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Check availability on Mesagne Spa Hotels

Our top choices for Mesagne hotels with a spa

Indoor spa tub
Tenuta Moreno

Tenuta Moreno

4.0 star property
Mesagne
8.4 out of 10, Very good, (57)
"Staff are lovely, especially Sonia in the restaurant! Pool is especially great - absolutely massive with loads of sun bed space."
United Kingdom
Alison
The price is 4.050.971 ₫
4.456.068 ₫ total
includes taxes & fees
11 Dec - 12 Dec
Tenuta Moreno
Couples treatment room(s), Turkish bath/hammam, body treatments
Hotel Monte Sarago

Hotel Monte Sarago

4.0 star property
Ostuni
9.2 out of 10, Wonderful, (268)
"Ecellent stay "
United Kingdom
maria
The price is 2.771.065 ₫
3.232.306 ₫ total
includes taxes & fees
10 Dec - 11 Dec
Hotel Monte Sarago
Seasonal outdoor pool
Le Scuderie - Castello Monaci

Le Scuderie - Castello Monaci

Salice Salentino
10.0 out of 10, Exceptional, (16)
"Beautiful place! And the staff amazing"
United States
Erika
Le Scuderie - Castello Monaci
Couples treatment room(s), sauna, hot tub, steam room
Laurito Resort & Spa

Laurito Resort & Spa

3.0 star property
Oria
8.8 out of 10, Excellent, (38)
"I noticed that the hallways were not cleaned otherwise everything outstanding."
United States
Anonymous traveller
Laurito Resort & Spa
Luxury Studio Suite (4) | Egyptian cotton sheets, premium bedding, down duvets, desk
FILIA SOLIS - Old Town SUITEs & SPA

FILIA SOLIS - Old Town SUITEs & SPA

Brindisi Historic Center
9.8 out of 10, Exceptional, (15)
"Had a wonderful stay at Filia Solis - the room was so beautiful and comfortable and the staff were incredibly communicative and helpful in providing recommendations. The location is great and very walkable. Would definitely return! "
Canada
Anonymous traveller
FILIA SOLIS - Old Town SUITEs & SPA
Couples treatment room(s), deep-tissue massages, Swedish massages
B&B Giardini di Marzo

B&B Giardini di Marzo

Lecce
9.6 out of 10, Exceptional, (22)
"Extremely friendly staff. Stefano made us feel welcomed. Conveniently located and very close to Lecce "
United States
Andre
B&B Giardini di Marzo
Suite, Balcony, Garden View | Balcony
Vinilia Wine Resort

Vinilia Wine Resort

4.0 star property
Manduria
9.4 out of 10, Exceptional, (84)
"Gorgeous room, a very peaceful stay "
United Kingdom
Camilla
Vinilia Wine Resort
Spa
Villa Neviera - Wine Resort and Spa

Villa Neviera - Wine Resort and Spa

San Donaci
10.0 out of 10, Exceptional, (1)
The price is 2.578.728 ₫
2.836.601 ₫ total
includes taxes & fees
7 Jan - 8 Jan 2026
Villa Neviera - Wine Resort and Spa
Junior Suite | In-room safe, iron/ironing board, free WiFi
Filippo de Raho Agri Bio Relais

Filippo de Raho Agri Bio Relais

Lecce
10.0 out of 10, Exceptional, (6)
"What a place! Swimming pool, dinners and breakfasts under orange trees, so much character and history. It’s place to return again and again! "
United Kingdom
Kristine
The price is 5.405.479 ₫
6.038.095 ₫ total
includes taxes & fees
16 Dec - 17 Dec
Filippo de Raho Agri Bio Relais
Couples treatment room(s), sauna, hot tub, steam room, body treatments
Ostuni Palace Hotel Bistrot & SPA

Ostuni Palace Hotel Bistrot & SPA

4.0 star property
Ostuni
9.2 out of 10, Wonderful, (145)
"Fantastic place!!!"
Australia
Joshua
The price is 3.412.636 ₫
3.938.035 ₫ total
includes taxes & fees
12 Dec - 13 Dec
Ostuni Palace Hotel Bistrot & SPA
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Mesagne Hotel Reviews

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Frequently asked questions

Looking to holiday at a spa hotel in Mesagne?
Book one of our lush spa hotels and pamper yourself from the moment you arrive. Enjoy the historical sites and restaurants in Mesagne—your day trip starts here. Take in the culture at the monuments and museums during your stay. Spa hotels are a great way to break out of your routine and add a layer of luxury to your stay.
How many spa hotels are there in Mesagne?
Among Expedia's 75 accommodation options in Mesagne, there are 3 spa hotels.
What's there to see and do in Mesagne?
When you're in Mesagne, enjoy exploring the sights and attractions here including Mesagne Castle, Court of Brindisi and Carrisiland Resort. If you have some spare time during your trip, you might want to check out Castle Dentice di Frasso and Cathedral of Brindisi.
What is a Mesagne spa hotel?
Spa hotels in Mesagne provide lodging and have a full on-site spa which offers services such as massages as well as body treatments. Some also offer in-room treatments. Spa hotels are great for rest, rejuvenation and relaxation.