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Check availability on Mission Valley Business Hotels

Our top choices for Mission Valley business-friendly hotels

Terrace/patio
Hampton Inn San Diego/Mission Valley

Hampton Inn San Diego/Mission Valley

Hampton Inn San Diego/Mission Valley
2.5 star property
Mission Valley
8.8 out of 10, Excellent, (1279)
"Room was clean,buffet bkfast was good,staff were friendly & helpful!"
United States
Barry
The price is 2.483.381 ₫
2.854.522 ₫ total
includes taxes & fees
5 Jan - 6 Jan 2026
Hampton Inn San Diego/Mission Valley
Outdoor pool
Crowne Plaza San Diego - Mission Valley by IHG

Crowne Plaza San Diego - Mission Valley by IHG

Crowne Plaza San Diego - Mission Valley by IHG
3.5 star property
Mission Valley
7.8 out of 10, Good, (1004)
"Good value Nice place to stay "
United States
John
The price is 2.325.539 ₫
2.684.077 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Crowne Plaza San Diego - Mission Valley by IHG
Outdoor pool, a heated pool
Days Inn by Wyndham San Diego Hotel Circle

Days Inn by Wyndham San Diego Hotel Circle

Days Inn by Wyndham San Diego Hotel Circle
3.0 star property
Mission Valley
8.0 out of 10, Very good, (2437)
"All was very nice. "
United States
Milton
The price is 2.325.539 ₫
2.673.091 ₫ total
includes taxes & fees
15 Dec - 16 Dec
Days Inn by Wyndham San Diego Hotel Circle
Garden
Legacy Resort Hotel & Spa

Legacy Resort Hotel & Spa

Legacy Resort Hotel & Spa
4.0 star property
Mission Valley
9.2 out of 10, Wonderful, (2947)
"Friendly, staff was very helpful, great size rooms, and over all was an amazing stay"
United States
Naya
The price is 4.002.610 ₫
4.600.800 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Legacy Resort Hotel & Spa
Lobby
Hilton San Diego Mission Valley

Hilton San Diego Mission Valley

Hilton San Diego Mission Valley
4.0 star property
Mission Valley
8.0 out of 10, Very good, (2242)
"Excelente hotel"
Mexico
Julio
The price is 3.108.172 ₫
3.572.688 ₫ total
includes taxes & fees
19 Dec - 20 Dec
Hilton San Diego Mission Valley
Breakfast and dinner served
Courtyard by Marriott San Diego Mission Valley/Hotel Circle

Courtyard by Marriott San Diego Mission Valley/Hotel Circle

Courtyard by Marriott San Diego Mission Valley/Hotel Circle
3.5 star property
Mission Valley
8.4 out of 10, Very good, (1439)
"Good place to stay, and clean"
United States
Yuke
The price is 2.609.654 ₫
2.999.667 ₫ total
includes taxes & fees
5 Jan - 6 Jan 2026
Courtyard by Marriott San Diego Mission Valley/Hotel Circle
Terrace/patio
DoubleTree by Hilton San Diego - Hotel Circle

DoubleTree by Hilton San Diego - Hotel Circle

DoubleTree by Hilton San Diego - Hotel Circle
4.0 star property
Mission Valley
7.4 out of 10, Good, (1772)
"Staff were very nice and helpful."
United States
Allen
The price is 3.108.172 ₫
3.572.688 ₫ total
includes taxes & fees
19 Dec - 20 Dec
DoubleTree by Hilton San Diego - Hotel Circle
Outdoor pool, pool umbrellas, pool loungers
Handlery Hotel

Handlery Hotel

Handlery Hotel
3.5 star property
Mission Valley
8.2 out of 10, Very good, (2228)
"Staff was amazing and very accommodating. Always recommended staying here. "
United States
Taja
Handlery Hotel
Terrace/patio
Homewood Suites by Hilton San Diego Hotel Circle/SeaWorld Area

Homewood Suites by Hilton San Diego Hotel Circle/SeaWorld Area

Homewood Suites by Hilton San Diego Hotel Circle/SeaWorld Area
3.0 star property
Mission Valley
8.8 out of 10, Excellent, (1295)
"Great location from restaurants and shopping malls and just 15. Min away from downtown The rooms.are great big highly recommend it "
United States
Carlos Gabriel
The price is 2.927.785 ₫
3.365.373 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Homewood Suites by Hilton San Diego Hotel Circle/SeaWorld Area
Outdoor pool
Sheraton Mission Valley San Diego Hotel

Sheraton Mission Valley San Diego Hotel

Sheraton Mission Valley San Diego Hotel
4.0 star property
Mission Valley
8.6 out of 10, Excellent, (1654)
"Decent room, great staff and close to am"
United States
siva
The price is 3.104.226 ₫
3.568.152 ₫ total
includes taxes & fees
18 Dec - 19 Dec
Sheraton Mission Valley San Diego Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Mission Valley Hotel Reviews

The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

10/10 Excellent
"Breakfast buffet was good. Room was clean. Friendly and helpful staff. San Diego was beautiful! "
Vito N 3-night trip
Posted 11 hours ago
The DEXTRO Little Italy, BW Premier Collection

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Frequently asked questions

Why book your business-friendly hotel in Mission Valley with Expedia?
We're here to help you find a fabulous business-friendly hotel when work takes you on the road. From room service and free WiFi to gyms and spas, our stays come with the conveniences you'll need to settle that big contract.
How can I find cheap business-friendly hotels in Mission Valley?
Select the "business friendly" filter, listed under the "traveller experience" heading, to find cheap business-friendly hotels in Mission Valley. Then fine-tune your search by your per-night budget. Looking for stays away from the centre is another good way to save.