Residence Inn Durham McPherson/Duke University Medical Center offers a refreshed retreat with practical comforts. Enjoy a to-go breakfast, relax by the lobby fireplace, and request complimentary grocery shopping. WiFi in all rooms and an area shuttle make attractions accessible.
Located in Trinity Park, a neighbourhood in Durham, Residence Inn Durham McPherson/Duke University Medical Cntr is near a train station. Durham Performing Arts Center and Sarah P. Duke Gardens are local attractions and those in the mood for shopping can visit Brightleaf Square and Northgate Mall. Looking to enjoy an event or a game while in town? See what's happening at Pauli Murray Center for History and Social Justice or Durham Bulls Athletic Park. Visit our Durham travel guide
1108 West Main Street, Durham, NC, 27701
What's nearby
Brightleaf Square
3 min walk - 0.3 km
Duke University
6 min walk - 0.6 km
Durham Convention Center
12 min walk - 1.1 km
Carolina Theatre
12 min walk - 1.1 km
Durham Performing Arts Center
16 min walk - 1.4 km
Getting around
Durham Station
8 min walk
Raleigh-Durham International Airport (RDU)
21 min drive
Restaurants
Atomic Clock Brewing Co
11 min walk
Grub Durham
12 min walk
The Can Opener
7 min walk
The Federal
3 min walk
It's A Southern Thing
7 min walk
About this property
Residence Inn Durham McPherson/Duke University Medical Cntr
Hotel remodelled in 2024 and located near Duke University
Consider a stay at Residence Inn Durham McPherson/Duke University Medical Cntr and take advantage of free on-the-go breakfast, a free food/drink shopping service and a terrace. In addition to dry cleaning/laundry services and a fireplace in reception, guests can connect to free in-room WiFi.
Other perks include:
A free local area shuttle, self-parking (surcharge) and express check-out
Express check-in, luggage storage and smoke-free property
A 24-hour front desk, coffee/tea in reception and laundry services
Guest reviews say great things about the helpful staff
Room features
All 147 rooms include comforts such as laptop-friendly workspaces and air conditioning, in addition to thoughtful touches such as free WiFi and desk chairs.
More conveniences in all rooms include:
Recycling and LED light bulbs
Shower/bath combinations, free toiletries and hairdryers
32-inch Smart TVs with Netflix and premium channels
Wardrobes/cupboards, separate sitting areas and kitchens
Free on-the-go breakfast available daily 7:00 AM to 9:00 AM
Coffee and tea in common areas
Things to do
24-hour gym
Family friendly
Dining table
Free area shuttle
Grocery/convenience store
In-room full-sized refrigerator/freezer
In-room kitchen
In-room microwave
Laundry facilities
Conveniences
24-hour front desk
Free newspapers in lobby
Grocery/convenience store
Laundry facilities
Luggage storage
Safe at front desk
Guest services
Change of bedsheets (on request)
Change of towels on request
Concierge services
Dry cleaning/laundry service
Free grocery shopping service
Housekeeping (daily)
Wedding services
Business services
2,530 square feet of conference space
Business centre
Computer station
Outdoors
Terrace
Accessibility
If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
Check-in start time: 3 PM; check-in end time: midnight
Express check-in available
Minimum check-in age - 21
Check-out
Check-out before noon
Contactless check-out
Express check-out available
Special check-in instructions
Front desk staff will greet guests on arrival at the property
Information provided by the property may be translated using automated translation tools
Access methods
Staffed front desk
Pets
Pets are allowed for an extra charge of USD 100.00 per pet (varies based on length of stay)
Service animals are welcome, and are exempt from fees
2 total (up to 45 kg per pet)
Restrictions apply; for more information contact the property on the number on the booking confirmation
Children and extra beds
Children are welcome
Rollaway/extra beds are not available.
Cots (infant beds) are not available
Payment types at the property
Important information
Optional extras
Self-parking fee: USD 15 per day
Pet fee: USD 100.00 per pet (varies based on length of stay)
Service animals are exempt from fees
The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.
You need to know
Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
Safety features at this property include a carbon monoxide detector, a fire extinguisher and a smoke detector
This property affirms that it follows the cleaning and disinfection practices of Commitment to Clean (Marriott)
We should mention
Guests under 18 years old are not allowed in the fitness facility, and guests under 18 years old are only allowed in the swimming pool and fitness facility with adult supervision
This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly)
Property is also known as
Residence Inn McPherson/Duke University Medical Cntr Hotel
Residence Inn Durham McPherson/Duke University Medical Cntr
Residence Inn McPherson/Duke University Medical Cntr
Residence Inn McPherson/Duke University Medical Cntr Hotel
Residence Inn McPherson/Duke University Medical Cntr Hotel
Residence Inn McPherson/Duke University Medical Cntr
Frequently asked questions
Is Residence Inn Durham McPherson/Duke University Medical Cntr pet-friendly?
Yes, Residence Inn Durham McPherson/Duke University Medical Cntr allows pets (limit 2 total) with a maximum weight of up to 45 kg per pet. There's a fee of USD 100.00 per pet, per stay. Service animals are exempt from fees. Some restrictions may apply, so please contact the property for more details.
How much does it cost to stay at Residence Inn Durham McPherson/Duke University Medical Cntr?
As of 27 Mar 2026, prices found for a 1-night stay for 2 adults at Residence Inn Durham McPherson/Duke University Medical Cntr on 30 Mar 2026 start from 4.381.534 ₫, excluding taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.
How much is parking at Residence Inn Durham McPherson/Duke University Medical Cntr?
Self-parking is available for USD 15 per day.
What time is check-in at Residence Inn Durham McPherson/Duke University Medical Cntr?
Check-in start time: 3 PM; check-in end time: midnight.
What time is check-out at Residence Inn Durham McPherson/Duke University Medical Cntr?
Checkout is at noon.
Where is Residence Inn Durham McPherson/Duke University Medical Cntr located?
Located in Trinity Park, this hotel is within a 10-minute walk of Brightleaf Square and Duke University. Carolina Theatre and Durham Convention Center are also within 15 minutes. Durham Station is 8 minutes by foot.
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Reviews
Residence Inn Durham McPherson/Duke University Medical Cntr Reviews
9.2
Wonderful
All reviews shown are from real guest experiences. Only travellers who have booked a stay with us can submit a review. We verify reviews according to our guidelines and publish all reviews, positive or negative.More informationOpens in a new window
Courteous staff, spotless rooms, comfortable bed and pillows.
Anna F
Stayed 4 nights in Dec 2025
Verified
6/10 Okay
Robert
30 Nov 2025
Liked: Cleanliness
3 of 5 drawers off track & stuck. "Extras" solicited included bid to upgrade at a charge for parking, late checkout, early checkin. 1/4 roll of toilet paper in room for the 3-day stay (had to request rm servicing, towels, etc. if you wanted them). Bar closed before published time, while breakfast stopped replenishing food before its time. All in all, what has been a pleasure in numerous past visits became a $$-focused, not customer-focused experience.
Nice hotel for the price. Good location. Big rooms. Quiet. Easy parking. Could be a little cleaner.
James
Stayed 2 nights in Oct 2025
Verified
10/10 Excellent
Anthony
27 Sep 2025
Liked: Amenities
Yes
Anthony
Stayed 4 nights in Sep 2025
Verified
8/10 Good
Maria
19 Aug 2025
Liked: Cleanliness, staff & service, amenities
Great location! You can walk to great restaurants and coffee shops. The room is clean and spacious. The bed is very comfortable and it felt like a nice treat at the end of long day. The staff is very friendly, specially Tiffani and Laura at the reception desk. They were very helpful and welcoming, always greeting you with a big smile and making sure we were doing fine. I will definitely stay there on my next visit.
Staff was amazing! Breakfast had so many options, quiche, waffles, fresh fruit, sausage, hard boiled eggs…. Room was very clean. Small market store in lobby. Lobby area with a tv and tons of seating. Nice workout room. But again, staff was incredible!
The room was clean and comfortable and the gym was good. However, I gave the hotel 3 stars because the shower lets out so much water that it is actually wasting water. There's no door for the shower, so when you bathe, the water streams out of the shower and onto the bathroom floor. So much water streams out that I had to place the bathmat 12 inches away from the shower entrance so that it wouldn't get wet.
The check in was super nice. The air conditioner was making a lot of noise - a racket. We had to complain multiple times. But they did respond 🙄 after the third vociferous complaint and replaced compressor. Friendly maintainence team , Barry the maintainence executive brought in a lot of smiles with his attitude.
We love staying here when we come to visit our family. Every stay has been wonderful. The room is very comfortable. We love the gym and the breakfasts. Having a nice laundry area on the premises is also a huge plus. The best part is the fantastic staff-everyone is so nice and helpful. Thank you for always making our trips memorable.
David
Stayed 7 nights in May 2025
Verified
6/10 Okay
Tian
30 May 2025
Disliked: Staff & service, amenities
It smelled musky and like urine in our room and much of the facility just smelled like cleaning supplies. The wifi wasn’t great in the room. The location is decently close to Duke, but the immediate area is at a street intersection right by a gas station. There was plenty of parking for pay by mobile 15$.