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Our top choices for Palestine Regional Medical Center hotels

Lobby
Comfort Suites Palestine

Comfort Suites Palestine

Comfort Suites Palestine
2.5 star property
0.8 km from Palestine Regional Medical Center
9.2 out of 10, Wonderful, (876)
"Room was clean, breakfast was great "
United States
Christopher
The price is 2.947.543 ₫
3.389.675 ₫ total
includes taxes & fees
9 Jan - 10 Jan 2026
Comfort Suites Palestine
Reception
Hampton Inn & Suites Palestine

Hampton Inn & Suites Palestine

Hampton Inn & Suites Palestine
2.5 star property
0.8 km from Palestine Regional Medical Center
9.0 out of 10, Wonderful, (623)
"Super clean. Quick and easy check in "
United States
Constance
The price is 2.805.179 ₫
3.225.955 ₫ total
includes taxes & fees
30 Dec - 31 Dec
Hampton Inn & Suites Palestine
Studio Suite, 1 King Bed, Non Smoking (Limited View) | Premium bedding, pillow-top beds, desk, blackout curtains
La Quinta Inn & Suites by Wyndham Palestine

La Quinta Inn & Suites by Wyndham Palestine

La Quinta Inn & Suites by Wyndham Palestine
3.0 star property
0.2 km from Palestine Regional Medical Center
8.8 out of 10, Excellent, (863)
"I always recommend LaQuinta Inns to my friends"
United States
Karen
The price is 3.026.225 ₫
3.480.158 ₫ total
includes taxes & fees
9 Jan - 10 Jan 2026
La Quinta Inn & Suites by Wyndham Palestine
Suite, 1 King Bed, Non Smoking, Jetted Tub | Desk, blackout curtains, free WiFi, bed sheets
Premier Inn Palestine

Premier Inn Palestine

Premier Inn Palestine
2.5 star property
3 km from Palestine Regional Medical Center
6.8 out of 10, (317)
"It was very clean and my room was well accommodated with a fridge, microwave, And a huge bed."
United States
Nathaniel
The price is 1.723.369 ₫
1.981.875 ₫ total
includes taxes & fees
6 Jan - 7 Jan 2026
Premier Inn Palestine
Standard Room, Multiple Beds, Non Smoking, Refrigerator & Microwave | In-room safe, desk, laptop workspace, iron/ironing board
Best Western Palestine Inn

Best Western Palestine Inn

Best Western Palestine Inn
2.5 star property
3.2 km from Palestine Regional Medical Center
7.8 out of 10, Good, (524)
"Yes"
United States
Leigh
The price is 1.899.943 ₫
2.184.935 ₫ total
includes taxes & fees
5 Jan - 6 Jan 2026
Best Western Palestine Inn
BBQ/picnic Area
Super 8 by Wyndham Palestine

Super 8 by Wyndham Palestine

Super 8 by Wyndham Palestine
2.0 star property
4.3 km from Palestine Regional Medical Center
7.8 out of 10, Good, (414)
"Rooms were clean and staff was very nice. "
United States
Donna
The price is 1.918.363 ₫
2.206.118 ₫ total
includes taxes & fees
22 Dec - 23 Dec
Super 8 by Wyndham Palestine
Exterior
Holiday Inn Express Palestine by IHG

Holiday Inn Express Palestine by IHG

Holiday Inn Express Palestine by IHG
2.5 star property
4.7 km from Palestine Regional Medical Center
8.8 out of 10, Excellent, (590)
"Clean room, staff was friendly and helpful "
United States
Jackie
The price is 3.131.485 ₫
3.601.208 ₫ total
includes taxes & fees
5 Jan - 6 Jan 2026
Holiday Inn Express Palestine by IHG
Free WiFi, bed sheets
Motel 6 Palestine, TX

Motel 6 Palestine, TX

Motel 6 Palestine, TX
2.0 star property
4.9 km from Palestine Regional Medical Center
7.8 out of 10, Good, (290)
"The room was extremely clean, appeared to be recently updated. Very nice. Courteous staff."
United States
Karen
The price is 1.973.625 ₫
2.269.670 ₫ total
includes taxes & fees
22 Dec - 23 Dec
Motel 6 Palestine, TX
Outdoor pool
Express Inn & Suites

Express Inn & Suites

Express Inn & Suites
2.5 star property
4.7 km from Palestine Regional Medical Center
7.4 out of 10, Good, (523)
"Excellent location, great staff, clean property and close proximity to local attractions."
United States
Roger
The price is 1.716.264 ₫
1.973.704 ₫ total
includes taxes & fees
1 Jan - 2 Jan 2026
Express Inn & Suites
Standard Room, 1 King Bed, Non Smoking | Free WiFi
Rodeway Inn Palestine

Rodeway Inn Palestine

Rodeway Inn Palestine
2.5 star property
4.6 km from Palestine Regional Medical Center
7.2 out of 10, Good, (43)
"No hot water at all, bathroom sink wouldnt drain. Stains on thr top sheet and black hair on the pillow case. "
United States
Michael
The price is 1.453.641 ₫
1.671.688 ₫ total
includes taxes & fees
20 Jan - 21 Jan 2026
Rodeway Inn Palestine
Lobby
Budget Inn By OYO Palestine Tx Hwy 79

Budget Inn By OYO Palestine Tx Hwy 79

Budget Inn By OYO Palestine Tx Hwy 79
2.5 star property
5.4 km from Palestine Regional Medical Center
4.2 out of 10, (25)
"This place is an hourly motel for prostitutes. Don’t book here. Mold on the walls, doors won’t close. Absolutely disgusting. "
United States
Leeah
The price is 1.208.623 ₫
1.547.807 ₫ total
includes taxes & fees
24 Dec - 25 Dec
Budget Inn By OYO Palestine Tx Hwy 79
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Palestine Regional Medical Center Hotel Reviews

Postcard Cabins Piney Woods, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Piney Woods, Outdoor Collection by Marriott Bonvoy

10/10 Excellent
"Always a perfect stay"
Joe 1-night trip
Posted 4 days ago
Postcard Cabins Piney Woods, Outdoor Collection by Marriott Bonvoy

Hotels near other Palestine Regional Medical Center attractions

Historic Anderson County Courthouse Located in Palestine, Texas

Anderson County Courthouse

4.1/5 (15 reviews)
Anderson County Courthouse is just one of the places to see in Palestine, so why not enjoy the other things to explore during your travels? Experience the entertainment choices and theatre scene in this family-friendly area.
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Texas State Railroad Station - Depot - Palestine Station.

Texas State Railroad: Palestine Depot

4.6/5 (58 reviews)
You can take time to visit Texas State Railroad: Palestine Depot during your travels to Palestine. Experience the festivals and theatre scene in this family-friendly area.
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Frequently asked questions

What's the area like around Palestine Regional Medical Center?
Palestine Regional Medical Center is located in Palestine. You'll find 22 hotels and other accommodations within a few miles for a convenient home base.
How many hotels will I find near Palestine Regional Medical Center?
Expedia has 22 hotels and other accommodation options a few miles from Palestine Regional Medical Center.
If I need to cancel the hotel reservation for my stay near Palestine Regional Medical Center, will I receive a refund?
Yes, most hotel room reservations are fully refundable if cancelled prior to the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of the scheduled arrival. If you have a non-refundable reservation, you might be able to cancel it and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then use the filter option "fully refundable" to review the top deals on offer near Palestine Regional Medical Center.
What can I see and do near Palestine Regional Medical Center?
Sights like Redlands Hotel and Palestine Community Theatre highlight some of the local culture. You might spend a leisurely day outdoors at Davey Dogwood Park and Green Park. If you want to see more of the surrounding area, you might plan a visit to Texas State Railroad: Palestine Depot and University of Texas at Tyler Palestine Campus.