The Best Hotels in Middletown, San Diego - 2026 Updated Prices

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for Middletown hotels

A modern living room with a sofa, a coffee table, and a rug. There is a kitchen area with cabinets and appliances.

1. City24 Hotel Little Italy Mission Hills

Middletown

Willie

4.224.134 ₫ total

includes taxes & fees

29 Nov - 30 Nov

A high-rise building complex with multiple floors, large windows, and a waterfront view.

2. Manchester Grand Hyatt San Diego

Marina District, 3.4 km from Middletown

Petra

6.368.030 ₫ total

includes taxes & fees

9 Dec - 10 Dec

A modern hotel with a courtyard featuring outdoor seating, a chess table, and a well-maintained lawn.

3. Hampton Inn & Suites by Hilton San Diego SeaWorld Near Old Town

3.3 km from Middletown

David

3.984.525 ₫ total

includes taxes & fees

22 Nov - 23 Nov

A spacious lobby with modern furniture, large windows, and a high ceiling with hanging lights.

4. Legacy Resort Hotel & Spa

2.1 km from Middletown

Cesar

4.781.988 ₫ total

includes taxes & fees

22 Nov - 23 Nov

A spacious lobby with a large seating area, a wooden ceiling, and large windows offering a view of the outdoor patio area.

5. Hampton Inn & Suites San Diego Airport Liberty Station

3.6 km from Middletown

Dean

4.607.484 ₫ total

includes taxes & fees

22 Nov - 23 Nov

A hotel lobby with a waterfall feature, outdoor seating area, and multiple floors with balconies.

6. Crowne Plaza San Diego - Mission Valley by IHG

2.4 km from Middletown

Yesenia

3.252.678 ₫ total

includes taxes & fees

16 Nov - 17 Nov

An outdoor seating area with wicker chairs and a fire pit, surrounded by palm trees and string lights.

7. DoubleTree by Hilton Hotel San Diego - Mission Valley

3.6 km from Middletown

Monique

3.633.686 ₫ total

includes taxes & fees

24 Nov - 25 Nov

A bar area with a glass ceiling, a central bar counter, and multiple stools.

8. Lafayette Hotel & Club

3.6 km from Middletown

Heather

8.048.656 ₫ total

includes taxes & fees

18 Nov - 19 Nov

A room with a large window overlooking a marina with boats and a bridge in the distance.

9. Hilton Garden Inn San Diego Downtown/Bayside

1.5 km from Middletown

Luis

4.897.374 ₫ total

includes taxes & fees

15 Nov - 16 Nov

An outdoor seating area with fire pits, lounge chairs, and a modern building in the background.

10. Homewood Suites by Hilton San Diego Hotel Circle/SeaWorld Area

2.2 km from Middletown

Edith

4.190.389 ₫ total

includes taxes & fees

1 Dec - 2 Dec

A hotel entrance with a stone archway, a reception desk, and potted plants.

11. Holiday Inn Express San Diego Airport - Old Town by IHG

1.3 km from Middletown

Alejandra

4.014.744 ₫ total

includes taxes & fees

17 Nov - 18 Nov

A hotel with a curved entrance, palm trees, and a parking lot.

12. Handlery Hotel

2.4 km from Middletown

Helen

2.662.247 ₫ total

includes taxes & fees

13 Dec - 14 Dec

A balcony with wicker furniture overlooking a marina and a coastal cityscape.

13. Sheraton San Diego Resort

2.5 km from Middletown

Solair

4.717.267 ₫ total

includes taxes & fees

22 Nov - 23 Nov

A poolside view with a lounge chair, a towel, a tray with a drink and a coconut, and a pool with palm trees in the background.

14. San Diego Mission Bay Resort

Mission Bay, 5.6 km from Middletown

Aaroosh

6.937.377 ₫ total

includes taxes & fees

29 Nov - 30 Nov

A hotel room with a large window offering a city view, a bed, a chair, and a small table.

15. The DEXTRO Little Italy, BW Premier Collection

2.2 km from Middletown

Kelly

3.766.410 ₫ total

includes taxes & fees

19 Nov - 20 Nov

A hotel courtyard with outdoor seating, palm trees, and a view of the ocean at dusk.

16. Wyndham San Diego Bayside

2.3 km from Middletown

Danielle

5.063.442 ₫ total

includes taxes & fees

22 Nov - 23 Nov

An outdoor lounge area with seating, a fire feature, and a view of the building's interior.

17. Hampton Inn San Diego/Mission Valley

2.2 km from Middletown

Blake Douglas

3.733.926 ₫ total

includes taxes & fees

19 Nov - 20 Nov

A hotel complex with multiple buildings, a landscaped garden, and a body of water reflecting the sunset.

18. Homewood Suites by Hilton San Diego Airport/Liberty Station

4 km from Middletown

Alicia

5.294.421 ₫ total

includes taxes & fees

19 Nov - 20 Nov

A modern outdoor seating area with wicker chairs, a round table, and a fire pit.

19. TownePlace Suites by Marriott San Diego Downtown

2.6 km from Middletown

Brajesh

3.682.521 ₫ total

includes taxes & fees

14 Dec - 15 Dec

A hotel lobby with a 'Lobby' sign, palm trees, and a sunset sky.

20. Best Western Seven Seas

2.5 km from Middletown

James

2.494.197 ₫ total

includes taxes & fees

18 Nov - 19 Nov

View all properties

Compare top hotels in Middletown

City24 Hotel Little Italy Mission Hills 4.5 star property Middletown View	Manchester Grand Hyatt San Diego 4.0 star property Marina District, 3.4 km from Middletown View	Hampton Inn & Suites by Hilton San Diego SeaWorld Near Old Town 4.0 star property 3.3 km from Middletown View	Legacy Resort Hotel & Spa 4.0 star property 2.1 km from Middletown View	Hampton Inn & Suites San Diego Airport Liberty Station 2.5 star property 3.6 km from Middletown View
9.6 Exceptional 245 reviews	9.0 Wonderful 2,902 reviews	9.2 Wonderful 1,489 reviews	9.2 Wonderful 3,099 reviews	9.2 Wonderful 1,740 reviews
The price is 2.972.976 ₫ 4.224.134 ₫ total includes taxes & fees 29 Nov - 30 Nov	The price is 4.286.874 ₫ 6.368.030 ₫ total includes taxes & fees 9 Dec - 10 Dec	The price is 3.466.462 ₫ 3.984.525 ₫ total includes taxes & fees 22 Nov - 23 Nov	The price is 4.160.227 ₫ 4.781.988 ₫ total includes taxes & fees 22 Nov - 23 Nov	The price is 4.008.426 ₫ 4.607.484 ₫ total includes taxes & fees 22 Nov - 23 Nov
No Breakfast included No Pool No Spa No Pet-friendly Yes, WiFi included Yes, Parking	No Breakfast included Yes, Pool No Spa Yes, Pet-friendly No WiFi included Yes, Parking	Yes, Breakfast included Yes, Pool No Spa Yes, Pet-friendly Yes, WiFi included Yes, Parking	No Breakfast included Yes, Pool Yes, Spa No Pet-friendly Yes, WiFi included Yes, Parking	Yes, Breakfast included Yes, Pool No Spa Yes, Pet-friendly Yes, WiFi included Yes, Parking

Hotels recommended for families in Middletown

City24 Hotel Little Italy Mission Hills

Middletown

4.224.134 ₫ total

includes taxes & fees

29 Nov - 30 Nov

Where to stay in Middletown

Find the best Middletown areas for the activities you enjoy most.

A large stadium with the sign "Cobo Park" and palm trees around it.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

See properties

A pier extending into the ocean with buildings at the end, under a partly cloudy sky.

Pacific Beach

The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Pacific Beach while you're exploring the area.

See properties

Gaslamp Quarter

Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Nova SD – discover Gaslamp Quarter, a destination also famous for its shopping.

See properties

A coastal cityscape with a long sandy beach, a pier, and dense urban buildings.

Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.

See properties

An aerial view of a coastal city with a marina, a large body of water, and a peninsula with buildings.

Mission Bay

If you're spending some time in Mission Bay, Mission Bay and Ski Beach are top sights worth seeing.

See properties

Top Middletown Hotel Reviews

Holiday Inn Express San Diego Airport - Old Town by IHG

Mission Hills

10/10 Excellent

Mark

A breakfast buffet area with a stone wall, a coffee station, and a fruit display.

Hampton Inn San Diego-Kearny Mesa

Kearny Mesa

10/10 Excellent

We selected this hotel for location, however the services provided by the hotel and staff were excellent. Staff could not have been more helpful, from the manager (very visible during our stay), to reception and housekeeping staff. The complimentary breakfast was very good, and again staff couldn't have been more attentive during this service. Rooms were well equipped (even had a microwave). I would highly recommend this hotel.

Claire

The DEXTRO Little Italy, BW Premier Collection

Downtown San Diego

10/10 Excellent

Nicola

TownePlace Suites by Marriott San Diego Downtown

Downtown San Diego

10/10 Excellent

Ruth

A hotel room with two beds, a desk, a chair, and a large window with a view of the outdoors.

Best Western Yacht Harbor Hotel

Point Loma

10/10 Excellent

George

Comfort Inn San Diego - SeaWorld Area

Point Loma

10/10 Excellent

Ehud

An outdoor patio area with tables and chairs, string lights, and a building with balconies.

Fairfield Inn & Suites San Diego Old Town

Old Town San Diego

8/10 Good

Ensari

A hotel with a Holiday Inn Express sign, a modern building with balconies, and a view of the city skyline at night.

Holiday Inn Express San Diego Downtown by IHG

Downtown San Diego

10/10 Excellent

Ben

Homewood Suites by Hilton San Diego Hotel Circle/SeaWorld Area

Mission Valley

10/10 Excellent

Busayo

Handlery Hotel

Mission Valley

10/10 Excellent

STEVE

City24 Hotel Little Italy Mission Hills

Middletown

10/10 Excellent

The Family Room was beautifully decorated. It is clean with loads of space and a very thoughtful layout. It is more than enough for 2 adults and 4 children (3 teens and 1 x 8 year old). It is equipped with quality high tech appliances and loads of USB / USBC sockets and therefore not requiring plugs and adapters. Some can find it a bit out of the way, but given we were driving, it is a very easy and convenient location. Close to the airport and within walking distance to Little...

Suzanne

Frequently Asked Questions

What's it like in Middletown?

Middletown is a neighbourhood that travellers like for its live music, bars and theatres. Consider a visit to The Casbah San Diego as part of your Middletown travel plans.

How many hotels can I expect to find in the Middletown area?

Expedia has 74 hotels and other accommodation options in Middletown to choose from, making this an ideal home base for exploring the greater San Diego area.

If I need to cancel my hotel reservation in Middletown, will I receive a refund?

Yes! The majority of hotel reservations are fully refundable provided that you cancel before the hotel’s cancellation deadline, which in most cases is within 24 or 48 hours of the scheduled arrival. If you have a non-refundable reservation, you might be able to cancel it and be given a refund within 24 hours of booking. Put your dates in and click on "Search", then use the "fully refundable" filter to view top deals in Middletown.

What are the top things to see and do in Middletown?

The Casbah San Diego is an attraction you might want to check out while you're in Middletown. When you're sightseeing in San Diego, San Diego Zoo and Marine Corps Recruit Depot are also worth a stop.

How can I get around Middletown and the greater San Diego area?

Ready to get out and explore the city? Middletown Station is the closest metro station.

Explore a world of travel with Expedia

Cars

Search Hotels in Middletown, San Diego

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Property class

Guest rating

Our top choices for Middletown hotels

1. City24 Hotel Little Italy Mission Hills

2. Manchester Grand Hyatt San Diego

3. Hampton Inn & Suites by Hilton San Diego SeaWorld Near Old Town

4. Legacy Resort Hotel & Spa

5. Hampton Inn & Suites San Diego Airport Liberty Station

6. Crowne Plaza San Diego - Mission Valley by IHG

7. DoubleTree by Hilton Hotel San Diego - Mission Valley

8. Lafayette Hotel & Club

9. Hilton Garden Inn San Diego Downtown/Bayside

10. Homewood Suites by Hilton San Diego Hotel Circle/SeaWorld Area

11. Holiday Inn Express San Diego Airport - Old Town by IHG

12. Handlery Hotel

13. Sheraton San Diego Resort

14. San Diego Mission Bay Resort

15. The DEXTRO Little Italy, BW Premier Collection

16. Wyndham San Diego Bayside

17. Hampton Inn San Diego/Mission Valley

18. Homewood Suites by Hilton San Diego Airport/Liberty Station

19. TownePlace Suites by Marriott San Diego Downtown

20. Best Western Seven Seas

Compare top hotels in Middletown

City24 Hotel Little Italy Mission Hills

Manchester Grand Hyatt San Diego

Hampton Inn & Suites by Hilton San Diego SeaWorld Near Old Town

Legacy Resort Hotel & Spa

Hampton Inn & Suites San Diego Airport Liberty Station

Hotels recommended for families in Middletown

City24 Hotel Little Italy Mission Hills

Where to stay in Middletown

Downtown San Diego

Pacific Beach

Gaslamp Quarter

Mission Beach

Mission Bay

Top Middletown Hotel Reviews

Holiday Inn Express San Diego Airport - Old Town by IHG

10/10 Excellent

Frequently Asked Questions

What's it like in Middletown?

How many hotels can I expect to find in the Middletown area?

If I need to cancel my hotel reservation in Middletown, will I receive a refund?

What are the top things to see and do in Middletown?

How can I get around Middletown and the greater San Diego area?

Explore a world of travel with Expedia