Mississippi County Holidays

Book a Hotel + Flight or Car together to unlock savings

Top hotels in Mississippi County

Quality Inn Charleston - Sikeston

Quality Inn Charleston - Sikeston

2.5 out of 5
102 Drake St, I-57 Exit 10, Charleston, MO
Fully refundableReserve now, pay when you stay
The price is 1.733.470 ₫ per night from 7 Sept to 8 Sept
1.733.470 ₫
1.923.720 ₫ total
7 Sept - 8 Sept
includes taxes & fees
6.8/10 (397 reviews)
"My stay went well."

Reviewed on 4 Aug 2025

Quality Inn Charleston - Sikeston
Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

2 out of 5
310 S Story St, Charleston, MO
Fully refundableReserve now, pay when you stay
The price is 1.560.149 ₫ per night from 17 Aug to 18 Aug
1.560.149 ₫
1.731.376 ₫ total
17 Aug - 18 Aug
includes taxes & fees
6.6/10 (577 reviews)
"Located very close to the expanse of corn fields, quiet, clean rooms, everything is neat, the bathroom is also very clean. Friendly receptionist."

Reviewed on 1 Aug 2025

Super 8 by Wyndham Charleston/Sikeston East MO
Best Western Plus Sikeston

Best Western Plus Sikeston

2.5 out of 5
120 S Interstate Drive, Sikeston, MO
Fully refundableReserve now, pay when you stay
The price is 2.310.332 ₫ per night from 17 Aug to 18 Aug
2.310.332 ₫
2.633.200 ₫ total
17 Aug - 18 Aug
includes taxes & fees
8.2/10 Very Good! (1,000 reviews)
Nice staff
"Hotel was old but in decent condition. Toilets were extremely low even when I viewed a disabled unit. Beds were not very comfortable. Food options were good but only had no sugar syrup. juice was watered down and not very flavorful. Overall, staff were not and accommodating in spite of the hotel ..."

Reviewed on 5 Aug 2025

Best Western Plus Sikeston
See all 94 properties in Mississippi County
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Mississippi County holiday package cost?
The most affordable Mississippi County package is , so your dream getaway can become a reality — without spending an arm and a leg. Bundle flights, hotels, car rentals and more to create a package that matches your travelling style.
How do I get a cheap travel package to Mississippi County?
You'll save piles of cash if you bundle your flights, hotels and car rentals into a Mississippi County holiday package. Sometimes cheap means fewer options. But not with Expedia. We offer more than 550 partner airlines and 1null000null000 hotels across the world, so you'll always have plenty of variety to choose from. Want to save even more? Add some interesting activities to your package deal to unlock even more bargains! After all, travel is about more than simply getting to your destination.
What are the top hotels in Mississippi County?
East Prairie is one destination that most visitors to Mississippi County put on their itinerary. For a comfortable stay here, look up Super 8 by Wyndham Charleston MO and Quality Inn Charleston I-57.
How far in advance should I book my Mississippi County holiday?
Browse Expedia to compare airfares as soon as possible. In many cases, you can purchase a ticket up to 12 months prior to departure. If you don't see your preferred carrier, or you have to book last minute, fear not. Cheap fares to Mississippi County occasionally appear just weeks before the date of departure.
What does an Expedia Mississippi County travel package include?
That depends on what you're looking for. If you're travelling alone, you might decide to combine hotels and flights. Bringing the whole crew to Mississippi County? A travel package including rental cars, flights and hotels might be a better fit. Expedia gives you the flexibility to build your own travel package.
What should I know before booking a Mississippi County travel package?
You'll enjoy amazing savings when you combine your flights, hotels and rental cars into a package. Plus, booking everything together will make your trip planning easier. So why waste your money or time? Whether you're organising a luxury romantic escape or a budget solo adventure, explore our holiday packages today.
Can I choose my airline with a Mississippi County Expedia holiday package?
Yes — that's the beauty of an Expedia package. You're the boss! We have access to more than 550 airline partners around the world, so you have loads of choice when organising your Mississippi County adventure.
If I'm not able to travel, can I cancel my Mississippi County holiday package?
Yes, you can. We totally understand that even the best-laid plans can fail, so we're happy to help if you have to make changes to your Mississippi County holiday package. It may be possible to cancel or amend your itinerary at no cost if you've booked within 24 hours. Your airline, hotel or car rental company may impose a fee if your booking was made more than 24 hours ago. Head to our Customer Service Portal for further information. Also, be sure to check your itinerary for the nitty-gritty on change fees.