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Check availability on Little Italy Business Hotels

Our top choices for Little Italy business-friendly hotels

Outdoor pool, pool umbrellas, pool loungers
Hampton Inn San Diego-Downtown

Hampton Inn San Diego-Downtown

Hampton Inn San Diego-Downtown
2.5 star property
Downtown San Diego
8.2 out of 10, Very good, (2269)
"Great stay, I recommend it"
United States
Furio
The price is 2.733.796 ₫
3.169.700 ₫ total
includes taxes & fees
24 Dec - 25 Dec
Hampton Inn San Diego-Downtown
City view from property
Courtyard by Marriott San Diego Downtown Little Italy

Courtyard by Marriott San Diego Downtown Little Italy

Courtyard by Marriott San Diego Downtown Little Italy
4.0 star property
Downtown San Diego
9.0 out of 10, Wonderful, (84)
"It was a nice place to stay at"
United States
Eric
The price is 2.899.270 ₫
3.361.559 ₫ total
includes taxes & fees
18 Dec - 19 Dec
Courtyard by Marriott San Diego Downtown Little Italy
Outdoor pool, open 7:00 AM to 10:00 PM, free pool cabanas, pool loungers
Hilton Garden Inn San Diego Downtown/Bayside

Hilton Garden Inn San Diego Downtown/Bayside

Hilton Garden Inn San Diego Downtown/Bayside
3.5 star property
Downtown San Diego
8.6 out of 10, Excellent, (1222)
"Great location, great hotel. Will stay again. "
United States
Felicia
The price is 3.409.014 ₫
3.952.581 ₫ total
includes taxes & fees
15 Dec - 16 Dec
Hilton Garden Inn San Diego Downtown/Bayside
Exterior
La Pensione Hotel

La Pensione Hotel

La Pensione Hotel
3.0 star property
Downtown San Diego
8.6 out of 10, Excellent, (1908)
"Friendly staff, very nice room, great location!"
United States
Lisa
La Pensione Hotel
Check-in/check-out kiosk
Urban Boutique Hotel

Urban Boutique Hotel

Urban Boutique Hotel
3.0 star property
Downtown San Diego
8.6 out of 10, Excellent, (1278)
"Locations is excellent and the front desk lady was friendly "
Canada
Ju
Urban Boutique Hotel
Rooftop terrace
Porto Vista Hotel Downtown

Porto Vista Hotel Downtown

Porto Vista Hotel Downtown
3.5 star property
Downtown San Diego
6.8 out of 10, (1199)
"Nice stay, staff excellent, friendly, helpful and great customer service. Hotel ok older"
United States
Mizael
The price is 2.391.107 ₫
2.924.836 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Porto Vista Hotel Downtown
Front of property
Harborview Inn & Suites San Diego Harbor

Harborview Inn & Suites San Diego Harbor

Harborview Inn & Suites San Diego Harbor
2.0 star property
Downtown San Diego
7.2 out of 10, Good, (1004)
"It was great and great location"
United States
Ernesto
The price is 1.555.063 ₫
2.668.317 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Harborview Inn & Suites San Diego Harbor
Property amenity
Residence Inn by Marriott San Diego Downtown

Residence Inn by Marriott San Diego Downtown

Residence Inn by Marriott San Diego Downtown
3.0 star property
Downtown San Diego
8.6 out of 10, Excellent, (1000)
"Close to the harbor."
United States
Evelyn
The price is 3.357.618 ₫
3.895.172 ₫ total
includes taxes & fees
5 Jan - 6 Jan 2026
Residence Inn by Marriott San Diego Downtown
Outdoor pool, open 7:00 AM to 10:00 PM, pool cabanas (surcharge)
San Diego Mission Bay Resort

San Diego Mission Bay Resort

San Diego Mission Bay Resort
4.0 star property
Mission Bay
8.4 out of 10, Very good, (1309)
"great stay! Food was great and my kids loved the pool and location"
United States
ANDREA
The price is 3.101.165 ₫
4.752.695 ₫ total
includes taxes & fees
14 Dec - 15 Dec
San Diego Mission Bay Resort
Standard Room, 1 King Bed, Non Smoking, Bay View | Premium bedding, pillow-top beds, in-room safe, desk
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection
3.0 star property
Downtown San Diego
8.8 out of 10, Excellent, (726)
"Great little boutique hotel ! Friendly staff as well"
Canada
Caroll
The price is 2.576.621 ₫
2.987.463 ₫ total
includes taxes & fees
14 Dec - 15 Dec
The DEXTRO Little Italy, BW Premier Collection
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Little Italy Hotel Reviews

Hampton Inn & Suites by Hilton San Diego SeaWorld

Hampton Inn & Suites by Hilton San Diego SeaWorld

10/10 Excellent
"Leigh at the front desk."
Randolph 1-night trip
Posted 2 days ago
Hampton Inn & Suites by Hilton San Diego SeaWorld

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Frequently asked questions

Why book your business-friendly hotel in Little Italy with Expedia?
Here at Expedia, our job is to help you choose the ideal stay at the right price. From deluxe, corporate-friendly getaways to affordable hotels loaded with conveniences, you'll have your next work trip booked in a few easy clicks.
How can I find cheap business-friendly hotels in Little Italy?
When you're travelling for work in Little Italy, our "business friendly" filter will help you find the ideal hotel. From fast WiFi to meeting rooms and workspaces, they have the amenities you need to get the job done. Another tip? Refine your search by your preferred star rating and budget to see the most affordable accommodation.