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Check availability on Los Osos Business Hotels

Our top choices for Los Osos business-friendly hotels

In-room safe, desk, laptop workspace, blackout curtains
Cambria Hotel Templeton - Paso Robles

Cambria Hotel Templeton - Paso Robles

Cambria Hotel Templeton - Paso Robles
3.0 star property
Templeton
9.4 out of 10, Exceptional, (149)
"Great location and ambience and amenity!"
United States
Stacy
The price is 2.551.280 ₫
2.819.164 ₫ total
includes taxes & fees
11 Jan - 12 Jan 2026
Cambria Hotel Templeton - Paso Robles
Family Studio Suite | Desk, blackout curtains, iron/ironing board, cots/infant beds
Vagabond Inn San Luis Obispo

Vagabond Inn San Luis Obispo

Vagabond Inn San Luis Obispo
2.0 star property
San Luis Obispo
8.4 out of 10, Very good, (1179)
"Clean room, reasonable rate, helpful staff"
United States
Thomas
The price is 1.558.677 ₫
2.085.046 ₫ total
includes taxes & fees
15 Dec - 16 Dec
Vagabond Inn San Luis Obispo
Exterior
Sea Air Inn & Suites - Downtown - Restaurant Row

Sea Air Inn & Suites - Downtown - Restaurant Row

Sea Air Inn & Suites - Downtown - Restaurant Row
2.5 star property
Downtown Morro Bay
8.8 out of 10, Excellent, (475)
"Great place would love to stay there again "
United States
Jaboree
The price is 1.829.602 ₫
2.094.894 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Sea Air Inn & Suites - Downtown - Restaurant Row
Exterior
Blufftop Inn & Suites - Wharf/Restaurant District

Blufftop Inn & Suites - Wharf/Restaurant District

Blufftop Inn & Suites - Wharf/Restaurant District
2.0 star property
Downtown Morro Bay
9.2 out of 10, Wonderful, (981)
"It was a great location and clean hotel. I loved the interior and the accommodation's where excellent!"
United States
Carla
The price is 1.908.589 ₫
2.189.056 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Blufftop Inn & Suites - Wharf/Restaurant District
Aerial view
Apple Farm

Apple Farm

Apple Farm
3.5 star property
San Luis Obispo
9.0 out of 10, Wonderful, (1567)
"Beautiful hotel and a wonderful staff."
United States
Nadia
Apple Farm
Lobby
Best Western Casa Grande Inn

Best Western Casa Grande Inn

Best Western Casa Grande Inn
2.5 star property
Pismo Beach
8.8 out of 10, Excellent, (1167)
"Check in was fast and the staff was very professional and friendly. Hotel is absolutely beautiful!"
United States
William
The price is 2.346.177 ₫
2.662.911 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Best Western Casa Grande Inn
Terrace/patio
Home2 Suites by Hilton Atascadero, CA

Home2 Suites by Hilton Atascadero, CA

Home2 Suites by Hilton Atascadero, CA
3.0 star property
Atascadero
9.4 out of 10, Exceptional, (865)
"Room was very comfortable great breakfast"
United States
Suzanne
The price is 2.274.826 ₫
2.702.303 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Home2 Suites by Hilton Atascadero, CA
Lobby sitting area
Inn at San Luis Obispo

Inn at San Luis Obispo

Inn at San Luis Obispo
2.5 star property
San Luis Obispo
7.6 out of 10, Good, (1001)
"The Inn was a terrific location for a visit to Cal Poly. The hotel was quiet and clean and a good value. We would definitely stay here again."
United States
Craig
The price is 1.562.363 ₫
1.773.282 ₫ total
includes taxes & fees
7 Jan - 8 Jan 2026
Inn at San Luis Obispo
Front of property
Aloha Inn

Aloha Inn

Aloha Inn
2.0 star property
Arroyo Grande
8.0 out of 10, Very good, (1001)
"Excellent stay"
United States
Justin
The price is 1.977.967 ₫
2.652.437 ₫ total
includes taxes & fees
27 Dec - 28 Dec
Aloha Inn
Bar (on property)
Residence Inn by Marriott San Luis Obispo

Residence Inn by Marriott San Luis Obispo

Residence Inn by Marriott San Luis Obispo
3.0 star property
San Luis Obispo
9.2 out of 10, Wonderful, (86)
"Love it"
United States
Jiexin
The price is 4.002.008 ₫
4.550.083 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Residence Inn by Marriott San Luis Obispo
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Los Osos Hotel Reviews

SeaCrest OceanFront Hotel

SeaCrest OceanFront Hotel

10/10 Excellent
"Everything was amazing ! I love staying at Seacrest "
Meredith 1-night trip
Posted 4 days ago
SeaCrest OceanFront Hotel

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Frequently asked questions

How much do business-friendly hotels in Los Osos cost?
You'll pay between 1.773.282 ₫ and 4.550.083 ₫ per night for business-friendly hotels in Los Osos. Top deals on stays that are suitable for work-related guests are only a click away on Expedia. These prices were available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
What are the best business-friendly hotels in Los Osos?
Take your pick of multiple business-friendly hotels in Los Osos that have a total average guest review rating of 8.7. Madonna Inn is a favourite with corporate travellers. This 3.5-stars hotel features amenities such as a tennis court and a cafe. La Serena Inn is another highly rated option. It has a 2.5-stars rating and conveniences including designer toiletries and an ocean view.
How many business-friendly hotels are there in Los Osos?
When work takes you on the road in Los Osos, you'll have 2 business-friendly hotels to select from. These stays combine a favourable location with the conveniences corporate travellers need.
What are the best cheap business-friendly hotels in Los Osos?
La Serena Inn is a great choice for corporate travellers after a cost-effective option. It features amenities like a terrace and an ocean view. Another inexpensive stay for a work trip is Hampton Inn & Suites San Luis Obispo. Pillow top mattresses and laundry services are two of the many conveniences here. Rates for business-friendly hotels in Los Osos start from 1.773.282 ₫ per night, so you'll have more dollars in your pocket to spend on post-conference entertainment. If you would like to squeeze in some exploring during your Los Osos business trip, there are loads of popular and free attractions to add to your to-do list. Morro Bay State Park and Morro Strand State Beach are favourites. This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
What are the top business-friendly motels in Los Osos?
Masterpiece Hotel is popular with both work and leisure guests. Around 10 km north of downtown Los Osos, you'll have access to designer toiletries, an ocean view and a selection of business amenities.You'll find plenty of things to see and do around Los Osos. Take time out from your busy schedule to visit top attractions like Morro Bay State Park and Morro Strand State Beach.
Are there any family-friendly hotels in Los Osos that are also business friendly?
Taking a trip with the family, and staying in touch with colleagues, is a breeze at Madonna Inn. Make use of amenities including WiFi and a picnic area at this popular 3.5-stars escape in Los Osos. Also consider La Serena Inn. Finish your meetings and then enjoy quality time with the kids at this 2.5-stars property. Complimentary breakfast and housekeeping services are just two of its many conveniences. Naturally, there's more to do in Los Osos than just work! Grab the kids and explore top family-friendly attractions, such as Morro Bay State Park and Morro Strand State Beach.
Why book your business-friendly hotel in Los Osos with Expedia?
Here at Expedia, we make it our business to help you track down an excellent stay at the right price. From upmarket, corporate-friendly retreats to affordable hotels loaded with conveniences, you'll have your next work trip planned in a few quick clicks.
How can I find cheap business-friendly hotels in Los Osos?
Select the "business friendly" filter, listed under the "traveller experience" heading, to find cheap business-friendly hotels in Los Osos. Then fine-tune your search by your nightly budget. Basing yourself away from the city centre is another good way to save.
What is there to do in Los Osos near my business-friendly hotel?
Whatever you're into, Los Osos has loads to keep you entertained. Morro Bay State Park, Morro Strand State Beach and Morro Rock Beach are on many travellers' to-do lists. Don't head home without exploring Montaña de Oro State Park, Elfin Forest Preserve and Los Osos Oaks State Reserve either. With Expedia's business-friendly hotel deals, you'll be able to see even more fabulous attractions like these with the money you save.