loved our stay "
United States
Jeremy
The price is 3.269.441 ₫
5.150.861 ₫ total
includes taxes & fees
2 Jan - 3 Jan 2026
Hyatt Regency Mission Bay Spa and Marina
Outdoor pool, open 7:00 AM to 10:00 PM, pool cabanas (surcharge)
San Diego Mission Bay Resort

San Diego Mission Bay Resort

San Diego Mission Bay Resort
4.0 star property
Mission Bay
8.4 out of 10, Very good, (1310)
"Room was super clean and updated, location up against the bay was perfect. We really enjoyed our stay and want to come back soon!"
United States
Haley
The price is 3.875.147 ₫
5.640.883 ₫ total
includes taxes & fees
1 Jan - 2 Jan 2026
San Diego Mission Bay Resort
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Little Italy Hotel Reviews

The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

10/10 Excellent
"The room was comfortable & the staff was incredibly friendly. The location is also ideal for exploration and looking around. Really solid pick."
Michael 5-night trip
Posted 2 days ago
The DEXTRO Little Italy, BW Premier Collection

Frequently asked questions

Why book your business-friendly hotel in Little Italy with Expedia?
Here at Expedia, our job is to help you choose the ideal stay at the right price. From deluxe, corporate-friendly getaways to affordable hotels loaded with conveniences, you'll have your next work trip booked in a few easy clicks.
How can I find cheap business-friendly hotels in Little Italy?
When you're travelling for work in Little Italy, our "business friendly" filter will help you find the ideal hotel. From fast WiFi to meeting rooms and workspaces, they have the amenities you need to get the job done. Another tip? Refine your search by your preferred star rating and budget to see the most affordable accommodation.