San Francisco Holidays

Book a Hotel + Flight or Car together to unlock savings

Photo by Panama Roadrunner

Where to stay in San Francisco

Find the best San Francisco areas and neighborhoods for the activities you enjoy most. Learn more about San Francisco
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Casco Viejo

3.5/5(3 area reviews)

Unique features of Casco Viejo include the historical sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

Find hotels in Casco Viejo

Top hotels in San Francisco

Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

4 out of 5
Av. Balboa con Calle 53 Panama City Panama
Fully refundableReserve now, pay when you stay
The price is 4.601.357 ₫ per night from 16 Jan to 17 Jan
4.601.357 ₫
5.061.466 ₫ total
16 Jan - 17 Jan 2026
includes taxes & fees
8.8/10 Excellent! (1,013 reviews)
It was a very nice stay. The room is nice, organized and clean with a great view of the city. The blankets are a little too warm and we wished for a lighter blankets. Breakfast buffet was very good with many food choices and best custom eggs cooked tailored to our demands. Uber to Casco Viejo was ...

Reviewed on 15 Dec 2025

Las Americas Golden Tower Panama
Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
Avenida Balboa Panama City
Fully refundableReserve now, pay when you stay
The price is 3.216.604 ₫ per night from 20 Dec to 21 Dec
3.216.604 ₫
3.538.264 ₫ total
20 Dec - 21 Dec
includes taxes & fees
8.4/10 Very Good! (1,267 reviews)
First time stay was nice .

Reviewed on 12 Dec 2025

Megapolis Hotel Panamá
Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel

3.5 out of 5
Italy Avenue, Punta Paitilla Panama City Panama
Fully refundableReserve now, pay when you stay
The price is 2.839.841 ₫ per night from 17 Dec to 18 Dec
2.839.841 ₫
3.123.957 ₫ total
17 Dec - 18 Dec
includes taxes & fees
9.2/10 Wonderful! (2,133 reviews)
Everything! View breakfast friendliness

Reviewed on 13 Dec 2025

Plaza Paitilla Inn Hotel
See all 1,697 properties in San Francisco
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a San Francisco holiday package cost?
Much less than you might think — from a low , in fact! By bundling hotels, flights and car rentals into a custom-built holiday package, your San Francisco escape is only clicks away.
How do I get a cheap travel package to San Francisco?
Lock in flights that suit your schedule, add a hotel to your booking and watch how much you save with a San Francisco holiday package. It's that easy! From flights and hotels to rental cars and activities, Expedia makes travelling on the cheap easy. And with more than 550 partner airlines and 1null000null000 hotel options around the globe to pick from, you'll never be short of choice.
Where should I stay in San Francisco?
Make sightseeing easy by staying near San Francisco's main attractions. Miraflores Locks and Metropolitan Cathedral of Panama are two which top many visitors' bucket lists.
What are the top hotels in San Francisco?
If this will be your first visit to San Francisco, secure a room at Sublime Apartment City Centre. Ph Boutique Quartier Atlapa or New Cosy Apartment Ocean View. Quartier Del Mar. Both hotels will make you feel at home and are popular options with lots of travellers.
How far in advance should I book my San Francisco holiday?
It can be hard to know when is the ideal time to book your trip to San Francisco. But typically the earlier you book, the lower the prices. Sometimes, you can reserve your flights and hotels up to a year prior to your departure date. If you're eager to escape on a last-minute getaway, no need to fret! There are unbeatable deals announced on Expedia every day.
What does an Expedia San Francisco travel package include?
That mostly depends on you. You can choose from a range of San Francisco packages, such as a hotel, rental car and flight. You can also book a hotel and a flight, or a flight and a rental car. Once you've made your booking, you can add the fun stuff like experiences and tours. Whatever your ideal San Francisco holiday looks like, you're sure to save!
What should I know before booking a San Francisco travel package?
So many places to go, so many things to see and do. With a travel package, you'll be able to afford more of them. Bundle your hotels, flights and rental cars and land big savings.
Can I choose my airline with a San Francisco Expedia holiday package?
Yes, definitely. Expedia has more than 550 airline partners to choose from worldwide. With such a huge range of choice, finding the ideal carrier to whisk you off to San Francisco won't be difficult.
If I'm not able to travel, can I cancel my San Francisco holiday package?
Your situation can change in a flash, so yes, you can. You may be able to amend or cancel your San Francisco holiday package for free if you've booked in the last 24 hours. For older bookings, you can still make changes, but your car rental company, airline or hotel may charge a fee. Need more information? Look up our Customer Service Portal. We'll help make sure your trip goes off without a hitch.

Popular places to visit

Multiplaza Pacific Mall

Multiplaza Pacific Mall

4.5/5(8 reviews)

During your trip to Panama City, you can search for that perfect souvenir at Multiplaza Pacific Mall. You can enjoy the restaurants while in the area.

Multiplaza Pacific Mall
Cinta Costera

Cinta Costera

4/5(5 reviews)

Explore the great outdoors at Cinta Costera, a lovely green space in Panama City. While you're in the area, stroll along the seaside.

Cinta Costera
Avenida Balboa

Avenida Balboa

3.5/5(9 reviews)

You can browse for the perfect souvenirs at Avenida Balboa during your stay in Panama City. While you're in the area, wander around the natural setting.

Avenida Balboa