New Madrid County Holidays

Book a Hotel + Flight or Car together to unlock savings

Top destinations in New Madrid County

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Sikeston

Sikeston

Top hotels in New Madrid County

Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 out of 5
1240 Commerce Drive Sikeston MO
Fully refundableReserve now, pay when you stay
The price is 2.439.475 ₫ per night from 29 Mar to 30 Mar
2.439.475 ₫
2.762.095 ₫ total
29 Mar - 30 Mar
includes taxes & fees
9/10 Wonderful! (497 reviews)
Overall our stay was great with the exception of the room smelling like a dog had been living there. The order was in the carpet and the bed covers.

Reviewed on 9 Mar 2026

Hampton Inn Sikeston
Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG

2.5 out of 5
115 Hospitality Dr Sikeston MO
Fully refundable
The price is 2.437.902 ₫ per night from 22 Mar to 23 Mar
2.437.902 ₫
2.760.315 ₫ total
22 Mar - 23 Mar
includes taxes & fees
8.6/10 Excellent! (449 reviews)
Nice room

Reviewed on 5 Mar 2026

Holiday Inn Express & Suites Sikeston Southwest by IHG
New Orleans Inn Portageville

New Orleans Inn Portageville

2.5 out of 5
600 US-61 Portageville MO
Fully refundableReserve now, pay when you stay
8/10 Very Good! (747 reviews)
The staff was great very helpful and friendly

Reviewed on 25 Feb 2026

Get rates
New Orleans Inn Portageville
See all 97 properties in New Madrid County
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a New Madrid County holiday package cost?
Customize your New Madrid County package from a low . Choose from any combination of hotels, flights and rental cars to pull together the getaway you've long been dreaming about. Remember to add on a few experiences or activities!
How do I get a cheap travel package to New Madrid County?
Bundling your hotel and flight with Expedia won't just save you time — it'll save you a pretty penny too. A New Madrid County holiday package makes it easy to put together your dream adventure. With more than 550 airlines across the world to choose from, finding convenient flights that fit your schedule won't be a hassle. Not only that, we've got over 1null000null000 properties globally to pick from. Now that's what we call choice. No matter who you are, Expedia puts more of the world within your reach.
What are the top hotels in New Madrid County?
Portageville is one place that most visitors to New Madrid County include in their itinerary. For a memorable stay here, check out Hampton Inn Sikeston and Holiday Inn Express & Suites Sikeston Southwest, an IHG Hotel.
How far in advance should I book my New Madrid County holiday?
To bag cheap prices, book nice and early. Air carriers usually advertise flights, along with some of the lowest fares, up to 12 months prior to departure. Hotels, activities and car rental should also be booked early so you can have the pick of the bunch. If you've decided on a last-minute getaway in New Madrid County, there are always plenty of great bargains to be had on Expedia. Book your escape today!
What does an Expedia New Madrid County travel package include?
Packages include hotels, rental cars and flights, but you can combine any of them to create your dream New Madrid County escape. You can also add on fun stuff like activities and tours once you've made your booking. You're in charge! When you bundle your bookings with Expedia, you'll score discounts you won't find elsewhere.
What should I know before booking a New Madrid County travel package?
You'll score great savings when you bundle your hotels, flights and rental cars into a package. Plus, booking everything in one spot makes trip planning easier. So why waste time or money? Whether you're organising a luxury romantic escape or a budget solo adventure, take a look at our holiday packages today.
Can I choose my airline with a New Madrid County Expedia holiday package?
Yes — and it's simple too. Expedia has access to more than 550 partner airlines around the world. Our holiday packages give you the flexibility to take your pick of available flight, hotel or activity options that fit your needs.
If I'm not able to travel, can I cancel my New Madrid County holiday package?
You sure can, and we're here to help. You may be able to change or cancel your New Madrid County holiday package for free within 24 hours of booking. But you may be charged a fee by your airline, hotel or car rental company for older bookings. If your circumstances suddenly change, visit our Customer Service Portal for further information.