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Our top choices for Mayo Clinic Florida hotels

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area
3.0 star property
1.1 km from Mayo Clinic Florida
9.4 out of 10, Exceptional, (493 reviews)
"Breakfast was ok nothing special but the staff were all helpful and upbeat. Would highly recommend this property especially if you’re going to Mayo Clinic."
United States
JOHN
The price is 3.650.931 ₫
4.143.806 ₫ total
includes taxes & fees
15 May - 16 May
Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Hilton Jacksonville At Mayo Clinic

Hilton Jacksonville At Mayo Clinic
4.5 star property
0.8 km from Mayo Clinic Florida
9.4 out of 10, Exceptional, (217 reviews)
"Property was very clean and convenient for access to Mayo Clinic."
United States
Paul
The price is 4.300.772 ₫
4.881.377 ₫ total
includes taxes & fees
9 May - 10 May
Hilton Jacksonville At Mayo Clinic

TownePlace Suites by Marriott Jacksonville East

TownePlace Suites by Marriott Jacksonville East
3.0 star property
Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida
9.2 out of 10, Wonderful, (607 reviews)
"I always give this place five stars. It’s conveniently located near the Mayo Clinic, where I receive medical treatment, so I stay here often and it truly feels like a second home. The area is great, with plenty of restaurants nearby, and both Walmart and Publix are just a short drive away. I especially appreciate having a full kitchen, which makes longer stays much easier and more comfortable. Most importantly, the property is extremely clean every time I visit. Highly recommend!"
United States
Miriam
The price is 2.898.610 ₫
3.289.923 ₫ total
includes taxes & fees
10 May - 11 May
TownePlace Suites by Marriott Jacksonville East

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
2.5 star property
Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (1,001 reviews)
"Close to Mayo Clinic and the Beach area "
United States
Kert
The price is 3.220.176 ₫
3.654.901 ₫ total
includes taxes & fees
10 May - 11 May
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
2.5 star property
2.6 km from Mayo Clinic Florida
8.8 out of 10, Excellent, (1,000 reviews)
"It was convenient to Mayo Clinic. Good breakfast and clean room."
United States
Michelle
The price is 2.614.515 ₫
2.967.474 ₫ total
includes taxes & fees
31 May - 1 Jun
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
3.0 star property
0.4 km from Mayo Clinic Florida
8.4 out of 10, Very good, (772 reviews)
"Location across from Mayo is ideal."
United States
Peter
The price is 4.243.316 ₫
4.816.164 ₫ total
includes taxes & fees
16 May - 17 May
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

Element Jacksonville Beach

Element Jacksonville Beach
3.0 star property
5.4 km from Mayo Clinic Florida
9.6 out of 10, Exceptional, (554 reviews)
"Excellent breakfast. Cleanest rooms I've experienced. 5 🌟's"
United States
Don
The price is 4.005.352 ₫
4.546.076 ₫ total
includes taxes & fees
17 May - 18 May
Element Jacksonville Beach

Hyatt Studios Jacksonville/St Johns Town Center

Hyatt Studios Jacksonville/St Johns Town Center
2.5 star property
Deerwood, 8 km from Mayo Clinic Florida
9.6 out of 10, Exceptional, (5 reviews)
"Clean room, friendly staff"
United States
Despina
The price is 3.113.961 ₫
3.534.347 ₫ total
includes taxes & fees
1 Jun - 2 Jun
Hyatt Studios Jacksonville/St Johns Town Center

Holiday Inn Express Jacksonville Beach by IHG

Holiday Inn Express Jacksonville Beach by IHG
3.0 star property
4.6 km from Mayo Clinic Florida
9.4 out of 10, Exceptional, (1,003 reviews)
"Great place. Not too far from beach and not too far from Mayo clinic! "
United States
Randy
The price is 3.451.981 ₫
3.917.999 ₫ total
includes taxes & fees
10 May - 11 May
Holiday Inn Express Jacksonville Beach by IHG

The Hotel Palms Courtyard

The Hotel Palms Courtyard
3.5 star property
7.8 km from Mayo Clinic Florida
9.6 out of 10, Exceptional, (295 reviews)
"Very cute updated 60’s-vibe motel. Perfect for our short stay in the Jacksonville beach area. We checked in on our own, with no problems. (Clear instructions emailed the day before.) The room Was clean, amenities nice, comfortable bed with lots of pillows. We did not have housekeeping, but technically really didn’t need. There was a coffee shop on premises, which is apparently popular with local runners after their beach run, and because our room was upfront across from the shop, we had about...
United States
Jill
The price is 5.010.223 ₫
5.686.603 ₫ total
includes taxes & fees
3 May - 4 May
The Hotel Palms Courtyard

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
2.5 star property
4.2 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (1,078 reviews)
"Friendly staff- very convenient for Mayo Hospital Apts."
United States
Marcia
The price is 3.562.013 ₫
4.042.885 ₫ total
includes taxes & fees
17 May - 18 May
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

The Lodge and Club at Ponte Vedra Beach

The Lodge and Club at Ponte Vedra Beach
5.0 star property
6.3 km from Mayo Clinic Florida
9.4 out of 10, Exceptional, (691 reviews)
"Fantastic stay at The Ponte Vedra Lodge and Club!!! This hotel met and exceeded my expectations, especially in regard to my clean and spacious room, which was convenient to both the pool and beach!!"
United States
Tracey
The price is 14.469.444 ₫
16.897.754 ₫ total
includes taxes & fees
31 May - 1 Jun
The Lodge and Club at Ponte Vedra Beach

Ponte Vedra Inn & Club

Ponte Vedra Inn & Club
5.0 star property
6.3 km from Mayo Clinic Florida
9.4 out of 10, Exceptional, (822 reviews)
"The Lodge at Ponte Vedra is truly exceptional. The staff goes above and beyond to make you feel welcome and cared for. The accommodations are elegant, comfortable, and immaculately maintained. Every detail—from the beautiful ocean views to the outstanding amenities—makes for a luxurious and relaxing experience. An unforgettable stay, and I can’t wait to return."
United States
James
The price is 14.469.444 ₫
16.897.754 ₫ total
includes taxes & fees
1 Jun - 2 Jun
Ponte Vedra Inn & Club

AC Hotel Jacksonville St Johns Town Center

AC Hotel Jacksonville St Johns Town Center
2.5 star property
Southside, 8.1 km from Mayo Clinic Florida
9.4 out of 10, Exceptional, (191 reviews)
"Best hotel in Jacksonville. Staff is outstanding, location is perfect and amenities are really impressive "
United States
JOHN
The price is 4.717.724 ₫
5.354.617 ₫ total
includes taxes & fees
10 May - 11 May
AC Hotel Jacksonville St Johns Town Center

TownePlace Suites by Marriott® Jacksonville Mayport

TownePlace Suites by Marriott® Jacksonville Mayport
3.0 star property
10.8 km from Mayo Clinic Florida
9.6 out of 10, Exceptional, (99 reviews)
"Loved the staff, the cleanliness, and the food was excellent. Really enjoyed my stay here!!"
United States
Toni
The price is 3.662.789 ₫
4.157.265 ₫ total
includes taxes & fees
10 May - 11 May
TownePlace Suites by Marriott® Jacksonville Mayport

Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach
2.5 star property
5.9 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (3,898 reviews)
"I have to be seen at Mayo Clinic every year and I found that this hotel is perfect. It’s a short drive to Mayo and the hotel is clean, has a large comfortable lounge, restaurant, and a cafe where you can get pizza, sodas etc and misc items. I found that the shower floor to be extremely slippery and worse when the liquid soap coated the basin. The employees from the front desk to housekeeping were very polite and helpful to make your stay relaxing and you have to love the sound of the waves...
United States
Christopher
The price is 4.483.156 ₫
5.088.382 ₫ total
includes taxes & fees
6 May - 7 May
Margaritaville Jacksonville Beach

Best Western Oceanfront

Best Western Oceanfront
3.0 star property
5.7 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (1,006 reviews)
"Great location, the beach and restaurants are right there! Clean rooms, good breakfast, tea and coffee in the lobby around the clock. Beach towels provided. Highly recommend!"
United States
Tatyana
The price is 3.668.492 ₫
4.163.739 ₫ total
includes taxes & fees
4 May - 5 May
Best Western Oceanfront

Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
3.0 star property
8.5 km from Mayo Clinic Florida
9.2 out of 10, Wonderful, (1,000 reviews)
"We were extremely pleased with our room and the breakfast. The staff was fantastic & very helpful at every turn :) "
United States
Tonya
The price is 3.674.026 ₫
4.096.539 ₫ total
includes taxes & fees
25 May - 26 May
Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

Holiday Inn Express & Suites Jacksonville - Town Center by IHG

Holiday Inn Express & Suites Jacksonville - Town Center by IHG
2.5 star property
Southside, 7.7 km from Mayo Clinic Florida
9.6 out of 10, Exceptional, (1,000 reviews)
"Room clean, excellent location near shooping and Restaurants. Good breakfast. 14 minutes to Mayo Clinic."
United States
Damaris
The price is 3.372.928 ₫
3.828.273 ₫ total
includes taxes & fees
17 May - 18 May
Holiday Inn Express & Suites Jacksonville - Town Center by IHG

Springhill Suites By Marriott Jacksonville Beach Oceanfront

Springhill Suites By Marriott Jacksonville Beach Oceanfront
4.0 star property
5.8 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (679 reviews)
"We stay here once a year and always enjoy it. Staff is great and so is the breakfast"
United States
Selina
The price is 5.903.744 ₫
6.700.750 ₫ total
includes taxes & fees
14 May - 15 May
Springhill Suites By Marriott Jacksonville Beach Oceanfront
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Compare popular hotels close to Mayo Clinic Florida

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
Lobby lounge
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
3.0 star property
9.4
Exceptional
493 reviews
View
Breakfast, lunch, dinner served; American cuisine
Hilton Jacksonville At Mayo Clinic
4.5 star property
9.4
Exceptional
217 reviews
View
Terrace/patio
TownePlace Suites by Marriott Jacksonville East
3.0 star property
9.2
Wonderful
607 reviews
View
Lobby
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
2.5 star property
9.0
Wonderful
1,001 reviews
View
Lobby sitting area
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
2.5 star property
8.8
Excellent
1,000 reviews
View

Top Mayo Clinic Florida Hotel Reviews

Frequently asked questions

What's the area like around Mayo Clinic Florida?
Mayo Clinic Florida is located in a welcoming area of Jacksonville known for its beautiful beaches and surfing. If you're looking for a convenient place to stay, take a look at the 49 hotels and other accommodation options you'll find within a mile.
How many hotels are there near Mayo Clinic Florida?
Expedia has 49 hotels and other accommodation options within a mile from Mayo Clinic Florida.
If I need to cancel the hotel reservation for my stay near Mayo Clinic Florida, will I receive a refund?
Yes! You'll find that most hotel bookings are fully refundable as long as you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you have a non-refundable reservation, you may still be able to cancel and get a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to view the top deals on offer near Mayo Clinic Florida.
What can I see and do near Mayo Clinic Florida?
You can catch a show at SeaWalk Pavillion, Players by the Sea and SeaWalk Pavillion. Spend some time exploring the the natural beauty of Huguenot Park, Oceanfront Park and Cradle Creek Preserve. Lounge by the water at Northeast Florida Beaches and Ponte Vedra Beach.

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