Find hotels in O Brien, FL from 1.547.889 ₫
- Change your mindBook hotels with free cancellation
- Be pickySearch almost a million properties worldwide
Go beyond your typical stay in O Brien
Family friendly
Cottage
Check prices for these dates
Top 10 O Brien hotels and places to stay

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
Alachua
9.4 out of 10, Exceptional, (1010)
The price is 2.979.245 ₫
3.351.650 ₫ total
includes taxes & fees
21 Dec - 22 Dec

Americas Best Value Inn Alachua
Alachua
4.8 out of 10, (596)
The price is 1.512.692 ₫
1.701.779 ₫ total
includes taxes & fees
2 Dec - 3 Dec

La Quinta Inn & Suite by Wyndham Lake City
Lake City
8.8 out of 10, Excellent, (1023)
The price is 2.330.666 ₫
2.621.999 ₫ total
includes taxes & fees
9 Dec - 10 Dec

Hampton Inn & Suites Alachua I-75
Alachua
9.4 out of 10, Exceptional, (468)
The price is 2.678.684 ₫
3.013.519 ₫ total
includes taxes & fees
10 Dec - 11 Dec

Best Western Plus Lake City
Lake City
9.2 out of 10, Wonderful, (1016)
The price is 2.135.565 ₫
2.402.511 ₫ total
includes taxes & fees
9 Dec - 10 Dec

High Springs Country Inn
High Springs
8.4 out of 10, Very good, (15)
The price is 1.945.737 ₫
2.188.954 ₫ total
includes taxes & fees
10 Dec - 11 Dec
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Learn more about O Brien
Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.

Top O Brien Hotel Reviews

Motel 6 – Lake City, Fl – Medical Center
10/10 Excellent

Postcard Cabins Gilchrest Spring, Outdoor Collection by Marriott Bonvoy
10/10 Excellent
More cheap stays in O Brien

Best Western Plus Lake City
350 SW Florida Gateway Dr Lake City FL
The price is 2.135.565 ₫ per night from 9 Dec to 10 Dec
2.135.565 ₫
2.402.511 ₫ total
9 Dec - 10 Dec
includes taxes & fees
9/10 Wonderful! (1,011 reviews)
Hotels in O Brien with star rating

3 Star Hotels
19 properties

2 Star Hotels
36 properties
Frequently asked questions
Explore a world of travel with Expedia
Accommodation near O Brien attractions
- Hotels near Ichetucknee Springs State Park
- Hotels near Ginnie Spring
- Hotels near Ruth B. Kirby Gilchrist Blue Springs State Park
- Hotels near Santa Fe River
- Hotels near Ichetucknee River
- Hotels near Southside Sports Complex
- Hotels near Lake City Veterans Affairs Medical Center
- Hotels near Southside Recreation Complex
- Hotels near Poe Springs Park
- Hotels near Lake City Mall
- Hotels near Stephen Foster State Folk Center
- Hotels near Florida Department of Transportation
- Hotels near Lafayette Blue Springs State Park
- Hotels near Bob's River Place
- Hotels near Big Shoals State Park
- Hotels near Troy Spring State Park
- Hotels near Blue Sink Canoe Launch
Hotels Near O Brien, Florida
More ways to book
Expedia's Latest Trends
Flights
















































































